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- 저자 : Se Ra Lim (검색결과 40 건)
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P-21 Introduction of national tuberculosis molecular typing service
( Se-mi Jeon ),( Na-ra Lim ),( Young-mi Kim ),( Dong-hyeok Kim ),( Seong-han Kim ),( Mi-sun Park ) 대한결핵 및 호흡기학회 2016 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.121 No.-
Molecular typing of Mycobacterium tuberculosis provides i) understanding the molecular epidemiology of nationwide TB, ii) early recognition of TB, iii) identification of incorrect TB diagnoses based on false-positive culture results, and iv) distinguishment relapse and re-infection. To achieve these objectives, national TB molecular typing service in many countries has been operated, such as TB Genotypes Information Management System of US CDC, TB national strain typing service of UK PHE, Molecular surveillance of MDR-TB in Europe. In 2014, Korea NRIH initiated TB molecular typing service to assist identify TB patients potentially involved in the same chain of recent TB transmission following routine contact investigations. A total of 1,788 isolates including epidemiological related strains were analyzed with 24 loci MIRU-VNTR and Spoligotyping and we established the database that was digitalization and enumeration, namely TBG type. The major lineage type of TB in our database is Beijing (81.04%). Results of TBG type showed that 51% of TBG type were unique pattern and the major TBG type was TBG0381 that take possession of 2.46%. Until now, national tuberculosis molecular typing service in Korea was limited to identify the suspected relationships between TB outbreaks cases, we will expand the service to distinguish relapse and re-infection in recurrent TB patient.
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Lim, Sooman,Cho, Byungjin,Bae, Jaehyun,Kim, Ah Ra,Lee, Kyu Hwan,Kim, Se Hyun,Hahm, Myung Gwan,Nam, Jaewook IOP 2016 Nanotechnology Vol.27 No.43
<P>Scalable sub-micrometer molybdenum disulfide (<img ALIGN='MIDDLE' ALT='${\mathrm{MoS}}_{2}$' SRC='http://ej.iop.org/images/0957-4484/27/43/435501/nanoaa3ca9ieqn1.gif'/>) flake films with highly uniform coverage were created using a systematic approach. An electrohydrodynamic (EHD) printing process realized a remarkably uniform distribution of exfoliated <img ALIGN='MIDDLE' ALT='${\mathrm{MoS}}_{2}$' SRC='http://ej.iop.org/images/0957-4484/27/43/435501/nanoaa3ca9ieqn2.gif'/> flakes on desired substrates. In combination with a fast evaporating dispersion medium and an optimal choice of operating parameters, the EHD printing can produce a film rapidly on a substrate without excessive agglomeration or cluster formation, which can be problems in previously reported liquid-based continuous film methods. The printing of exfoliated <img ALIGN='MIDDLE' ALT='${\mathrm{MoS}}_{2}$' SRC='http://ej.iop.org/images/0957-4484/27/43/435501/nanoaa3ca9ieqn3.gif'/> flakes enabled the fabrication of a gas sensor with high performance and reproducibility for <img ALIGN='MIDDLE' ALT='${\mathrm{NO}}_{2}$' SRC='http://ej.iop.org/images/0957-4484/27/43/435501/nanoaa3ca9ieqn4.gif'/> and <img ALIGN='MIDDLE' ALT='${\mathrm{NH}}_{3}$' SRC='http://ej.iop.org/images/0957-4484/27/43/435501/nanoaa3ca9ieqn5.gif'/>.</P>
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Association between hair mineral and age, BMI and nutrient intakes among Korean female adults
Se Ra Hong,Seung Min Lee,Na Ri Lim,Hwan Wook Chung,Hong Seok Ahn 한국영양학회 2009 Nutrition Research and Practice Vol.3 No.3
This study was performed to investigate the association between hair mineral levels and nutrient intakes, age, and BMI in female adults who visited a woman's clinic located in Seoul. Dietary intakes were assessed by food frequency questionnaire and mineral levels were measured in collected hairs, and the relationship between these was examined. The average daily nutrient intakes of subjects were compared to those of the KDRIs, and the energy intake status was fair. The average intake of calcium in women of 50 years and over was 91.35% of KDRIs and the potassium intake was greatly below the recommended levels in all age groups. In the average hair mineral contents in subjects, calcium and copper exceeded far more than the reference range while selenium was very low with 85.19% of subjects being lower than the reference value. In addition, the concentrations of sodium, potassium, iron, and manganese in the hair were below the reference ranges in over 15% of subjects. The concentrations of sodium, chromium, sulfur, and cadmium in the hair showed positive correlations (P<0.05) with age, but the hair zinc level showed a negative correlation (P<0.05) with age. The concentrations of sodium, potassium, chromium, and cadmium in the hair showed positive correlations (P<0.05) with BMI. Some mineral levels in subjects of this study showed significant correlations with nutrient intakes, but it seems that the hair mineral content is not directly influenced by each mineral intake. As described above, some hair mineral levels in female adults deviated from the normal range, and it is considered that nutritional intervention to control the imbalance of mineral nutrition is required. Also, as some correlations were shown between hair mineral levels and age, BMI, and nutrient intakes, the possibility of utilizing hair mineral analysis for specific purposes in the future is suggested.
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Se Ra Park,Jeong-Hwan Lee,Sohee Lim,Taek Min Kim,Seung Ho Lee,Dae Heon Kim,Chao Gao,Richard D. Cummings,Kisung Ko 한국당과학회 2021 한국당과학회 학술대회 Vol.2021 No.07
Overexpression of human epidermal growth factor receptor type 2 (HER2) protein is one of the prognostic factors for breast cancer, and HER2 is most likely to be recurrence when cancer metastasizes to lymph nodes. This study demonstrated the expression of the anti-HER2 camelid single domain antibody VHH in tobacco plant. And we confirmed the function of recombinant VHH for the treatment of breast cancer. The anti-HER2 VHH was fused to human IgG Fc domain along with KDEL endoplasmic reticulum (ER) (VHH-FcK) in a gene expression cassette. The plant gene expression cassette was transferred to tobacco plants using Agrobacterium-mediated transformation. The transformants were screened by PCR and western blots. ELISA confirmed the binding activity of purified anti-HER2 VHH-FcK to HER2 positive breast cancer cell line SK-BR-3. In conclusion, this study verified the possibility of anti-HER2 VHH-FcK as a therapeutic agent and suggests that the anti-breast cancer anti-HER2 VHH-FcK can be expressed, properly assembled and purified from plant expression system, which can be as an alternative system for antibody production. This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT)(2021R1F1A1063869).
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Electroacupuncture for Carpal Tunnel Syndrome: A Review of Randomized Controlled Trials
박철우,Lim Min Ji,Lee Se Won,Yi Yeon Hoo,Song Da Woon,Yu Sang Gu,Kim Min Ju,Oh Da Yoon,Choi Hyo Jung,Ju Ah Ra 대한침구의학회 2022 대한침구의학회지 Vol.39 No.2
This study aimed to examine the clinical efficacy of electroacupuncture treatment for carpal tunnel syndrome by reviewing published randomized controlled trials. Among the 186 studies retrieved from 7 online databases (PubMed, Cochrane library, CNKI, NDSL, RISS, OASIS, KMbase) on October 29, 2021, 4 studies were selected according to the inclusion, exclusion criteria, and were evaluated using risk of bias. Control groups for electroacupuncture were wearing a splint at night, traditional acupuncture, and medication. Methods such as total effective, functional status scale, symptom severity scale, electromyography, tip pinch strength, visual analogue scale, numeric rating scale, and ultrasound were used to evaluate the therapeutic effect. Electroacupuncture was reported to have significant treatment results compared with the control group in methods such as total effectiveness, electromyography, and tip pinch strength. However, the quality of the studies (using risk of bias) does not allow reliable conclusions to be made. Many high quality (low risk of bias) randomized controlled trials are needed to examine the efficacy of electroacupuncture treatment for carpal tunnel syndrome.
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Park Se Ra,Ko Kisung,Lim Sohee,Cha So Yeon,정현주,Park Soon Ju,Myung Soon‐Chul,Kim Mi Kyung 한국곤충학회 2020 Entomological Research Vol.50 No.4
The monoclonal antibody (mAb) CO17-1A specifically binds to the tumor associated cell surface glycoprotein GA733 in colorectal cancer cells. Thus, mAb CO17-1A has the potential to act as an immune therapeutic protein against colorectal cancer. Recently, it was shown that the baculovirus insect cell expression system produces anti-colorectal cancer mAb CO17-1A. In this study, the colorectal cancer antibody mAb CO17-1A fused to the endoplasmic reticulum (ER) retention signal sequence (KDEL), and the (mAb CO17-1AK) was expressed in Spodoptera frugiperda Sf9 insect cells. The yield, cell cytotoxicity, and in vitro anti-tumor activity of mAb CO17-1AK were verified. Western blotting was performed to confirm that both heavy and light chains of mAb CO17-1A were expressed in Sf9 insect cells. The insect-derived mAb (mAbI ) CO17-1A was purified using a protein G affinity column. An in vitro wound healing assay was conducted to determine the inhibition activity of mAb CO17-1A during tumor cell migration, showing that mAbI CO17-1AK was effective as mammalian-derived mAb CO17-1A (mAbM CO17-1A). These results suggest that the insect cell expression system can produce and properly assemble mAbs that inhibit tumor cell migration.
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어린이집 아동학대 예방을 위한 원장의 역할에 대한 연구: 「어린이집 아동학대 예방 및 대응 매뉴얼」을 기반으로
이세라피나 ( Se Ra Phi Na Lee ),임여정 ( Yoe Jung Lim ) 한국영유아아동정신건강학회 2021 영유아아동정신건강연구 Vol.14 No.2
본 연구는 ‘어린이집 아동학대 예방 및 대응 매뉴얼’을 기반으로 하여 어린이집 아동학대 예방을 위한 원장의 역할과 의미, 원장의 예방 역할을 위해 필요한 지원은 무엇인지를 심층적으로 살펴보고자 하였다. 이러한 연구목적에 따라 직장어린이집 원장 8명을 세 그룹으로 나누어 포커스 그룹 인터뷰를 한 뒤 수집된 자료를 분석하였다. 자료 분석에 따른 연구 결과는 다음과 같다. 첫째, 원장은 채용 면접 및 기본 예방 교육을 통해 어린이집 아동학대 예방지침을 교육하고, 이를 통해 아동학대 발생의 위험을 낮추었다. 둘째, 원장은 정기적 예방 교육에서 다양한 방법의 반복 교육을 통해 교사의 아동 인권 감수성을 향상시킨다. 셋째, 원장은 상시 모니터링 및 적절한 지원을 제공함으로써 어린이집 내에서 부주의한 지도가 재발되는 것을 막는다. 넷째, 원장은 사례 장학을 통해 교사의 직무전문성을 향상시키고, 이를 통해 가정과의 신뢰를 구축해나간다. 다섯째, 원장은 민주적 분위기 조성을 통해 아동학대 행위에 대한 조직의 예방선을 지켜나간다. 여섯째, 원장의 아동학대 예방 역할을 지원하기 위해서는 숙련된 경력교사와 더불어 사례관리 협의체 등 조직차원의 지원체계가 마련되어야 한다. 본 연구는 이러한 결과를 통해 어린이집 아동학대 예방을 위해 원장의 역할이 갖는 의미를 논의하였고, 원장의 예방 역할을 위한 조직지원체계 마련에 대한 시사점을 도출하였다. The purpose of this study was to pay attention to and listen to their various experiences through the role of the director to prevent child abuse at daycare centers. According to this research purpose, eight directors of the workplace daycare center were divided into three groups to conduct focus group interviews and then analyze the collected data. The research results according to data analysis are as follows. First, when hiring, the director lowers the risk of child abuse at daycare centers through interviews and basic preventive education, and meets the standards for careless guidance. Second, the director improves teachers' sensitivity to children's rights through regular preventive education. Third, the director looks into the classroom through regular monitoring and provides appropriate support to prevent the occurrence of repetition of careless guidance (reduce). Fourth, the director improves the professionalism of teachers through case scholarship, and through this, builds trust with the family. Fifth, the director maintains the organization's boundaries against child abuse through the creation of a democratic organizational culture. Sixth, in order to support the director's role in preventing child abuse, a support system at the organizational level through the social safety net must be established along with direct manpower support. Based on the results of this study, implications, policy utilization plans, and future studies for the prevention of child abuse in daycare centers were proposed.
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