우리나라 간암 환자에서의 Cytochrome P450 2E1 유전자의 다형성에 관한 연구

백승운,윤정한,황유진,장유현,이효석,김정룡 大韓消化器病學會 1997 大韓消化器病學會誌 Vol.30 No.4

抗癌丹을 投與한 胃癌 患者 105例에 對한 臨床報告

유화승,최우진,이용연,서상훈,조정효,이연월,손창규,조종관 대전대학교 한방병원 2000 惠和醫學 Vol.9 No.2

Clinical studies were carried out 105 cases of patients with stomach cancer treated by Hangamdan(抗癌丹) from January 1th 1998 to September 30th 2000. The results were summarized as follows; 1. Distribution of those attached by stomach cancer, by sex, showed that Male is more then Female, by age, showed that the number of forties, fifties, sixties are majority. 2. Distribution of diagnostic stage, in descending order; stage Ⅲ(45.1%, top), stage Ⅳ(40.2%). 3. The effects of maintenance and improvement in the symptoms with traditional oriental therapy(77.8%) and combined treatment of western and oriental therapy(92.3%) were observed. The effects of the symptoms were as follows; abdominal pain (16.3%), general body weakness(10.5%), nausea&vomiting (8.6%), diarrhea(6.7%) and etc, in orders. 4. Analysis of hematology attached by stomach cancer, maintenance and increasing of WBC(89.4%), RBC(63.6%), Hgb(62.3%), Platelet(95.6%) were observed. After taken Hangamdan, the safety of the liver and kidney were as follows; maintenance and decreasing of AST(85.3%), ALT(91.6%), BUN(84.8%), Creatinine(92.4%) were observed. 5. Analysis of IL-12 and IFN-γ attached by stomach cancer, increasing of IL-12(39.1%), IFN-γ(69.6%) were observed. 6. Analysis of QOL attached by stomach cancer, maintenance and improvement of combined treatment of western and oriental therapy(91%), traditional oriental therapy(85.2%) were observed. 7. Analysis of survival in patients with Ⅳ stage of stomach cancer, above 6 months(17.1%), 12 months(85.2%) were observed. 8. Analysis of antitumor effects, maintenance of traditional oriental therapy(81.5%) and maintenance and improvement of combined treatment of western and oriental therapy(89.7%) were observed. Analysis of tumor marker attached by stomach cancer, maintenance of CEA(85.7%) were observed. 9. Analysis of curative valuation, maintenance and improvement of traditional oriental therapy(77.7%), combined treatment of western and oriental therapy(82.1%) were observed. From the above results, it is suggested that Hangamdan has significant effects of antitumor and immune activity, also could be usefully applied for stomach cancer patients by combination with western therapy or alone.

急性 骨髓性 白血病 患者 1例에 對한 臨床報告

조정효,유화승,최우진,이용연,서상훈,이연월,손창규,조종관 대전대학교 한방병원 2000 惠和醫學 Vol.9 No.2

AML is the most common type of leukemia in adults. AML(acute myeloid leukaemia) is characterised by a rapid accumulation of abnormal white blood cells in the blood and bone marrow, resulting in severe anemia, and possibly infection, and hemorrhage during the course of the disease. In general the prognosis of patient with relapsed AML is poor. At this time, however, the only potentially curative therapy for relapsed patients is allogeneic BMT(bone marrow transplantation). This clinical study were carried out 1 case of female patient aged 44 with relapsed AML treated by herb medicine. At the time of admission, she complained of mild fever, nausea, vomitting, abdominal pain, anorexia and no sign of bleeding. For the 10 days of admission, she was treated with Oriental-Western medicine and all the symptoms were disappeared. After that, the syptoms were aggravated because of secondary infection. Anyway, above result showed the possibility of Oriental therapy as Supportive Care in AML.

부력기구를 활용한 수중운동 프로그램이 편마비 환자의 보행 동작에 미치는 효과

홍승범,조효구,정태운 용인대학교 특수체육연구소 2009 특수체육연구 Vol.6 No.-

본 연구는 부력기구를 활용한 수중운동 프로그램이 편마비 환자의 보행동작에 미치는 효과를 분석하는데 목적이 있다. 대상자는 S시 B복지관을 이용하고 독립보행이 가능하지만 수중운동 프로그램에 참여 경험이 없는 뇌졸중 좌측편마비 환자 21명중 7명을 무선표집법에 의해 선정하였다. 수중운동 프로그램을 실시 한 후 신체중심 이동, 보행 주기, 다리관절각, 다리관절 각속도의 자료를 분석하기 위하여 SPSS ver. 13.0 통계프로그램을 이용하여 대응표본 t-test를 실시하였다. 이상의 자료 분석 결과를 기초로 도출한 연구의 결론은 다음과 같다. 첫째, 보행주기는 환측의 입각기와 단일지지기의 비율이 향상되고, 환측과 건측의 비율 차이가 줄어들어 보행주기가 개선된 것으로 나타났다. 둘째, 신체중심의 이동은 거리가 늘어나고 시간은 줄어들어 속도가 빨라지는 결과는 수중운동프로그램이 편마비 환자의 보행 동작에서 신체중심 이동에 영향을 미친것으로 나타났다. 셋째, 관절각은 환측의 사전 측정결과 보다 관절각이 커지고 건측의 사전 측정결과 보다 작아져 수중운동 프로그램 참여 후에 환측과 건측의 좌우불균형이 개선된 것으로 나타났다. 넷째, 관절각속도는 보행주기에서 나타난 근력향상과 관절각 결과에서 나타난 관절가동범위 향상으로 인해 관절각속도 또한 긍정적인 결과를 보이며, 특히 모든 관절이 입각기 시 보다 유각기에서 각속도가 개선된 것으로 나타났다. The purpose of this research is to investigate the effects of the underwater exercise program that utilizes buoyancy appliances on the hemiplegics’ walking. The subjects are selected randomly among 21 patientswho have had been hemiplegic more than 5 years in B Rehabilitation Center in Seoul. The final 7 patients who had no exercise with left side hemiplegia were selected. After they have participated in 8-week underwater exercise program, central body movement, gait cycle, the angle of legs joints and the angular speed of leg joints are analyzed with paired t-test using statistics program, SPSS 13.0. Based on the analysis of collected data, this research makes following conclusions. First, while the subject is walking, there is increase in displacement for central body movement and decrease in time resuted in increase in speed. This result made the central body movement affected the gait. Second, Improvement in the ratio of stance phase to single needling support phase and decrease in the ratio difference between hemiplegic and normal side leads to improvement of gait cycle. Third, the disparity between hemiplegic and normal side have improved with increase of the angle of leg joint for hemplegic side and decrease of the normal side after participating in the underwater exercise program. Lastly, as a result of muscular strengthening from gait cycle and range increase of joint angle, angular speed also shows improvement, especially in the swing phase compared to stance phase.

회전하는 유연한 조작기의 진동 해석

김승호,하영균,정승호,박영필,황효성 연세대학교 산업기술연구소 1985 논문집 Vol.17 No.2

An analytical and experimental investigation is made to the dynamic response of a cantilever with a tip mass that models some of the basic phenomena involved in the response of a flexible manipulator with a tip mass on its free end under the given rotating motion. The system equation is derived from the Hamilton's principle on the basis of the Euler-Bernoulli hypothesis and an approximate solution is obtained from modal analysis using Galerkin's method for the vibration response of the system subjected to a sudden stop after an impulsive rotation. Experiment was performed to verify the validity of the theoretical analysis. Results are given for the vibration amplitude of the free end with respect to tip mass ratio, non-dimensionalized rotating velocity, rotating angle and non-dimensionalized hub length. The rotating condition to minimize the vibration amplitude of the free end can be determined for the given basic parameters.

DNA 증거의 집단유전학적 분석을 위한 SAS시스템

이효정,이혜승,한길로,이재원,황적준 大韓法醫學會 2000 대한법의학회지 Vol.24 No.1

DNA analysis has become one of the most powerful tools in forensic inference for human identification and is now used worldwide. It is used to be statistical technique for the individual identification of a civil and criminal action. The purpose of this article is computerization of the statistical technique for the population study and DNA evidence analysis. The system using SAS/AF and SAS/SCL is the graphic user interface and the correspondence of the changed experimental circumstances

한계계단 응답특성을 이용한 영구자석형 동기전동기 속도제어

박승엽,전인효,최중경 창원대학교 공작기계기술연구센터 1999 연구업적집 Vol.1 No.1

본 논문에서는 한계계단 응답특성을 이용하여 영구자석형 동기전동기의 속도 제어계에 대한 새로운 자동 동조 PI(Proportional Integral)제어기를 설계하였다. 과도응답 기간동안 소위 한계입력이라고 하는 계단입력을 인가하여 PI 제어기의 자동동조를 위한 정보를 얻기 위한 기법을 제안한다. 시스템 파라메터 추정과 동시에 속도제어가 온라인으로 이루어지는데, 이것은 시스탬의 불확실성에도 불구하고 한계입력에 의해서 얻어진 시스템 파라메터 정보가 연속적으로 PI 제어기에 적용될 수 있다는 것이다. 제안된 자동동조 알고리즘은 단조증가 계단응답 특성을 갖는 영구 자석형 동기전동기의 속도제어에 대한 시뮬레이션과 실험결과를 통하여 그 유효함을 확인하였다. In this paper, a new auto-tuning PI controller for the speed servo system of a PMSM is designed by using limited step response characteristics. The method is proposed that gets information about auto-tuning of PI regulator by the injection fo step input, called limited input, during a transient response time of control. System parameter estimation and speed control could be continuously executed. This means that in despite of system uncertainty the system information obtained by limited input can be continuously applied to the PI regulator. We demonstrate the effectiveness of the proposed auto-tuning algorithm through simulation and experiment result of the speed control for a PMSM having monotone increasing step response.

사하구 대기오염물질 배출원 자료체계 구축에 관한 연구

조효정,정장표,박명호,이승훈 慶星大學校 環境問題硏究所 1996 環境硏報 Vol.6 No.1

The air quality has been deteriorated dux to the rapid industrialization and the increase of traffic volume. Especially, the concentrations of air pollutants of Saha-Gu including Shinp'yong-Jangrim industrial complex showed severe air pollution level compared to other districts in Pusan. To establish proper and comprehensive cnntrol strategies for the reduction of air pollutant levels, the information on the emission quantities of air pollutants are necessarily needed. Although there are a few data on the emissions of air pollutants of various sourxes, the data have not been used enough dux to the deficiency of quality and content. Therefore, it is nexessary to establesh the data system of emission inventory for the purpose of being used in air quality management. In this study, the database program of emissions inventory was made using the clipper version 5.2 program. The major functions of datavase program are to estimate the emission quantities and contributions of air pollutants by the grid, the source scale, the source type, and the season in Saha-Gu.

경도관 동맥색전술을 이용한 비정상 자궁출혈의 치료

양승부,최교창,이상진,정영진,임한혁,한효상,황인철,조환성 순천향의학연구소 2005 Journal of Soonchunhyang Medical Science Vol.11 No.1

Objective : Our purpose of this study is to evaluate the effectiveness of the transcatheter arterial embolization for the management of abnormal uterine bleeding. Materials and Methods : 14 patients with massive or recurrent uterine bleeding underwent percutaneous transcatheter arterial embolization between February 2003 and September 2004. We reviewed 14 cases of uterine artery or internal iliac artery embolization using gelfoam or PVA particles. Results : Good management of uterine bleeding was achieved in 13 of 14(93%) cases. The cause of abnormal uterine bleeding was myoma(5 case), post D & E bleeding(3), acquired vascular malformation(3), pseudoaneurysm(1), adenomyosis(1), and endometrial hyperplasia(1). Conclusion : Transcatheter artery embolization is an effective and life-saving procedure in massive or recurrent uterine bleeding. Early diagnosis and prompt transcatheter arterial embolization is a useful mangement of uterine bleeding.

한국판 상호애착척도의 신뢰도와 타당도 연구(Ⅰ)

김휘중,원승희,임효덕 大韓神經精神醫學會 1999 신경정신의학 Vol.38 No.6

연구목적: 저자들은 West와 Sheldon-Keller가 성인애착을 평가하기 위해 개발한 상호애착척도(Reciprocal Attachment Questionnaire 이하 RAQ)를 우리나라의 사회문화적 배경에 적용가능한 척도로 표준화하기 위해 본 연구를 시행하였다. 방 법: 1998년 4월 29일부터 1998년 6월1일까지 경북대학교 의과대학에 재학중인 의학과 및 간호학과 학생 총 483명(남자: 234명, 여자:249명)을 대상으로 하였다. 한국판 상호애착척도(RAQ-K)의 신뢰도와 타당도를 검정하였고 이를 원 저자의 연구결과와 비교하였다. 결 과: 상호애착척도는 `애착 차원 척도`와 `애착유형 척도`로 나누어지는데, `애착차원 척도`는 5개의 하위척도로 이루어지고, `애착유형 척도`는 4개 하위척도로 구성되어 있다. 각 척도별로 결과는 다음과 같다. `애착차원 척도`의 경우 높은 검사-재검사 신뢰도와 하위척도간 상관관계를 보여 주었고, 하위척도의 내적일치도는 `유용성`과 `이용` 하위척도를 제외하고 높은 결과를 보여 주었다. `유용성` 하위척도는 13번 문항, `이용` 하위척도는 34번 문항이 문항-하위척도 상관관계가 유의하게 낮았다. `애착유형 척도`의 경우 높은 신뢰도를 보여 주었다. RAQ-K의 요인분석 결과 `애착차원 척도`와 애착유형 척도` 모두 이론적 구성처럼 두 개의 요인이 전체의 73.9%, 74.8%를 설명하여 높은 구성타당도를 보였다. 결 론: RAQ-K는 `유용성`·`이용` 하위척도를 제외하고 West와 Sheldon-Keller의 결과와 유사한 정도의 높은 신뢰도와 타당도를 보여 주었다. 향후 일부 문항의 재검정과 다양한 연령과 사회경제적 배경을 가진 집단에 대한 추가연구가 필요하다고 생각된다. Objective: The aim of this study was to develop the Reciprocal Attachment Questionnaire-Korean version(RAQ-K). Methods: The authors tested the reliability of dimensional and pattern scales of RAQ-K with Crohnbach`s alpha, test-retest reliability and interscale correlation, and construct validity with factor analysis. The subjects were Korean undergraduate students: 234 males and 249 females in the medical and nursing schools of Kyungpook National University. Results; The dimensional scale of RAQ-K proved to be reliable in terms of Crohnbach`s alpha coefficient except Availability and Use subscales, test-retest reliability and interscale correlation. The pattern scales of RAQ-K were reliable. Both dimensional and pattern scales were valid with two factor orthogonal rotation. Conclusion: The authors found RAQ-K retained available psychometric properties. But further study with some consideration to develop RAQ-K is expected. This research should assess samples of various age groups or various kinds of patients after considering two subscales. The authors stress that it is very important to consider the cultural difference between the East and the West and characteristics of Korean culture in developing a Korean version of foreign scales.