생체분해성 망막압정을 이용한 망막고정에 대한 실험적 연구

김용백,민병무,김창식,박근성,김승영,길숙종,조항진,이성복,노승무,송규상,강대영,조준식,양준묵,정경수,최선웅,이진호,김학용,인현빈 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

Biodegradable retinal fixation devices obtain mechnical fixation of the retina with desirable chorioretinal scarring and with the potential for local, sustained release of antimetabolites and steroids to inhibit proliferative vitreoretinopathy. We manufactured a biodegradable retinal tack with barb that was designed in order to prevent intrusion from implantation of retinal tacks. This study was carried to evaluate the efficacy for retinal fixation and the capability for sustained release of drugs with a newly designed biodegradable retinal tack Biodegradable retinal tacks were made of polymers of glycolic acids and were designed with barbs in a shape to prevent the disinsertion. Biodegradale retinal tacks are divided into 3 parts, a conical portion that is inserted into the sclera, a cylinder portion that remains in the vitreous, and a neck portion between the pin and the cylinder. The tapered conical end was manufactured to allow easy insertion through the retina and choroid into the sclera. A cylinder portion was manufactured with a tapered angle that fixes firmly into the orifice of 19 gauge spinal needle. A neck portion, 0.4 mm in diameter, was designed to prevent disinsertion from following implantation of retinal tack. The applicator was a 19 gauge spinal needle and its orifice was prepared to 15°angle to accept the tapered cylinder portion of the retinal tack. The retinal tacks, secured in the needles, were passed through the formed vitreous and inserted into the retina, choroid, and sclera and were released by pushing the internal needle, usually within 2-3mm of the medullary ray of the posterior rabbit retina A retinal tack was placed in each of 8 pigmented rabbit eyes. Slit-lamp biomicroscopy, indirect ophthalmoscopy and fundus photography were performed periodically from 1 day to 8 weeks after surgery. Eight eyes were enucleated and studied by light microscopy at 8 weeks. Biomicroscopic evaluation of the animals revealed edemas adjacent to the retinal surfaces immediately after insertion of the biodegradable retinal tacks in all the animals. These edemas disappeared after 1 week. The first noticeable change in the size of retinal tacks was shown after 2weeks. The size of the retinal tacks gradually got smaller, decreasing to about one-half at 4 weeks and about one-third at 8 weeks. All retinal tacks remained in inserted places without any movement for an 8 week period. On light microscopy, epiretinal proliferations were seen to extend into the vitreous cavity. Cellular capsules that lined the inner aspect of the scleral defect caused by tack insertion were found. However the adjacent retina had a normal cytologic appearance and architecture in all specimens. We manufactured a biodegradable retinal tack that is designed to prevent intrusion from implantation of retinal tacks. All biodegradable retinal tacks reduce in size with time, but no retinal tacks extruded from the inserted place. The newly designed biodegradable retinal tack can be used for retinal fixation and may be used as a vehicle for the introduction of pharmacologic agents to prevent the cellular events that promote proliferative vitreoretinopathy.

생체분해성 고분자를 이용한 사시수술용 제형개발 및 효용성에 대한 연구

민병무,김용백,김승영,김창식,박근성,길숙종,조항진,이성복,노승무,송규상,강대영,조준식,양준묵,정경수,최선웅,이진호,김학용,인현빈 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

A new device, muscle clamping system was developed to facilitate exact quatifying technique A strabismus surgery, and reduce the risk of complications. The device is composed of a lower fixing body with three jaws and an upper supporting body. They are used to clip an extraocular muscle and fix it to the sclera with a single bite. Superior rectus recession on 16 rabbit eyes were performed with this new device. Conjunctival injection, muscle adhesion strength, and light microscopic findings were examined at 1, 2, 4 and 8 weeks postoperatively. The Conjunctival injection were minimal, adhesion power ranged from 420 to 600 gram gravity, which is sufficient in withstand the normal pull of human extraocular muscle. In microscopic exam, some Inflammatory cells and fibrosis were found. The new device was technically easy, fast, and accurate, so it may be useful in stabismus surgery.

한국의 전자민주주의 : 정부부문을 중심으로

김용철,이축묵, 윤성이 연세대학교 동서문제연구원 2001 東西硏究 JOURNAL OF EAST AND WEST STUDIES Vol.13 No.1

본 논문은 정부의 정보제공 방식과 특성을 파악하고, 가상공간에서 정부와 시민 사회간의 의사소통 내용을 분석함으로써, 정부부문에서의 전자민주주의 현황을 평가함과 동시에 이의 실현을 위한 구체적인 방안을 모색하는 것을 목적으로 한다. 정보제공과 관련하여, 공개하는 정보의 질과 양, 그리고 자료의 갱신주기 등은 정부부처에 따라 매우 상이한 것으로 나타난다. 일반적으로 인터넷으로 제공되는 정보의 질적 · 양적 수준은 대민접촉이 빈번하고 국민 실생활과 직접 관련되는 부서(즉, 교육부, 노동부, 보건복지부, 환경부 등)일수록 높은 것으로 보인다. 반면, 대민접촉이 그다지 활발하지 않은 부서의 경우 상대적으로 정보에 대한 수요가 많지 않고, 그에 따라 정보의 수준도 낮은 것으로 판단된다. 한편 정보의 보다 효율적인 제공을 위한 방안으로서, 정부 홈페이지는 현재 관련 사이트에만 국한되어 있는 항해기능을 좀 더 확대하여 정보유통 네트워크의 핵심 결절점 역할을 수행할 필요가 있다. 이를 위해서는 관련 연구소의 주요 정보, 즉 정책정보, 현황정보, 통계정보 등의 목록 및 소재 정보를 제공하고 그에 연계될 수 있는 링크기능을 확보해야 한다. 아울러 모든 정부기관이 보유하고 있는 현황정보나 정책정보에 대해 총괄적으로 검색할 수 있는 기능을 담당하는 기관으로서 청와대 홈페이지의 위상을 재정립 할 필요가 있다. 청와대는 행정부 전체의 활동을 총괄적으로 관장하는 기관이며, 또한 현재 홈페이지 접속 빈도도 매우 높기 때문에 이 기능을 수행하는데 가장 적합하다고 볼 수 있다. 가상공간에서 정부와 시민간의 의사소통은 진지하고 건설적인 방식으로만 이루어지지 않는 것으로 보인다. 행정상담이나 정보요청을 제외하면, 대부분은 항의성 메일, 일방적인 비난 · 비방으로 채워져 있고, 정책토론이나 정책건의와 같은 발전적인 논의는 극히 일부라고 볼 수 있다. 그러나 가상공간을 '사이버 아고라'로 만들려던 정부의 시도가 별 성과를 거두지 못한 데에는 정부의 안이한 대응에도 책임이 있다. 따라서 정부는 의사소통의 공간을 체계적으로 조직화 할 방안을 도출해 야 한다. 우선 행정상담 및 시민게시판의 효과적인 운영을 위해서는, 문의란과 답변란의 구별운영, 담당자의 즉각적 회신, 분야별 Q&A의 활성화 등이 시급하다. 둘째, '자유게시판' 코너의 운영을 개선하기 위해서는, 시민들의 의견에 대해 담당기관에서 적극적으로 대응할 필요가 있다. 또한 게시판의 주제에 맞지 않는 내용에 대해서는 네티즌의 의견을 물은 후 삭제하거나, 게시자에게 경고 후 접근을 제한하는 방법도 신중하게 고려할 필요가 있다. 셋째, 주제별 정책토론의 생산적 결과를 위해서는, 주제선택에 있어서의 시의성 고려, 토론에 필요한 자료의 확보, 담당자들의 적극적인 개입, 그리고 토론성과를 통한 정책반영 노력 등이 필요할 것이다.

기체온도 변화에 따른 질소레이저의 출력특성

김성훈,양준묵,추한태,이치원 충남대학교 자연과학연구소 1993 忠南科學硏究誌 Vol.20 No.2

While the temperature of the gas was being changed by modifying the value of E/P which being effects the output characteristics of gas laser into a temperature function, the optimum value of E/P was calculated, being applied to Nitrogen laser and was compared with experimental values. The optimum operational characteristics by the variation of the nitrogen gas temperature is observed at 30 ℃ in gas temperature and 120 torr in gas pressure. Also the value of E/P is evaluated to be 423 V ㎝^-1torr^-1 which is 2.2 times as large as that of theoretical value. According to increasing the nitrogen gas temperature, the nitrogen gas pressure for the laser action is to be broaded. However in this case, the maximum output power is slightly decrease.

생체분해성 안과제형의 안구내흡수정도와 안독성

민병무,김용백,박근성,송규상,양준묵,이성복,조항진,길숙종,김승영,김학용 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

An improved retinal tack can be used to fix the retina in complicated retinal detachment and proliferative vitreoretinopathy. We used the retinal tack made by biodegradable polyglycolic acid, polylactic acid and copolymers. The tacks with polyglycolic acid were placed in the retina the right eyes of 10 rabbits as group 1, with polylactic-polyglycolic acid copolymers as group 2 in each left eyes. We examined the absorption rates and degree of intraocular inflammation at 1 day, 1, 2, 4, and 8 weeks and compared both eyes. The tacks were absorbed with time in both eyes, but more rapid in copolymers. And there was no inflammation in both eyes. Now, this study will be a base on the drug delivery system in intraocular pharmacological and surgical management.

영구형 항서맥 심박조율기 환자의 장기추적관찰

최현석,이무용,최영진,최성준,김효수,손대원,오병희,이명묵,박영배,최윤식,이영우,이명용 대한순환기학회 1998 Korean Circulation Journal Vol.28 No.5

Lumbar Intradural Extramedullary Non-Metastatic Carcinoid Tumor: A Case Report

Kim Young-Mook,Lee Sangpyung,Ryou Kyoung-Soo,Kim Seong-Hwan,Park Tae-Joon 대한말초신경학회 2020 The Nerve Vol.6 No.2

Carcinoid or neuroendocrine tumors (NETs) are slow-growing neoplasms originating from neuroendocrine cells. The central nervous system(CNS) involvement of carcinoid tumor, not only metastasis to CNS or primary originated, is reported rarely. This study presented a case of a primary spinal intradural extramedullary carcinoid tumor accompanied by urinary incontinence. CNS involvement in carcinoid tumors is rarely reported, and its intradural spinal metastasis or primary spinal NET is extremely rare. A 63-year-old woman came to hospital with urinary incontinence, and a 2.5-cm-sized intradural extramedullary mass was found at the lumbosacral level on spinal magnetic resonance imaging. The patient underwent L5-S2 laminectomy to remove the intradural extramedullary mass at the L5-S1 level. The patient recovered without complications, and there was progress in urinary incontinence. The patient did not complain of urinary incontinence after discharge, and no evidence of recurrence was observed after a 1-year follow-up

The Effectiveness of Additional Treatment Modalities after the Failure of Recanalization by Thrombectomy Alone in Acute Vertebrobasilar Arterial Occlusion

Kim, Seong Mook,Sohn, Sung-Il,Hong, Jeong-Ho,Chang, Hyuk-Won,Lee, Chang-Young,Kim, Chang-Hyun The Korean Neurosurgical Society 2015 Journal of Korean neurosurgical society Vol.58 No.5

Objective : Acute vertebrobasilar artery occlusion (AVBAO) is a devastating disease with a high mortality rate. One of the most important factors affecting favorable clinical outcome is early recanalization. Mechanical thrombectomy is an emerging treatment strategy for achieving a high recanalization rates. However, thrombectomy alone can be insufficient to complete recanalization, especially for acute stroke involving large artery atheromatous disease. The purpose of this study is to investigate the safety and efficacy of mechanical thrombectomy in AVBAO. Methods : Fourteen consecutive patients with AVBAO were treated with mechanical thrombectomy. Additional multimodal treatments were intra-arterial (IA) thrombolysis, balloon angioplasty, or permanent stent placement. Recanalization by thrombectomy alone and multimodal treatments were assessed by the Thrombolysis in Cerebral Infarction (TICI) score. Clinical outcome was determined using the National Institutes of Health Stroke Scale (NIHSS) at 7 days and the modified Rankin Scale (mRS) at 3 months. Results : Thrombectomy alone and multimodal treatments were performed in 10 patients (71.4%) and 4 patients (28.6%), respectively. Successful recanalization (TICI 2b-3) was achieved in 11 (78.6%). Among these 11 patients, 3 (27.3%) underwent multimodal treatment due to underlying atherosclerotic stenosis. Ten (71.4%) of the 14 showed NIHSS score improvement of >10. Overall mortality was 3 (21.4%) of 14. Conclusion : We suggest that mechanical thrombectomy is safe and effective for improving recanalization rates in AVBAO, with low complication rates. Also, in carefully selected patients after the failure of recanalization by thrombectomy alone, additional multimodal treatment such as IA thrombolysis, balloons, or stents can be needed to achieve successful recanalization.

Korean Ginseng-Induced Occupational Asthma and Determination of IgE Binding Components

Kim, Kyung-Mook,Kwon, Hyouk-Soo,Jeon, Sung-Gyu,Park, Chang-Han,Sohn, Seong-Wook,Kim, Duck-In,Kim, Sun-Sin,Chang, Yoon-Seok,Kim, Yoon-Keun,Cho, Sang-Heon,Min, Kyung-Up,Kim, You-Young The Korean Academy of Medical Sciences 2008 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.23 No.2

<P>A number of case reports on occupational asthma caused by herbal medicines have been issued, for example, on Sanyak, Chunkung, Banha, and Brazilian ginseng. Recently, cases of occupational asthma induced by Sanyak and Korean ginseng have been reported, but the pathogenic mechanisms involved are unknown. This study was carried out to evaluate the immunologic mechanism underlying Korean ginseng-induced occupational asthma. A patient engaged in Korean ginseng wholesale was referred for recurrent dyspnea, wheezing, and nasal symptoms, which were aggravated at work. Allergen bronchial provocation testing to Korean ginseng extract showed a typical immediate response, and skin prick testing to Korean ginseng extract also showed a strong positive response. Moreover, serum-specific IgE levels to Korean ginseng extract were significantly higher than in controls. Enzyme-linked immunosorbent assay (ELISA) inhibition tests showed a dose-dependent inhibition by Korean ginseng, but not by <I>Dermatophagoides farinae</I>, wheat flour, or Chinese balloon flower. Sodium dodecylsulfate-poly-acrylamide gel electrophoresis (SDS-PAGE) and immunoblotting revealed four specific Immunoglobulin E (IgE) binding components at 26, 30, 47, and 60 kDa, which were not bound by control sera. These results strongly suggest that occupation asthma induced by Korean ginseng is induced via an IgE-mediated mechanism.</P>

유아기의 가와사키병에 의한 성인에서의 관상동맥질환 1 예

김상현,김지영,김영권,이명묵,한기훈,전호춘,김경영,차성은,손인,김안나,조성욱 대한내과학회 1995 대한내과학회지 Vol.49 No.1

Kawasaki disease is an acute febrile vasculitis of the unknown etiology, affecting mainly infant and young children. During the acute stage of the Kawasaki disease, coronary aneurysm develops in about 20 % of the patients, which may cause sudden death or ischemic heart disease as a result of the thrombotic or stenotic occlusion of the coronary artery. Coronary artery sequala of the Kawasaki disease may become an important cause of the ischemic heart disease in young adult. A 20-year old man was admitted because of the exertional chest pair, who had suffered from persistent fever of one month's duration associated with oropharyngeal mucosal changes and cervical lymphadenopathy at infancy. He did not have the coronary risk factors except Kawasaki disease. The exercise electrocardiography test was positive. The left ventriculography showed hypokinesia of the anterolateral, the diaphragmatic segments, and the inferolateral portion of the posterolateral segment. The coronary arteriography showed oval calcified aneruysms with luminal stenosis at the proximal right coronary artery, distal circumflex artery, and proximal left anterior descending artery. Abundant intra and intercoronary collateral vessels were found. We report a case of the adult coronary artery disease due to infantile Kawasaki disease with the review of the literatures.