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( Hwa Seon Koo ),( Hyun Jeong Yi ),( Min Young Lee ),( Min Hye Choi ),( Na Young Sung ),( Yu Im Hwang ),( In Ok Song ),( Mi Kyoung Koong ),( Inn Soo Kang ),( Kwang Moon Yang ) 대한산부인과학회 2012 대한산부인과학회 학술대회 Vol.99 No.-
Objective: To evaluate whether increased peripheral blood inflammatory immune cell can induce decrease of uterine blood flow in patients with unexplained recurrent spontaneous abortion (RSA). Methods: This study designed prospectively 33 pregnant women between 5 to 7 gestational weeks with a history of unexplained RSA included in this study. 47 normal pregnant women between 5 to 7 gestational weeks without history of infertility and/or RSA included as a control. Peripheral blood natural killer (pbNK) (CD3-/56+) fractions among peripheral blood monocyte (PBMC) were checked by flow cytometry. Uterine color-pulsed Doppler trans-vaginal ultrasound for evaluation of uterine radial artery RI was checked. Uterine radial artery resistance index (RI) compared between study and control group. After then, uterine radial artery RI was compared between high pbNK cell fraction above 12.1% among PBMC and normal pbNK cells fraction below 12.1%. Correlation between pbNK cell fraction to uterine radial artery RI was also evaluated. Results: Uterine radial artery RI in early pregnancy was significantly higher in patients with RSA than that of normal control (0.60 ± 0.14 vs. 0.54 ± 0.12, P = 0.039). Especially, the mean value of uterine radial artery RI in RSA patients with elevated pbNK cells was significantly increased than that of normal control (0.62 ± 0.13 vs. 0.54 ± 0.12, P =0.029). Otherwise, pbNK cell fractions among PBMC displayed strong positive correlation to uterine radial artery RI (Pearson`s correlation coefficient P=0.001, r = 0.667). Conclusion: Increased pbNK cells can evoke decreased uterine blood flow by their pro-inflammatory action on micro vascular structure such as uterine radial artery. This can be a one causative mechanism of inducing spontaneous abortion by increased NK cells. But, larger scaled study is needed for clarify our results.
Trichostatin A-mediated upregulation of p21WAF1 contributes to osteoclast apoptosis
Yi, TacGhee,Baek, Jeong-Hwa,Kim, Hye-Jin,Choi, Mi-Hye,Seo, Sang-Beom,Ryoo, Hyun-Mo,Kim, Gwan-Shik,Woo, Kyung Mi Springer Science and Business Media LLC 2007 Experimental and molecular medicine Vol.39 No.2
<P>Histone deacetylase inhibitors (HDIs), a new class of anti-cancer agents, have been reported to suppress formation of osteoclast precursors and their fusion into multinucleated cells. However, little is known about the effect of HDIs on mature osteoclasts, which may have significance for their therapeutic use. Here, we demonstrate a novel action of HDIs on osteoclast apoptosis. Primary multinucleated mature osteoclasts were prepared from mouse bone marrow cells. Treatment of osteoclasts with the HDI trichostatin A (TSA) caused apoptosis, as confirmed by annexin V staining and caspase activation. TSA caused the upregulation of p21WAF1 in osteoclasts. To understand the role of p21(WAF1) upregulation in TSA-treated osteoclasts, shRNA against p21(WAF1)-containing lentivirus was introduced into osteoclasts. The suppression of p21(WAF1) decreased TSA-directed osteoclast apoptosis. Collectively, our results provide evidence that TSA causes osteoclast apoptosis, which involves, in part, TSA-induced upregulation of p21(WAF1), and strongly supports HDIs as potential therapeutic agents for excessive bone resorption.</P>
PX-An Innovative Safety Concept for an Unmanned Reactor
Yi, Sung-Jae,Song, Chul-Hwa,Park, Hyun-Sik Korean Nuclear Society 2016 Nuclear Engineering and Technology Vol.48 No.1
An innovative safety concept for a light water reactor has been developed at the Korea Atomic Energy Research Institute. It is a unique concept that adopts both a fast heat transfer mechanism for a small containment and a changing mechanism of the cooling geometry to take advantage of the potential, thermal, and dynamic energies of the cold water in the containment. It can bring about rapid cooling of the containment and long-term cooling of the decay heat. By virtue of this innovative concept, nuclear fuel damage events can be prevented. The ultimate heat transfer mechanism contributes to minimization of the heat exchanger size and containment volume. A small containment can ensure the underground construction, which can use river or seawater as an ultimate heat sink. The changing mechanism of the cooling geometry simplifies several safety systems and unifies diverse functions. Simplicity of the present safety system does not require any operator actions during events or accidents. Therefore, the unique safety concept of PX can realize both economic competitiveness and inherent safety.
( Sung-hun Min ),( Ja-seong Koo ),( Hyun-jung Kim ),( Yi-jo Jeung ),( Hwa-sook Moon ) 대한산부인과학회 2019 대한산부인과학회 학술대회 Vol.105 No.-
Objective: LAH was proposed to improve the implantation rate in FET cycles, but conflicting information exists in the literature with respect to the efficacy of AH in FET cycles. Methods: Embryo freezing was performed by vitrification at the cleavage stage 3 days after oocyte retrieval. Frozen embryos were thawed on the day of FET cycle. In the LAH group, zona thinning was performed by an experienced embryologist using a RI laser. During the operation, the outer half of the zona pellucida over a quarter of the diameter of the zona was removed. In the control group, embryos were replaced without LAH. Pregnancy and implantation rates were compared, p-value of <0.05 was considered statistically significant. Results: There were no differences in age of women at embryo freezing/thawing, body mass index, duration of infertility, primary/secondary infertility, cause of infertility, basal serum FSH concentration, cycle number, percentage of smokers or number of embryos frozen between the LAH group and the control group. The HMG dosage and duration and number of eggs retrieved/fertilized of the index stimulated cycle did not differ. However, pregnancy rates (43.5 vs 37.2%), and ongoing implantation rates (19.2 vs 16.3%) were higher in LAH treatment group compared to control, but these differences did not reach statistical significance. Conclusion: The findings of this study indicate that LAH treatment improves implantation and clinical pregnancy rates in women undergoing frozen-thawed embryo transfer. Furthermore, this treatment may be considered as a preferable strategy during the IVF treatment. However, this method does not seem to completely resolve the FET cycle.
Yi, Sum-Gyun,Park, Myung Uk,Kim, Sung Hyun,Lee, Chang Jun,Kwon, Junyoung,Lee, Gwan-Hyoung,Yoo, Kyung-Hwa American Chemical Society 2018 ACS APPLIED MATERIALS & INTERFACES Vol.10 No.37
<P>We fabricated MoS<SUB>2</SUB>-based flash memory devices by stacking MoS<SUB>2</SUB> and hexagonal boron nitride (hBN) layers on an hBN/Au substrate and demonstrated that these devices can emulate various biological synaptic functions, including potentiation and depression processes, spike-rate-dependent plasticity, and spike-timing dependent plasticity. In particular, compared to a flash memory device prepared on an hBN substrate, the device fabricated on the hBN/Au exhibited considerably more symmetric and linear bidirectional gradual conductance change curves, which may be attributed to the device structure incorporating double floating gate. For the device on the hBN/Au, electron transfers may occur between the floating gate MoS<SUB>2</SUB> and Au, as well as between the floating gate MoS<SUB>2</SUB> and the channel MoS<SUB>2</SUB>, allowing for more control over electron tunneling and injection. To test our hypothesis, we also fabricated a MoS<SUB>2</SUB>-based flash memory device on an hBN/Pd substrate and found behavior similar to the device fabricated on hBN/Au. Our results demonstrate that flexible synaptic electronics may be implemented using MoS<SUB>2</SUB>-based flash memory devices with double floating gates.</P> [FIG OMISSION]</BR>
Sang-Hwa Yi,Don-Ha Hwang,Wee Sang Park 대한전기학회 2016 Journal of Electrical Engineering & Technology Vol.11 No.6
For on-line partial discharge (PD) monitoring of rotating machines, a novel sensor is proposed, which can be installed on the power lead inside the terminal box of the machine. The sensor has been designed to have high capacitance, and minimal reflection of measured pulses. As a sensitivity of the sensor, transfer impedance Zt has been measured and compared to conventional coupler-type sensors. A simple method is presented for measuring Zt of coupler sensors, using a vector network analyzer and a practical lead-cable of rotating machine. Through this method, it became possible to measure the Zt of coupler sensors including the installation environment of them. The Zt of the proposed sensor is higher than that of same sized other conventional couplers at frequencies between 30 and 92 MHz. Another sensitivity test has been performed using a PD calibrator as a test pulse source. The proposed sensor has higher measured peak voltage than the conventional coupler type sensors when the same charges were input.
Yi, Sang-Hwa,Hwang, Don-Ha,Park, Wee Sang The Korean Institute of Electrical Engineers 2016 Journal of Electrical Engineering & Technology Vol.11 No.6
For on-line partial discharge (PD) monitoring of rotating machines, a novel sensor is proposed, which can be installed on the power lead inside the terminal box of the machine. The sensor has been designed to have high capacitance, and minimal reflection of measured pulses. As a sensitivity of the sensor, transfer impedance $Z_t$ has been measured and compared to conventional coupler-type sensors. A simple method is presented for measuring $Z_t$ of coupler sensors, using a vector network analyzer and a practical lead-cable of rotating machine. Through this method, it became possible to measure the $Z_t$ of coupler sensors including the installation environment of them. The $Z_t$ of the proposed sensor is higher than that of same sized other conventional couplers at frequencies between 30 and 92 MHz. Another sensitivity test has been performed using a PD calibrator as a test pulse source. The proposed sensor has higher measured peak voltage than the conventional coupler type sensors when the same charges were input.