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양승원,정윤기,Cheol-Min Han,Eugene Lih,Seul-Ki Choia,한동근,손준식 한국고분자학회 2021 한국고분자학회 학술대회 연구논문 초록집 Vol.46 No.2
Polydioxanone (PDO) has been widely used in bio-medical fields for its high flexibility and biocompatibility. However, PDO stent carries several drawbacks such as its low mechanical stability during degradation. In this study, we designed the PLLA-PDO core-sheath monofilament based stents for the optimized mechanical properties, biodegradability, and drug release. Decreases in tensile strength, elastic modulus, and elongation properties were delayed in the PLLA-PDO monofilament compared to the PDO monofilament during degradation. In addition, we loaded dexamethasone in the PLLA-PDO monofilament. Dexamethasone-loaded PLLA-PDO monofilament showed no difference in the degradation behavior compared to the drug unloaded PLLA-PDO monofilament. Furthermore, we confirmed the sustained release of dexamethasone from PLLA-PDO monofilaments. Overall, our drug-eluting sheath-core monofilament stents can be a promising model for advanced nonvascular implantation.