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Kang, Jae Seung,Kim, Ha Na,Jung, Da Jung,Kim, Jee Eun,Mun, Ga Hee,Kim, Yeong Seok,Cho, Daeho,Shin, Dong Hoon,Hwang, Young-Il,Lee, Wang Jae Williams & Wilkins 2007 The Journal of investigative dermatology Vol.127 No.3
It is well known that UVB (290–320 nm) induces inflammation in skin by the transcription and release of cytokines and chemokines from skin keratinocytes. In addition, it is considered that intracellular reactive oxygen species (ROS) plays an important role in UVB-induced inflammatory response in the skin. Therefore, we investigated the effect of vitamin C, a potent antioxidant, on the regulation of UVB-induced skin inflammation via the modulation of chemokines production. Vitamin C uptake into keratinocytes is increased by UVB irradiation in a time- and dose-dependent manner through the translocation of sodium-dependent vitamin C transporter-1 (SVCT-1), a vitamin C-specific transporter, from the cytosol to the membrane. To evaluate the effect of vitamin C on the chemokine mRNA expression, we performed RNase protection assay. As a result, there was a remarkable change in chemokine mRNA expression, especially IL-8 and monocyte chemoattractant protein (MCP)-1 expression. In addition, increased IL-8 and MCP-1 mRNA expressions were suppressed by vitamin C treatment. We also confirmed the results of protein levels measured by ELISA. Taken together, vitamin C uptake is increased in UVB-irradiated keratinocytes through the translocation of SVCT-1 and regulates inflammatory response in the skin via the downregulation of IL-8 and MCP-1 production.Journal of Investigative Dermatology (2007) 127, 698–706. doi:10.1038/sj.jid.5700572; published online 28 September 2006
The optimal duration of ischemic preconditioning for renal ischemia-reperfusion injury in mice
Hyun Su Choi,Jeong Kye Hwang,Jeong Goo Kim,Hyeon Seok Hwang,Sang Ju Lee,Yoon kyung Chang,Ji Il Kim,In Sung Moon 대한외과학회 2017 Annals of Surgical Treatment and Research Vol.93 No.4
Purpose: The aim of the present study was to investigate the protective effects of ischemic preconditioning for different periods of time and to elucidate the optimal safe ischemic preconditioning time for renal ischemia-reperfusion (I/R) injury in mice. Methods: A total of 25 male C57BL/6 mice were randomly divided into 5 groups (sham, I/R, ischemic preconditioning [IP]-3, IP-5, and IP-7 groups), in which the kidney was preconditioned with IP of various durations and then subjected to I/R injury (the last 3 groups). To induce renal ischemia, the left renal pedicle was occluded with a nontraumatic microaneurysm clamp for 30 minutes followed by reperfusion for 24 hours. The effects of IP on renal I/R injury were evaluated in terms of renal function, tubular necrosis, apoptotic cell death and inflammatory cytokines. Results: Results indicated that BUN and creatinine (Cr) levels increased significantly in the I/R group, but the elevations were significantly lower in IP groups, especially in the IP-5 group. Histological analysis revealed that kidney injury was markedly decreased in the IP-5 group compared with the I/R group, as evidenced by reduced renal necrosis/apoptosis. In addition, IP significantly inhibited gene expression of pro-inflammatory cytokines (TNF-α, IL-1β, and IL-6) and chemokines (monocyte chemoattractant protein-1). Western blot analysis indicated that the expression levels of Toll-like receptor 4 (TLR4) and nuclear factor-kappa B (NF-kB) were upregulated in the I/R group, while expression was inhibited in the IP groups. Conclusion: Five-minute IP had the greatest protective effect against I/R injury.
황대규,오태석,김일환 江原大學校 産業技術硏究所 2002 産業技術硏究 Vol.22 No.B
This paper describes a design of an induction motor control system using a 2 degree-of-freedom PI controller to compensate the effects of disturbance without degrading tracking performance. On the basis of vector control principle, the control system is simulated by using the ACSL and implemented on a DSP system(TMS320C31). In designing the 2 DOF controller, we can tune the performance of either the tracking or disturbance rejection independently without affecting the other. With the experimental results, the 2 DOF controller has shown a better performance in command tracking and disturbance rejection than a conventional PI controller.
노일호,김병완,정광조,曺政孝,黃相畯,吳旼錫 대전대학교 한의학연구소 2003 한의학연구소 논문집 Vol.12 No.1
This study is about the relationship between the effect of Radiating Qui Therapy on human body and the resulting subjective qui sensation. Patients were between 30 and 50 years of age. n=21 persons received DITI (n=14 patients were provided, n=9 control group) twice examination with Radiating Qui Therapy. First all patients were examined by DITI. After treatment with Radiating Qui Therapy (n=14) both the treated and the control groups were eaxmined again. Radiating Qui Therapy is provided upright position. After Radiating Qui Therapy 92% of the treated group felt a significant qui sensation and 43.5 % felt a warmth at the abdomen and over the whole body. A data of this study show Radiating Qui Therapy has s stimulating effect on human skin temperature. As disease region and Qui sensation are very closely related to each other results strongly suggest that Radiating Qui Therapy could be used as a treatment for a several disease.
Perovskite형 복합산화물 LnCoO_3(Ln=Pr,Nd)의 환원성
박일현,황호순,최원석 성균관대학교 기초과학연구소 1990 論文集 Vol.41 No.1
Nonstoichiometry, thermal stability and reduction reaction of Perovskite-type LnCoO_(3-y)(Ln=Pr, Nd) mixed oxides under static H2 atmosphere were investigated by means of temperature-programmed reduction(TPR) method, X-ray diffraction, Infrared spectroscopy and Scanning electron microscopy. Nonstoichiometry of these mixed oxides were determined as PrCoO_2.94, NdCoO_2.99, respectively. According to kinetic studies, these mixed oxides were revealed that the first reduction stages of LnCoO_(3-y)(Ln=Pr,Nd) oxides were followed by Ginstling-Brounshtein equation indicating three dimensional diffusion of reactant. The second reduction stages were controlled by formation and growth of reaction nuclei via the reaction interface. Activation energies of the first reduction stages of LnCoO_(3-y)(Ln=Pr,Nd) were 22.2, 26.5 kcal/mole, respectively and for the second reduction stages of LnCoO_(3-y)(Ln=Pr,Nd) were 33.4, 29.1 kcal/mole, respectively.
Clinical Impacts of CD38+ B Cells on Acute Cellular Rejection With CD20+ B Cells in Renal Allograft
Hwang, Hyeon Seok,Song, Ji Hyun,Hyoung, Bok Jin,Lee, So Young,Jeon, Youn Joo,Kang, Seok Hui,Chung, Byung Ha,Choi, Bum Soon,Choi, Yeong Jin,Kim, Ji Il,Moon, In Sung,Kim, Yong Soo,Yang, Chul Woo Lippincott Williams Wilkins, Inc. 2010 Transplantation Vol.89 No.12
BACKGROUND.: There is an increasing evidence that the presence of CD20 B cells is associated with poor clinical outcomes in acute cellular rejection (ACR), but clinical significance of CD38 B cells is undetermined. We attempted to examine the clinical significance of the CD38 B cells alone or in combination with CD20 B cells in renal transplant recipients with ACR. METHODS.: Fifty-four patients with ACR were included. Biopsy specimens were stained for CD20 and CD38. The clinical outcomes of CD20 or CD38 B cells were evaluated with late-onset and repeated ACR, steroid resistance, incomplete recovery after rejection treatment, and allograft survival. RESULTS.: Twenty-three patients (42.6%) had CD20 and 25 (46.3%) patients had CD38 B cells. Of these, 15 patients (27.8%) were positive for both CD20 and CD38 (CD20CD38). CD38 patients had higher rates of late-onset or repeated ACR and incomplete recovery compared with CD38 patients (P<0.05). The patients with CD20CD38 had a higher incomplete recovery rate than did patients with only CD20 or CD38 (P<0.05). The 5-year allograft survival was lower in CD20 and CD38 patients than in CD20 or CD38 patients (P<0.05 for each). CD20CD38 patients had lower graft survival than did patients with CD20 or CD38 alone (P<0.05). CONCLUSION.: Infiltration of CD38 B cells alone or in combination with CD20 B cells is a predictor for poor clinical outcomes of ACR in renal allograft.
황영일(Hwang Young-il),고기석(Koh Ki Seok),한승호(Han Seung Ho),이규석(Lee Kyu Seok),최병영(Choi Byoung Young),김희진(KIm Hee Jin),이경훈(Lee Kyung Hoon),정민석(Chung Min Suk) 대한체질인류학회 1994 대한체질인류학회지 Vol.7 No.2
중국 서쪽 신장성 위그르자치구에 거주하는 위그르인을 대상으로 하여 그들의 체질인류학적 특질을 알아 보고자 하는 연구의 일환으로 눈과 코를 중심으로 한 계측자료를 구하였다. 대상인원은 서부지역에 거주하는 18세 이상의 남자 120명, 여자 94명과 동부지역에 거주하는 18세 이상의 남자 182명, 여자66명이 있으며 계측항목은 눈을 중심으로 한 9가지, 코를 중심으로 한 4가지로 모두 13가지 였다. 실제 계측은 표준화된 방법으로 촬영한 전면, 왼쪽측면 및 왼쪽45˚ 경사면 사진을 대상으로 image analyzer를 이용하여 시행하였다. 계측치는 남녀를 공히 동쪽 및 서쪽으로 나누어 비교하였다. 또한 이들의 자료를 기존의 한국인 자료와 비교하여 보았다. 남자의 경우 동쪽은 서쪽에 비하여 코너비가 넓었으며 검은자직경이 컸다. 또한 눈꺼풀틈새의 경사도가 약간 올라가고 눈꼬리 사이거리가 긴 경향을 보였다. 한편 여자의 경우에는 동쪽여자가 서쪽에 비해 눈구석사이거리가 매우 유의하게 길었으며 반대로 눈꺼풀 틈새 길이는 잛았다. 눈꼬리가 치켜 올라간 것이 또 하나의 특징이 였으며 검은자직경 역시 남자에서와 마찬가지로 동쪽여자에서 컸다. 한국인의 기존자료와 비교하여 보았을 때 대다수 항목의 측정값은 남녀 모두에서 서쪽보다는 동쪽에 거주하는 위그리인의 수치가 한국인에 가까웠다.