http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Shinya Sato,Kei Moriya,Masanori Furukawa,Soichiro Saikawa,Tadashi Namisaki,Mitsuteru Kitade,Hideto Kawaratani,Kosuke Kaji,Hiroaki Takaya,Naotaka Shimozato,Yasuhiko Sawada,Kenichiro Seki,Koh Kitagawa,T 대한간학회 2019 Clinical and Molecular Hepatology(대한간학회지) Vol.25 No.1
Background/Aims: L-carnitine not only alleviates hyperammonemia and reduces muscle cramps in patients with liver cirrhosis, but also improves anemia in patients with chronic hepatitis and renal dysfunction. This study prospectively evaluated the preventative efficacy of L-carnitine supplementation against hemolytic anemia during antiviral treatment using ribavirin in patients with hepatitis C virus (HCV)-related chronic liver disease. Methods: A total of 41 patients with chronic hepatitis were consecutively enrolled in this study. Group A (n=22) received sofosbuvir plus ribavirin for 3 months, whereas group B (n=19) was treated with sofosbuvir, ribavirin, and L-carnitine. Hemoglobin concentration changes, the effects of antiviral treatment, and the health status of patients were analyzed using short form-8 questionnaires. Results: A significantly smaller decrease in hemoglobin concentration was observed in group B compared to group A at every time point. Moreover, the prescribed dose intensity of ribavirin in group B was higher than that of group A, resulting in a higher ratio of sustained virological response (SVR) 24 in group B compared with group A. The physical function of patients in group B was also significantly improved compared to group A at the end of antiviral treatment. Conclusions: L-carnitine supplementation alleviates ribavirin-induced hemolytic anemia in patients with HCV and helps relieve the physical burden of treatment with ribavirin-containing regimens. These advantages significantly increase the likelihood of achieving SVR.
S.-J. Lee,Suguru Sato,Tomohiko Niizeki,Hideto Yanagihara,Eiji Kita,Chiharu Mitsumata 한국물리학회 2013 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.63 No.3
A numerical simulation of magnetic materials with random magnetic anisotropy was performed. The magnetization of an assembly of magnetically-interacting grains with randomly-oriented uniaxialanisotropy was calculated using the Landau-Lifshitz-Gilbert equation. For simplicity in thesimulation, the magnetizations in a grain were assumed to be aligned in the same direction; thisassumption is known as the single spin model. The interaction at the interface of the grains wastaken into account by including an interaction energy between the unit vectors that represent themagnetization directions of the grains. Calculations were carried out for an N × N × N system,where the grain sizes D ranged from 5 to 40 nm and N ranged from 10 to 80. The relation betweenthe coercive forces HC and the grain size is represented by HC ~ Dk. For the case of N = 10,k = 5.7, which corresponds to the primitive theory of the random anisotropy model (RAM) wherek = 6. As N increased, k decreased slightly from 5.7 to 4.2. The gradient of the log-log plot of thecoercive force versus the grain size (d logHC/d logD) was deduced by smoothing the data and wasfound to have a peak value of approximately 6. This result suggests that the RAM is supported bythe simulation within the range of grain sizes where the peak was observed.
Kei Moriya,Tadashi Namisaki,Shinya Sato,Masanori Furukawa,Akitoshi Douhara,Hideto Kawaratani,Kosuke Kaji,Naotaka Shimozato,Yasuhiko Sawada,Soichiro Saikawa,Hiroaki Takaya,Koh Kitagawa,Takemi Akahane,A 대한간학회 2019 Clinical and Molecular Hepatology(대한간학회지) Vol.25 No.4
Background/Aims: We previously reported the comparable efficacy of bi-monthly hepatic arterial infusion chemotherapy (B-HAIC) to that of sorafenib chemotherapy for the treatment of advanced hepatocellular carcinoma (aHCC) in patients with compensated cirrhosis. In this study, we demonstrate the efficacy of B-HAIC in patients with decompensated cirrhosis. Methods: Forty-five patients with aHCC refractory to transcatheter arterial chemo-embolization (TACE) were treated with B-HAIC and were divided into two groups according to hepatic functional reserve (Child-Pugh grade). Overall survival period, treatment response, and adverse events in each group were analyzed. Results: Efficacy and disease control rates in the Child-Pugh B group (n=24; 21% and 71%, respectively) were not significantly impaired compared the Child-Pugh A group (n=21; 38% and 67%, respectively). Median survival time and survival rate at 12 months in the Child-Pugh B group were 422 days and 58.3%, respectively, whereas those in the Child- Pugh A group were 567 days and 70.8%, respectively. Importantly, the hepatic functional reserve of patients did not worsen in either group during the treatment period. Furthermore, the occurrence rate of adverse events leading to discontinuation of anti-tumor treatment was not significantly increased in the Child-Pugh B group. Conclusions: Given the preservation of hepatic functional reserve afforded by B-HAIC chemotherapy in patients with decompensated cirrhosis, B-HAIC might be an acceptable alternative strategy for aHCC patients who do not respond to TACE.
전라남도 지역의 하천수에 존재하는 내분비 장애물질(Bisphenol A와 Styrene oligomer)의 실태조사
박송인 ( Song In Park ),정선용 ( Seon Yong Chung ),( Saido Kstsuhiko ),( Sato Hideto ),나숙현 ( Suk Hyun Na ) 한국물환경학회 2012 한국물환경학회지 Vol.28 No.5
Recently, there have been active researches regarding endocrine-disrupting chemicals (EDCs). In this study, fifteen small freshwater streams in Cholla-namdo province, South Korea were investigated with respect to the concentration of the endocrine disruptors - Bisphenol A (BPA), styrene monomer (SM), styrene dimer (SD), and styrene trimer (ST) by gas chromatography-mass spectrometry (GC-MS). Measured concentration of the target compounds in the sampled water ranged from <ND to 5.03 ng/mL, <ND to 0.1 ng/mL, <ND to 0.04 ng/mL, and ND to 0.45 ng/mL for BPA, SM, SD, and ST, respectively. The endocrine disruptors analysis of the water samples showed that the concentration of BPA and ST were much higher than the other two compounds. These results imply that the streams of Cholla-namdo province were contaminated by materials generated from decomposition of polystyrene (PS) chemically and physically.
Masanori Furukawa,Akira Mitoro,Takahiro Ozutumi,Yukihisa Fujinaga,Keisuke Nakanishi,Koh Kitagawa,Soichiro Saikawa,Sinya Sato,Yasuhiko Sawada,Hiroaki Takaya,Kosuke Kaji,Hideto Kawaratani,Tadashi Namisa 대한소화기내시경학회 2021 Clinical Endoscopy Vol.54 No.3
Background/Aims: Endoscopic resection (ER) for superficial non-ampullary duodenal epithelial tumors (SNADETs) is challenging. Conventional endoscopic mucosal resection (CEMR) is also problematic due to the anatomical features of the duodenum. Wecompared the safety and efficacy of underwater endoscopic mucosal resection (UEMR) with those of CEMR through a retrospectiveanalysis. Methods: Altogether, 44 consecutive patients with 46 SNADETs underwent ER (18 CEMR cases and 28 UEMR cases) betweenJanuary 2016 and October 2019. We investigated the proportions of en bloc resection, R0 resection, complications, resection time,and total procedure time and compared the outcomes of patients from the CEMR group with those of patients from the UEMRgroup. Results: The median tumor size was 8.0 mm (range, 2.0–20.0 mm). The UEMR group showed a higher proportion of en blocresection (96.4% vs. 72.2%, p<0.05) and significantly lower median resection time and total procedure time (4 min vs. 9.5 min,p<0.05 and 13 min vs. 19 min, p<0.05; respectively) than the CEMR group. No complications were observed. However, two patientstreated with piecemeal resection in the CEMR group had residual tumors. Conclusions: UEMR is a feasible therapeutic option for SNADETs. It can be recommended as a standard treatment.