소목(Caesalpinia sappan) 추출물의 Streptococcus mutans에 대한 성장, 산생성, 부착 및 비수용성 글루칸 합성 억제에 미치는 영향

유용욱,유현희,김윤정,유미선,서세정,이황,이흥수 대한구강보건학회 2003 大韓口腔保健學會誌 Vol.27 No.2

Streptococcus mutans is known as the causative bacterial playing the most important role in forming plaque and it is being noticed as major causative bacteria of dental caries. Therefore, development of more effective, substantial and safe preventive agent against dental caries and periodontal disease is honestly required. The present study was designed to investigate the effect of chloroform extract(CE), n-butanol extract(BE),methanol extract(ME) and water extract(WE) of Caesalpinia on the growth, acid production, adhesion, and insoluble glucan synthesis of Streptococcus mutans. The CE, BE, ME and WE decreased the growth and acid production of S.mutans than that of control, especially, the ME was more effective than other extracts. The effect of CE, BE, ME and WE on the adherences to saliva-coated hydroxyapatite bead(S-HA) were evaluated. At the concentration of 2,000 ㎍/㎖, the CE showed 32% rate of bacterial adherence to S-HA, whereas, other extracts of the same concentration producedgreater than 50% rate. The CE and BE were significantly decreased the reduction rates of water insoluble glucan formation from sucrose by crude glucosyltransferase of S.mutans. Thus, the application of C. sappan can be considered a useful and a practical method for the prevention of dental caries.

대퇴동맥을 통한 경피적 관동맥 중재시술 환자의 천자부위 지혈을 위한 Angioseal^(�) 사용과 고식적 용수 압박법의 비교 : 전향적 연구

김용훈,권현철,김필호,안석진,유철웅,최진호,이상철,김준수,김덕경,전은석,이상훈,홍경표,박정의,서정돈 대한내과학회 2004 대한내과학회지 Vol.66 No.5

목적 : 경피적 관동맥 중재술은 최근 양적 및 질적으로 급격한 발전을 보였지만 시술 시 천자부위의 혈관 합병증은 아직 해결해야 할 문제점이다. 저자들은 대퇴동맥을 통한 경피적 관동맥 중재술을 환자에게 천자부위 지혈을 위한 혈관폐쇄기구인 안지오실의 안전성과 유용성을 고식적인 용수 압박법과 비교 연구하고자 하였다. 방법 : 2002년 4월부터 2003년 5월 사이에 삼성서울병원 심장혈관센터에서 대퇴동맥을 통한 경피적 관동맥 중재술을 성공적으로 시행한 200명의 환자(안지오실 사용군: A군, 100명, 고식적 용수압박법 사용군 B군, 100명)를 대상으로 시술 후 주요 합병증 및 경한 합병증, 지혈 후 환자가 자리에 앉기까지의 시간, 보행개시 가능시간, 총 재원 기간과 시술 1주 후의 합병증을 전향적으로 조사하여 비교 연구하였다. 결론 : 두 군에서 연령, 성별, 기저질환, 심혈관 질환의 위험요소, 시술의 종류, 시술 중 사용한 헤파린의 양, clopidogrel의 양, ticlopidine의 양, 지혈 시 수축기와 확장기혈압, ACT (activated clotting time)는 차이가 없었다. A군이 B군에 비해 시술 후 자리에 앉기까지의 시간 (A군: 4.3±0.3시간, B군: 13.7±0.8시간, p=0.004) 및 보행개시까지의 시간(A군: 6.8±0.5시간, B군: 18.8±2.1시간, p=0.013)이 유의하게 짧았다. 시술 후 주요 합병증은 두군 모두에서 관찰되지 않았으며, 경한 합병증의 전체발생은 A군에서 유의하게 적었다(A군: 28명, B군: 19명, p=0.003). 반상출혈의 경우는 A군에서 유의하게 낮았지만(A군: 3명, B군: 12명, p=0.01), 혈종, 출혈의 발생은 두군간에 차이가 없었다. 총 재원기간에는 두 군간에 차이가 없었다(p=0.239). 시술 1주 후 경과관찰에서 주요합병증은 역시 두 군 모두에서 관찰되지 않았으며, 경한 합병증의 전체발생은 두 군에서 차이가 없었다(A군: 15명, B군: 13명 p=0.418), 반상출혈의 빈도는 차이가 없었지만 혈종의 발생은 A군에서 더 낮았다(A군: 2명, B군:6명, p=0.004). 두 군 모두에서 출혈은 발생하지 않았다. 결론 : 대퇴동맥을 통한 경피적 관동맥 중재술을 시행한 환자에서 안지오실의 사용은 고식적 용수 압박법에 비해 환자의 침상 안정시간을 줄여 조기 활동개시가 가능하게 하였으며 국소합병증의 위험도를 일부 낮추어, 시술에 따른 환자의 불편을 현저하게 감소시킬 수 있다고 할 수 있을 것으로 기대된다. Background : Although the number and the quality of percutaneous coronary intervention have been recently increased dramatically, the vascular complication at puncture site is still the major cause of patients' morbidity. We evaluated the safety and efficacy of newly of newly-developed collagen-based arterial closure device, Angioseal after transfemoral percuatenous coronary intervention. Methods : This study was designed as a prospective single center non-randomized comparative study. A total 200 patients undergoing transfemoral percutaneous coronary intervention were enrolled between April 2002 and May 2003. They were divided into two groups; Angioseal group (group A, n=100) and manual compression group (group B, n=100). The baseline clinical and angiographic characteristics were reviewed. The time to sit up, the time to ambulation, the duration of hospital stay, major and minor vascular puncture site complications were monitored. The patients were followed-up for 1 week after procedure by telephone. Results : The baseline clinical characteriwtics, clinical diagnosis, cardiocascular risk factors, typesof procedure, doses and numbers of anticoagulants were similar between two groups. The blood pressure and activated clotting time were also similar. The time to sit up (group A: 4.3±0.3 hours, group B: 13.7±0.8 hours, p=0.004) and the time to ambulation (group A: 6.8±0.5 hours, group B: 18.8±2.1 hours, p=0.013) were shorter in group A. No major vascular complications were noted. The incidence of hematoma and bleeding were not significantly different between two groups. The incidence of ecchymosis, however, was significantly lower in group A (group A:12%, group B: 3%, p=0.001) The duration of gospital stay was similar between groups. During 7 days of follow-up period incidence of hematoma was significantly lower in group A (p=0.004). Although the incidence of ecchymosis was not significantly different between two groups. Conclusion : The angioseal may be associated with earlier ambulation and less patients' morbidity with low incidence of local complication rate compared to manual compression after transfemoral percutaneous coronary intervention.

광양만의 저질 중금속 농도 분포 특성

김도희,유한홍,정종성,조현서,신현출 木浦海洋大學校 2002 論文集 Vol.10 No.1

The main goals of the study were to investigate the sediment quality and trace metal distribution in sediment of Kwangyang Bay, south coastal of Korea. Surface sediment sampling were performed in November, 2000 and February and March, 2001. The concentration of H₂S, IL and COD in sediment were measured by a manual of the Department of Marine Environment of Korea. The extracted trace metals Fe, Cu, Cd, Pb, and Zn in sediments mean analyzed by the flame atomic absorption spectrophotometer with an instrument of model Shimadzu AA-6701F. H₂S, IL and COD in the surface sediment were 1.3 mg/g, 5.9 % and 15.0 mg/g, respectively. The mean content of Fe, Cu, Cd, Pb and Zn were 1523 mg/kg, 4.799 mg/kg, 1.321 mg/kg 9.285 mg/kg and 9.353 mg/kg, respectively. All of these measured trace metals level were over the other reported trace metal level in sediment of coastal area. According to histograms, the content of H₂S, IL and COD and trace metals in sediment of this study were affected by artificial activities rather than natural process.

Design, Synthesis, and Evaluation of 3,5-Disubstituted 7-Azaindoles as Trk Inhibitors with Anticancer and Antiangiogenic Activities

Hong, Seunghee,Kim, Jinhee,Seo, Ju Hyeon,Jung, Kyung Hee,Hong, Soon-Sun,Hong, Sungwoo American Chemical Society 2012 Journal of medicinal chemistry Vol.55 No.11

<P>Tropomyosin-related kinase A (TrkA) is considered a promising target in the development of a therapeutic treatment of cancer and pain. In this study, we designed and synthesized a series of novel 7-azaindole-based Trk kinase inhibitors through the structure-based design strategy. By varying the functional groups at the 3 and 5 positions of a 7-azaindole scaffold, we studied the structure–activity relationships (SAR) profiles and identified a series of potent Trk inhibitors. Representative derivatives showed desirable activity in cellular proliferation and apoptosis assays. Moreover, these inhibitors exhibited noteworthy antiangiogenic activity.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jmcmar/2012/jmcmar.2012.55.issue-11/jm3002982/production/images/medium/jm-2012-002982_0008.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/jm3002982'>ACS Electronic Supporting Info</A></P>

여수연안 이상고수온 출현에 따른 멸치 난자치어 분포 특성

홍서현(Seo Hyeon Hong),이하민(Ha Min Lee),김동화(Dong Hwa Kim),김영혜(Younghye Kim) 한국해양환경·에너지학회 2017 한국해양환경공학회 학술대회논문집 Vol.2017 No.10

문화예술교육사 2급 현장실습 제도와 정교사 2급의 현장실습 제도 비교연구

홍서현(Hong Seo-hyeon) 한국문화예술교육학회 2020 모드니 예술 Vol.17 No.-

This study aims to compare and analyze ‘Understanding of Culture and Arts Education Field and Practice’which is one of subjects of curriculum for 2nd grade arts & culture education instructor license designated by the Ministry of Culture, Sports and Tourism as a national license of Korea in accordance with the 「Act on Support for Arts and Culture Education」 and field practice for 2nd grade regular teachers which is the most representative qualification system in Korea for training of teachers. This study is also aiming at suggesting direction for development by heightening the value and efficiency of field practice for 2nd grade arts & culture education instructor license by raising problems with operation system of current field practice and suggesting improvement plans for the problems. For the foregoing, the researcher of this study investigated operation system and syllabus of the subject‘Understanding of Culture and Arts Education Field and Practice’which is the curriculum for 2nd grade arts & culture education instructors, and pointed out problems in both quantitative and qualitative levels after investigating, comparing and analyzing operation system of field practice for 2nd grade regular teachers. As a result of comparative analysis at quantitative level, this study found that field practice for 2nd grade arts & culture education instructors is just an experience and the times are insufficient as compared to 2nd grade regular teachers. As an improvement plan for the aforementioned, this study suggested to operate‘Understanding of Culture and Arts Education Field’and‘Culture and Arts Education Field Practice’subjects by dividing into two categories for expanding times of field practice. Results of comparison and analysis at the qualitative level show that field practice for 2nd grade arts & culture education instructors has ambiguity of operation system, lacks in field practice operation manual, operating and practice agencies. As improvement plans for such problems, this study suggested to systemization of field practice operation system, setting up field practice management system and establishment of field practice support center by regional groups. In addition to the above, continued interest and a lot of researches other than this study for heightening the value and efficiency of arts & culture education instructor license are considered necessary, and various possibilities of development shall also be suggested for arts & culture education instructor system as society, culture and times change.

일차성 쇼그렌증후군 환자에서 나타나는 자가항체와 선외증상의 양상

서수홍 ( Soo Hong Seo ),김현숙 ( Hyun Sook Kim ),곽승기 ( Seung Ki Kwok ),주지현 ( Ji Hyeon Ju ),김상현 ( Sang Hyon Kim ),윤종현 ( Chong Hyeon Yoon ),김호연 ( Ho Youn Kim ),박성환 ( Sung Hwan Park ) 대한류마티스학회 2007 대한류마티스학회지 Vol.14 No.1

Objective: To investigate the extraglandular manifestations and serological features of Korean patients with primary Sjogren`s syndrome (pSS). Methods: Clinical and laboratory data of 125 patients with pSS attending rheumatology clinic of Kangnam St. Mary`s hospital, with a mean follow-up period of 64.8 months, were assessed retrospectively. Results: Arthralgia was the most common extraglandular manifestation of pSS. Other extraglandular manifestations, such as myalgia, peripheral neuropathy, Raynaud`s phenomenon, and hypothyroidism were frequently presented, but lymphoma was rare manifestation in Korean patients with pSS. Some extraglandular manifestations of pSS were associated with hypocomplementemia and antibodies against Ro, and La, and antinuclear antibody. Conclusion: The clinical manifestations and extraglandular manifestations of Korean patients with pSS patients were similar to other studies except low prevalence of lymphoma. Positivity of anti-Ro/SS-A, anti-La/SS-B antibodies and hypocomplementemia were closely associated with extraglandular manifestations in patients with pSS.

벼 가공단계별 잔류농약의 가공계수 산출

조승현 ( Seung Hyeon Jo ),강현우 ( Hyeon Woo Kang ),신현우 ( Hyeon Woo Shin ),김동주 ( Dong Ju Kim ),이다영 ( Da Yeong Lee ),김정아 ( Jeong Ah Kim ),김서홍 ( Seo Hong Kim ),임무혁 ( Moo-hyeog Im ),경기성 ( Kee Sung Kyung ) 한국환경농학회 2019 한국환경농학회 학술대회집 Vol.2019 No.-

벼 도정 정도 및 쌀의 가공품별 농약의 실제 섭취율을 산출하기 위하여 cGAP및 TMDI를 고려하여 벼 재배과정에서 사용하는 buprofezin, flubendiamide, tebufenozide, etofenprox을 시험농약으로 선정하고 주산지 3개 지역에서 안전사용기준에 따라 시험농약을 살포하고 수확한 후 왕겨, 쌀겨, 현미, 백미, 현미밥, 백미밥, 떡으로 가공하고 각 가공품 중 잔류량을 GC-MS/MS 또는 LC MS/MS로 분석하여 가공단계별 가공계수를 산출할 예정이다. 또한 개발된 분석법은 신뢰도를 높이기 위하여 codex 기준에 따라 외부 실험실 검증을 수행할 예정이다. 이 연구의 결과를 이용하여 잔류농약의 정확한 섭취량을 산출함으로써 도정 정도 및 쌀 가공품 중 잔류농약의 과학적인 위해성 평가에 기여할 것으로 판단된다.

[PB-0100] Functional Analysis of Heat-induced RING-type E3 Ligases in Sorghum: Expression Patterns, Subcellular Localizations and Interaction Partners

Yu Kyong Hu(Yu Kyong Hu),Hong-Ju Lee(Hong-Ju Lee),Jeong Ho Shin(Jeong Ho Shin),Sang Hun Kim(Sang Hun Kim),Min Seok Choi(Min Seok Choi),Hyeon Ung Seo(Hyeon Ung Seo),Cheol Seong Jang(Cheol Seong Jang),S 한국육종학회 2022 한국육종학회 공동학술발표집 Vol.2022 No.-

JAG1 Intracellular Domain JICD1 Forms Novel Transcription Complex with DDX17, SMAD3, TGIF2 without Contact Notch Receptor

Hyeon Ju JEONG,Eun-Jung KIM,Jung Yun KIM,Seok Won HAM,Sang-Hun CHOI,Nayoung HONG,Min Gi PARK,Junseok JANG,Sunyoung SEO,Sung-Ok KIM,Sung-Chan KIM,Hyunggee KIM 한국생물공학회 2021 한국생물공학회 학술대회 Vol.2021 No.10

The Jagged-1 (JAG1) is a Notch ligand that contact-dependently activates Notch receptors and regulates cancer progression. When Notch receptor activate, NOTCH intracellular domain (NICD) is released through proteolytic cleavage and forms transcription complex. Here, we show that JAG1 also releases JAG1 intracellular domain (JICD1) and JICD1 forms a transcription complex with DEAD-Box Helicase 17, SMAD Family Member 3, and TGFB induced factor homeobox 2. The JICD1 transcription complex binds to the promoter of Sex determining region Y-box 2 (SOX2) and regulates transcription of SOX2. JICD1 promotes acquisition of glioblastoma (GBM) stem cell properties by JICD1 transcription complex mediated SOX2 expression. JAG1 is highly expressed in GBM and induce reverse signal via JICD1 transcription complex. By regulating transcription of SOX2, JICD1 transcription complex is an important player in the maintenance of GBM properties. The inhibition of JICD1 transcription complex may be a novel strategy to target Notch signal.