http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Sang-Pil Mun(문상필),Sang-Hwa Jung(정상화),Chang-Il Kim(김창일),Sang-Don Kim(김상돈),Mutsuo Nakaoka 한국조명·전기설비학회 2008 한국조명·전기설비학회 학술대회논문집 Vol.2008 No.5월
This paper presents a novel prototype of ZCS-PFM high frequency series resonant inverter using IGBT power module for electromagnetic induction eddy current-heated roller in copy and printing machines. The operating principle and unique features of this voltage source half bridge inverter with two additional soft commutation inductor snubber are presented including the transformer modeling of induction heated rolling drum. This soft switching inverter can achieve stable zero current soft commutation under a discontinuous and continuous resonant load current for a widely specified power regulation processing. The experimental results and computer-aided analysis of this inverter are discussed from a practical point of view.
Nutrient Removal Using Bauxsol<sup>TM</sup> for Treated Wastewater Reuse
Mun, Jung Soo,Lee, Sang Ho,Lee, Jung Hun,Suh, Jeong Yul,Kim, Ree Ho Trans Tech Publications, Ltd. 2011 Materials science forum Vol.695 No.-
<P>Urban areas consume huge amounts of water and produce much wastewater, which deteriorate the aquatic environment and exhaust the country’s freshwater resources. Water reuse from sewage and wastewater is recognized as a good option for securing water. There are several kinds of processes for improving the water quality. Nutrient removal is very important for water reuse, especially in water supply for outdoor use, to prevent water quality deterioration via eutrophication. Moreover, low cost and easy maintenance should be considered for nutrient removal. In this study, red mud and Bauxsol<SUP>TM</SUP>, a mixed mineral powder made of physicochemically modified red mud residue generated by the Bayer process for alumina refineries, was used for the removal of nitrate and heavy metals in artificial solution, and of phosphate in final effluent, from a sewage treatment plant in Dae-gu, Republic of Korea. Nitrate removal by red mud showed little efficiency while heavy metal removal showed high efficiency. The concentrations of the total phosphate in the effluent and treated water were 1.51 and 0.14 mg/L, respectively, which represent about 90.7% removal. Before and after the treatment, the pH was maintained at a neutral range of 6.5-7.2. Bauxsol<SUP>TM</SUP> also showed a high heavy metal removal capacity. Therefore, Bauxsol<SUP>TM</SUP> in powder and pellet form can be applied individually or mixed with soil to improve water quality for water reuse.</P>
Generation of expandable human pluripotent stem cell-derived hepatocyte-like liver organoids
Mun, Seon Ju,Ryu, Jae-Sung,Lee, Mi-Ok,Son, Ye Seul,Oh, Soo Jin,Cho, Hyun-Soo,Son, Mi-Young,Kim, Dae-Soo,Kim, Su Jung,Yoo, Hyun Ju,Lee, Ho-Joon,Kim, Janghwan,Jung, Cho-Rok,Chung, Kyung-Sook,Son, Myung Elsevier 2019 Journal of hepatology Vol.71 No.5
<P><B>Background & Aims</B></P> <P>The development of hepatic models capable of long-term expansion with competent liver functionality is technically challenging in a personalized setting. Stem cell-based organoid technologies can provide an alternative source of patient-derived primary hepatocytes. However, self-renewing and functionally competent human pluripotent stem cell (PSC)-derived hepatic organoids have not been developed.</P> <P><B>Methods</B></P> <P>We developed a novel method to efficiently and reproducibly generate functionally mature human hepatic organoids derived from PSCs, including human embryonic stem cells and induced PSCs. The maturity of the organoids was validated by a detailed transcriptome analysis and functional performance assays. The organoids were applied to screening platforms for the prediction of toxicity and the evaluation of drugs that target hepatic steatosis through real-time monitoring of cellular bioenergetics and high-content analyses.</P> <P><B>Results</B></P> <P>Our organoids were morphologically indistinguishable from adult liver tissue-derived epithelial organoids and exhibited self-renewal. With further maturation, their molecular features approximated those of liver tissue, although these features were lacking in 2D differentiated hepatocytes. Our organoids preserved mature liver properties, including serum protein production, drug metabolism and detoxifying functions, active mitochondrial bioenergetics, and regenerative and inflammatory responses. The organoids exhibited significant toxic responses to clinically relevant concentrations of drugs that had been withdrawn from the market due to hepatotoxicity and recapitulated human disease phenotypes such as hepatic steatosis.</P> <P><B>Conclusions</B></P> <P>Our organoids exhibit self-renewal (expandable and further able to differentiate) while maintaining their mature hepatic characteristics over long-term culture. These organoids may provide a versatile and valuable platform for physiologically and pathologically relevant hepatic models in the context of personalized medicine.</P> <P><B>Lay summary</B></P> <P>A functionally mature, human cell-based liver model exhibiting human responses in toxicity prediction and drug evaluation is urgently needed for pre-clinical drug development. Here, we develop a novel human pluripotent stem cell-derived hepatocyte-like liver organoid that is critically advanced in terms of its generation method, functional performance, and application technologies. Our organoids can contribute to the better understanding of liver development and regeneration, and provide insights for metabolic studies and disease modeling, as well as toxicity assessments and drug screening for personalized medicine.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Pluripotent stem cell (PSC)-derived expandable human hepatocyte-like liver organoids were generated. </LI> <LI> PSC-derived human hepatic organoids are capable of long-term expansion with competent liver functionality. </LI> <LI> PSC-derived human hepatic organoids provide a robust hepatic model for toxicity prediction and drug screening. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Jung, Sang-Min,Yang, Seung-Min,Mun, Kyung-Hak,Han, Sang-Kook Optical Society of America 2014 Optics express Vol.22 No.15
<P>A novel technique for mitigating the optical beat interference (OBI) noise in an optical orthogonal frequency division multiple access passive optical network (OFDMA-PON) uplink transmission is presented. By using an out of signal band RF clipping tone to the optical seed carrier, the OBI noise has been reduced and the resulting throughput and spectral efficiency has been improved. As an experimental verification, we demonstrate that the spectral efficiency of 23 km and 50 km have been doubled in the OFDMA-PON uplink transmission.</P>
Imaging-Pathology Discordant Thyroid No-dules: Analysis of Causes on Ultrasonography
( Jung Hee Shin ),( Boo-kyung Han ),( Eun Young Ko ),( Suk Jung Kim ),( Sung Hee Mun ),( Young Lyun Oh ),( Jee Soo Kim ) 대한갑상선학회 2008 International Journal of Thyroidology Vol.1 No.2
Background and Objectives: The purpose of this study was to evaluate causes and ultrasonographic features of imaging-pathology discordant thyroid nodules. Materials and Methods: We prospectively collected cases with imaging-pathology discordant thyroid nodules by comparing the initial ultrasonographic impressions with at least more than two fine-needle aspiration (FNA) or surgical results between March 2006 and March 2007. An experienced radiologist retrospectively evaluated the causes and ultrasonographic findings of these cases. Results: Of 4747 patients, 122 patients (2.6%) had imaging-pathology discordant nodules. Of 78 patients with at least two or more FNA (n=25) or surgical (n=53) discordant nodules, 29 imaging-pathology discordant benign lesions were associated with non-neoplastic nodules with focal malignant findings (n=12), thyroiditis (n=7), cysts mimicking solid nodules (n=4), post-aspiration cystic nodules (n=4) and pharyngoesophageal diverticulum (n=2). Forty-nine imaging-pathology discordant malignant lesions were associated with papillary carcinomas without definitely suspicious ultrasonographic findings (n=31), other thyroid carcinomas (n=12, including five follicular carcinomas, three follicular variants of papillary carcinoma and four medullary carcinomas), cystic malignancies (n=4) and calcified nodules with a spongiform appearance (n=2). Following a retrospective review, cysts mimicking solid nodules and pharyngoesophageal diverticulum mimicking a calcified nodule could be reclassified into correct ultrasonographic diagnoses. Conclusion: Failure to understand correctly the ultrasonographic findings of imaging-pathology discordant nodules may lead to unnecessary ultrasonography-guided FNA or a delayed diagnosis of cancer.