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Poster Session : Biotechnology ; Study on anti-inflammatory activity of Isatis tinctoria L.
( Woo A Jo ),( Young Hun Kim ),( Soon Ju Cheon ),( Min Jung Jang ),( Ji Yeun Sung ),( Whan Sin Oh ),( Yeon Kyoung Hwang ),( Bong Jeun An ),( Chang Eon Lee ),( Uk Jin Baek ),( Jong Woong Park ),( Ho Ju 한국생화학분자생물학회 (구 한국생화학회) 2007 생화학분자생물학회 춘계학술발표논문집 Vol.2007 No.-
Solubilized Formulation of Olmesartan Medoxomil for Enhancing Oral Bioavailability
Bong Sang Lee,강명주,Woo Sik Choi,Yoon Bae Choi,Hyung Soo Kim,Sang Kil Lee,Jaehwi Lee,최영욱 대한약학회 2009 Archives of Pharmacal Research Vol.32 No.11
Olmesartan medoxomil (OLM) is an antihypertensive angiotensin Ⅱ receptor blocker. OLM has a low bioavailability (BA), approximately 26% in humans, due to its low water solubility and efflux by drug resistance pumps in the gastrointestinal tract. Self-microemulsifying drug delivery system (SMEDDS), which is easily emulsified in aqueous media under gentle agitation and digestive motility, was formulated to increase the oral BA of OLM. Among the surfactants and oils studied, Capryol 90, Tween 20, and Tetraglycol were chosen and combined at a volume ratio of 1:6:3 on the basis of equilibrium solubility and phase diagram experiments. The mean droplet size of SMEDDS was 15 nm. In an oral absorption study in rats, SMEDDS formulation brought faster absorption compared to suspension, showing a Tmax value of 0.2 hr. The Cmax and AUC values of SMEDDS formulation were significantly higher than those of suspension, revealing a relative BA of about 170%. Our study demonstrated the potential usefulness of SMEDDS for the oral delivery of poorly absorbable compounds, including OLM.
( Woo Hyeon Kim ),( Borami Kang ),( Byung Wook Kim ),( Joon Sung Kim ),( Hae Mi Lee ),( Eun Joo Lim ),( Jong In Kim ),( Bong Koo Kang ),( Jeong Seon Ji ),( Bo In Lee ),( Hwang Choi ) 대한간학회 2013 Gut and Liver Vol.7 No.2
Extraintestinal manifestations are not uncommon in Crohn`s disease, and a thromboembolic event is a disastrous potential complication. Deep vein thrombosis is the most common manifestation of a thromboembolic event and typically occurs in association with active inflammatory disease. Peripheral neuropathy in Crohn`s disease has rarely been reported and is considered an adverse effect of metronidazole therapy. Here, we describe a patient who was initially diagnosed with Crohn`s disease complicated with deep vein thrombosis and ulnar neuropathy without metronidazole exposure. The simultaneous occurrence of these complications in the early stage of Crohn`s disease has never been reported in the English literature. (Gut Liver 2013;7:252-254)
( Bong Seok Kim ),( Sang Gu Lim ),( Hyun Woo Gil ),( In Seok Park ) 한국수산과학회(구 한국수산학회) 2011 Fisheries and Aquatic Sciences Vol.14 No.4
Eggs of Korean rose bitterling Rhodeus uyekii were collected and fertilized to observe temperature-related cleavage rates and mitotic intervals (τ0). As the water temperature was increased, the slope of first cleavage frequency with elapsed time after fertilization increased, and approximately 30% of fertilized eggs reached first cleavage frequency at every 15 min. At higher temperatures, eggs developed faster and underwent further identical developmental processes. There were strong, negative correlations between τ0 and water temperatures at all temperatures studied (Y = -1.225X + 70.05, r2 = 0.988, where Y is τ0 and X is temperature).