Stainless steel wire in a figure-of-eight for repair of distal femoral physeal fractures in ten cats - a case report

Camilla Spångberg,Inga-Britt Spångberg,Annika Bergström 대한수의학회 2019 Journal of Veterinary Science Vol.20 No.6

Ten cats were treated for distal femoral Salter-Harris fractures types I and II, using a stainless steel wire in a figure-of-eight configuration. Healing was uneventful in eight 8 of the cats. Early fixation failure occurred in one cat, that which required revisional surgery. In one cat, lameness recurred after fracture healing, which and was related to breakage of the wire. The lLameness was resolved following after removing removal of the wire. At the long-term follow-up, one 1 out of six 6 cats was lame. The This report indicates that the figure-of-eight stainless steel wire technique offers is an alternative method for the repair of distal femoral Salter-Harris fractures types I and II in cats.

Vascularization of Microvascular Fragment Isolates from Visceral and Subcutaneous Adipose Tissue of Mice

Später Thomas,Marschall Julia E.,Brücker Lea K.,Nickels Ruth M.,Metzger Wolfgang,Menger Michael D.,Laschke Matthias W. 한국조직공학과 재생의학회 2022 조직공학과 재생의학 Vol.19 No.1

BACKGROUND: Adipose tissue-derived microvascular fragments (MVF) represent effective vascularization units for tissue engineering. Most experimental studies in rodents exclusively use epididymal adipose tissue as a visceral fat source for MVF isolation. However, in future clinical practice, MVF may be rather isolated from liposuctioned subcutaneous fat tissue of patients. Therefore, we herein compared the vascularization characteristics of MVF isolates from visceral and subcutaneous fat tissue of murine origin. METHODS: MVF isolates were generated from visceral and subcutaneous fat tissue of donor mice using two different enzymatic procedures. For in vivo analyses, the MVF isolates were seeded onto collagen-glycosaminoglycan scaffolds and implanted into full-thickness skin defects within dorsal skinfold chambers of recipient mice. RESULTS: By means of the two isolation procedures, we isolated a higher number of MVF from visceral fat tissue when compared to subcutaneous fat tissue, while their length distribution, viability and cellular composition were comparable in both groups. Intravital fluorescence microscopy as well as histological and immunohistochemical analyses revealed a significantly reduced vascularization of implanted scaffolds seeded with subcutaneous MVF isolates when compared to implants seeded with visceral MVF isolates. Light and scanning electron microscopy showed that this was due to high amounts of undigested connective tissue within the subcutaneous MVF isolates, which clogged the scaffold pores and prevented the interconnection of individual MVF into new microvascular networks. CONCLUSION: These findings indicate the need for improved protocols to generate connective tissue-free MVF isolates from subcutaneous fat tissue for future translational studies.

Clinical and patient-reported outcomes after recession coverage using modified vestibular incision subperiosteal tunnel access with a volume-stable collagen matrix as compared to a coronally advanced flap with a subepithelial connective tissue gra

Chun-Teh Lee,Marlena Lange,Alain Jureidini,Nurit Bittner,Ulrike Schulze-Späte 대한치주과학회 2022 Journal of Periodontal & Implant Science Vol.52 No.6

Purpose: Coronally advanced split-or full-thickness (CAST or CAFT) flaps in combination with subepithelial connective tissue grafts (SCTGs) are commonly used in root-coverage procedures despite postoperative pain and bleeding from the graft donor site. Therefore, the modified vestibular incision subperiosteal tunnel access procedure (VISTAX) uses a novel collagen matrix (VCMX) instead of autogenous tissue to address the limitations associated with autogenous tissue grafting. This retrospective study compared the clinical outcomes of VISTAX to the results obtained after using a CAST or CAFT flap in combination with SCTG for root coverage. Methods: Patients with single or multiple adjacent recession I/II defects were included, with 10 subjects each in the VISTAX, CAFT, and CAST groups. Defect coverage, keratinized tissue width, esthetic scores, and patients’ perceived pain and dentinal hypersensitivity (visual analogue scale [VAS]) were assessed at baseline, 3 months, and 6 months. Results: All surgical techniques significantly reduced gingival recession (P<0.0001). Defect coverage, esthetic appearance, and the reduction in dentinal hypersensitivity were comparable. However, the VAS scores for pain were significantly lower in the VISTAX group than in the CAFT and CAST groups, which had similar scores (P<0.05). Furthermore, the clinical results of VISTAX and CAFT/CAST generally remained stable at 6 months. Conclusions: The clinical outcomes of VISTAX, CAFT, and CAST were comparable. However, patients perceived significantly less pain after VISTAX, indicating a potentially higher patient acceptance of the procedure. A prospective trial with a longer follow-up period and a larger sample size should therefore evaluate VISTAX further.

Characterization of Components from Aerial part of Artemisia mongolica

SP Jang,MK Inn,JH Jeong,CS Yook 대한약학회 1999 大韓藥學會 總會 및 學術大會 Vol.2004 No.1

Nobiletin Inhibits Angiogenesis by Regulating Src/FAK/STAT3-Mediated Signaling through PXN in ER ⁺ Breast Cancer Cells

Sp, Nipin,Kang, Dong Young,Joung, Youn Hee,Park, Jong Hwan,Kim, Wan Seop,Lee, Hak Kyo,Song, Ki-Duk,Park, Yeong-Min,Yang, Young Mok MDPI AG 2017 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Vol.18 No.5

<P>Tumor angiogenesis is one of the major hallmarks of tumor progression. Nobiletin is a natural flavonoid isolated from citrus peel that has anti-angiogenic activity. Steroid receptor coactivator (Src) is an intracellular tyrosine kinase so that focal adhesion kinase (FAK) binds to Src to play a role in tumor angiogenesis. Signal transducer and activator of transcription 3 (STAT3) is a marker for tumor angiogenesis which interacts with Src. Paxillin (PXN) acts as a downstream target for both FAK and STAT3. The main goal of this study was to assess inhibition of tumor angiogenesis by nobiletin in estrogen receptor positive (ER<SUP>+</SUP>) breast cancer cells via Src, FAK, and STAT3-mediated signaling through PXN. Treatment with nobiletin in MCF-7 and T47D breast cancer cells inhibited angiogenesis markers, based on western blotting and RT-PCR. Validation of in vitro angiogenesis in the human umbilical vein endothelial cells (HUVEC) endothelial cell line proved the anti-angiogenic activity of nobiletin. Electrophoretic mobility shift assay and the ChIP assay showed that nobiletin inhibits STAT3/DNA binding activity and STAT3 binding to a novel binding site of the <I>PXN</I> gene promoter. We also investigated the migration and invasive ability of nobiletin in ER<SUP>+</SUP> cells. Nobiletin inhibited tumor angiogenesis by regulating Src, FAK, and STAT3 signaling through PXN in ER<SUP>+</SUP> breast cancer cells.</P>

철결핍성 빈혈치료에서 근주 Iron-Sorbitol ( Sorbiron - 50 ) 과 근주 Iron-Dextran ( Ferridex - 50 ) 의 치료효과 비교

김수평(SP Kim),최형락(HR Choi),나종구(Rha CG),황순경(SK Whang) 대한산부인과학회 1977 Obstetrics & Gynecology Science Vol.20 No.4

저자들은 1975년 4월 1일부터 1976년 3월 31일까지 가톨릭 의과대학 부속 성모병원, 산부인과에 입원 및 외래를 방문한 철결핍성 빈혈 환자들 중 추적검사가 가능하였던 129명을 무작위하게 두 대상군으로 나누어, 분자량의 크기에 차이가 있는 Iorn-Sorbitol과 Iron-Dextran을 투여하여, 혈액상의 치료개선 소견을 비교관찰 하였던바 다음과 같은 결론을 얻었다. 1.Iron-Sorbitrol 투여군과 혈색소의 개선소견을 보면, 치료전 각각 9.1±0.9g/dl와 9.2±0.9g/dl이던 것이 치료후 4주째 각각 12.8±0.8g/dl 와 12.2±0.7g/dl로서 모두유의하게 증가하였으며(P>0.01), 두 투여군간에 유의차를 인정할 수 있었다(p>0.01) 2.Iron-Sorbitol투여군과 Iron-Dextran 투여군의 Hematocrit개선소견을 보면 치료전 각각29.5 ±3.1%와 30.5±3.3% 이던 것이 치료후 4주째 각각 41.4±2.6%와 39.9±2.2%로서 모두 유의하게 증가하였으며(p0.05). 4.망상적혈구의 증가는 치료 시작후 1주째에 모두 최고치에 달해 각각 6.9±1.3%와 5.7±1.2%를 나타냈으며, 이때 Iron-Sorbitol 투여군이 Iron-Dextran 투여군보다 유의하게 증가 하였다.(P * 논문각주 It has been known that the parenteral therapy of iron is effective in the treatment of iron deficiency anemia For a simple method when the iron preparation administered intramuscularly the degree of correction of anemic state in blood is depend upon the effectiveness in the absorpion of iron. We sampled 129 cases among patients who were possible to follow up. They were hospitalized or visited to the out patient clinic of Obstet. and Gynecol. Dept. for the treatment of anemia. In an analysis of 129 patients undergoing treatment of anemia using Iron-Sorbitol (Sorbirone-50) and Iron-Dextran (Ferridex-50) it is concluded that the patieits with Iron-Sorbitol showed faster in correcting anmia. Anemia is commonly seen in every field of medicine Prophylaxis and treatment are clinically very important in this respect. Especially, in the field of Obsterics and Gynecology level of iron in an acute of chonic nature. It is also commonly experienced in pregnancy deliveries neoplastic disease radiotherapy and post-operative cases transfusion But the recent trend showed careful restrictjon on transfusion which administration is a well known method in the treatment for iron deficiency anemias the delay in absorption and G-I troubles are always present. For the amelioration of the disadvantages the parenteral of infusion of iron was developed and it showed merits over the oral therapy We studied two different group of patients on the basis of studies done by Svard and Lindvall(1961) In an analysis of 129 patients undergoing treatment of anemia using Iron-Sorbitol (Sorbiron-50) and Iron-Dextran (Ferridex-50), it is concluded that the patients with Iron-Sorbitol which is smaller in molecular weight compared with Iron-Dextran showed faster in correcting anemia. And the response of anemia correction was like that of total dose infusion at once.

임신중 선천성 단심실 심장기형아의 초음파적 진단 2 례

최승필(SP Choi),조수용(SY hough),주갑순(KS Ju),이갑노(KN Lee) 대한산부인과학회 1987 Obstetrics & Gynecology Science Vol.30 No.8

선천성 심장기형의 발생빈도가 출생아의 1%에 해당하며, 그 중 단심실 심장기형인 경우와 같이 출생후 수술이 불가능한 경우나, 출생후 수술이 가능한 질환인 경우라도 산전에 noninvasive, nonteratogenic, nontoxic procedure의 초음파적 조기발견으로 출생직후 적절한 치료 및 대책을 세울 수 있을 것이다. 저자들은 초음파를 이용한 산전 선천성 단심실 심장기형을 진단한 2례를 문헌 고찰과 함께 보고하는 바이다. Diagnostic ultrasound has been used for a number of years for assessment of the human fetus. because of the improved technology and ability to handle the mordern realtime cross-sectional ultrasound scanners, it has become possible to study cardiac anatomy during intrauterine life. Recently, two cases of single ventricular heart of fetus were detected by the long axis four-chamber plane. Accordingly we present these cases with a brief review of the literature.

Cost-effectiveness of olaparib versus routine surveillance in the maintenance setting for patients with BRCA-mutated advanced ovarian cancer after response to first-line platinum-based chemotherapy in Singapore

David SP Tan,Jack Junjie Chan,Robert Hettle,Wrik Ghosh,Amrita Viswambaram,Cindy Chen Yu 대한부인종양학회 2021 Journal of Gynecologic Oncology Vol.32 No.2

Objective: To evaluate the cost-effectiveness of olaparib as a maintenance treatment versusroutine surveillance (RS) in patients with BRCA mutated (BRCAm) advanced ovarian cancer(OC) following response to first-line platinum-based chemotherapy in Singapore. Methods: A 4-health state partitioned survival model was developed to simulate the lifetime(50 years) incremental cost-effectiveness ratio (ICER) of olaparib versus RS from a healthcarepayer perspective. Progression-free survival, time to second disease progression, andoverall survival were estimated using SOLO-1 data and extrapolated beyond the trial periodusing parametric survival models. Any patient who remained progression-free at year 7was assumed to be no longer at risk of progression. Mortality rates were based on all-causemortality, adjusted based on BRCA1/2 mutation. Health state utilities and adverse eventfrequencies were from SOLO-1. Drug costs were from local public healthcare institutions. Healthcare resource usage and costs were from local clinician input and publications. A 3%discount rate was applied to costs and outcomes. Deterministic and probabilistic sensitivityanalyses (PSA) were performed to assess the robustness of results. Results: The base-case analysis of olaparib maintenance therapy versus RS resulted in anICER of Singapore dollar (SGD) 19,822 per quality-adjusted life-year (QALY) gained. TheICER was most sensitive to variations in the discount rate. PSA demonstrated that olaparibhad an 87% probability of being cost-effective versus RS at a willingness-to-pay of SGD60,000 per QALY gained. Conclusion: Olaparib has a high potential of being a cost-effective maintenance treatmentversus RS for patients with BRCA1/2m advanced OC after response to first-line chemotherapyin Singapore.

트리코모나스 질염치료에 있어서 [ 티베랄 ] ( Ro7 - 0207 ) 1일 요법의 효과

김수평(SP Kim),조윤원(YW Cho),장문기(MK Chang),김승조(SJ Kim) 대한산부인과학회 1977 Obstetrics & Gynecology Science Vol.20 No.3

저자들은 1975년 10월부터 1976년 9월까지 만 1년동안 가톨릭 의과대학 부속 성모병원 산부인과를 방문한 환자들중「트리코모나스」 질염으로 확진된 환자에서 티베랄 1일 요법후 2 개월간 추적 검사가 가능하였던 95명을 약제의 투여량에 따라 세군으로 나누어 치료 성적, 부작용 및 1일 대량 투여에 따른 약물의 독성 여부를 관찰하였던 바 다음과 같은 결과를 얻 었다. 1. 임상 증상은 A군 93.5%, B군 97.5%, C군 92.2%에서 소실 되었다. 2. 질 트리코모나스의 음전화율은 A군 91.4%, B군 89.3%, C군 90.6%로서 세 투여군이 비슷한 성적을 보였다. 3. 부작용은 환자의 경우 A군 14.3%, B군 21.4%, C군 9.4%에서 나타났으며 배우자의 경우 A.B군의 배우자에서 9.6%, C군의 배우자에서 6.9%를 보였다. 4. 전환자에서 치료전, 치료후에 실시한 혈액검사, 간 및 신장기능 검사상 투약으로 인한 이상은 발견되지 않았다, 따라서 트리코모나스 질염의 치료는 티베랄 1.5gm의 경구 투여와 함께 국소 치료로 1일 요법을 도모함으로써 높은 치료효과와 적은 부작용을 얻을 수 있으리라 생각한다. One day therapy of Tiberal with three different dosage of 2.0gm p.o., 2.0gm p.o., and 500 gm vaginal route, and 1.5gm p.o. to group A,B and C was tried on three divided groups of 95 patients suffering from Trichomonas vaginitis during a period of one-year from Oct. 1975 to Sept. 1976 at out-patient clinic in Dept. of Obstet. and Gynecol., St, Mary`s Hosp. of Catholic medical College. The results were summarized as follows: 1. Clinical symptoms of Trichomonas vaginitis were subsided in 93.5%, 97,5% and 92.2% of group A,B and C respectively. 2.Parasitologic cure rates were showed in 91.4%, 89.3% and 90.6% of group A,B and C respectively. 3. Side effects, but transitory were appeared in 14.3%, 21.4% and 9.4% of group A,B and C about the patient group and 9.6%, and 6.9% of group A-B`s partner`s group and group C`s partners respectively. 4. No significant changes of laboratory data on including CBC, liver and kidney function tests were noticed by the administration of the drug. Therefore, it is valuable for the treatment of Trichomonas vaginitis with 1.5gm single oral therapy and local treatment of Tiberal, and the side effects were minimzed from, this treatment.

바르샤바 Grzybowska 거리의 오피스 빌딩

Grupa 5 Architekci Sp.zo.o. 현대건축사 2013 월간 CONCEPT Vol.- No.174