장기간 항갑상선제 투여 후 임의 중단 뒤 재복용시 발생한 무과립구증 1 예

김승만;김태영;박수영;배영환;서영경 정은주;김태균;권민정;박정현;이순희 인제대학교 2011 仁濟醫學 Vol.32 No.-

Agranulocytosis, one of the major side effects of antithyroid a gents, probably occurs in less than 0.25% of cases treated with antithyroid agents. It usually occurs within the first several weeks or months after the initiation of therapy, when drug dosage is higher. Most reported cases of agranulocytosis have occurred during the first 3 months of therapy. We describe here a rare case that did not experience the side effect for 6 years of antithyroid agent treatment but presented with agranulocytosis in one month after re-exposure. It suggests that the major side effect such as agranulocytosis can occur in patients who had undergone prior uneventful antithyroid drug therapy.

조선대학병원에서 경험한 삼일열 말라리아의 임상적 고찰

서영선,김양수,김태균,박유환,홍순표,정춘해 조선대학교 부설 의학연구소 1999 The Medical Journal of Chosun University Vol.24 No.1

In the five years since 1993 Malaria has made a ceaseless attack on the native Koreans as an indigenously formed disease in addition to the imported one. This study was aimed at clinical symptoms and signs of Malaria which had occurred indigenously in Cheon-Nam. 18 cases were reviewed retrospectively in this study which was composed of 17 men and 1 woman. They were admitted to Chosun Hospital because of the indigenous Malaria in 1998. Fever and chill , the most frequent symptoms in early stages made a 100% occurrence followed by general myalgia(89%) and headache(83%). Physical examination of those admitted showed the splenomegaly most frequently in 61% of the patients. It took four to ten days to visit the hospital since the symptoms first occurred in the patients. Gametocytes among the Malarial life cycle were observed most commonly (91.3%) in the occurrence of the disease and the prestages of the life cycle as well. The hematologic abnormalities observed was Anemia(89%), Thrombocytopenia(61%), and Neutropenia(50%) in the order named. On the third hospital day since giving the standard Malarial drugs parasitemia decreased remarkably (1540/㎕ : Mean parasitic concentration) and 28th day of treatment no parasitemia were found. In conclusion the patients suffering from malaria in Cheon-Nam had been in an armistice area and the symptoms were so relatively mild that the responses to treatment were good and relapses occurred. But, it requires further epidemiologic survey and more concern about the indigenous Malaria.

간장 허혈 및 재관류시 vitamin C와 E가 간장기능에 미치는 영향

서민영,김순애,조태순,이선미 성균관대학교 약학연구소 1995 成均藥硏論文集 Vol.7 No.1

Abstract - This study was done to investigate the effect of vitamin C and E on hepatic biliary and microsomal function during ischemia and reperfusion. Rats were treated with vitamin C, E or with vehicle(saline) and then subjected to 60 min no-flow hepatic ischemia in vivo. Control animals were time-matched sham ischemic animals. After 1 or 5 hr of reperfusion, bile was collected, blood was obtained from the abdominal aorta, and liver microsomes were isolated. In vehicle-treated ischemic rats, serum ALT levels peaked at 5 hr and were significantly attenuated by vitamin C, E individually and combination of vitamin C and E treatment. Similarly hepatic wet weight-to-dry weight ratio was increased in the vehicle-treated ischemic group. Vitamin C and E combination minimized the increase in this ratio. Lipid peroxidation was elevated in vehicle-treated ischemic group, but this elevation was also inhibited by vitamin C or E, respectively. Bile flow and cholate output, but not bilirubin output, were markedly decreased by ischemia/reperfusion. Vitamin C treatment restored the secretion. Cytochrome P-450 content was decreased by ischemia/reperfusion and restored by vitamin E treatment to the level of sham operated group. Aminopyrine N-demethylase activity was decreased and aniline p-hydroxylase activity was increased by ischemia/reperfusion. These changes were prevented by vitamin C or E treatment, but not by vitamin C and E combination treatment. Our findings suggest that vitamin C or E individually significantly ameliorates these ischemia/reperfusion-induced hepatic damages and there is no evidence of synergism between vitamin C and E in our system.

비타민 E와 알츠하이머병

서애리,이현숙,김영순 高麗大學校 倂設 保健大學 保健科學硏究所 2000 保健科學論集 Vol.26 No.1

Cognitive decline is perceived to be a characteristic of the aging process, and is profoundly manifested in age-related neurodegenerative disorders such as Aizheimer's Disease(AD). The pathologic mechanisms underlying neurodegeneration are complex and not completely understood, but a contributing factor is believed to be oxidative stress. The brain has a high metabolic requirement for oxygen and a high concentration of polyunsaturated fatty acids, and therefore is prone to lipid peroxidation. Lipid peroxidation leads to the production of free radicals that may attack and irreversibly damage neural tissue, thus contributing directly or synergistically to neurodegenerative process. Accumulating evidence from preclinical and clinical studies supports the hypothesis that oxidative stress may be associated with the onset and progression of AD. Antioxident therapies are being promoted in the lay press to enhance mental functions and delay cognitive losses with aging. This paper summarizes the oxidative stress hypothesis of AD and reviews the strengths and limitations of published antioxidant studies in AD in relation to the role of such therapies in practice.

여대생의 피부유형에 따른 식생활습관 및 식품기호도

서동희,박금순,신영자 한국식생활문화학회 2005 韓國食生活文化學會誌 Vol.20 No.1

This study seeks to classify the skin types and determined the relation between the dietary habit and preference of foods targeting college women in Daegu and Gyeong-Buk Province. Skin types of the subjects were 31% of combination skin, 25% of dry skin and 22% of normal ? oily skin. College women mostly had two meals a day, and those who had less frequent meals developed more combination skin. Many of them did not exercise, and women with normal skin who did not exercise showed the lowest at 13.9%, supporting the significance (p〈.05). It was exposed that don't have breakfast and have irregular meal and don't have easy meal in all skin types. Instant foods was exposed that ingested the most in dry skin and the least in oily skin, supporting the significance(p〈.05) and fruit or vegetable ingested much in dry skin. It was exposed that considered atmosphere at meal and meal helps in health in all skin types, normal skin type considered balanced diets the most and supporting the significance(p〈.01) Food preference in all skin types showed the strongest in drinks and showed strong in greenish yellow vegetables, fruits, confectioneries, drinks, milk and dairy goods. On the other hand. it showed low in nuts and salted fishes. In sum, regular and balanced meals give the skin a healthy status. and intake of protein, vitamins and minerals has impact on the skin status. Thus. sufficient quality nutrition is crucial in staying a healthy skin.

주사전자현미경을 이용한 온실가루이(Trialeurodes vaporarium) 성충 부속지의 외부 미세구조 관찰

서미자,김기덕,김남성,박수진,채순용,윤영남 충남대학교 농업과학연구소 1999 농업과학연구 Vol.26 No.2

온실가루이의 외부형태적 특징을 주사전자현미경 사진을 통해 관찰하였다. 우선 이들은 포탄모양의 알을 산란하는데 짧은 갈고리모양의 구조에 의해 잎 뒷면에 붙어있는 것이 확인되었다. 촉각의 길이는 0.3㎜로 전체가 6마디로 구성되어 있고, 첫마디는 굵고 짧으며 둘째 마디부터 가늘고 긴 채찍모양을 하고 있다. 끝마디인 6번째 마디의 끝에는 길이가 10㎛정도의 가늘고 비교적 긴 감각기를 가지고 있어 기주를 탐색하는 과정에서 식물체의 표면을 탐지하는데 사용하는 것으로 사료되며, 바로 밑부분에는 길이가 7-8㎛정도의 비교적 굵은 감각기 2개가 존재하고 있는 것으로 확인되었다. 이 감각기는 반대편에는 존재하고 있지 않은 비대칭 분포를 보이고 있으며, 또한 두개의 모양이 서로 상이함으로 볼 수 있다. 이들의 기능은 주로 기주식물을 탐색하거나 후각기능의 화학적 감각기의 역할을 하는 것으로 추정할 수 있다. 섭식행동이 이루어지는 온실가루이 구기는 전형적인 piercing-sucking type으로, 구침이 길게 잘 발달되어 있다. 구기의 끝부분은 10여개의 미세감각기가 분포고 있어 식물체 표면을 탐색하고 맛을 보는 미각기능을 하고 있으리라 추측할수 있다. 구침은 종종 구기에서 분리되기도 하지만, 구침을 잡아주는 지지대가 기부쪽에 자리하고 있음을 알 수 있다. 구침은 두 개의 반원형이 붙어 있는 형상을 하고 있으며, 다른 흡즙형 구침과는 달리 톱날모양의 구조를 볼 수 없었다. 한편 온실가루이의 다리 끝에 붙어 있는 발톱은 식물체에 고정시키기 위한 구조로 보이는 두 개의 갈고리 형태의 발톱과 그 사이에 중앙지지대 형태의 구조인 paranychium을 포함하여 3갈래의 구조를 하고 있다. External morphology characteristics of the greenhouse whitefly, Trialeurodes vaporarium were investigated by scanning electron microscopy. The antennae of the greenhouse whitefly was 6 segments, rod-shape, and 0.3mm length. On the 6th segment, there were many sensilla for searching host-plant as olfactory receptor. The mouthpart of the greenhouse whitefly was a piercing-sucing type, then its stylet was well developed for piercing plant leaf tissue. Claw of the foreleg was a 3-war hook shape including paranychium for attaching plant surface to pierce and lay egg.

교원효소로 유발된 랫드 대뇌 출혈병변의 병리학적 관찰

서일복,소경순,김광호,김영석 世明대학교 한의학연구소 1998 韓醫學硏究所 論文集 Vol.1 No.-

This study was carried out to characterized the hemorrhagic lesion sof the collagenase induced hemorrhagic stroke in rats. Fifty three Sprague-Dawley male rats were divided into two group. Group Ⅰ was served as model animals for hemorrhagic stroke, which were infused with 2㎕ saline containing 0.5unit collagenase(type Ⅶ) into the caudaate nuclei. Group Ⅱ was served as control animals, which were infused with 2㎕ saline only into the caudate nuclei. Six heaks of the rats of group Ⅰ were sacrificed at 30 min, 1, 5, 24 hours, 2, 5, 10 days after the infusion , and 3 heads of rats were sacrificed at 15 days after the infusion. Two heads of the rats of group Ⅱ were sacrificed at 30min, 1,5, 24 hours after the infusion. The brains of the rats were removed and examined grossly and histopathologically. Grossly, pin point sized or linear hemorrhage were occurred at 30minutes and the hemorrhagic lesions extended to 5mm in diameter at 24 hours. After then the hemorrhagic lesions faded gradually. Histopathologically, extended hemorrhage with degeneration of brain parenchyma were observed at 5 hours. Large area of malacia were observed at 24 hours. At 5 days, proliferation of astrocytes, proliferation of newly formed capillaries, and infiltration of lipid laden macrophages were seen at the periphery of the area of malacia. At 15 days, most of the area of malacia were replaced by granulation tissue. These observations may be useful parameters for the screening of therapeutic drugs using collagenase induced hemorrhagic stroke animal model.

Helicobacter pylori 양성인 소화성 궤양 및 위염 환자에서 Helicobacter pylori 제균에 대한 판토프라졸 포함 삼제 요법의 임상효과 및 내약성에 대한 연구

서영호,이완식,주영은,김현수,최성규,유종선,김행재,서순팔,김세종 최신의학사 2000 最新醫學 Vol.43 No.11-12

유치 상아질의 표면조도가 글라스 아이오노머 시멘트의 결합강도에 미치는 영향

김영진,남순현,서정필 大韓小兒齒科學會 1991 大韓小兒齒科學會誌 Vol.18 No.1

상아질면의 표면조도가 글래스 아이오노머 시멘트의 결합강도에 미치는 영향을 알아보고자 30개의 유구치를 대상으로 하여 상아질면을 노출시키고 600번 연마지로 연마한 뒤 최종 마무리 방법에 따라 다음의 5군으로 나누어 실험하였다. 1군;대조군(600-grit silicon carbide paper로 마무리한 군) 2군;diamond bur(medium grain)로 마무리한 군 3군;carbide cross-cut taperd fissure burwet pumice로 마무리한 군 4군;wet pumice로 마무리한 군 5군;detin conditioner(25% polyacrylic acid)로 10초간 적용시킨 군 상아질 마무리 후의 표면조도는 표면조도측정기로 측정하였고 시멘트 접합 후 결합강도는 만능시험기로 측정하였으며,마무리 후의 표면양상과 시편의 파절면 양상을 주사전자 현미경으로 관찰하여 다음과 같은 결과를 얻었다 상아질 마무리 후의 표면양상은 diamond bur군에서표면굴곡이 가장 두드러지고 도말층도 많이 나타났으며,pumice군에서 가장 표면양상이 평할 하였고 도말층도 거의 없었다. 표면조도 수치는 diamond bur군에서 가장 높게 나타났고,그 다음으로 carbide bur군,대조군,detin conditioner군의 순이었고 pumice군에서 가장 낮게 나타났으며 (f=104.29,P<0.001),대조군과 detin conditioner군,pumice군과 detin conditioner군 사이에만 유의한 차이가 없었다(P<0.05). 결합강도는 pumice군에서 가장 높게 나타났고,그 다음으로 detin conditioner군과 대조군,carbide bur군의 순이었고 diamond bur군에서 가장 나타났으며 (f=18.65,P<0.001),pumice군에서 다른 모든 군애 비해 유의성있게 높게 나타났고 detin conditioner군에서도 diamond,carbide bur군에 비해 유의성있게 높게 나타났다(P<0.05). 상아질면이 평활할 수록 글래스 아이오노머 시멘트의 결합강도는 높게 나타났다. 시편의 파절면 양상 관찰결과,결합강도가 클수록 응집성파절(cohesive fracture)양상을 나타냈다. The purpose of this study was to evaluate the effect of the dentin surface roughness on the bond strengh of a glass ionomer cement in the primary teeth. In this study,30 deciduous molars with sound and healthy crown portion which were extracted in nomal exfoliative period were used.The dentin surfaces of these teeth exposed and polished with 600-grit silicon carbide paper and divided into 5 groups according to the detin finishing procedures: Group 1:control group(finished with 600-grit silicon carbide paper) Group 2:group finished with diamond bur(medium grain) Group 3:group finished with carbide cross-cut taperd fissure bur Group 4:group finished with wet pumice Group 5:group finished with detin conditioner(25% polyacrylic acid) for 10 secends The detin surface roughness(Rmax;μm) after finishing procedures were measured by a surface roughness tester and the tensile bond strength (Kg.f/㎠) after cementation was measured by a universal testing machine.Then,the dentin surfaces after dentin finishing procedures and fractured detin surfaces were examined with a scanning electron microscope. The results of this stydy were as follows: On the dentin surfaces after finishing procedures,the grinding grooves and the smear layer were the most prominent in the diamond bur group.The surface was the smoothest and also the smear layer was the least prominent in the pumice group. The surface roughness value was the highest in the diamond bur group,next came the caribde bur group, dentin conditioner group, control group and lowest in the pumice group(f=104.20,P<0.001).There were not statistical difference between control and dentin conditioner group, pmuice and dentin conditioner group only(P<0.05). The tensile bond strength was the highest in the pumic group,next came the dentin conditioner group, control group, caribde bur group and lowest in the diamond bur group(f=18.65,P<0.001).In the pumice group significantly highrer than the other groups and also in the detin conditioner group significantly highre than the diamond bur,caribde bur group(P<0.05). The smoother the dentin surface,the highre the bond strengh.On the fractured dentin surfaces,as the bond strength increased,the more cohesive fracture pattern was examined.

주사전자현미경을 이용한 토마토에 발생하는 아메리카잎굴파리(Liriomyza trifolii)의 외부형태적 특징

윤영남,김기덕,박수진,김남성,서미자,채순용 충남대학교 농업과학연구소 2000 농업과학연구 Vol.27 No.1

SEM을 이용하여 아메리카잎굴파리(Liriomyza trifolii)의 암 ·수컷 성충의 외부형태적 특징을 살펴보았다. 더듬이에 있어 감각모의 3가지 형태는 더듬이가는마디(funicle)에서 관찰되었으며, 모상감각기(trlchold sensillum)는 말단 부위가 뽀족한 특징적인 형태를 하고 있고 감각기들 중에서 가장 많이 분포하고 있다. 원추상 감각기(basiconic sensillum)는 길이가 13㎛, 지름이 1.4㎛에서 1.2㎛인 원형곡선형이다. 홈형 감각기(grooved sensillum)는 간상(peg) 끝에서 나온 손 모양을 하고 있으며, 이 모든 감각기들은 후각과 연관되어져 있는것으로 추정된다. 구기는 홉즙형으로 작고 펼쳐진 윗입술(labrum)과 합쳐져서 하나의 연결된 주둥이(rostrum)을 형성하고 있다. 가느다란 한 쌍의 작은턱수염(maxillary palp)은 긴 관 모양으로 각각의 세로로 이어져 있다. 발마디는 5마디로 이루어져 있으며 그 한가운데에는 패드모양의 흡착반(pulvillus)과 가시모양의 발톱사이돌기(empodium)가 있다. 아메리카잎굴파리는 흡착반과 발톱사이돌기에서 미끄러운 표면에 부착할 수 있는 물질을 분비한다. 수컷의 생식기는 매우 복잡하며 삽입구(aedeagus)는 생식기관으로서 가장 일반적인모양이다. 반면에 암컷의 생식기는 상대적으로 간단한데 이 구조는 외부로 돌출된 관모양이었다. 또한 이러한 결과를 이미 발표된 다른 여러 종의파리와 비교하였다. The external morphology of male and female of Liriomyza trifolii (Burgess) was studied using the scanning electron microscopy (SEM). Three types of sensilla were identified on the funicle of antennae. The trichoid sensilla were most conspicious and distributed with a characteristic sharp structure at the apical end. Basiconic sensilla were showed distal curvature about 13㎛ long and 1.2㎛ to 1.4㎛ in diameter. Grooved sensilla were showed a finger-like projections at the peg apex. The function of these sensilla likely to be olfactory. The mouthparts were adapted for sucking food, and formed a elongate rostrum which was incorporated with labrum. The labrum was a small and flap-like shape. The slender and paired maxillary palp seemed to combine with each other lengthwise to long tube. The tarsus typically consisted of 5 segments, which might be variously modified, principally by thickening or flattening. The segment healed a pair of claws. Beneath the claws, there was a pair of pad-like pulvillia and a bristle-like median empodium. L. trifolii secreted on the pulvillus and empodium an adhesive substance that enable them to cling to smooth surfaces. Male terminalia was complicated. The name 'aedeagus' seemed the best available general term for the copulatory organ, otherwise, female terminalia was usually relatively simple. This structure was reduced and formed a telescopic, eversible, and tubular ovipositor.