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다발성 간종괴의 형태로 나타난 특발성 과호산구 증후군 치험1예
최승오,연규민,이승민,김순제,왕준호,박형석,이재동,진춘조,이창훈,신현준,김정은 건국대학교 의과학연구소 2004 건국의과학학술지 Vol.14 No.-
Hypereosinophilic syndrome is characterized by persistent blood eosinophilia of 1,500/ul or more in the absence of known causes and multiorgan dysfunction by eosinophil-related tissue damage. In Korea, some cases of hypereosinophilic syndrome with hepatic involvement have been described with prolonged benign clinical courses. Most of them were diffuse or multifocal lesions in imaging studies, and a few case presenting as a single mass has been described. Here we report a case of hypereosinophilic syndrome with hepatic involvement in a 65-year-old man who presented with multifocal mass lesions. By abdominal US and CT scan, multiple, ill-defined nodules were detected in throughout the liver. Liver biopsy revealed severe eosinophilic hepatitis, suggestive of hypereosinophilic syndrome. Hepatic mass lesions improved after steroid administration for several weeks.
Seung-Hyun Wang,Jung-Hyun Lim,Yasuhito Sakuraba,Nam-Chon Paek 한국육종학회 2015 한국육종학회 심포지엄 Vol.2015 No.07
Lesion mimic mutants commonly display spontaneous cell death in pre-senescent green leaves under normal conditions, without pathogen attack. Despite molecular and phenotypic characterization of several lesion mimic mutants, the mechanisms of the spontaneous formation of cell death lesions remain largely unknown. Here, we examined the rice lesion mimic mutant spotted leaf3 (spl3). In mutants grown under a light/dark cycle, spl3 mutants appeared similar to wild type at early developmental stages, but lesions gradually appeared in the mature leaves close to heading stage. By contrast, in mutants grown under continuous light, severe cell death lesions formed in developing leaves, even at the seedling stage. Histochemical analysis showed that hydrogen peroxide accumulated in the mutants, likely causing the cell death phenotype. By map-based cloning and complementation, we showed that a 1-bp deletion in the first exon of Oryza sativa Mitogen-Activated Protein Kinase Kinase Kinase1 (OsMAPKKK1)/OsEDR1/ OsACDR1 causes the spl3 mutant phenotype. We found that the spl3 mutants were insensitive to abscisic acid (ABA), showing normal root growth in ABA-containing media and delayed leaf yellowing during dark-induced and natural senescence. Expression of ABA signaling-associated genes was also less responsive to ABA treatment in the mutants. Furthermore, the spl3 mutants had lower transcript levels and activities of catalases, which scavenge hydrogen peroxide, probably due to impairment of ABA-responsive signaling. Finally we discuss a possible molecular mechanism of lesion formation in the mature leaves of spl3 mutants.
재래종 유래 찰옥수수 교잡종의 주요 농업 및 식미 관련 형질에 대한 이면교잡 분석
왕승현(Seung Hyun Wang),정종욱(Jong Wook Chung),강민정(Min jeong Kang),심완석(Wan Seok Shim),소윤섭(Yoon Sup So) 한국육종학회 2018 한국육종학회지 Vol.50 No.1
본 연구는 국내 수집 재래종 찰옥수수로부터 개발된 얇은 과피를 가진 찰옥수수 원종을 이용하여 원종간 반이면교배조합의 평가를 통해 주요 농업 및 식미 관련 형질에 대한 이면교잡분석을 실시하여 찰옥수수 품종 개발 시 중요한 관심 형질들의 일반 및 특수조합능력을 파악하여 앞으로의 품종개발 과정에서 tester로써 사용할 원종들을 선발할 목적으로 실시되었으며 그 결과를 요약하면 다음과 같다. 1. 대비품종을 포함하는 모든 14개 공시 교잡종의 2개 지역통합 분산분석 결과 지역과 교잡종간의 상호작용이 유의한 형질은 간장, 착수고, 주당 분얼수, 이삭당 무게, 끝달림 정도, 상품성 그리고 당도로 나타났다. 2. 대비품종을 제외한 반이면교배조합 10개 교잡종만을 가지고 실시한 이면교잡분석에서 일반조합능력과 지역간 상호작용 효과의 유의성이 인정된 형질은 착수고, 주당 분얼수, 이삭당 무게, 이삭 길이, 당도 였으며 특수조합능력과 지역간 상호작용 효과의 유의성은 이삭폭, 상품성 및 당도에서만 인정되었으며 당도는 모든 조합능력에서 지역간 상호작용이 나타났다. 3. 일반조합능력의 추정값은 첫 번째 원종과 네 번째 원종에서 선발에 긍정적인 영향을 미치는 형질에서 유의성이 인정된 것이 많았다. 4. 첫 번째 원종은 출사기, ASI, 출사기의 누적적산온도, ASI의 누적적산온도, 이삭폭, 이삭둘레 그리고 당도에서 품종의 특성을 향상시키는 일반조합능력을 장점이 있었으며 포엽감쌈정도에서는 단점으로 작용하였다. 5. 네 번째 원종의 일반조합능력을 살펴보면 이 원종과의 교배조합에서는 출웅기, 출사기, 출웅기의 누적적산온도, 출사기의 누적적산온도, 간장, 착수고, 이삭당 무게, 이삭길이를 향상시킬 것으로 기대되나 질김성은 다소 높게 나타날 것으로 기대된다. 6. 조사 형질 21개 중 19개의 형질에서 일반조합능력 분산이 특수조합능력 분산에 비해 높게 나타났으며 특히 포엽의 감쌈정도는 그 비율이 12.1로 매우 높게 나타났다. 이에 반하여 간장과 주당 분얼수는 특수조합능력 분산이 더 높게 나타났는데 이 중 간장은 그 비가 0.2로 특수조합능력의 분산이 매우 높은 형질로 조사되었다. This study was carried out to select waxy corn inbreds with good general combining ability through a diallel analysis of 10 half diallel crosses among five inbreds developed from Korean maize landraces. Total of 21 agronomic and palatability traits were investigated over two locations in 2016. There was a significant hybrid by location interaction found in plant height, ear height, number of tillers/plant, per ear weight, ear tip filling, ear commercial value and sweetness when four additional check cultivars were included in the analyses. A significant general combining ability by location interaction was found in ear height, number of tillers/plant, per ear weight, ear length and sweetness while ear width, ear commercial value and sweetness were significant for specific combining ability by location interaction. Sweetness was found significant for both interactions. The first and fourth inbred lines had the most number of traits with good estimate of general combining ability. The first inbred is expected to improve days to tasseling, anthesis silking interval, ear width, ear circumference and sweetness while decreasing husk cover in a hybrid combination. The fourth inbred line would improve days to tasseling, days to silking, plant height, ear height, per ear weight and ear length but ears would be a bit tougher than the average. A total of 19 traits had higher variance of general combining ability than that of specific combining ability. Husk cover was 12.1 times higher. Plant height and number of tillers/plant had higher variance of specific combining ability.
Kang, Hyun-Seung,Moon, Youn-Joo,Kim, Young-Yim,Park, Woong-Yang,Park, Ae Kyung,Wang, Kyu-Chang,Kim, Jeong Eun,Phi, Ji Hoon,Lee, Ji Yeoun,Kim, Seung-Ki Journal of Neurosurgery Publishing Group 2014 Journal of Neurosurgery Vol.120 No.2
<B>Object</B><P>Moyamoya disease (MMD) is a cerebrovascular occlusive disease affecting bilateral internal carotid termini. Smooth-muscle cells are one of the major cell types involved in this disease process. The characteristics of circulating smooth-muscle progenitor cells (SPCs) in MMD are poorly understood. The authors purified SPCs from the peripheral blood of patients with MMD and sought to identify differentially expressed genes (DEGs) in SPCs from these patients.</P><B>Methods</B><P>The authors cultured and isolated SPCs from the peripheral blood of patients with MMD (n = 25) and healthy control volunteers (n = 22). After confirmation of the cellular phenotype, RNA was extracted from the cells and DEGs were identified using a commercially available gene chip. Real-time quantitative reverse transcription polymerase chain reaction was performed to confirm the putative pathogenetic DEGs.</P><B>Results</B><P>The SPC-type outgrowth cells in patients with MMD invariably showed a hill-and-valley appearance under microscopic examination, and demonstrated high α-smooth muscle actin, myosin heavy chain, and calponin expression (96.5% ± 2.1%, 42.8% ± 18.6%, and 87.1% ± 8.2%, respectively), and minimal CD31 expression (less than 1%) on fluorescence-activated cell sorter analysis. The SPCs in the MMD group tended to make more irregularly arranged and thickened tubules on the tube formation assay. In the SPCs from patients with MMD, 286 genes (124 upregulated and 162 downregulated) were differentially expressed; they were related to cell adhesion, cell migration, immune response, and vascular development.</P><B>Conclusions</B><P>With adequate culture conditions, SPCs could be established from the peripheral blood of patients with MMD. These cells showed specific DEGs compared with healthy control volunteers. This study provides a novel experimental cell model for further research of MMD.</P>
Circulating Vascular Progenitor Cells in Moyamoya Disease
Kang, Hyun-Seung,Wang, Kyu-Chang,Kim, Seung-Ki The Korean Neurosurgical Society 2015 Journal of Korean neurosurgical society Vol.57 No.6
Various approaches have been attempted in translational moyamoya disease research. One promising material for modeling and treating this disease is vascular progenitor cells, which can be acquired and expanded from patient peripheral blood. These cells may provide a novel experimental model and enable us to obtain insights regarding moyamoya disease pathogenesis. We briefly present the recent accomplishments in regard to the studies of vascular progenitor cells in moyamoya disease.