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타리비드 정(오플록사신 100㎎)에 대한 파비드 정의 생물학적동등성
박완수,조성희,이헌우,임호택,홍성제,서성훈,류재환,이경태 한국약제학회 2005 Journal of Pharmaceutical Investigation Vol.35 No.1
The purpose of the present study was designed to evaluate the bioequivalence of two ofloxacin tablets, Tarivid (Jell Pharm. Co., Ltd.) and Favid (ILHWA Co., Ltd.), according to the guidelines of Korea Food and Drug Administration (KFDA). Twenty-four normal male volunteers, 23.67±3.12 year in age and 68.50±7.23 kg in body weight, were divided into two groups and a randomized 2x2 cross-over study was employed. After four tablets containing 100 mg of ofloxacin were orally administered, blood was taken at predetermined time intervals and concentrations of ofloxacin in plasma were deter mined using HPLC. Pharmacokinetic parameters such as AUC_(t) and T_(max) were calculated and ANOVA test was utilized for the statistical analysis of the parameters using logarithmically transformed AUC_(t), and C_(max) and untransformed T_(max). There were no sequence effects between two formulations in these parameters. The 90% confidence intervals for the log transformed data were acceptance range of log 0.8 to log 1.25 (e.g., log 0.94-log 1.04 and log 0.90-log 1.07 for AUC_(t) and C_(max) respectively). The major parameters. AUC_(t) and C_(max) met the criteria of KDFA for bioequivalence indicating that Favid tablet is bioequivalent to Tarivid tablet.
High-Volume 플라이애쉬 콘크리트의 기포조직에 관한 연구
강수근,서완용,정철우,김영수 釜山大學校生産技術硏究所 2002 生産技術硏究所論文集 Vol.61 No.-
산업 부산물인 플라이애쉬를 사용한 콘크리트는 내부에 존재하는 다량의 플라이애쉬에 의해 발생하는 공극의 분화 효과에 의해 보통의 콘크리트와는 다른 기포조직을 가질 수 있다. 콘크리트가 동결작용을 받을 시 발생하는 수압을 완화할 수 있는 기포의 영향범위는 기포간의 거리에 의해 결정되며, 이것의 최대값이 기포간격수라고 불리고 있다. 본 연구에서는 High-Volume 플라이애쉬 콘크리트의 기포조직을 카메라를 통하여 입력된 화상의 데이터를 컴퓨터에 의해 정략적으로 처리하는 화상분석법을 이용하여, 연행공기량과 플라이애쉬 콘크리트의 공기량, 비표면적, 기포간격계수 등을 보통 콘크리트와 비교, 분석함으로서 High-Volume 플라이애쉬 콘크리트의 기포조직을 파악하고자 한다. The purpose of this paper is to investigate the air-void spacing factor of high-volume fly ash concrete. For this purpose, the air-void spacing factor of the hardened fly ash concrete was determined by image analysis method for a large number of parameters adjusting such as air contents and the rate of fly ash replacement. Based on the study of the test results, the following conclusions may be drawn. 1) As the rate of fly ash replacement for high-volume fly ash concrete increases, air contents decrease. Furthermore the air content is varied approximately 1 % before and after hardening. 2) As the replacement of fly ash increases, the spacing factor increases due to adsorption of air entraining agent. 3) As the air content decreases and the specific surface increases, the spacing factor of High-Volume fly ash concrete increases.
유경미,서우영,서한석,김완수,박재복,황인경 한국조리과학회 2004 한국식품조리과학회지 Vol.20 No.4
The purposes of this study were to investigate the physicochemical characteristics and storage stabilities of various sauces with added Yuza(Citrus Junos). Yuza consisted of three parts: peeled (46.17%), fleshed (43.74%) and seeded (10.09%). Yuza juice revealed 11.33% extraction yield, pH 2.85, 4.18% total acidity, 11° Brix, 1.16% transmittance and 2.63° Brix/acid ratio. Five kinds of sauces with added Yuza juice were Yuza red pepper paste sauce, Yuza soybean sauce for meat, Shahu shabu Yuza sauce, Korean Yuza vegetable sauce and Japanese Yuza soybean sauce. These sauces showed slight changes in pH, total acidity, total bacterial counts and overall sensory characteristics during storage period (60 days). In conclusion, Yuza juice could be applied to various sauces, which remained usable for 60 days.
Seo, Dong-Wan,Nam, Suk-Woo,Nam, Tae-Kyun,Lee, Young-Jin,Ko, Young-Kwon,Lee, Hyang-Woo The Pharmaceutical Society of Korea 1995 Archives of Pharmacal Research Vol.18 No.6
In pancreatic cells, NO formation is associated with increased levels of cGMP and endocrine/exocrine secretion. In the present study, the role of NO in the regulation of exocrine secretion was investigated in rat pancreatic tissues. Treatment of rat pancreatic tissue with sholecystokinin-pancreozymin (CCK-PZ) resulted in an significant increase in arginine conversion to citruline, the amount of nitrite/nitrate, the release of amylase, and the level of cGMP. Furthermore, CCK-PZ stimulated increase of amylase release and conversion of arginine to citrulline transformation were counteracted by the inhibitor of NO synthase, $N^G-nitro-L-arginine$ methyl ester. The results on the time course of CCK-PZ-induced citrulline formation within the first seconds of simulation. The kinetics of citrulline accumulation correlate well with those of cGMP rise, which further confirms the conclusion that NO mediates the response to CCK-PZ by cGMP.
TiCl₄ 농도와 교반강도가 수중 인 제거에 미치는 영향
서완우(Wan Woo Seo),이봉희(Bong Hee Lee),박화수(Hwa Soo Park),김종호(Jong Ho Kim),안종화(Johng Hwa Ahn) 大韓環境工學會 2016 대한환경공학회지 Vol.38 No.3
본 연구는 TiCl₄의 농도(0.25-0.59 mM)와 급속교반속도(100-250 rpm), 완속교반속도(30-60 rpm)의 변화가 인 제거효율에 미치는 영향을 알아보고자 하였다. 응집제 농도가 0.25≤[TiCl₄]≤0.39 mM 범위에서 인 제거 효율은 TiCl₄의 농도가 증가할수록 증가하였으며 처리후 인의 농도는 0.2 mg/L 이하였다. 응집제 농도 0.39 mM, 급속교반속도 100 rpm, 완속교반속도 30 rpm에서 인 제거효율이 약 99%로 가장 높았다. TiCl₄의 농도가 낮을 경우(0.25-0.27 mM) 인제거효율의 편차는 급속교반속도 변화(2-3%)보다 완속교반속도 변화(7-10%)에서 더 민감하였다. This study evaluates the efficacy of titanium tetrachloride (TiCl₄) on phosphorus (P) removal in synthetic wastewater. Jar test experiments were performed at various TiCl₄ concentration (0.25-0.59 mM), and intensities of slow (30-60 rpm) and rapid (100-250 rpm) mixings to determine the conditions at which P removal was most efficient. The P-removal efficiency was highest (about 99%) at TiCl₄ concentration ([TiCl₄])=0.39 mM with rapid-mixing intensity=100 rpm and slow-mixing intensity=30 rpm. The slow-mixing intensity was more sensitive than the rapid-mixing intensity to the P removal efficiency when [TiCl₄] was low (0.25≤[TiCl₄]≤0.27 mM).