40세 이하 관상동맥 질환자에서 장기적 임상 관찰

이승욱,정명호,박종철,박형욱,조상희,김원,김계훈,이상현,강경태,조장현,김남호,김건형,안영근,조정관,박종춘,강정채 全南大醫大 2001 전남의대학술지 Vol.37 No.2

한우, 칡소 및 제주 흑우 Calpain-Calpastatin 유전자 다양성

이승환,김승창,조수현,최봉환,Aditi Sharma,임다정,당창권,장선식,김재환,고문석,양보석,강희설 충남대학교 농업과학연구소 2013 농업과학연구 Vol.40 No.2

The aim of study was to investigate genetic diversity for the calpain/calpastatin gene in three Hanwoo breeds [(Brown (n=62), Brindle (n=81) and Jeju Black (n=30)]. Random samples from three breeds of Hanwoo were selected and genotyped for the 7 SNPs of calpain/calpastatin using TaqMan method. Allele frequencies were investigated for CAPN1/CAST gene. Allele frequency of CAST2 SNP was 0.75, 0.59 and 0.22 for Brown, Brindle and Jeju black, respectively. The CAST3 revealed allele frequency of 0.59 and 0.57 in Brown and Jeju Black, while it showed very low allele frequency (0.07) in Brindle. In particular, favorable allele (G allele) for the CAPN1-2 SNP which was shown a strong association with tenderness in Taurine and Indicine cattle revealed 16% and 17% higher allele frequency in Brown Hanwoo (0.82) comparing Brindle (0.66) and Jeju Black Hanwoo (0.65). AMOVA demonstrated that among population variance occupied only 10% of total variance and among individual variance was 0%, while within individual variance was 90% of total variance. This result showed that population effect contributed very small portion of genetic to these three Hanwoo breeds, while within individual variance contributed large portion of genetic diversity within these Hanwoo breeds. In conclusion, three Hanwoo breeds (Brown, Brindle and Jeju black) showed a genetically homogeneous based on the 7 SNPs of CAPN1/CAST gene and it came from same ancestor to form modern Hanwoo breed.

여성 복압성요실금 환자에서 안정 시 방광조영술상 Inverted Tear-drop Sign의 의의

오승준,문경현,주명수,조경식 大韓泌尿器科學會 2001 Korean Journal of Urology Vol.42 No.4

비유피-4 정(염산프로피베린 20㎎)에 대한 건일염산프로피베린 정의 생물학적동등성

조혜영,박은자,강현아,백승희,김세미,박찬호,오인준,문재동,이용복 한국약제학회 2004 Journal of Pharmaceutical Investigation Vol.34 No.5

The purpose of the present study was to evaluate the bioequivalence of two propiverine hydrochloride tablets. BUP-4 (Jeil Pharm. Co., Ltd.) and Kuhnil Propiverine Hydrochloride (Kuhnil Pharm. Co., Ltd.), according to the guidelines of the Korea Food and Drug Administration (KFDA). The propiverine release from the two propiverine hydrochloride formulations in vitro was tested using KP Ⅷ Apparatus Ⅱ method with a variety of dissolution media (pH 1.2, 4.0, 6.8 buffer solutions, water and blend of polysorbate 80 into pH 6.8). Twenty six healthy male subjects, 23.73 ± 2.79 years in age and 67.04 ± 7.93 kg in body weight, were divided into two groups and a randomized 2 x 2 cross-over study was employed. After one tablet containing 20 mg as propiverine hydrochloride was orally administered, blood was taken at predetermined time intervals and the concentrations of propiverine in serum were determined using HPLC method with UV detector. The dis-solution profiles of two formulations were similar at all dissolution media. Besides, the pharmacokinetic parameters such as AUC" C _(max) and T _(max) were calculated and ANOVA test was utilized for the statistical analysis of the parameters using logarithmically transformed AUC, C_(max), and untransformed T_(max). The results showed that the differences between two formulations based on the BUP-4 were 0.17%, 7.98% and 4.55% for AUC,, C_(max), and respectively. There were no sequence effects between two formulations in these parameters. The 90% confidence intervals using logarithmically trans-formed data were within the acceptance range of log(0.8) to log(1.25) (e.g., log(0.88)-log(l .12) and log(0.90)-log(l.15) for AUC, and _(max), respectively). Thus, the criteria of the KFDA bioequivalence guideline were satisfied, indicating Kuhnil Propiverine Hydrochloride tablet was bioequivalent to BUP-4 tablet.

급성세균성전립선염의 임상적 특징 및 치료 결과

조수연,배웅진,조용현,이승주 대한감염학회 2009 감염과 화학요법 Vol.41 No.1

Background : Acute bacterial prostatitis is an uncommon male urinary tract infection that is the result of severe prostatic infection mainly by gram-negative bacteria. We conducted a retrospective study to report clinical outcomes of patients with acute bacterial prostatitis. Materials and Methods : The clinical records of 49 patients diagnosed with acute bacterial prostatitis were reviewed retrospectively and patients' symptoms, investigations, and treatments were analyzed. Results : All patients presented with fever and voiding symptoms. Some patients (22.4%) had a history of prior manipulation of the lower urinary tract including transrectal prostate biopsy. Urine cultures were positive for 51% of the patients. The most common pathogen was Escherichia coli (60%), followed by Pseudomonas aeruginosa (20%) and Staphylococcus aureus (12%). The ciprofloxacin susceptibility against E. coli was 80%. All patients were treated with parenteral antibiotics in the hospital followed by oral antibiotics for average of three weeks. The major drugs used for empirical treatment were cephalosporins, aminoglycosides, and fluoroquinolones. Prostatic abscess was found in two (4.1%) Patients and chronic pelvic pain syndrome developed in six (12.2%) patients during follow-up. Conclusion : The currently used empirical antibiotics were mostly effective in the treatment of acute bacterial prostatitis. Continuous monitoring on antimicrobial susceptibility of acute bacterial prostatitis was necessary for providing proper treatment guideline.

다중 제어루프에 의한 자기부상용 DC-DC 전원장치에 관한 연구

조주현,조정민,전기영,이상집,이승환,오봉환,이훈구,한경희 明知大學校 産業技術硏究所 2004 産業技術硏究所論文集 Vol.23 No.-

The author present a modified multi-loop algorithm including feedforward for controlling a 55kW step down chopper in the power supply of Maglev. The control law for the duty cycle consists of three terms. The first is the feedforward term which compensates for variations in the input voltage. The second term consists of the difference between the slowly moving inductor current and output current. The third term consists of proportional and integral terms involving the perturbation in the output voltage. This perturvation is derived by subtracting the desired output voltage from the actual output voltage. The proportional and integral action stabilizes the system and minimizes output voltage error. In order to verify the validity of the proposed multi-loop controller, simulation study was tried using Matlab simulink.

4종 전자근관장측정기의 정확성과 일관성에 관한 in vitro 연구

조재현,금기연,이승종 대한치과보존학회 2006 Restorative Dentistry & Endodontics Vol.31 No.5

이번 연구는 서로 다른 4개의 전자근관장측정기의 정확성을 측정하고 각각 0.5지점과 Apex지점에서의 일관성을 비교하고자 하였다. 40개의 발치된 상하악 소구치를 대상으로 치수강 개방 후 alginate model에 고정시키고 근관장을 측정하였다. 사용된 전자근관장측정기는 Root ZX (Morita, Tokyo, Japan), SmarPex (META, Seoul, Korea), Elements Diagnostic Unit (SybronEndo, CA, USA), E-Magic Finder Deluxe (S-Denti, Seoul, Korea)이다. 먼저 모든 치아에서 4개의 전자근관장측정기를 사용하여 0.5지점과 Apex지점에서 근관장을 측정하여 한 치아당 8개의 측정값을 얻었다. 다음으로 치아를 각 전자근관장측정기당 10개씩 4개의 그룹으로 나누어, 각각 제조사의 지시대로 Root ZX, Elements Diagnostic Unit 및 E-Magic Finder Deluxe는 "0.5"지점에서, SmarPex는 ''Apex" 지점에서 file을 치아에 cement로 고정시켰다. 이후 치근단부 4 mm를 삭제하여 100배율의 Image ProPlus로 관찰하여 file 끝에서 주근단공의 외연까지의 실제거리를 측정한 후, 4개의 전자근관장측정기의 0.5지점 및 Apex지점에서 file 끝과 주근단공 사이의 거리를 계산하여 비교하였다. 그 결과 Root ZX와 E-Magic Finder는 실험군 100%, SmarPex는 90%, Elements Diagnostic Unit는 70%에서 주근단공과의 거리가 임상적 허용범위인 土0.5 mm 이내에 있었다. 또한 각 전자근관장측정기마다 0.5지점과 Apex지점에서의 근관장의 표준편차와 사분위 범위를 구하여 두 지점간의 일관성을 비교한 결과, Root ZX, E-Magic Finder는 0.5지점과 Apex지점에서 비슷한 일관성을 보였으며 SmarPex와 Elements Diagnostic unit는 Apex지점에서 0.5지점보다 더 높은 일관성을 보였다. 전자근관장측정기는 근관 내의 조건에 관계없이 근첨협착부에서 항상 일정한 거리를 재현해 낼 수 있는 일관성이 중요하므로, 이렇게 0.5지점 또는 Apex지점에서의 일관성이 증명된다면 실제 임상에서 사용할 때 전자근관장에서 일정한 거리를 가감하여 사용할 수 있다. The purpose of this study was to evaluate the accuracy and the consistency of four different electronic apex locators in an in vitro model. Fourty extracted premolars were used for the study. Four electronic apex locators (EAL) were Root ZX, SmarPex, Elements Diagnostic Unit (EDU), and E-Magic Finder Deluxe (EMF). After access preparation, the teeth were embedded in an alginate model and the length measurements were carried out at "0.5" and "Apex" mark using four EALs. The file was cemented at the location of the manufacturers' instruction (Root ZX, EDU, EMF: 0.5 mark, SmarPex: Apex mark). The apical 4mm of the apex was exposed and the distance from the file tip to the major foramen was measured by Image ProPlus (× 100). The distance from the file tip to the major foramen was calculated at 0.5 and Apex mark and the consistency of 0.5 and Apex mark was compared by SD and Quartile of Box plots. In this study, Root ZX and EMF located the apical constriction accurately within ± 0.5 mm in 100%, whereas SmarPex and EDU located in 90% and in 70% respectively. For Root ZX and EMF, there was no significant difference between the consistency of 0.5 and Apex mark. However, for the EDU and SmarPex, Apex mark was more consistent than 0.5 mark. From the evaluation of the consistency in this study, for Root ZX and EMF, both 0.5 and Apex mark can be used as a standard mark. And for EDU and SmarPex, the Apex mark can be recommended to be used as a standard mark.

新興家內工業의 地域形成과 存立形態 : 全南 海南郡 黃山面 옥연의 옥돌工藝業을 中心으로 Hwangsan-myeon, Haenam-gun, Chonnam Province

曺勝鉉 全南大學校 人文科學硏究所 1985 용봉인문논총 Vol.15 No.-

The purpose of this thesis is to investigate how agalmatolite-product domestic industry has grown in Ockyeon village. Through this case study, it is hoped that we can shed some light on the origin and formation process of Korean traditional handicraft industry. The primary data for the present study were collected by utilizing interview schedule. In addition, informal interviews were held to all producers. The study results can be summarized as the followings : 1) The agalmatolite-product industry in this area was originated from a village which is located 10km away from Ockyeon village, in 1930s. But one of the producers migrated to Ockyeon village in 1959. After this happened, the village had become a new center of the industry. The major reason for this relocation- diffusion was that it was much easier to acquire the material, i.e., agalmatolite, in Ockyeon village than in the original village. It is noted that the industry is material-oriented one in its nature. 2) The development of the industry can be marked by two phases : the first phase covers 1959 ~ 1969 time period, and the second phase falls into 1970 ~ 1985 time period. The first phase refers to the period when the products were made through handicraft. The second phase characterized by the use of machines in its production. During this phase, the products became more diverse, and production level increased. 3) The industry is not specialized in terms of production and merchandizing. With respect to specialization, it is also noted that about half of the producers have additional jobs.

환경친화적 수용성 대전방지제의 합성 및 그 응용에 관한 연구

조승현,하진욱 순천향대학교 부설 산업기술연구소 2001 순천향 산업기술연구소논문집 Vol.7 No.2

Water soluble anti-static coating composition(AS-2001), multi-functional(anti-static and slip-stop)and anti-static functional paint coating agents were formulated. Firstly, the multi-functional coating agents were formulated with AS-2001 and slip stop(SㆍS) with water-born polyurethane. The additive of multi-functional coating agent varied from 5 to 12 wt%, depending on the amount of polyurethane used. The optimum amount of coating agent was 10 wt%, The ratio of coating composition AS-2001: SㆍS was 8:2. The surface resistance and friction factor of coated layer were 10^(9)Ω/㎠ and 0.88 in optimum condition, respectively. Secondly, the anti-static functional paint was formulated with AS-2001 and water soluble paint. The additive amounts of AS-2001 are varied from 5 to 20 wt% depending on the amount of water soluble paint. Results showed that the surface resistance of coated gypsum board decreased up to 10^(6)Ω/㎠ as the amount of coating agent increased. However, water soluble paint was aggregated in 20wt% addition of AS-2001, causing coating problems. Anti-static and anti-stain effects were excellent even though 5 wt% of AS-2001 was added in the board.

파킨슨씨병에서 Selegiline HCI (MAO-B^(�))의 효과 및 안전성

조기현,김명규,김태선,김병채,이승한,황인용,김준태,김종기 全南大醫大 2000 전남의대학술지 Vol.36 No.2