팔로3징의 외과적 치료

천종록,전상훈,장봉현,이종태,김규태 慶北大學校 醫科大學 1997 慶北醫大誌 Vol.38 No.2

목적 : 비교적 드물게 보는 선천성 심질환중의 하나인 팔로3징에 대한 본원에서의 진단 및 치료 경험을 임상적으로 관찰하여 보고함으로써 향후 이 질환의 개심술 성적을 향상시키는데 기여하고자 하였다. 대상 및 방법 : 경북대학교병원 흉부외과에서 1980년 3월부터 1997년 2월 사이에 개심술을 받았던 환자들 중에서 심도자검사 및 수술소견에 의해 팔로3징으로 진단되었던 8례를 대상으로 술전증상과 진찰소견, 술전의 심초음파검사, 심도자검사 및 심혈관조영술의 소견들을 검토하였고, 수술소견으로는 폐동맥협착과 심방중격결손의 해부학적 형태, 체외순환시간과 대동맥차단시간, 수술방법, 술후 합병증 및 수술사망률 등을 조사하였다. 그리고 평균 4.8년에 걸친 술후 추적관찰을 하였다. 결과 : 술전 진단에 있어서는 2례에서 오진되어 있었고, 술후 조기의 병원사망례는 없었으나 1례에서 류마치스성으로 추정되는 다발성 심장판막질환으로 8년후 인공판막치환술을 받았는데 패혈증으로 사망하였다. 나머지 환자들은 모두 양호한 경과를 취하였다. 결론 : 이 질환의 술전 진단에 있어서 과거에는 상당한 오진이 있었음을 알 수 있었고, 술전 증상이 심한 환자가 많았던 사실을 감안하면 개심술 성적과 술후 경과는 양호한 편이었다. Eight parients with trilogy of Fallot, characterized by the combination of pulmonary stenosism, atrial septal defect(ASD) and Rt-to-Lt shunt in the atrial level in the presence of an intact ventricular septum, underwent surgical correction between March 1980 and February 1997. Four patients were male and four were female. Their ages ranged from 2 months to 20 years with a mean age of 12.1 years. Cardiac catheterization and angiocardiogram were performed in all patients and 2D-Echocardiographic studies were obtained in 4 patients before operation. The preoperative diagnoses were tetralogy of Fallot(TOF) + ASD in 2 cases, trilogy of Fallot in 6 cases had combined pulmonary stenosis. The atrial septal defect was closed by primary suture in 6 cases and patch closure was done in 2 cases. The pulmonary stenosis was correctied by valvotomy in 2 cases, valvotomy + infundibulectomy in 2 cases, valvotomy + infundibulectomy + right venr tricular outflow tract reconstruction in one case, valvotomy + infundibulectomy + transannular patching in 3 cases. No operative death resulted, but one patient expired after undergoing mitral valve replacement and tricuspid annuloplasty for mitral insufficiency, tricuspid insufficiency and pulmonary valve insufficency 8 years later. All surviving patients have remained in good condition.

Detection of Lung Cancer using MAGE A1-6 and SSX4 RT-PCR Expression Profiles in the Bronchial Wash Fluid

Kwan-Ho Lee,Kyung-Chul Shin,Chae-Hun Lee,Sang-Hoon Jheon,전창호 대한암학회 2007 Cancer Research and Treatment Vol.39 No.2

Purpose: Bronchial wash fluid may be a useful for detecting lung cancer. To increase the detection rates, we performed molecular analysis with using MAGE A1-6 and SSX4 RT-PCR on bronchial wash fluid specimens.Materials and Methods: We obtained 57 lung cancer tissue specimens by bronchoscopic biopsy and 131 bronchial washes from 96 patients with lung cancer and 35 patients with benign lung diseases. The MAGE A1-6 and SSX4 gene expressions were investigated in the cancer tissue specimens and bronchial wash fluids. We evaluated the positive detection rates of these methods according to the cytology results and the clinical findings.Results: For the cancer tissue specimens and the bronchial wash fluid, the positive detection rate of MAGE or SSX4 was 91.2% and 75.0%, respectively. Combined MAGE and SSX4 PCR and cytology tests showed an 83.3% detection rate for the bronchial wash fluid. From bronchial washes of patients with benign lung diseases, the positive rates of using MAGE or SSX4 was 11.4%. In the bronchial wash fluid of lung cancer patients, 66.7% of the peripheral cancers were detected by MAGE or SSX4, while examination with cytology did not detect any peripheral lung cancer.Conclusion: The application of both MAGE and SSX4 showed high sensitivity and specificity for the detection of lung cancer. Thus, MAGE and SSX4 RT-PCR may be effectively utilized as additional methods to improve detection of lung cancer with using bronchial wash fluids. (Cancer Res Treat. 2007;39:69-73) Purpose: Bronchial wash fluid may be a useful for detecting lung cancer. To increase the detection rates, we performed molecular analysis with using MAGE A1-6 and SSX4 RT-PCR on bronchial wash fluid specimens. Materials and Methods: We obtained 57 lung cancer tissue specimens by bronchoscopic biopsy and 131 bronchial washes from 96 patients with lung cancer and 35 patients with benign lung diseases. The MAGE A1-6 and SSX4 gene expressions were investigated in the cancer tissue specimens and bronchial wash fluids. We evaluated the positive detection rates of these methods according to the cytology results and the clinical findings. Results: For the cancer tissue specimens and the bronchial wash fluid, the positive detection rate of MAGE or SSX4 was 91.2% and 75.0%, respectively. Combined MAGE and SSX4 PCR and cytology tests showed an 83.3% detection rate for the bronchial wash fluid. From bronchial washes of patients with benign lung diseases, the positive rates of using MAGE or SSX4 was 11.4%. In the bronchial wash fluid of lung cancer patients, 66.7% of the peripheral cancers were detected by MAGE or SSX4, while examination with cytology did not detect any peripheral lung cancer. Conclusion: The application of both MAGE and SSX4 showed high sensitivity and specificity for the detection of lung cancer. Thus, MAGE and SSX4 RT-PCR may be effectively utilized as additional methods to improve detection of lung cancer with using bronchial wash fluids. (Cancer Res Treat. 2007;39:69-73)

Parasitological and Histopathological Studies of Experimental Paragonimiasis

Jheon, Sang-Hoon,Yoo, Young-Sun,Joo, Chong-Yoon 啓明大學校 醫科大學 1995 계명의대학술지 Vol.14 No.1

고양이 폐흡충증에서 폐흡충의 분포상과 발육에 따른 조직병리학적 변화를 규명하기 위해 실험하였다. 실험군 고양이는 두 군으로 나누어 한 군에는 5, 10, 20개의 각각 다른 수의 피낭유충을 경구감염시킨 후 다시 10개의 피낭유충으로 2차 감염시켰다. 다른 군은 10개의 피낭유충의 경구투여, 복강내 주사 및 10개의 탈낭유충의 복강내 주사 등 3가지 방법으로 감염시켰다. 감염 후 90일과 150일에 고양이를 도살하여 기생충학 및 조직병리학적으로 관찰하였다. 투여한 피낭유충수가 많을수록 폐흡층 성충회수율은 낮았고, 왼쪽 폐보다 오른쪽 폐에서 더 많은 수의 성충이 기생되어 있었다. 양쪽 폐 모두 하엽에서 가장 많은 수의 성충이 회수되었다. 폐흡충을 감염시키는 방법으로는 피낭유충의 복강내 주사가 피낭유충의 경구투여나 탈낭유충의 복강내 주사보다 더 효과적인 것을 알 수 있었다. 감염 후 90일째 폐흡충낭을 둘러싼 엷은 섬유조직층과 침윤된 백혈구를 볼 수 있었고, 주변 조직에도 염증 소견을 볼 수 있었다. 감염 후 150일째에는 폐흡충낭이 두꺼운 섬유 육아조직과 형질세포로 싸여 있었다.

Phase Contrast Imaging of Female Breast Tissues with Synchrotron Radiation

Sung Hwan Park,Hong Tae Kim,Jong Ki Kim,Sang Hoon Jheon,Hwa Shik Youn 대한외과학회 2006 대한외과학회 학술대회 초록집 Vol.2006 No.11

A Functional Variant, rs967591G>A, in the 19q13.3 and Survival of Early-Stage Lung Cancer

박재용,( Hyo Sung Jeon ),( Seung Soo Yoo ),( Shin Yup Lee ),( Jaehee Lee ),( Seung Ick Cha ),( Chang Ho Kim ),( Eung Bae Lee ),( Young Tae Kim ),( Sang Hoon Jheon ) 대한결핵 및 호흡기학회 2012 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.114 No.-

Purpose: This study was conducted to investigate the associations between single nucleotide polymorphisms (SNPs) in 19q13.3 and survival of early-stage non-small cell lung cancer (NSCLC) patients, and to define the causative functional SNP of the association. Methods: A two-stage study design was used to evaluate five SNPs in relation to survival outcomes in 328 patients and then to validate the results in an independent patient population (n=565). Luciferase assay and real-time PCR was performed to examine functional relevance of a potentially functional SNP. Results: Of the five SNPs, three SNPs (rs105165C>T, rs967591G>A and rs735482A>C) were significantly associated with survival outcomes in a stage 1 study. The rs967591A allele had significantly higher promoter activity of CD3EAP compared with the rs967591G allele (P=0.002), but the SNP did not have an effect on the promoter activity of PPP1R13L. The rs967591G>A was associated with the level of CD3EAP mRNA expression in lung tissues (P=0.01). The rs967591G>A exhibited consistent associations in a stage 2 study. In combined analysis, the rs967591 AA genotype exhibited a worse overall survival (adjusted hazard ratio=1.69, 95% confidence interval=1.29-2.20, P=0.0001). Conclusion: The rs967591G>A affects CD3EAP expression and thus influences survival in early-stage NSCLC. The analysis of the rs967591G>A polymorphism can help identify patients at high risk of a poor disease outcome.

Infestation of larval trematodes from fresh-water fish and brackish-water fish in River Wyangpi, Kyungpook Province, Korea

Joo,Chong Yoon,Jheon,Sang Hoon 啓明大學校 醫科大學 1990 계명의대학술지 Vol.9 No.1

慶北 蔚珍郡 聖留山밑에 形成된 天然記念物 第 155號인 聖留窟앞으로 흘러내리는 王避川에 棲息하는 淡水魚와 半鹹水魚에서의 吸蟲類 被襄幼蟲 寄生狀을 알아보기 위해 1989年 5月부터 10月까지 王避川 流域에서 投網하는, 낚시등으로 淡水魚와 半鹹水魚를 採集하였다. 採集된 10種의 魚類에서 5種의 被襄幼蟲과 4種의 所屬未定幼蟲을 檢出할수 있었으며, 이 가운데 肝吸蟲은 1種의 魚類에서, Echinochasmus species와 構川吸蟲은 3種의 魚類에서, Exorchis oviformis, Cyathocotyle orientalis는 2種의 魚類에서 檢出 할 수 있었으며. 그 寄生率은 魚種別로 큰 差異를 나타내었다. 魚肉 1g當 肝吸蟲 被襄幼蟲數는 돌고기에서는 0.01 個였고, 構川吸蟲 被襄幼蟲數는 은어에서 4.17個였는데 비하여 피래미와 갈견이에서는 各各 0.11個 였다. 以上의 成績으로 미루어 보아 慶北 蔚珍郡 王被川에 棲息하고 있는 淡水魚와 半鹹水魚에서의 吸蟲類被襄幼蟲 寄生率과 感染度는 비교적 낮았으나. 이들 魚類를 生食하면 肝吸蟲과 構川吸蟲에 感染될 것으로 思料된다.

<i>EML4-ALK</i> Fusion Gene in Korean Non-Small Cell Lung Cancer

Jin, Guang,Jeon, Hyo-Sung,Lee, Eung Bae,Kang, Hyo-Gyoung,Yoo, Seung Soo,Lee, Shin Yup,Lee, Jae Hee,Cha, Sung Ick,Park, Tae In,Kim, Chang Ho,Jheon, Sang Hoon,Park, Jae Yong The Korean Academy of Medical Sciences 2012 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.27 No.2

<P>A fusion gene between echinoderm microtubule-associated protein-like 4 (<I>EML4</I>) and the anaplastic lymphoma kinase (<I>ALK</I>) has been identified in non-small cell lung cancers (NSCLCs). Although a few studies have evaluated <I>EML4-ALK</I> fusion genes in Korean NSCLCs, the prevalence of different <I>EML4-ALK</I> fusion variants has yet to be clearly assessed. Herein, we have examined the profiles of <I>EML4-ALK</I> fusion gene variants in Korean patients of NSCLCs. <I>EML4-ALK</I> fusion genes have been detected in 10 (6.0%) of 167 patients of NSCLCs and in 9 (7.4%) of 121 patients of adenocarcinoma. Of the 10 patients with fusion genes identified, 8 (80%) were E13;A20 (variant 1) and 2 (20%) were E6;A20, with an additional 33-bp sequence derived from intron 6 of <I>EML4</I> (variant 3b). These results indicate that the profiles of <I>EML4-ALK</I> fusion gene variants in Korean patients of NSCLC may differ from those in other ethnic populations. Herein, we describe for the first time the profiles of <I>EML4-ALK</I> fusion variants of Korean patients with NSCLCs.</P>

慶北道內 國民學校 學童들에서의 蟯蟲의 最近 感染樣相

朱鍾潤,錢相勳 최신의학사 1983 最新醫學 Vol.26 No.5

Free Paper Presentation : OS-73 ; Surgical Resection of Nodular Ground-Glass Opacities Without Percutaneous Needle Aspiration or Biopsy

( Jae Young Cho ),( Sung Jun Ko ),( Se Joong Kim ),( Yeon Joo Lee ),( Jong Sun Park ),( Young Jae Cho ),( Ho Il Yoon ),( Suk Ki Cho ),( Kwhanmien Kim ),( Sang Hoon Jheon ),( Jae Ho Lee ),( Choon Taek 대한결핵 및 호흡기학회 2014 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.118 No.-

Background: Percutaneous needle aspiration or biopsy (PCNA or PCNB) is an established diagnostic technique that has a high diagnostic yield. However, its role in the diagnosis of nodular ground-glass opacities (nGGOs) is controversial, and the necessity of preoperative histologic confirmation by PCNA or PCNB in nGGOs has not been well addressed. Thus, we here evaluated the rates of malignancy and surgery-related complications, and the cost benefits of resecting nGGOs without prior tissue diagnosis when those nGGOs were highly suspected for malignancy based on their size, radiologic characteristics, and clinical course. Methods: Patients who underwent surgical resection of nGGOs without preoperative tissue diagnosis from January 2009 to October 2013 were retrospectively analyzed. Results: Among 356 nGGOs of 324 patients, 330 (92.7%) nGGOs were resected without prior histologic confirmation. The rate of malignancy was 95.2% (314/330). In the multivariate analysis, larger size was found to be an independent predictor of malignancy (odds ratio, 1.086; 95% confidence interval, 1.001-1.178, p = 0.047). A total of 324 (98.2%) nGGOs were resected by video-assisted thoracoscopic surgery (VATS), and the rate of surgery-related complications was 6.7% (22/330). All 16 nGGOs diagnosed as benign nodules were resected by VATS, and only one patient experienced postoperative complications (prolonged air leak). Direct surgical resection without tissue diagnosis significantly reduced the total costs, hospital stay, and waiting time to surgery. Conclusions: With careful selection of nGGOs that are highly suspicious for malignancy, surgical resection of nGGOs without tissue diagnosis is recommended as it reduces costs and hospital stay.

Epidermal Growth Factor Receptor Gene Amplification Predicts Worse Outcome in Patients With Surgically Resected Nonadenocarcinoma Lung Cancer

Chang, Hyun,Yang, Yaewon,Lee, Jong-Seok,Jheon, Sang-hoon,Kim, Yu Jung,Chung, Jin-Haeng Elsevier 2019 Clinical lung cancer Vol.20 No.1

<P><B>Abstract</B></P> <P><B>Purpose</B></P> <P>The aim of the present study was to examine the prognostic role of amplification and increased expression of the epidermal growth factor receptor (<I>EGFR</I>) gene in surgically resected non-adenocarcinoma of non-small cell lung cancer (NA-NSCLC).</P> <P><B>Materials and Methods</B></P> <P>The present retrospective study included 114 consecutive NA-NSCLC patients with available tumor tissue and survival data. <I>EGFR</I> gene copy number and protein expression were evaluated using fluorescent in situ hybridization (FISH) and immunohistochemistry in tissue microarray sections, respectively.</P> <P><B>Results</B></P> <P>Among 114 patients, 99 (86.8%) had squamous cell carcinoma histologic features. <I>EGFR</I> gene amplification and high polysomy (<I>EGFR</I> FISH<SUP>+</SUP>) were observed in 7.9% and 31.6% of cases, respectively. Patients with <I>EGFR</I> FISH<SUP>+</SUP> had significantly shorter overall survival (<I>P</I> = .011). A multivariate model confirmed that patients with <I>EGFR</I> FISH<SUP>+</SUP> had a significantly greater risk of death than <I>EGFR</I> FISH<SUP>−</SUP> patients after adjusting for pathologic stage, presence of pleural invasion, venous invasion, and surgical margins (hazard ratio, 1.36; 95% CI, 1.040 to 1.782; <I>P</I> = .025). EGFR protein expression by immunohistochemistry was not associated with overall survival in the same group. Neither <I>EGFR</I> gene amplification nor EGFR immunohistochemistry expression was associated with relapse-free survival.</P> <P><B>Conclusion</B></P> <P>An increased <I>EGFR</I> gene copy number in surgically resected NA-NSCLC was associated with worse survival.</P>