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- 저자 : Seong Bok Jang (검색결과 122 건)
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Jang, Jae Seong,Shin, Dong Gue,Cho, Hye Min,Kwon, Yujin,Cho, Dong Hui,Lee, Kyung Bok,Park, Sang Soo,Yoon, Jin,Jang, Yong Seog,Kim, Il Myung The Korean Gastric Cancer Association 2013 Journal of gastric cancer Vol.13 No.4
Purpose: In Korea, the entire population must enroll in the national health insurance system, and those who are classified as having a lower socioeconomic status are supported by the medical aid system. The aim of this study was to evaluate the association of the medical insurance status of gastric cancer patients with their survival after gastrectomy. Materials and Methods: A total of 247 patients who underwent surgical treatment for gastric cancer between January 1999 and December 2010 at the Seoul Medical Center were evaluated. Based on their medical insurance status, the patients were classified into two groups: the national health insurance registered group (n=183), and the medical aid covered group (n=64). The survival rates were calculated using the Kaplan-Meier method. Results: The median postoperative duration of hospitalization was longer in the medical aid covered group and postoperative morbidity and mortality were higher in the medical aid group than in the national health insurance registered group (P<0.05). The overall 5-year survival rate was 43.9% in the medical aid covered group and 64.3% in the national health insurance registered group (P=0.001). Conclusions: The medical insurance status reflects the socioeconomic status of a patient and can influence the overall survival of gastric cancer patients. A more sophisticated analysis of the difference in the survival time between gastric cancer patients based on their socioeconomic status is necessary.
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Jang, Seong Han,Jang, Ho Am,Lee, Junbeom,Kim, Jong Uk,Lee, Seung Ah,Park, Kyoung-Eun,Kim, Byung Hyun,Jo, Yong Hun,Lee, Bok Luel American Society for Microbiology 2017 Applied and environmental microbiology Vol.83 No.11
<P>IMPORTANCE Bacterial polyhydroxyalkanoate (PHA) biosynthesis is a complex process requiring several enzymes. The biological roles of PHA granule synthesis enzymes and the surface proteins of PHA granules during host-gut symbiont interactions are not fully understood. Here, we report the effects on colonization ability in the host midguts and the fitness of host insects after feeding Burkholderia mutant cells (four phaP-depleted mutants and one phaR-depleted mutant) to the host insects. Analyses of both synthesized PHA granule amounts and CFU numbers suggest that the phaR gene is closely related to synthesis of the PHA granule and the colonization of the Burkholderia gut symbiont in the host insect's midgut. Like our previous report, this study also supports the idea that the environment of the host midgut may not be favorable to symbiotic Burkholderia cells and that PHA granules may be required to adapt in the host midgut.</P>
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Jang, Choon-Gon,Kang, Moonkyu,Cho, Jae-Han,Lee, Sun-Bok,Kim, Hyuntaek,Park, Soonkwon,Lee, Jinwoo,Park, Seong-Kyu,Hong, Moochang,Shin, Min Kyu,Shim, In-Sup,Bae, Hyunsu WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 2004 東西醫學硏究所 論文集 Vol.2004 No.-
Depression is associated with a dysfunctional serotonin (5-hydroxytryptamine; 5-HT) system. More recently, several lines of evidence suggest that an important factor in the development of depression may be a deficit in the function and expression of 5-HT_(1A) receptors. The present study assessed if Nelumbinis Semen (N. s.) had an anti-depression effect through reversing a decrease in 5-HT_(1A) receptor binding in rats with depression-like symptoms induced by chronic mild stress. Using a 5-HT_(1A) receptor binding assay, with a specific 5-HT_(1A) receptor agonist, 8-OH-DPAT (8-hydroxy-2-(di-n-propylamino) tetralin), the mechanism of the anti-depression effect of N. s. on rats was investigated, and the effects compared with two well-known antidepressants, Hyperium Perforatum (St. Johns Wort) and fluoxetine (Prozac). Animals were divided into live groups: the normal (N) group without chronic mild stress (CMS), the control (C) group under CMS for 8 weeks, the Nelumbinis Semen (N. s.) treatment group under CMS for 8 weeks, the Hyperium Perforatum (H. p.) treatment group under CMS for 8 weeks and finally, the fluoxetine (F) treatment group under CMS for 8 weeks. Each treatment was administered to rats during the last 4 weeks of the 8-week CMS. A sucrose intake test was performed to test the anti-depression effect of N. s. The N. s. treatment significantly reversed the decreased sucrose intake under CMS (P<0.05 compared to control group under CMS). In the CA2 and CA3 regions of the hippocampus, both N. s. and H. p. reversed the CMS-induced decrease in 5-HT_(1A) receptor binding. In the Ⅰ to II regions of the frontal cortex, N. s. and H. p. also reversed the CMS-induced decrease in 5-HT_(1A) receptor binding, and even showed a significant increase in 5-HT_(1A) receptor binding compared to the F treatment group (N. s. vs. P₁ p<0.05, H. p. vs. P₁ p<0.05). However, in the hypothalamus, all treatments reversed the CMS-induced decrease in 5-HT_(1A) receptor binding. This reversal effect of N. s. on the decrease in 5-HT_(1A) receptor binding in the frontal cortex, hippocampus and hypothalamus of rat brains was very similar to that of H. p, but different from that of F. It is concluded that N. s. presents an anti-depression effect through enhancing 5-HT_(1A) receptor binding.
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An Adaptive Closed Loop Synchronization Scheme for Burst-mode SatCom Systems
Seong-Bok Park,Dhong-Woon Jang 대한전자공학회 2009 ITC-CSCC :International Technical Conference on Ci Vol.2009 No.7
In this paper, a closed loop synchronization technique for burst-mode SatCom systems is proposed. In the process of entry of a TDMA burst into the assigned epoch, false acquisition can cause high rates of error in those parts of each adjacent burst that overlaps. The maximum-likelihood (ML) rule which is near optimal in search for the desired time slot is robust to carrier frequency and phase offset. This robustness, however, is achieved at the expense of SNR loss of more than 3dB around zero frequency offset compared to that of ordinary correlation rule. To deal with this drawback, an adaptive closed loop synchronization technique is proposed. In the proposed technique, both the peak values according to ML rule and ordinary correlation rule are first calculated, then one of them is adaptively selected based on statistical characteristics of the values to estimate the accurate target position on the satellite time line. Simulation results showed that the proposed scheme can provide significant performance improvement over the conventional schemes regardless of the carrier frequency and phase offsets maintaining reasonable system complexity.
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Structure and function of vascular endothelial growth factor and its receptor system
( Seong Ah Park ),( Mi Suk Jeong ),( Ki-tae Ha ),( Se Bok Jang ) 생화학분자생물학회(구 한국생화학분자생물학회) 2018 BMB Reports Vol.51 No.2
Vascular endothelial growth factor and its receptor (VEGF-VEGFR) system play a critical role in the regulation of angiogenesis and lymphangiogenesis in vertebrates. Each of the VEGF has specific receptors, which it activates by binding to the extracellular domain of the receptors, and, thus, regulates the angiogenic balance in the early embryonic and adult stages. However, de-regulation of the VEGF-VEGFR implicates directly in various diseases, particularly cancer. Moreover, tumor growth needs a dedicated blood supply to provide oxygen and other essential nutrients. Tumor metastasis requires blood vessels to carry tumors to distant sites, where they can implant and begin the growth of secondary tumors. Thus, investigation of signaling systems related to the human disease, such as VEGF-VEGFR, will facilitate the development of treatments for such illnesses. [BMB Reports 2018; 51(2): 73-78]
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Jang, Jeongin,Ryu, Byungki,Joo, Sung-Jae,Kim, Bong-Seo,Min, Bok-Ki,Lee, Hee-Woong,Park, Su-Dong,Lee, Ho Seong,Lee, Ji Eun Elsevier 2018 Journal of Alloys and Compounds Vol.739 No.-
<P><B>Abstract</B></P> <P>In order to achieve enhancements in thermoelectric efficiency, microstructures that can form numerous interfaces have been investigated intensively for controlling the transport of charge carriers and heat-carrying phonons. In this paper, we report the heterogeneous microstructure of Mg<SUB>2</SUB>Si<SUB>0.6</SUB>Sn<SUB>0.4</SUB> thermoelectric materials synthesized by a simple B<SUB>2</SUB>O<SUB>3</SUB> encapsulation method and investigation of its influence on thermoelectric properties. The addition of Sb causes the evolution of a Sn-rich secondary phase and a heterogeneous microstructure consisting of Sn-deficient grains and a Sn-rich boundary phase, with coherent interfaces between them. The secondary phase induced by Sb doping suppressed the bipolar effect and reduced the thermal conductivity because of minority carrier blocking and phonon scattering at phase boundaries. However, high concentration of Sb in Sn-rich phase led to insufficient doping in Si-rich main phase and electron-hole compensation by Mg vacancies, resulting in decrease of the doping efficiency of Sb.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Heterogeneous microstructured Mg<SUB>2</SUB>Si<SUB>0.6</SUB>Sn<SUB>0.4</SUB> was synthesized. </LI> <LI> Antimony doping caused the formation of a Sn-rich grain boundary phase. </LI> <LI> Coherent interfaces were formed between the Si-rich phase and the Sn-rich phase. </LI> <LI> The bipolar effect was suppressed and the thermal conductivity was reduced. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
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Effect of Cr Content on Supercritical Water Corrosion of High Cr Alloys
Jang, Jin Sung,Lee, Yong Bok,Han, Chang Hee,Yi, Yong Sun,Hwang, Seong Sik Trans Tech Publications, Ltd. 2005 Materials science forum Vol.475 No.-
<P>High Cr alloys were corrosion tested in supercritical water and the oxide scale was analyzed. Commercial grade two steel specimens; 9CrMoVNb steels, one 9CrMoVNbW steel, one 12Cr-MoVNbWCu steel and one 20Cr Fe-based O.D.S (Oxide Dispersion Strengthened) alloy specimen were investigated. Corrosion tests were conducted within non-deaerated pure supercritical water at 627, 550, and 500oC with 25 MPa. Corrosion rate was estimated by the weight change per unit surface area and the oxide layer was analyzed using a grazing incidence X.R.D (x-ray diffractometer), S.E.M (scanning electron microscope) and T.E.M (transmission electron microscope) equipped with an E.D.S (energy dispersive spectroscope). Corrosion rates of the 9Cr steel specimens were observed to follow the parabolic growth rate law, while those of the specimens with a 12 per cent or higher Cr content showed significantly lower rates. Oxide scale on the 9Cr steel specimen after a corrosion test in a supercritical water was found to consist of three distinctive layers. Through the cross-section T.E.M the outermost layer with about a 35 µm thickness after 200 hr at 627 oC was identified to be magnetite type Fe3O4, and about 25 µm thick intermediate layer was a Cr partitioned magnetite type (Fe,Cr)3O4. The outermost layer showed a coarse columnar structure, while the intermediate one revealed an agglomerate of tiny oxide particles (several tens nm in diameter). The innermost layer next to the matrix phase was found to be the internally oxidized zone. Oxygen atoms seemed to have attacked along the grain boundaries and the lath boundaries and formed oxide CrO3 along the boundaries. Also a Cr depleted zone, and consequently a carbide-free zone, was observed along the interface between the internal oxidation zone and the matrix phase.</P>
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Engineering of Cell Derived-Nanovesicle as an Alternative to Exosome Therapy
Jang Hye-Jeong,Shim Kyu-Sik,Lee Jinah,Park Joo Hyeon,Kang Seong-Jun,Shin Young Min,Lee Jung Bok,Baek Wooyeol,Yoon Jeong-Kee 한국조직공학과 재생의학회 2024 조직공학과 재생의학 Vol.21 No.1
Background Exosomes, nano-sized vesicles ranging between 30 and 150 nm secreted by human cells, play a pivotal role in long-range intercellular communication and have attracted significant attention in the field of regenerative medicine. Nevertheless, their limited productivity and cost-effectiveness pose challenges for clinical applications. These issues have recently been addressed by cell-derived nanovesicles (CDNs), which are physically synthesized exosome-mimetic nanovesicles from parent cells, as a promising alternative to exosomes. CDNs exhibit structural, physical, and biological properties similar to exosomes, containing intracellular protein and genetic components encapsulated by the cell plasma membrane. These characteristics allow CDNs to be used as regenerative medicine and therapeutics on their own, or as a drug delivery system. Methods The paper reviews diverse methods for CDN synthesis, current analysis techniques, and presents engineering strategies to improve lesion targeting efficiency and/or therapeutic efficacy. Results CDNs, with their properties similar to those of exosomes, offer a cost-effective and highly productive alternative due to their non-living biomaterial nature, nano-size, and readiness for use, allowing them to overcome several limitations of conventional cell therapy methods. Conclusion Ongoing research and enhancement of CDNs engineering, along with comprehensive safety assessments and stability analysis, exhibit vast potential to advance regenerative medicine by enabling the development of efficient therapeutic interventions. Background Exosomes, nano-sized vesicles ranging between 30 and 150 nm secreted by human cells, play a pivotal role in long-range intercellular communication and have attracted significant attention in the field of regenerative medicine. Nevertheless, their limited productivity and cost-effectiveness pose challenges for clinical applications. These issues have recently been addressed by cell-derived nanovesicles (CDNs), which are physically synthesized exosome-mimetic nanovesicles from parent cells, as a promising alternative to exosomes. CDNs exhibit structural, physical, and biological properties similar to exosomes, containing intracellular protein and genetic components encapsulated by the cell plasma membrane. These characteristics allow CDNs to be used as regenerative medicine and therapeutics on their own, or as a drug delivery system. Methods The paper reviews diverse methods for CDN synthesis, current analysis techniques, and presents engineering strategies to improve lesion targeting efficiency and/or therapeutic efficacy. Results CDNs, with their properties similar to those of exosomes, offer a cost-effective and highly productive alternative due to their non-living biomaterial nature, nano-size, and readiness for use, allowing them to overcome several limitations of conventional cell therapy methods. Conclusion Ongoing research and enhancement of CDNs engineering, along with comprehensive safety assessments and stability analysis, exhibit vast potential to advance regenerative medicine by enabling the development of efficient therapeutic interventions.
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