Comparison of controlled ovarian stimulation outcomes for fertility preservation in women with breast cancer according to KI-67, histologic grade, pathologic type, and cancer stage

( Eun Ji Oh ),( Yeon Hee Hong ),( Seul Ki Kim ),( Jung Ryeol Lee ),( Byung Chul Jee ),( Chang Suk Suh ),( Seok Hyun Kim ) 대한산부인과학회 2020 대한산부인과학회 학술대회 Vol.106 No.-

Objective: This study aims to analyze that specific prognostic factors such as Ki-67 value, histologic grade, pathology type, and cancer stage can affect controlled ovarian stimulation outcomes(COS) for fertility preservation in women with breast cancer. Methods: This retrospective cohort study included 92 patients with breast cancer aged 21-44 who underwent COS from August 2012 to April 2020, excluding patients with previous gonadotoxic therapy history. All COS cycles were conducted letrozole-combined random start GnRH antagonist protocol. COS outcomes were compared according to prognostic factors;Ki-67 (< 30% vs. ≥ 30%), histologic grade (low vs. high), and pathologic type (intraductal carcinoma(IDC) vs. triple-negative breast cancer(TNBC)), and cancer stage (early (I, II) vs. advanced (III, IV)). Multivariate analysis was also conducted to find any parameter that can impact over 10 mature oocytes acquisition. Results: Among the 92 patients, 42 were Ki-67≥30% compared to 49 of Ki-67<30%. The number of oocytes, and initial mature oocytes were comparable between Ki-67<30% and ≥30 group. The maturation rate was significantly higher in Ki-67≥30% group than Ki-67<30% group (57.4±36.8% vs. 44.8±28.3%, p=0.041). The same results were drawn when divided according to IDC or TNBC. The maturation rate was significantly higher in TNBC than the IDC group (73.0±17.6% vs. 47.0±28.1% p=0.001). However, the histologic grade or stage did not show any difference in COS outcomes between high and low grade or early and advanced stages. With multivariate analysis, age and AMH are parameters associated with the acquisition of over 10 mature oocytes (OR 0.863, 95% CI [0.755-0.987], OR 1.408, 95% CI [1.145-1.732], respectively). Conclusion: Either Ki-67 or pathologic type can be a potential reliable marker for predicting COS outcome, especially maturation rate. Further study with larger sample size with specific conditions is necessary to clarify the correlation between breast cancer prognostic factors and COS outcomes.

Possibility of Empowerment in The Surrendered by Chang-rae Lee

Seul Ki Lee Ewha Institute of English and American Studies 2022 Journal of English and American studies Vol.20 No.1

This paper supports the interpretation that the main characters in Chang-rae Lee’s The Surrendered find liberation in being surrendered. As a novel written by a recognized Korean-American writer about The Korean War, The Surrendered received many reviews concentrating on the author’s writing style and artistry. These early critics stated that the novel’s varying temporal and geographical shifts and the fact that the novel revolves around three different characters make the novel unnecessarily complex. In addition, the scholarly works that do analyze the novel concentrate on the trauma, disability, and post-traumatic stress disorder resulting from the violence. Although prior research touched upon the characters and the symbolism within the setting, I would like to do a more in depth analysis. I use the concept of “abjection” to analyze the symbolism of the three main characters: June, Hector, and Sylvia. All three characters have distinct individuals while also representing others who have survived the social situations they faced. Therefore, it is meaningful to analyze three characters and how they use their status as abjects to find a form of liberation and empowerment.

The Conjugated Double Bond of Coniferyl Aldehyde Is Essential for Heat Shock Factor 1 Mediated Cytotoprotection

Choi, Seul-Ki,Mun, Gil-Im,Choi, Eun,Kim, Seo-Young,Kwon, Youngjoo,Na, Younghwa,Lee, Yun-Sil American Society of Pharmacognosy 2017 Journal of natural products Vol.80 No.8

<P>Coniferyl aldehyde (1) is previously reported as a potent inducer of heat shock factor 1 (HSF1). Here, we further examined the active pharmacophore of 1 for activation of HSF1 using the derivatives coniferyl alcohol (2), 4-hydroxy-3-methoxyphenylpropanal (3), and 4-hydroxy-3-methoxyphenylpropanol (4). Both 1 and 2 resulted in increased survival days after a lethal radiation (IR) dose. The decrease in bone marrow (BM) cellularity and Ki67-positive BM cells by IR was also significantly restored by 1 or 2 in mice. These results suggested that the vinyl moiety of 1 and 2 is necessary for inducing HSF1, which may be useful for developing small molecules for cytoprotection of normal cells against damage by cytotoxic drugs and radiation.</P>

초등학교 고학년 학생의 장애아동에 대한 인식 조사

김보람,김호영,손유라,오진주,윤슬기,이효정,장문영 대한감각통합치료학회 2011 대한감각통합치료학회지 Vol.9 No.1

목적 : 초등학교 고학년 학생의 장애아동에 대한 인식을 알아보는 것이다. 연구방법 : 연구 대상은 김해시에 소재한 통합교육을 실시하지 않는 초등학교의 4, 5, 6학년의 비장애 아동이었다. 연구 기간은 2008년 10월 2일부터 10월 17일까지였으며, 설문지를 사용하였다. 설문지의 하위 영역은 사귐, 활 동, 학업 영역의 세 부분으로 각 10문항으로 이루어져 있으며 SPSS 12.0을 사용하여 분석하였다. 결과 : 장애아동에 대한 인식조사 결과 첫째, 성별에 따른 인식은 남학생보다 여학생의 평균 점수가 높았으나 통계 적으로 유의미한 차이는 없었다. 둘째, 학년에 따른 인식은 4학년의 평균 점수가 가장 높았고 6학년이 가장 낮았으 며 통계적으로 유의미한 차이가 있었다(F=3.546, p<0.05). 셋째, 장애인 접촉 유무에 따른 인식은 접촉 경험이 없 는 학생이 있는 학생보다 평균점수가 높았으나 통계적으로 유의미한 차이는 없었다. 결론 : 비장애학생의 장애아동에 대한 인식은 학년에 따라 차이가 있었다. 본 연구는 작업치료사들에게 장애아동에 대한 또래집단의 인식에 대한 정보를 제공함으로써 학교환경에 대한 이해를 도울 수 있을 것이다. Objective : The purpose of this study was to investigate attitude of grade-schoolers toward children with disabilities. Methods : The subjects of this study were grade-schoolers who have not received an inclusive education in Gim-hae. The study was surveyed from October second to 17th in 2008. The survey was categorized into three parts; comradeship, activity, and study. Each part of the survey consists of 10 questions. Data were analyzed by SPSS (version 12.0). Results : The results were as follows; First, the attitude of girls toward disabled students was non-significant compared to boys. Second, the order of attitude degree in grade of students was 4, 6, and 5. The attitude toward children with disabilities showed statistically significant difference according to grade(F=3.546, p<0.05). Third, the attitude of students who have experience of contact with people with disabilities was non-significant compared to non-experienced students. Conclusion : In conclusion, therefore peer groups in lower class levels showed more positive attitude toward the children with disabilities. The result will be useful information for understanding disabled children and making positive attitude. Also it is expected that occupational therapists help disabled children to participate in school life successfully using these information.

Multiple Hypercoagulability Disorders at Presentation of Non-Small-Cell Lung Cancer

Lee, Jeong Min,Lim, Jun Hyeok,Kim, Jung-Soo,Park, Ji Sun,Memon, Azra,Lee, Seul-Ki,Nam, Hae-Seong,Cho, Jae-Hwa,Kwak, Seung-Min,Lee, Hong Lyeol,Kim, Hyun-Jung,Hong, Geun-Jeong,Ryu, Jeong-Seon The Korean Academy of Tuberculosis and Respiratory 2014 Tuberculosis and Respiratory Diseases Vol.77 No.1

Hypercoagulability disorders are commonly encountered in clinical situations in patients with a variety of cancers. However, several hypercoagulability disorders presenting as first symptoms or signs in cancer patients have rarely been reported. We herein described a case of a woman with adenocarcinoma of the lung presenting with deep vein thrombosis, nonbacterial thrombotic endocarditis, recurrent cerebral embolic infarction, and heart failure.

Inhibitory Effect of Ore Minerals on the Allergic Inflammation in Mouse

( Seul Ki Park ),( Chang Won Lee ),( Mi Young Lee ) 한국응용생명화학회 2008 Applied Biological Chemistry (Appl Biol Chem) Vol.51 No.4

Efficacy of omalizumab in chronic refractory urticaria: Practical experiences in Korean patients

( Seul Ki Lee ),( Shin Young Song ),( Se Ha Park ),( Jeong Soo Kim ),( Hee Joo Kim ),( Jin Ok Baek ),( Hyang Joon Park ),( Joo Young Roh ) 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.2

Background: More than half of chronic spontaneous urticaria ( CSU ) patients do not respond adequately to H1-antihistamine treatment. Omalizumab is a humanized anti-IgE monoclonal antibody that has proved to be effective in treatment of patients with chronic urticaria refractory to antihistamines. Objectives: We analyzed real world experiences with using omalizumab for CSU patients who did not respond to treatment with high dose antihistamine. Methods: Twenty five patients (male : female=12 : 13, mean age, 51.0 years) were treated with 150mg or 300mg omalizumab every 4 weeks more than 12 weeks. The duration of CSU ranged 3 months and 12 years (mean, 3.3 years). Mean serum IgE level was 127.4 IU/ml (2~362 IU/ml). Treatment efficacy were assessed primarily based on Weekly urticaria activity scores (UAS-7), Weekly itch severity score (ISS-7) and Investigator’s Global assessment (IGA) changes from baseline to week 12. Results: After 12 weeks of therapy, mean UAS-7 decreased from 26.0 to 3.8, mean ISS-7 decreased from 13.5 to 2.1 and mean IGA decreased from 3.3 to 1.0. Complete remission (UAS-7 =0) was seen in 54.5% of patients who started with 300mg and in 35.7% of those who started with 150mg. Partial response (UAS-7≤6) was observed in 84.0 % of patients. Four patients(16%) had treatment failure(UAS-7>6) to omalizumab treatment. Conclusion: This real world experience demonstrated that omalizumab is a well-tolerated, beneficial option for the treatment of CSU patient refractory to antihistamine.

Clinical efficacy and safety of alitretinoin in chronic hand eczema

( Seul Ki Lee ),( Se Ha Park ),( Jeong Soo Kim ),( Ha Ryeong Ryu ),( Hee Joo Kim ),( Jin Ok Baek ),( Hyang Joon Park ),( Joo Young Roh ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.2

Background: Chronic hand eczema (CHE) is common inflammatory skin disease that affects approximately 10% of papulation. Most of Patients are paced with heavy psychosocial and impair the ability to work. Alitretinoin is systemic agent for treatment of CHE in patients unresponsiveness to potent topical corticosteroids. efficay and safety in Korean CHE patients are limited. Objectives: We performed a pilot study to evaluate the treatment efficacy and safety of alitretinoin in moderate to severe CHE patients Methods: A total of 70 patients diagnosed with CHE were enrolled. All patients were administrated 30mg of alitretinoin once daily for up to 24 weeks. Efficacy was assessed by physician’s global assessment (PGA), patient’s global assessment (PaGA), and modified total symptom score (mTLSS). Patient with all type of CHE including hyperkeratotic (43%), vesicular (27%), fingertip eczema (30%) were included. Results: Systemic alitretinoin (30mg/day) was remarkably effective in chronic hand eczema. The proportion of PGA, defined as clear or almost clear were 57% (40/70) of patients. The average mTLSS was significantly decreased (72.4% improvement,13.4 to 3.7). It was effective for all type of CHE and tolerated for most of the patients. In total 20% of patients experienced adverse events such as, headache and gastrointestinal discomfort. But there was no serious event Conclusion: Our results suggest that oral alitretinoin is effective and tolerable treatment option for patients with refractory CHE.

Reconceptualizing the Other in Anchee Min’s Pearl of China

Seul Ki Lee 한국아메리카학회 2021 美國學論集 Vol.53 No.1

Anchee Min is the Chinese-American author of Pearl of China (2010), a historical fiction novel that reinterprets the life and influence of Nobel Prize-winning writer Pearl Sydenstricker Buck through her relationship with a fictional best friend named Willow Yee. Reading the historical backdrop of twentieth century China and Pearl S. Buck’s unique position in it through the lens of Emmanuel Levinas’s theory of the self and the Other, I examine the development of Willow’s selfhood through her subsequent relationship with Pearl, and how this relationship influences her relationship to the systems in which she lives. This paper argues that Willow and Pearl’s ‘religious bond’ becomes their strength as they define themselves and maintain each other’s identities against the traditional patriarchy of Qing and Nationalist China, as well as the totalizing forces of communist China under Mao.

P288 : MIDAS syndrome diagnosed as Linear skin atrophy on face

( Seul Ki Lim ),( Young Lee ),( Young Joon Seo ),( Jeung Hoon Lee ),( Myung Im ) 대한피부과학회 2014 대한피부과학회 학술발표대회집 Vol.66 No.1