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Clinical Impact of MDR Pathogen during Bridge to Lung Transplantation
( Yunha Nam ),( Dong Kyu Oh ),( Tae Sun Shim ),( Kyun-wook Jo ),( Dong Kwan Kim ),( Sehoon Choi ),( Geun Dong Lee ),( Sung-ho Jung ),( Pil-je Kang ),( Seung-il Park ),( Sang-bum Hong ) 대한결핵 및 호흡기학회 2020 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.128 No.-
Background As lung transplantation and extracorporeal membrane oxygenation (ECMO) are increasing in worldwide, bridge to lung transplantation (BTT) is also increasing and showing good Results. A few reports of lung transplantation, whether multidrug resistance (MDR) pathogens or not showed no difference of clinical outcome. However there are only a few reports about effects of MDR during BTT. Therefore, this study aimed to examine whether the presence of an MDR pathogen in the respiratory system before transplantation could affect clinical outcome. Methods We retrospectively analyzed medical records of adult patients who underwent ECMO before lung or heart-lung transplantation from 2011 to 2018 in Asan Medical center. Culture result performed in the respiratory system before transplantation were analyzed and divided into MDR and non-MDR groups to determine intensive care unit (ICU) stay, post-operation hospital duration, and post-operation ventilator duration. Results Of 41 patients, the median age was 55 years and 26 (63.4%) were male. MDR pathogen was identified in 20 patients, and MDR-Acinetobacter baumanii was cultured the most (13 patients, 31.7%) among pathogens. Pre-operative duration was longer in MDR group, about 14 [Interquartile range (IQR) 11-13] vs 10 [IQR 4-15] days (p=0.009). There was no difference in total ICU stay (43 [IQR 28-62] vs 33 [IQR 22-55], p=0.175), post-operation ICU stay (16 [9-25] vs 15 [11-35], p=0.638), post-operation hospital duration (64 [32-214] vs 60 [42-111], p=0.990), and post-operation ventilator duration (10 [5-18] vs 11 [6-31], p=0.744) between two groups. Also, there was no significant difference in 1-year survival between the two groups (70% vs 76%, p=0.462). Conclusion In patients who underwent BTT, even though the MDR pathogen was detected before transplantation, post-transplantation outcomes are no different.
Exploration of Biological Markers of Suicidal Behavior in Major Depressive Disorder
YongKu Kim,SungDoo Won,JiWon Hur,BunHee Lee,HwaYoung Lee,SeHoon Shim,SangWoo Han,SoHyun Choi 대한신경정신의학회 2007 PSYCHIATRY INVESTIGATION Vol.4 No.1
Objective-Most suicides occur in the context of depressive disorders. In this study, new candidate biological markers for suicide were explored. Methods-The suicidal subjects consisted of 48 depressed patients (18 males and 30 females) admitted to emergency rooms following suicide attempts. The levels of nitric oxide, brain-derived neurotrophic factor (BDNF), insulin-like growth factor-1 (IGF-1), beta-nerve growth factor (β-NGF), and transforming growth factor-beta 1 (TGF-β1) were measured in the plasma of these 48 patients and 50 normal controls. The levels of tumor necrosis factor-alpha (TNF-α), interferon-gamma (IFN-γ), interleukin-2 (IL-2), interleukin-4 (IL-4), and interleukin-6 (IL-6) were measured in the culture supernatant after mitogen stimulation of whole blood from both groups. The lethality of the suicide attempt was measured using the Lethality Suicide Attempt Rating Scale (LSARS), and the Risk-Rescue Rating (RRR). Results-The suicidal depressed patients had significantly higher IL-6, TGF-β1, and nitric oxide (NO) levels compared with the normal controls after controlling for body mass. On the other hand, the BDNF, IL-2, IL-4 and IFN-γ levels were lower in the suicidal depressed patients than in the normal controls. The NO levels in the suicidal depressed patients were negatively significantly correlated with the LSARS and RRR scores. The IFN-γ levels in the suicidal depressed patients were positively correlated with the LSARS scores, but their TGF-β1 levels were negatively correlated with the LSARS scores. When the suicidal behaviors were divided into violent or nonviolent, the IL-6 and IFN-γ levels of the violent suicidal patients were significantly higher than those of the nonviolent suicidal patients. Conclusions-These results suggest that BDNF, NO, and cytokines could be useful as biological markers of suicidal behavior in major depression.
Noh, Su Bum,Kim, Ran Hee,Kim, Won Jin,Kim, Sehoon,Lee, Kwang-Sup,Cho, Nam Sung,Shim, Hong-Ku,Pudavar, Haridas E.,Prasad, Paras N. Royal Society of Chemistry 2010 Journal of materials chemistry Vol.20 No.35
<P>This paper reports synthesis and semiempirical modeling of 1,4-bis(cyanostyryl)benzene (CSB)-based quadrupolar isomeric molecules (<I>α</I>- and <I>β</I>-CSB-TPs), designed to produce enhancement in fluorescence quantum yield and two-photon absorption cross-sections for the nanoaggregate form. Fluorescence yield together with high two-photon optical properties of the isomers have been fine-tuned by moving the cyano group from <I>α</I> to <I>β</I> position, which results in longer absorption-fluorescence wavelengths, and higher one- and two-photon absorptivities for the <I>β</I>-CSB-TP. In nonpolar toluene solution, both isomers exhibit strong one- and two-photon induced fluorescence. Both isomers followed a trend of strong solvatochromisms which was gradually on increasing solvent polarity. Aqueous dispersions of nanoparticles with diameters of <I>ca.</I> 150 nm have been prepared by aggregation of each isomer. The quenched fluorescence in polar media was greatly intensified followed by a 21 fold increase in TPA cross-sections. This helped achieve intense up-converted fluorescence by two-photon absorption of excited <I>β</I>-CSB-TP organic nanoparticles. Coaggregation-enhanced tunable fluorescence has also been demonstrated as a possible application of the isomeric <I>α</I>- and <I>β</I>-CSB-TP mixture.</P> <P>Graphic Abstract</P><P>We report synthesis and semiempirical modeling of 1,4-bis(cyanostyryl)benzene-based quadrupolar isomeric molecules, for enhancement in fluorescence quantum yield and two-photon absorption cross-sections for the nanoaggregate form. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c0jm00716a'> </P>
Hyeon-Ah Lee,Ji Sun Kim,Yeon Jung Lee,Nam-Hun Heo,Sehoon Shim,Young Joon Kwon 대한신경정신의학회 2018 PSYCHIATRY INVESTIGATION Vol.15 No.12
Objective The aim of this study was to evaluate differences in psychopathology between offspring of parents with bipolar I disorder (BP-I) and those with bipolar II disorder (BP-II). Methods The sample included 201 offspring between 6 and 17 years of age who had at least one parent with BP-I or BP-II. The offspring were diagnostically evaluated using the Korean Kiddie-Schedule for Affective Disorders and Schizophrenia-Present and Lifetime Version. Psychopathology and Clinical characteristics were evaluated, including lifetime DSM-5 diagnoses, depression, and childhood trauma. Lifetime DSM-5 diagnoses were also compared between schoolchildren aged 6 to 11 years and adolescents aged 12 to 17 years. Results In lifetime DSM-5 diagnoses, offspring of parents with BP-I had significantly increased risk of developing MDD and BP-I than those with BP-II. Regarding clinical characteristics, ADHD rating scale and childhood trauma scale were significantly higher in offspring of parents with BP-I than that in those with BP-II. Conclusion The present study supports that BP-I may be etiologically distinct from BP-II by a possible genetic liability. Our findings indicate that additional research related to bipolar offspring is needed to enhance understanding of differences between BP-I and BP-II.
HwaYoung Lee,ChaeKeun Oh,ByungJoo Ham,HunSoo Chang,JongWoo Paik,EunSoo Won,SangWoo Hahn,SeHoon Shim,YoungJoon Kwon,HeeYeon Jung,MinSoo Lee 대한신경정신의학회 2013 PSYCHIATRY INVESTIGATION Vol.10 No.2
Objective-Activation of one or more serotonin (5-HT) receptors may play a role in mediating the antidepressant effects of serotonergic antidepressants. The serotonin 2C (5HT 2C) receptor is known to be associated with antidepressant action and weight gain. We sought to determine whether the 5-HTR 2C receptor -759C/T polymorphism was associated with weight gain and treatment response to mirtazapine in major depressive disorder (MDD) patients. Methods-The 5-HT 2C receptor -759C/T polymorphism was analyzed in 323 MDD patients. All patients were evaluated using the 21-item Hamilton Depression Rating Scale at the beginning of the study and at 1, 2, 4, and 8 weeks of mirtazapine treatment. Results-There was no significant difference in the 5-HT 2C receptor -759C/T genotype distribution between responder and non-responder groups. The 5-HT 2C receptor -759C/T polymorphism was not associated with weight change over time after mirtazapine administration. Conclusion-The 5-HT 2C receptor -759C/T polymorphism does not appear to be a predictor of treatment response to mirtazapine. This polymorphism was not associated with weight change after 8 weeks of mirtazapine treatment. Further investigation on other polymorphisms of the 5-HT 2C gene is required to determine whether the 5-HT 2C gene influences treatment response and weight change after mirtazapine administration in patients with major depressive disorder.
SeonCheol Park,HwaYoung Lee,DongWoo Lee,SangWoo Hahn,SangHo Park,YeoJu Kim,JaeSung Choi,HoSung Lee,SoyoungIrene Lee,KyoungSae Na,SungWon Jung,SeHoon Shim,KiWon Kim,JongWoo Paik,YoungJoon Kwon 대한신경정신의학회 2017 PSYCHIATRY INVESTIGATION Vol.14 No.3
Objective-We aimed to identify depressive symptom profiles that indicated the presence of depressive disorder and present optimal cut-off sub-scores for depressive symptom profiles for detecting depressive disorder in elderly subjects with chronic physical diseases including diabetes, chronic obstructive pulmonary disease/asthma, and coronary artery disease, using the Patient Health Questionnaire-9 (PHQ-9). Methods-Two hundred and thirty-one elderly patients with chronic physical diseases were recruited consecutively from a university-affiliated general hospital in South Korea. Results-Greater severities of all 9 depressive symptoms in the PHQ-9 were presented in those with depressive disorder rather than those without depressive disorder. A binary logistic regression modeling presented that little interest [adjusted odds ratio (aOR)=4.648, p<0.001], reduced/increased sleep (aOR=3.269, p<0.001), psychomotor retardation/agitation (aOR=2.243, p=0.004), and concentration problem (aOR=16.116, p<0.001) were independently associated with increased likelihood of having depressive disorder. Receiver operating characteristics (ROC) curve analysis presented that the optimal cut-off value of score on the items for little interest, reduced/increased sleep, psychomotor retardation/agitation and concentration problem (PHQ-9) for detecting depressive disorder was 4 with 61.9% of sensitivity and 91.5% of specificity [area under curve (AUC)=0.937, p<0.001]. Conclusion-Our findings suggested that the diagnostic weighting of little interest, reduced/increased sleep, psychomotor retardation/agitation, and concentration problem is needed to detect depressive disorder among the elderly patients with chronic physical diseases.