응급실에 내원한 국내 간질중첩증 소아의 발생율과 특성

신은주(Eun Ju Shin),황세희(Se Hee Hwang) 대한소아신경학회 2016 대한소아신경학회지 Vol.24 No.1

Purpose: Status epilepticus (SE) is the most common life-threatening neurological condition in childhood. To clarify the incidence and outcome, we have evaluated the epidemiological and clinical characteristics of SE patients in Korea. Methods: In evaluating data from the National Emergency Department Information System (NEDIS), we retrospectively analyzed patients, and classified them by age and sex distribution, body temperature, time on arrival, seasonal variation and treatment outcome. The patients were under 8 years old who visited 111 general hospital emergency rooms in Korea between 2007 and 2013. Results: There were 4,257 total patients enrolled in our study. The ratio of males to females was 1.11:1. The incidence of SE in Korean children was 14.5/100,000 in 2010, and the highest incidence was seen in patients 1 to 2 years old. We could not find a seasonal variation. Febrile patients with temperatures over 38 °C accounted for 1,901 patients(44.7%). Peak time on arrival was 6 p.m. to midnight for 1,301 patients (30.5%). 3,356 patients (78.8%) were admitted immediately for proper treatment, while 678 patients(15.9%) were allowed to go home after emergency treatment. Unfortunately, 4 patients (0.1%) died despite first aid. Conclusion: The most common age in SE is 1 to 2 years. Regarding the correlation of fever with SE, patients who exhibit fever accounted for almost half of the patients with SE. In our study, the mortality rate in emergency room was 0.1%. Therefore, anyone who is suspected to have SE should be immediately transferred to a general hospital with ICU facilities for intensive treatment under the direction of medical experts.

흰쥐 Kupffer 세포에 대한 Propofol의 작용

박세훈,지대림,성언기,김희선,송인환,박희영,김준수,이덕희,박대팔 대한마취과학회 2002 Korean Journal of Anesthesiology Vol.43 No.4

Background: Propofol has an antioxidant capacity and can be used for ischemia-reperfusion injury of the liver. However, the effects of propofol on the Kupffer cells have not been establisked. Methods: Kupffer cells were isolated and cultured from male Sprague-Dawley rats. The effects of propofol on the Kupffer cells were evaluated by a phagocytosis assay, TNF-α gene expression, and superoxide anion release after administering propofol in different concentrations on the cultured Kuprrer cells. Results: The latex bead phagocytosis by the Kupffer cells was suppressed when the Kupffer cells were exposed to propofol irrespective of concentrations. Higher propofol concentrations decreased the loss of Kupffer cells after latex bead phagocytosis. Propofol induced TNF-α mRNA expression in the Kupffer cells, but the mRNA expression level after 50㎍/ml of propofol decreased. The pattern of TNF-α mRNA expression induced by propofol was different to that induced by LPS: TNF-α mRNA was expressed continuously in the propofol-treated cells until 16 hours after exposure to propofol, whereas the level of TNF-α mRNA expression induced by LPS was evident after 2 hours and was not found thereafter. TNF-α production after propofol treatment was not higher than that of the control. Formazan presipitation did not show any qualitative differences between cells untreated or treated with propofol concentrations of 0.5, 5.0, and 50 ㎍/ml. Conclusions: These results showed that propofol might inhibit Kupffer cells. This suggests that propofol and be used for patients with ischemia-reperfusion injury of the liver. (Korean J Anesthesiol 2002; 43: 475~484)

동·서양 고전에 나타난 도덕적 통념에 관한 비판적 해석 -『논어』와 『에우티프론』에 나타난 아버지를 고발한 아들의 사례를 중심으로-

임명희 ( Lim Myung Hee ),김세원 ( Kim Se Won ) 동양철학연구회 2017 東洋哲學硏究 Vol.89 No.-

The aim of this study is to examine an issue of moral beliefs and moral conceptions in the Eastern and Western Classics. This paper focuses on the texts with one specific common material. That is the son who accused the father in the Analects(Lunyu) and the Plato`s Euthyphron. Confucius has a conversation with his follower about `Zhi(直)` and Socrates makes dialectical arguments with Euthyphron about a definition of `piety(to hosion)`. The philosophers critically examine opinions of the opposing parties to support the accusation. Other papers studied on aspects of moral dilemma(the private or the public, Physis and Nomos) or relation of religion and philosophy. But the important problem is relation between rightness(or justice) and honesty. In conclusion, this paper illuminates that the philosophers emphasize personal moral beliefs and their reflective attitudes toward one` own and lives, rather than the dilemma`s solution or the definition of moral ideas per se. Also, it is necessarily that the reflective courses involve a conversation with others.

Association between Socioeconomic Status and Altered Appearance Distress, Body Image, and Quality of Life Among Breast Cancer Patients

Chang, Oliver,Choi, Eun-Kyung,Kim, Im-Ryung,Nam, Seok-Jin,Lee, Jeong Eon,Lee, Se Kyung,Im, Young-Hyuck,Park, Yeon Hee,Cho, Juhee Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.20

Background: Breast cancer patients experience a variety of altered appearance - such as loss or disfigurement of breasts, discolored skin, and hair loss - which result in psychological distress that affect their quality of life. This study aims to evaluate the impact of socioeconomic status on the altered appearance distress, body image, and quality of life among Korean breast cancer patients. Materials and Methods: A cross-sectional survey was conducted at advocacy events held at 16 different hospitals in Korea. Subjects were eligible to participate if they were 18 years of age or older, had a histologically confirmed diagnosis of breast cancer, had no evidence of recurrence or metastasis, and had no psychological problems at the time of the survey. Employment status, marital status, education, and income were assessed for patient socioeconomic status. Altered appearance distress was measured using the NCI's cancer treatment side effects scale; body image and quality of life were measured by the EORTC QLC-C30 and BR23. Means and standard deviations of each outcome were compared by socioeconomic status and multivariate linear regression models for evaluating the association between socioeconomic status and altered appearance distress, body image, and quality of life. Results: A total of 126 breast cancer patients participated in the study; the mean age of participants was 47.7 (SD=8.4). Of the total, 83.2% were married, 85.6% received more than high school education, 35.2% were employed, and 41% had more than $3000 in monthly household income. About 46% had mastectomy, and over 30% were receiving either chemotherapy or radiation therapy at the time of the survey. With fully adjusted models, the employed patients had significantly higher altered appearance distress (1.80 vs 1.48; p<0.05) and poorer body image (36.63 vs 51.69; p<0.05) compared to the patients who were unemployed. Higher education (10.58, standard error (SE)=7.63) and family income (12.88, SE=5.08) was positively associated with better body image after adjusting for age, disease stage at diagnosis, current treatment status, and breast surgery type. Similarly, patients who were married and who had higher education had better quality of life were statistically significant in the multivariate models. Conclusions: Socioeconomic status is significantly associated with altered appearance distress, body image, and quality of life in Korean women with breast cancer. Patients who suffer from altered appearance distress or lower body image are much more likely to experience psychosocial, physical, and functional problems than women who do not, therefore health care providers should be aware of the changes and distresses that these breast cancer patients go through and provide specific information and psychosocial support to socioeconomically more vulnerable patients.

특수 언어발달 장애 환아의 임상 및음향음성학적 특성연구

김연희,박세훈,신용일,김찬양,김현기,김정수 大韓再活醫學會 2000 Annals of Rehabilitation Medicine Vol.24 No.1

노즐 직경이 충돌제트에 의하여 열전달에 미치는 영향

이대희,원세열,이영민,조헌노 인제대학교 1999 仁濟論叢 Vol.14 No.3

본 연구는 축대칭 난류원형제트가 평판에 충돌하는 경우에 노즐직경이 국소 Nusselt 수 분포에 미치는 영향을 연구하였다. 노즐출구에서의 유동은 완전 발달된 속도형상을 지니고 있다. 그리고, 금박막이 된 Intrex를 사용하여 평판에는 등열유속 경계조건을 형성시켰다 또한, 액정은 평판의 벽면온도를 측정하기 위하여 사용하였다. 실험시 Reynolds 수는 Re=23,000으로 고정하였으며, 노즐과 평판사이의 거리는 L/d=2~14 까지, 노즐 직경은 d=1.36, 2.16, 3.40으로 변화시켰다. 실험결과 정체점과 정체점 영역에서의 Nusselt 수는 노즐 직경이 증가함에 따라 증가함을 알았다. The effect of nozzle diameter on the local Nusselt number distributions has been investigated for an axisymmetric turbulent jet impinging on the flat Plate surface. The flow at the nozzle exit has a fully developed velocity profile. A uniform heat flux boundary condition at the plate surface was created using gold film Intrex. Liquid Crystal was used to measure the plate surface temperature. The experiments were made for the jet Reynolds number (Re) 23,000, the dimensionless nozzle to surface distance (L/d) from 2 to 14., and the nozzle diameter (d) from 1.36 to 3.40 cm. The results show that the Nusselt number at and near the stagnation point increase with an increasing value of the nozzle diameter.

일산화탄소 폭로후 고압산소 재폭로시 흰쥐 신장 및 심장의 SOD 활성 변동에 관한 연구

전영희,백두진,황세진,박준숙,정호삼 한양대학교 의과대학 1997 한양의대 학술지 Vol.17 No.1

Carbon monoxide is generated from the incomplete combustion of carbon-containing materials. Carbon monoxide cause muscle necrosis leading to myoglobinuria and acute renal failure. The hyperbaric oxygen exposure is increased production of active free radicals. Free radicals which promoted peroxidation of unsaturated fatty acids may destroy essential cellular components and itself cytotoxic materials. Superoxide dismutase, one of the protective mechanisms against tissue damage, catalyzed the dismutation of superoxide anion to less toxic product. The author performs the present study to investigate on Mn-SOD and Cu, Zn-SOD immunoreactivities in kidney and heart carbon monoxide (CO) and hyperbaric oxygen (HBO) exposure. The animals were divided CO exposure group, air release after CO exposure group, HBO exposure group and, CO and HBO exposure group. The specimen were sectioned in 16㎛ with cryostate. The Mn-SOD and CuZn-SOD immunohistochemistry was performed in renal corpuscle, proximal and distal convoluted tubules of kidney and, in sarcoplasm and sarcolemma of heart muscle. The results obtained were as follows: 1. The immunoreactivity of Mn-SOD were increased in renal corpuscles and distal convoluted tubules, were similar to control group in proximal convoluted tubules. 2. The immunoreactivity of Cu, Zn-SOD were increased than that of control group in renal corpuscles and distal convoluted tubules, were same that of the control group in proximal convouted tubules. 3. The immunoreactivity of Mn-SOD were increased at all experimental group of sarcoplasms of heart muscle. 4. The immunoreactivity of Cu,Zn-SOD were increased than that of control group in sarcolemma of heart muscle. These results suggest that the immunoreactivity of SOD after CO or HBO exposure is greatly increased in kidney and heart.

P.S 콘크리트 구조물의 신뢰성 해석

안세희,김두환 서울産業大學校 1999 논문집 Vol.49 No.2

P.S 콘크리트 구조물의 신뢰성 해석을 위해서는 구조물에 작용하는 외력의 분포와 각 요소의 피로강도에 작용하는 외력의 분포, 피로강도 및 수명 등에 대한 정량적인 해석이 필요하다. 따라서 본 연구에서는 2 Piece Wedge 와 3 Piece Wedge를 장착한 P.S 콘크리트 시험체의 정적 최대하중의 60%, 70%, 75%의 응력 수준으로 피로시험을 수행하여, S-N 선도에 의한 피로수명 예측과 피로 수명 분포특성을 고찰하였으며, 이에 대한 실험결과는 피로해석에 적합한 Weibull 분포에 적용하였다. 먼저 Weibull 분포에 따른 P.S 콘크리트 시험체의 피로강도해석과 2 Piece Wedge 와 3 Piece Wedge 시험체의 안전계수 및 위험함수, Weibull 분포의 계수들을 결정한 수, 2 Piece Wedge 와 3 Piece Wedge 시험체의 응력 수준별 피로수명 분포도를 산출하며, 응력 수준이 높을수록 파괴되어질 확률을 알아보았으며, 신뢰성함수를 산출하였다.

소형환편기 자동화기술개발에 관한 연구

최세환,장승호,허유,박준희,권영하 경희대학교 산학협력기술연구원 1995 산학협력기술연구논문집 Vol.1 No.-

소형환편기의 자동화기술을 위해 편환을 이동시킬 수 있는 편침과 cam을 편환이송용 장치를 고안하였다. 위편기의 편환이송 mechanism을 해석하고 소형환편기의 물리적 모사를 통해 편침과 cam의 형상을 최적화하였다. 편환이송장치를 사용하여 편물에 다양한 조직을 편성할 수 있는 편기의 개발이 가능하도록 하였다. The latch needle and cam are newly designed and manufactured to transfer the loop for automation of small circular knitting machine. The loop transfer mechanism is analized by the simulation of needle motion on the V-bed flat knitting machine to which optimum designed cam is attached. This loop transfer mechanism can be applied to small circular knitting machine for automation and variable knitted structure.

고령토로부터 알루미나 추출에 관한 연구(Ⅲ):염산에 의한 추출

최세영,이용근,이희수,김형국 연세대학교 산업기술연구소 1992 논문집 Vol.24 No.1

The preparation conditions of alumina powder extracted by hydrochloric acid from domestic San-Cheong kaolin have been investigated. In order to obtain best conditions to extract alumina by hydrochloric acid, experiments carried out with various acid concentrations, reaction temperatures, reaction times, and pH. The optimum conditions were 20 wt.-% for hydrochloric aicd concentration, 100℃ for reaction temperature, 7hrs for reaction time and pH8. The yield of alumina found to be 89.2wt.-% under these conditions. Two drying methods, direct and ethanol distillation drying method to control the precipitated agglomeration have deen compared. The ethanol distillation drying method revealed more narrow particle size distribution and less agglomerate than the direct drying method.