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Choi, Dukhyun,Choi, Min-Yeol,Choi, Won Mook,Shin, Hyeon-Jin,Park, Hyun-Kyu,Seo, Ju-Seok,Park, Jongbong,Yoon, Seon-Mi,Chae, Seung Jin,Lee, Young Hee,Kim, Sang-Woo,Choi, Jae-Young,Lee, Sang Yoon,Kim, Jo WILEY-VCH Verlag 2010 ADVANCED MATERIALS Vol.22 No.19
<B>Graphic Abstract</B> <P>The cover shows an image of fully rollable transparent nanogenerators synthesized using chemical vapor deposition grown large-scale graphene sheets as transparent electrodes and piezoelectric ZnO nanorod arrays. Sang-Woo Kim, Jae-Young Choi, and co-workers report on p. 2187 the electrical and structural stability of the nanogenerators, with excellent charge scavenging performance under external mechanical loads such as bending and rolling. This study shows that graphene-based nanogenerators are very promising for self-powered rollable transparent device applications. <img src='wiley_img_2010/09359648-2010-22-19-ADMA201090066-content.gif' alt='wiley_img_2010/09359648-2010-22-19-ADMA201090066-content'> </P>
Mitochondrial dysfunction and calcium deregulation by the RanBP9-cofilin pathway
Roh, Seung-Eon,Woo, Jung A.,Lakshmana, Madepalli K.,Uhlar, Courtney,Ankala, Vinishaa,Boggess, Taylor,Liu, Tian,Hong, Yun-Hwa,Mook-Jung, Inhee,Kim, Sang Jeong,Kang, David E. The Federation of American Societies for Experimen 2013 The FASEB Journal Vol.27 No.12
<P>Mitochondrial dysfunction and synaptic damage are important features of Alzheimer's disease (AD) associated with amyloid β (Aβ) and tau. We reported previously that the scaffolding protein RanBP9, which is overall increased in brains of patients with AD and in mutant APP transgenic mice, simultaneously promotes Aβ generation and focal adhesion disruption by accelerating the endocytosis of APP and β1-integrin, respectively. Moreover, RanBP9 induces neurodegeneration <I>in vitro</I> and <I>in vivo</I> and mediates Aβ-induced neurotoxicity. Here we show in primary hippocampal neurons that RanBP9 potentiates Aβ-induced reactive oxygen species (ROS) overproduction, apoptosis, and calcium deregulation. Analyses of calcium-handling measures demonstrate that RanBP9 selectively delays the clearance of cytosolic Ca<SUP>2+</SUP> mediated by the mitochondrial calcium uniporter through a process involving the translocation of cofilin into mitochondria and oxidative mechanisms. Further, RanBP9 retards the anterograde axonal transport of mitochondria in primary neurons and decreases synaptic mitochondrial activity in brain. These data indicate that RanBP9, cofilin, and Aβ mimic and potentiate each other to produce mitochondrial dysfunction, ROS overproduction, and calcium deregulation, which leads to neurodegenerative changes reminiscent of those seen in AD.—Roh. S.-E., Woo, J. A., Lakshmana, M. K., Uhlar, C., Ankala, V., Boggess, T., Liu, T., Hong, Y.-H., Mook-Jung, I., Kim, S. J., Kang, D. E. Mitochondrial dysfunction and calcium deregulation by the RanBP9-cofilin pathway.</P>
Glomus Tumor Causing Anterior Thigh Pain: A Case Report
( Sang Young So ),( Byng Mook Kim ),( Sun Yeul Lee ),( Young Kwon Ko ),( Yong Sup Shin ),( Won Hyung Lee ) 대한통증학회 2014 The Korean Journal of Pain Vol.27 No.2
Glomus tumors are a rare, benign neoplasm and 75% exist in the subungual region. Extradigital glomus tumors are much more difficult to diagnose because of their atypical location and symptoms. Furthermore, if their symptoms are similar to neuropathic pain, the patient can suffer from misdirected treatment due to misdiagnosis. It is essential to perform careful evaluation of the lesion itself in order to reduce misdiagnosis. Ultrasonography is a useful, non-invasive method that can be easily performed in the pain clinic for local evaluation and diagnosis. We report a case of misdiagnosed glomus tumor in the thigh which was properly diagnosed after ultrasonography. (Korean J Pain 2014; 27: 174-177)
Kim, Ki Seok,Kim, Sang-Mook,Jeong, Hyun,Jeong, Mun Seok,Jung, Gun Young WILEY-VCH Verlag 2010 Advanced Functional Materials Vol.20 No.7
<P>The improvement of the light extraction efficiency (LEE) of a conventional InGaN blue light-emitting diode (LED) by the incorporation of one-dimensional ZnO sub-microrods is reported. The LEE is improved by 31% through the wave-guiding effect of ZnO sub-microrods compared to LEDs without the sub-microrods. Different types of ZnO microrods/sub-microrods are produced using a simple non-catalytic wet chemical growth method at a low temperature (90 °C) on an indium-tin-oxide (ITO) top contact layer with no seed layer. The crystal morphologies of needle-like or flat-top hexagonal structures, and the ZnO microrods/sub-microrod density and size are easily modified by controlling the pH value and growth time. The wave-guiding phenomenon within the ZnO rods is observed using confocal scanning electroluminescence microscopy and micro-electroluminescence spectra.</P> <B>Graphic Abstract</B> <P>1D ZnO rod structures as an optical wave-guiding medium are proposed as a means of improving the light extraction efficiency of InGaN/GaN multiple quantum well blue LEDs. Different shapes of ZnO rod structures are produced using a simple non-catalytic wet-chemical growth method at low temperature on an ITO contact layer. Confocal scanning electroluminescence microscopy and micro-electroluminescence spectra confirmed the wave-guiding phenomenon within the ZnO sub-microrods. <img src='wiley_img_2010/1616301X-2010-20-7-ADFM200901935-content.gif' alt='wiley_img_2010/1616301X-2010-20-7-ADFM200901935-content'> </P>
Nanopatterned aluminum nitride template for high efficiency light-emitting diodes.
Kim, Sang-Mook,Park, Tae-Young,Park, Seong-Ju,Lee, Seung-Jae,Baek, Jong Hyeob,Park, Yun Chang,Jung, Gun Young Optical Society of America 2009 Optics express Vol.17 No.17
<P>Nanopatterned aluminum nitride (NP-AlN) templates were used to enhance the light extraction efficiency of the light-emitting diodes (LEDs). Here, the NP-AlN interlayer between the sapphire substrate and GaN-based LED was used as an effective light outcoupling layer at the direction of bottom side and as a buffer layer for growth of GaN LEDs. The cross-sectional transmission electron microscopy (TEM) analysis showed that the formation of stacking faults and voids could help reduce the threading dislocations. Micro Raman spectra also revealed that the GaN-based epilayer grown on the NP-AlN template had smaller residual stress than that grown on a planar sapphire substrate. The normalized electroluminescence (EL) spectra at the top and bottom sides of device revealed that the enhancement of the bottom side emission of the LED with the NP-AlN interlayer was more notable than a planar sapphire substrate due to the graded-refractive-index (GRIN) effect of the NP-AlN.</P>
Wafer-Level Packaged Light-Emitting Diodes Using Photodielectric Resin
Sang-Mook Kim,Kwang-Cheol Lee,Young Moon Yu,Jong Hyeob Baek,Gun Young Jung IEEE 2009 IEEE electron device letters Vol.30 No.6
<P>A large area (1600 mum times 800 mum) high-brightness light-emitting diode (HB LED) employing rearranged metal pads and multipassivation layers is presented. To enlarge the active layer with a smaller mesa area and improve package productivity using large bonding pads, two electrodes were used to fabricate the LED; a primary electrode was in contact with the n, p-GaN as a conventional LED, and the second electrode was connected to the primary electrode with a passivation layer having photodielectric resin interposed between them. The LED was directly bonded to the metal-core printed circuit board without wire bonding or epoxy molding. The resultant HB LED has a low forward voltage ( ~3.2 V at 350 mA) due to the optimized n, p-contact scheme, and an optical power of 75 mW with no encapsulation.</P>
Korean Ginseng-Induced Occupational Asthma and Determination of IgE Binding Components
Kim, Kyung-Mook,Kwon, Hyouk-Soo,Jeon, Sung-Gyu,Park, Chang-Han,Sohn, Seong-Wook,Kim, Duck-In,Kim, Sun-Sin,Chang, Yoon-Seok,Kim, Yoon-Keun,Cho, Sang-Heon,Min, Kyung-Up,Kim, You-Young The Korean Academy of Medical Sciences 2008 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.23 No.2
<P>A number of case reports on occupational asthma caused by herbal medicines have been issued, for example, on Sanyak, Chunkung, Banha, and Brazilian ginseng. Recently, cases of occupational asthma induced by Sanyak and Korean ginseng have been reported, but the pathogenic mechanisms involved are unknown. This study was carried out to evaluate the immunologic mechanism underlying Korean ginseng-induced occupational asthma. A patient engaged in Korean ginseng wholesale was referred for recurrent dyspnea, wheezing, and nasal symptoms, which were aggravated at work. Allergen bronchial provocation testing to Korean ginseng extract showed a typical immediate response, and skin prick testing to Korean ginseng extract also showed a strong positive response. Moreover, serum-specific IgE levels to Korean ginseng extract were significantly higher than in controls. Enzyme-linked immunosorbent assay (ELISA) inhibition tests showed a dose-dependent inhibition by Korean ginseng, but not by <I>Dermatophagoides farinae</I>, wheat flour, or Chinese balloon flower. Sodium dodecylsulfate-poly-acrylamide gel electrophoresis (SDS-PAGE) and immunoblotting revealed four specific Immunoglobulin E (IgE) binding components at 26, 30, 47, and 60 kDa, which were not bound by control sera. These results strongly suggest that occupation asthma induced by Korean ginseng is induced via an IgE-mediated mechanism.</P>