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( Hyun Su Baek ),( Hye Sung Lee ),( Bok Joo Kim ),( In Kyo Chung ),( Chul Hoon Kim ),( Sun Mi Jin ),( Hie Sung Hwang ),( Sang Hun Shin2 ) 한국조직공학·재생의학회 2011 조직공학과 재생의학 Vol.8 No.6
The objective of this study was to evaluate platelet-rich fibrin (PRF)’s effectiveness in repairing articular disc defect in the temporomandibular joint (TMJ) of rabbits. Eight rabbits were divided into four groups of two rabbits each, corresponding to groups A, B, C, and D. Both TMJs of all of the rabbits were used in the experiments: the right joints comprised the experimental groups, and the left ones, the control groups. The disc defect was circular and 2 mm in diameter. In the experimental groups, the PRF was compressed into the defect, whereas the control group defects were left untreated. A, B, C, and D groups were sacrificed at the 1st, 2nd, 4th and 6th weeks, respectively. The defects of each control group exhibited no specific changes. Contrastingly, in each experimental group, there was an increased number of chondroblasts at the margins of the defects, along with accelerated cell differentiation and a columnar cell arrangement observable at the time of cell differentiation. The experimental groups showed inflammatory cell infiltrations and fibrosis by the 1st week, maturation of chondrocytes by the 2nd week, and proliferation by the 4th week, after which the defects began to be filled with chondrocytes, a process that was complete after the 6th week. In the histological evaluation (H-E), the experimental groups showed significant increases of chondroblasts after the 2nd and 4th weeks, as well as regular columns of chondrocyte arrays observable during cell division. After 6 weeks, the defects were filled with chondrocytes.
Shin, Jong Won,Han, Ji Hoe,Kim, Bong Gon,Jang, Sang Hun,Lee, Sang Gyeong,Min, Kil Sik Elsevier 2009 Inorganic Chemistry Communications Vol.12 No.12
<P><B>Graphical abstract</B></P><P>Novel supramolecular solids depending on the counteranion have been constructed from AgX (X=<SUB>CF3</SUB>CO2- (<B>1</B>) and <SUB>CF3</SUB>SO3- (<B>2</B>)) with pyrazinecarbonitrile via the methanolysis of pyrazinecarbonitrile in the silver(I) methanolic solution. They are both one-dimensional ladder-like coordination polymers due to the π–π interactions. Both compounds display relatively strong photoluminescent behaviors.</P><ce:figure></ce:figure> <P><B>Abstract</B></P><P>New supramolecular solids whose topologies depend on the counteranion, [Ag(MPCI)(CF<SUB>3</SUB>CO<SUB>2</SUB>)] (<B>1</B>) and [Ag<SUB>2</SUB>(MPCI)<SUB>2</SUB>(CH<SUB>3</SUB>OH)(CF<SUB>3</SUB>SO<SUB>3</SUB>)]CF<SUB>3</SUB>SO<SUB>3</SUB> (<B>2</B>), have been prepared by the self-assembly of AgX (X=<SUB>CF3</SUB>CO2-and<SUB>CF3</SUB>SO3-) with pyrazinecarbonitrile (MPCI=methyl pyrazine-2-carboximidate). Both compounds are composed of methyl pyrazine-2-carboximidate (MPCI), in which the pyrazinecarbonitrile ligand is transformed into an MPCI by methanolysis in the presence of silver(I) ions. The coordination geometry around silver(I) ion in <B>1</B> is a distorted tetrahedral structure, while two silver(I) ions in the asymmetric unit of <B>2</B> are a seesaw-like structure and a square-planar one. Furthermore, <B>1</B> and <B>2</B> display one-dimensional ladder-like coordination polymers due to the π–π interactions. <B>1</B> shows a visible light emission ranging from violet to blue wavelengths, whereas <B>2</B> appears a weak visible emission at around 470nm.</P>
( Shin Hwang ),( Gi-won Song ),( Chul-soo Ahn ),( Ki-hun Kim ),( Deok-bog Moon ),( Tae-yong Ha ),( Dong-hwan Jung ),( Sung-gyu Lee ) 대한간학회 2020 춘·추계 학술대회 (KASL) Vol.2020 No.1
Aims: Salvage liver transplantation is a treatment for recurrent hepatocellular carcinoma (HCC) after hepatectomy. ADV score is calculated by multiplying a-fetoprotein and des-γ-carboxy-prothrombin concentrations and tumor volume. Prognostic accuracy of ADV score was assessed in patients undergoing salvage living donor liver transplantation (LDLT) and their outcomes were compared with patients undergoing primary LDLT. Methods: This was a retrospective observational study. Outcomes were compared in 125 patients undergoing salvage LDLT from 2007 to 2018 and in 500 propensity score-matched patients undergoing primary LDLT. Results: In patients undergoing salvage LDLT, the median intervals between hepatectomy and tumor recurrence, between first HCC diagnosis and salvage LDLT, and between hepatectomy and salvage LDLT were 12.0, 37.2, and 29.3 months, respectively. Disease-free survival (DFS, P=0.98) and overall survival (OS, P=0.44) rates did not differ significantly in patients undergoing salvage and primary LDLT. ADV score was significantly predictive of DFS and OS in patients undergoing salvage and primary LDLT (P<0.001). DFS after hepatectomy (P=0.52) and interval between hepatectomy and LDLT (P=0.82) did not affect DFS after salvage LDLT. Milan criteria and ADV score were independently prognostic of DFS and OS following salvage LDLT, and the prognosis of patients within and beyond Milan criteria was further stratified by ADV score. Conclusions: Risk factors and post-transplant outcomes were similar in patients undergoing salvage and primary LDLT. ADV score is a surrogate biomarker for post-transplant prognosis in salvage and primary LDLT recipients. A prognostic model incorporating ADV scores can help determine whether to perform salvage LDLT.
( Shin Jae Rhim ),( Seung Hun Son ),( Hyun Su Hwang ),( Joo Han Sung ),( Go Eun Park ),( Chan Ryul Park ) 한국임학회 2014 산림과학 공동학술대회 논문집 Vol.2014 No.-
This study was examined characteristics of small rodent populations using live trappings between natural deciduous forest and Japanese larch Larix leptolepis plantation on Mt. Gariwang, Pyeongchang, Gangwon Province, Korea. There were significant differences in foliage profiles, diameter at breast height distribution of standing trees, stand structure attributes, and characteristics of downed trees between natural deciduous forest and Japanese larch plantation. Moreover, differences in both species richness and abundance of small mammals were observed in this study. The number of captured individuals, age structure, and sex ratio varied over the course of the trapping sessions in both study areas. For the forest managers, an understanding of interaction between habitat characteristics and small mammal population dynamics is important to forest management.
Sung-Hwa Kang,Shin Hwang,Tae-Yong Ha,Gi-Won Song,Dong-Hwan Jung,Ki-Hun Kim,Chul-Soo Ahn,Deok-Bog Moon,Gil-Chun Park,Bo-Hyun Jung,Young-In Yoon,Sung-Gyu Lee 한국간담췌외과학회 2014 한국간담췌외과학회지 Vol.18 No.2
Backgrounds/Aims: There are few guidelines for tailored immunosuppressive regimens for liver transplantation (LT) recipients with hepatocellular carcinoma (HCC). To establish long-term immunosuppressive regimens suitable for Korean adult LT recipients, we analyzed those that were currently in use at a single high-volume institution. Methods: This cross-sectional study comprises three parts including review of the immunosuppressive regimens used to manage 2,147 adult LT outpatients, review of LT recipients who were diagnosed of HCC at LT, and review of LT recipients who suffered from HCC recurrence. Results: In 1,000 adult LT recipients who were living more than 5 years with no adverse events, 916 received a calcineurin inhibitor (CNI)-based therapy (CNI only in 520; CNI with mycophenolate mofetil [MMF] in 396) and 84 were receiving an MMF-based therapy (MMF only in 45; MMF with minimal CNI in 39). Tacrolimus was preferred over cyclosporine for both monotherapy and combination therapy along the passage of posttransplant period. There was no difference in selection of immunosuppressants, target blood concentration, and rate of combination therapy between LT recipients with and without HCC, except for the first 1 year. Sirolimus-based regimens were applied in 21 patients who showed HCC recurrence. Sorafenib was often used after conversion to sirolimus. Conclusions: Tailored immunosuppressive regimen covering the long-term posttransplant period should be established after consideration of individualized patient profiles including HCC.
( Shin Hwang ),( Deok-bog Moon ),( Ki-hun Kim ),( Chul-soo Ahn ),( Gi-Won Song ),( Dong-hwan Jung ),( Gil-chun Park ),( Sung-gyu Lee ) 대한간학회 2020 춘·추계 학술대회 (KASL) Vol.2020 No.1
Aims: We assessed the prognostic accuracy of ADV score (a-fetoprotein [AFP]-des-γ-carboxyprothrombin [DCP]-tumor volume [TV] score) following resection of hepatocellular carcinoma (HCC) with portal vein tumor thrombosis (PVTT). Methods: This was a retrospective observational study. This study included 147 patients who underwent hepatic resection for HCC with PVTT. They were followed up for ≥66 months or until patient death. Results: The grades of PVTT were Vp1 in 121 (14.3%), Vp2 in 41 (27.9%), Vp3 in 71 (48.3%), and Vp4 in14 (9.5%) cases. Preoperative HCC treatment was performed in 48 (32.7%) patients. R0 and R1 resections were performed in 119 (81.0%) and 28 (19.0%) cases, respectively. The 5-year tumor recurrence, HCC-specific survival and post-recurrence survival rates were 79.2%, 43.5% and 25.4%, respectively. Neither PVTT grade nor history of preoperative HCC treatment was a significant prognostic indicator. Stratification in accordance with ADV scores of 1log- and 3log-intervals resulted in high prognostic accuracy in predicting tumor recurrence and patient survival. Following cluster analysis, the cutoff for ADV score was determined at 9log and was more prognostically significant in terms of tumor recurrence and patient survival than surgical curability or microvascular invasion. Further comparisons revealed that prognostic prediction with an ADV score cutoff at 9log was more accurate than that using the Eastern Hepatobiliary Surgery Hospital-PVTT score. Conclusions: ADV score is an integrated surrogate biomarker for post-resection prognosis in HCC with PVTT. Our prognostic prediction model using ADV scores provides reliable post-resection prognosis for patients with various grades of these tumors.
Stimulation of Innate Immune Function by <i>Panax ginseng</i> after Heat Processing
Shin, Myoung-Sook,Song, Ji Hoon,Choi, Pilju,Lee, Jong Hun,Kim, Song-Yi,Shin, Kwang-Soon,Ham, Jungyeob,Kang, Ki Sung American Chemical Society 2018 Journal of agricultural and food chemistry Vol.66 No.18
<P><I>Panax ginseng</I> Meyer has been used for the treatment of immune diseases and for strengthening the immune function. In this study, we evaluated the innate immune-stimulating functions and action mechanisms of white ginseng (WG) and heat-processed ginseng (HPG) in RAW264.7 cells. According to LC-MS analysis results, WG contained typical ginsenosides, such as Rb1, Rc, Rb2, Rd, and Rg1, whereas HPG contained Rg3, Rk1, and Rg5 as well as typical ginsenosides. HPG, not WG, enhanced NF-κB transcriptional activity, cytokine production (IL-6 and TNF-α), and MHC class I and II expression in RAW264.7 cells. In addition, HPG phosphorylated MAPKs and NF-kB pathways. In experiments with inhibitors, the ERK inhibitor completely suppressed the effect of HPG on IL-6 and TNF-α production. HPG-induced c-Jun activation was suppressed by an ERK inhibitor and partially suppressed by JNK, p38, and IκBα inhibitors. Collectively, these results suggested that HPG containing Rg3, Rg5, and Rk1 increased macrophage activation which was regulated by the ERK/c-Jun pathway in RAW264.7 cells.</P> [FIG OMISSION]</BR>