특수 언어발달 장애 환아의 임상 및음향음성학적 특성연구

김연희,박세훈,신용일,김찬양,김현기,김정수 大韓再活醫學會 2000 Annals of Rehabilitation Medicine Vol.24 No.1

Thiamine결핍 유도후 쥐 전뇌의 성상교세포 Glial Fibrillary Acidic Protein(GFAP) 면역화학 활성도에 대한 변화

김승현,김희태,김주한,김명호,황세진,김명권,백태경 대한신경과학회 1999 대한신경과학회지 Vol.17 No.1

동진강 유역 비점오염원 정밀조사

원찬희,정팔진,김민정,조선영,김세훈,김종천 전북대학교 공학연구원 ( 구 전북대학교 공업기술연구소 ) 2002 工學硏究 Vol.33 No.-

Nonpoint source pollution(NSP) arises due to agriculture activity and it is quite an extensive and complicated problem in order to control and has received a great deal of concern during the recent years, whereas point source are known to originate from an estimated volume of contaminant discharged from a distinguishable source. Extensive research work have been conducted and presented in the past with regard to the various characteristics of watershed on Dong Jin River(DJR), however there are certain drawbacks of existing survey for determining important polluting sources, distribution features of pollutants and estimated load of the organic and nutrients from the creeks. Unfortunately, investigation for loadings originating due to agricultural drainage was not satisfactory, although the regional consideration for DJR across Kim Je Field(KJF) as an agricultural area receives a reasonable source point in the agri-pollution management. Therefore it was necessary to carry out a thorough investigation into the diffuse sources resulting, to form the pollution-developing estimation and to evaluate the output roperties and determining various factors in the generation of non-point pollution. Eventually, this research work would serve as an useful tool for the development of predictive pollution management for DJR. Non-point sources in the present work were classified as municipal non-treated sewage water discharged into the river, loadings through agricultural drainages in the dry/wet field and inadequate treatment of wastewater generated from livestocks. The entire duration of the research work was from December-2001 to July-2002. Site measurement were conducted during various season, in a dry season(December), in rainfall, in seed-sowing time and also collecting data from the rural public organizations related to water management was done and examined and examined during the mid of research work. Similarly, domestic wastewater loadings due to population was based on area unit, as City, Country, Up, Myon, Dong, Ri. The Dong Jin River watershed contains small three Creeks, KoBu(KB), DongJin(DJ, including JeongEup(JE) and ChilBo(CB), WonPyong(WP). It was further divided into 32 sub-watersheds which comprises of further 5,18,9 watersheds in the creeks respectively. The results obtained from research work are presented as follows. Animal productions have marked differences in the rate of pollutant loadings reported in the following sequence: DJ(only CE)>WP>CB>KB, in a case of Korean cow and milk cow. However, it was revealed that WP creek became significantly higher than any other livestocks. According to statistical data for land use, rice field(369.0㎢) and forest(378㎢) have much occupation prior to dry paddies(125.0㎢), residential land(32.0㎢) and others(5.0㎢). Especially, rice fields receives 2.5∼3 times than dry paddies in size.

직무특성과 직무스트레스가 아동병원 간호사의 이직의도에 미치는 영향

김세영(Se-Young Kim),백성희(Seong-Hee Back) 한국콘텐츠학회 2016 한국콘텐츠학회논문지 Vol.16 No.4

목적: 본 연구는 아동병원 간호사를 대상으로 직무특성, 직무스트레스, 이직의도 정도 및 이들 변수간의 관계를 파악하고, 이직의도에 미치는 영향 요인들을 규명하기 위한 서술적 조사연구이다. 연구의 대상은 G시에 위치한 60병상이상의 아동병원에서 근무하는 간호사 129명이며, 본 연구에 사용된 연구도구는 대상자의 일반적 특성을 묻는 12개의 문항과 직무특성 관련 16문항, 직무스트레스 36문항, 이직의도 6문항으로 총 70개 문항으로 구성된 설문지를 이용하였다. 연구자료는 SPSS 21.0 프로그램을 이용하여 분석하였으며 빈도분석 및 기술통계, t-test, ANOVA, Pearson 상관관계 분석, stepwise 방법에 의한 다중회귀분석을 이용하여 검정하였다. 본 연구의 결과는 직무특성의 하위요인은 직무도전성과 직무적합성, 직무스트레스, 급여는 이직의도에 영향을 미치는 것으로 확인되었다. Purpose: This study was performed to investigate the influence of childrens hospital nurses job characteristics and job stress on turnover intention. Method: The subjects were 148 nurses who have been working in 6 childrens hospitals located in G city. Measurement tools used for this study included job characteristics were created by Lee, and modified by Hong, and job stress tool developed Kim & Ku and modified by Choi. And the tools used for assessing turnover intention were created by Mobley and Becker and modified by Kim. The collected data was analyzed using descriptive statistics, the independent t-test, one-way ANOVA, Pearson Correlation and regression on SPSS 21.0 program. Result: Job challenge and job fitness among the sub-areas of job characteristics, job stress and salary were identified as factors influencing turnover intention. These factors explained 36.5% of variance of turnover intention. Conclusion: In conclusion, this results can be used to help the childrens hospitals creates an environment where nurses can enhance Job challenge and job fitness also, reduce job stress which lead to turnover rate and turnover intention.

흰쥐 Kupffer 세포에 대한 Propofol의 작용

박세훈,지대림,성언기,김희선,송인환,박희영,김준수,이덕희,박대팔 대한마취과학회 2002 Korean Journal of Anesthesiology Vol.43 No.4

Background: Propofol has an antioxidant capacity and can be used for ischemia-reperfusion injury of the liver. However, the effects of propofol on the Kupffer cells have not been establisked. Methods: Kupffer cells were isolated and cultured from male Sprague-Dawley rats. The effects of propofol on the Kupffer cells were evaluated by a phagocytosis assay, TNF-α gene expression, and superoxide anion release after administering propofol in different concentrations on the cultured Kuprrer cells. Results: The latex bead phagocytosis by the Kupffer cells was suppressed when the Kupffer cells were exposed to propofol irrespective of concentrations. Higher propofol concentrations decreased the loss of Kupffer cells after latex bead phagocytosis. Propofol induced TNF-α mRNA expression in the Kupffer cells, but the mRNA expression level after 50㎍/ml of propofol decreased. The pattern of TNF-α mRNA expression induced by propofol was different to that induced by LPS: TNF-α mRNA was expressed continuously in the propofol-treated cells until 16 hours after exposure to propofol, whereas the level of TNF-α mRNA expression induced by LPS was evident after 2 hours and was not found thereafter. TNF-α production after propofol treatment was not higher than that of the control. Formazan presipitation did not show any qualitative differences between cells untreated or treated with propofol concentrations of 0.5, 5.0, and 50 ㎍/ml. Conclusions: These results showed that propofol might inhibit Kupffer cells. This suggests that propofol and be used for patients with ischemia-reperfusion injury of the liver. (Korean J Anesthesiol 2002; 43: 475~484)

주의력결핍/과다활동장애(ADHD) 아동에 대한 약물-부모훈련 병합치료의 효과

김세실,이양희,안동현 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.4

목 적 : 주의력결핍/과다활동장애 아동의 문제 행동, 어머니의 양육태도 및 양육스트레스에 대한 약물 및 부모 훈련 병합치료의 효과를 검증하고자 한다. 대상 및 방법 : 한양대학교병원에서 주의력결핍/과다활동장애로 진단받은 24명의 아동(만 5∼11세)과 어머니를 대상으로 하였다. 세 군으로 나누었는데, 약물단독치료군(N=6), 약물 및 부모훈련 병합치료군(N=6), 병합치료 대기군(N=6)으로 구분하였다. 약물치료는 메칠페니데이트를 0.5∼0.7㎎/㎏/day를 투여하였다. 부모훈련은 주 1회, 9주간 실시하였고, 4주후 추후모임을 가졌다. 평가는 약물치료군(N=12)과 병합치료군(N=12)에서 각각 치료 전후에 비교하였으며, 병합치료군에서는 장기 효과를 보기 위하여 6개월후에 재평가하였다. 평가는 아동변인(아동행동조사표, 코너스부모용평정척도, 가정상황질문지), 어머니변인(어머니양육태도검사도구, 부모양육스트레스목록표, 결혼적응척도), 프로그램변인(부모사용자만족도 질문지)을 각각 조사하였다. 결 과 : 어머니의 양육태도 및 양육스트레스, 아동의 문제 행동에서 약물 단독치료군에 비해 약물-부모훈련 병합치료군에서 월등히 좋은 결과를 얻었다. 또한 이 효과는 6개월후의 추적조사에서도 대부분 유지되었고, 어머니들의 프로그램에 대한 만족도도 매우 높았다. 결 론 : 주의력결핍/과다활동장애 아동의 치료에 있어서 약물단독보다는 약물-부모훈련병합치료가 매우 우수한 치료 효과를 갖는다. Objective : We attempted to confirm the effects of the combined treatment of medication and parent training on the behavioral problems of referred ADHD chidren, the maternal behavior and the parenting stress of their mothers. Methods : Twenty-four children between the ages of 5 to 11 and their mothers were selected as subjected from Child Psychiatric Clinics of Hanyang University Hospital. Three groups were organized : combined treatment group of medication and parent training(N=6) ; wating list group(N=6) ; and medication only group(N=6). Methylphenidate(0.5-0.7㎎/㎏/day) was prescribed for children. Mothers of the combined treatment group of medication and parent training and the wating list group attended the parent training once a week for nine weeks and a booster session 4 weeks later. Treatment outcomes were evaluated by comparing both treatment groups at pre- and post-treatment using the various rating scales. Especially the combined treatment group was followed up after 6 months to evaluate the stability of treatment effects. Results : This study showed greater effectiveness of the combined treatment of medication and parent training relative to the medication only in decreasing the overall behavioral problems of ADHD children and the parenting stress of mothers as well as in increasing the desirable maternal behavior. In addition, these improvements were maintained at 6 month follow-up. Conclusion : The combined treatment of medication and parent training facilitated the behavioral improvement of referred ADHD children in several aspects.

Fenton산화에 의한 쓰레기 埋立場 浸出水의 處理

김선희,이병대,김세정,이철희 嶺南大學校 工業技術硏究所 1995 工業技術硏究所論文集 Vol.23 No.1

This study was aimed to investigate treatment feasibility of leachate from landfill that was located in Bancheung-Dong Kyungbuk Talsung-Kun. From the analytical results of leachate, high concentration of organic and nonbiodegradable matters was contained. It could not be treated by biological process only thus required a combined treatment able to high rate COD removal efficiency. Two types of Fenton's oxidation were adapted in this study. The first one is pre treatment before biological treatment. The second one is post treatment after biological treatment. Thus, the optimal conditions in both methods were investigated. From the survey of treatment conditions, in case of pre treatment, the optimal condition was ?? 0.1, ?? 27.08, pH 3, temperature 30℃ and reaction time 2 hr. On the other hand, ?? 0.14, ?? 57.42, pH 3, temperature 30℃ and reaction time 1.25 hr was obtained for post treatment as optimal conditions. In the above optimal conditions, high COD removal efficiency was shown in pre and post treatment. Also it can be expected that nonbiodegradable matters are degraded and converted to biodegradable matters.

고성능감수제 구성비율에 따른 고유동콘크리트의 유동특성에 관한 실험적 연구

김무한,최세진,김용로,김재환,이태희 忠南大學校 産業技術硏究所 2002 산업기술연구논문집 Vol.17 No.2

It is the of this study to propose the fundamental data for the establishment of the application and quality standard of the mixed type superplasticizer after investigating and comparing the fluidity of high flowing concrete according to the component ratio of superplasticizer such as naphthalene sulfonated and melamine sulfonated. The results of this study were shown as the followings: 1) The fluidity and adsorption ratio of cement-paste were improved according to the increasing of naphthalene sulfonated component ratio, and apparent viscosity of cement-paste was improved according to the increasing of melamine sulfonated component ratio. 2) In case of using the granulated blast-furnace slag, the fluidity of cement-paste was considerably good and the adsorption ratio was decreased and in case of using fly-ash, the apparent viscosity and adsorption ratio of cement-paste were improved. 3) The dispersive capacity performance of concrete can be improved by means of the increasing of naphthalene sulfonated component ratio. Also the viscosity and early strength can be improved by means of the increasing of melamine sulfonated component ratio.

국내 환자에서 분리된 Orientia tsutsugamushi에서 doxycycline 내성

김은실,김미경,이혜명,길세희,정문현,이진수,강재승 대한감염학회 2008 감염과 화학요법 Vol.40 No.5

Background : Doxycycline has been the drug of choice for the treatment of scrub typhus. However, scrub typhus with poor response to doxycycline was first reported in Thailand in 1996. To date, it is not known whether doxycycline resistant scrub typhus is present in Korea. To investigate the doxycycline resistance of scrub typhus in Korea, we performed an experiment to evaluate the degree of growth inhibition of Orientia tsutsugamushi at the minimal inhibitory concentration (MIC) of doxycycline. Materials and Methods : 37 isolates of Orientia tsutsugamushi were collected from Korean patients with scrub typhus during 10 year period (from 1997 to 2007). 34 isolates consisted of Boryong serotype or related serotypes. These strains were stained with FS15, a monoclonal antibody against the linear epitope on the protein located at the outer membrane of O. tsutsugamushi. Three isolates were confirmed as serotype Gilliam, which was stained by anti-Gilliam antibody. The antibody-stainable 35 isolates were incubated in media containing 0.1 and 0.2 ug/mL of doxycycline for 3 days. Then the growth indices of Orient/a were measured by flow cytometry. If the growth index was greater than 10%, the isolate was tentatively classified as an isolate resistant to doxycycline and its MIC was measured. Results : Demographic and treatment data were similar to the results of previous reports. Infection was mainly observed in Inchon and the Chungcheongnam province. No patient showed delayed response to antibiotics. Of 35 hospitalized patients, 4 (11.4%) were managed at the intensive care unit and 1 (2.9%) died of nosocomial pneumonia. All the 2 patients whose isolates were serotype Gilliam Yonchon/Ikeda-like strain were managed at the intensive care unit. Six of the 34 isolates from Korean patients exhibited growth indices greater than 10% at the MIC of doxycycline; however, the MICs of these isolates did not exceed 0.2 ug/mL. One isolate of serotype Gilliam showed an MIC of 0.0125 ug/mL, which seemed to be underestimated due to weak fluorescence of the anti-GiIIiam antibody. Conclusions : Although the number of tested isolates is small, insensitivity of scrub typhus to doxy-cycline is not a major reason for treatment failure in Korea. Serotype Gilliam, especially Yochon/Ikeda-like strain may be associated with severe form of scrub typhus. More studies concerning the antibiotic susceptibility for serotype Gilliam are warranted.

In situ hybridization기법을 이용한 shiga toxin-producing Escherichia coli의 검출 및 stx2의 염기서열분석

김의종,이동영,최혜심,주세익,이정희,김상현,반성환 대한임상미샐물학회 2000 Annals of clinical microbiology Vol.3 No.2