S6K1 Phosphorylation of H2B Mediates EZH2 Trimethylation of H3: A Determinant of Early Adipogenesis

Yi, S.,Um, S.,Lee, J.,Yoo, J.,Bang, S.,Park, E.,Lee, M.,Nam, K.,Jeon, Y.,Park, J.,You, J.,Lee, S.J.,Bae, G.U.,Rhie, J.,Kozma, Sara C.,Thomas, G.,Han, J.W. Cell Press 2016 Molecular Cell Vol.62 No.3

S6K1 has been implicated in a number of key metabolic responses, which contribute to obesity. Critical among these is the control of a transcriptional program required for the commitment of mesenchymal stem cells to the adipocytic lineage. However, in contrast to its role in the cytosol, the functions and targets of nuclear S6K1 are unknown. Here, we show that adipogenic stimuli trigger nuclear translocation of S6K1, leading to H2BS36 phosphorylation and recruitment of EZH2 to H3, which mediates H3K27 trimethylation. This blocks Wnt gene expression, inducing the upregulation of PPARγ and Cebpa and driving increased adipogenesis. Consistent with this finding, white adipose tissue from S6K1-deficient mice exhibits no detectable H2BS36 phosphorylation or H3K27 trimethylation, whereas both responses are highly elevated in obese humans or in mice fed a high-fat diet. These findings define an S6K1-dependent mechanism in early adipogenesis, contributing to the promotion of obesity.

Oxide-free Sb₂S₃ sensitized solar cells fabricated by spin and heat-treatment of Sb(III)(thioacetamide)₂Cl₃

You, M.S.,Lim, C.S.,Kwon, D.H.,Heo, J.H.,Im, S.H.,Chae, K.J. Elsevier Science 2015 ORGANIC ELECTRONICS Vol.21 No.-

Pure Sb<SUB>2</SUB>S<SUB>3</SUB> without oxide impurities was formed by thermal decomposition of Sb(thioacetamide: TA)<SUB>2</SUB>Cl<SUB>3</SUB> precursor. From the analysis of thermal properties of Sb(TA)<SUB>2</SUB>Cl<SUB>3</SUB>, we developed a spin-coating and heat-treatment process to form pure Sb<SUB>2</SUB>S<SUB>3</SUB> thin-films with controllable thickness due to the formation of insoluble Sb<SUB>2</SUB>S<SUB>3</SUB> by heat-treatment. Through the spin-coating and heat-treatment process, we could fabricate oxide-free Sb<SUB>2</SUB>S<SUB>3</SUB> planar type sensitized solar cell with 8.12mA/cm<SUP>2</SUP> of short circuit current density (J<SUB>sc</SUB>), 0.616V of open circuit voltage (V<SUB>oc</SUB>), 45.9% of fill factor (F.F), and overall power conversion efficiency (η) of 2.3% at 1 sun condition.

DROWSY BEHAVIOR DETECTION BASED ON DRIVING INFORMATION

M. S. WANG,N. T. JEONG,K. S. KIM,S. B. CHOI,S. M. YANG,S. H. YOU,J. H. LEE,서명원 한국자동차공학회 2016 International journal of automotive technology Vol.17 No.1

Drowsy behavior is more likely to occur in sleep-deprived drivers. Individuals’ drowsy behavior detection technology should be developed to prevent drowsiness related crashes. Driving information such as acceleration, steering angle and velocity, and physiological signals of drivers such as electroencephalogram (EEG), and eye tracking are adopted in present drowsy behavior detection technologies. However, it is difficult to measure physiological signal, and eye tracking requires complex experiment equipment. As a result, driving information is adopted for drowsy driving detection. In order to achieve this purpose, driving experiment is performed for obtaining driving information through driving simulator. Moreover, this paper investigates effects of using different input parameter combinations, which is consisted of lateral acceleration, longitudinal acceleration, and steering angles with different time window sizes (i.e. 4 s, 10 s, 20 s, 30 s, 60 s), on drowsy driving detection using random forest algorithm. 20 s-size datasets using parameter combination of accelerations in lateral and longitudinal directions, compared to the other combination cases of driving information such as steering angles combined with lateral and longitudinal acceleration, steering angles only, longitudinal acceleration only, and lateral acceleration only, is considered the most effective information for drivers’ drowsy behavior detection. Moreover, comparing to ANN algorithm, RF algorithm performs better on processing complex input data for drowsy behavior detection. The results, which reveal high accuracy 84.8 % on drowsy driving behavior detection, can be applied on condition of operating real vehicles.

Detection of Genotype associated with Disease Activity and Development of Probe

Jang,S. I.,Yoo,S. K.,Im,M. K.,Kim,J. H.,Kim,W. S.,You,Y. O.,Lee,D. K.,Kim,K. J.,Kim,W. S. 大韓顎顔面成形再建外科學會 1994 Maxillofacial Plastic Reconstructive Surgery Vol.16 No.4

질환성과 관련된 세균의 분포 및 유전자형을 탐색하고자 구강농양 및 골수염의 급성감염 혼자와 진료실 및 실험실의 정상인을 대상으로 시료를 채취하여 포도상구균을 분리 및 동정을 시행하고, 특성을 규명하였으며, plasmid 및 염색유전자를 분리하여 제한효소를 처리후 전기영동을 실시하고 분리된 plasmid로 탐색자를 제작하여 dot blot을 시행하였다. 대부분의 급성환자에서 분리된 포도상구균을 S. lugdunensis와 S. aureus이었으나, 진료실 및 실험실에서는 coagulase 음성 staphylococci가 분리되었다. 급성환자에서 분리된 포도상구균은 ampicillin과 penicillin에 내성을 보였다. 분리된 S. lugdunensis균주중 네 균주는 δ형의 용혈소를 생산하였다. Plasmid를 분리한 결과 S. lugdunensis균주중 세 균주는 약 6.5 kilobases이었으나 S. aureus는 약 4.3 kilobases 정도 크기의 band를 보였다. S. lugdunensis에서 분리된 plasmid로 제작한 탐색자로 dot blot를 시행한 결과 치과 영역에서 분리한 plasmid를 갖는 균주는 양성반응을 보였다. 염색체유전자의 유전자형을 분석한 결과 δ형의 용혈소를 생산한 네 균주의 S. lugdunensis는 유사한 유전자형을 보였다. 이러한 연구결과 질환의 진행에 S. lugdunensis가 중요한 역할을 하는 것으로 생각되고, 치과영역에 존재하는 plasmid는 공통적인 유전자 서열을 갖는 것으로 추정된다.

Triarylamine-based dual-function coadsorbents with extended π-conjugation aryl linkers for organic dye-sensitized solar cells

Choi, I.T.,You, B.S.,Eom, Y.K.,Ju, M.J.,Choi, W.S.,Kang, S.H.,Kang, M.S.,Seo, K.D.,Hong, J.Y.,Song, S.H.,Yang, J.W.,Kim, H.K. Elsevier Science 2014 ORGANIC ELECTRONICS Vol.15 No.11

Triarylamine-based dual-function coadsorbents containing a carboxylic acid acceptor linked by extended π-conjugation aryl linkers (e.g., phenylene: HC-A3, naphthalene: HC-A4 and anthracene: HC-A5) were newly designed and synthesized. They were used as coadsorbents in organic dye-sensitized solar cells (DSSCs) based on a porphyrin dye (hexyloxy-biphenyl-ZnP-CN-COOH (HOP)). For comparison, the π-conjugated phenyl linker (HC-A3) previously developed by our group was also used as a coadsorbent. The structural effects on the photophysical and electrochemical properties and DSSC performance were systematically investigated. As a result, the DSSCs based on HC-A4 and HC-5 displayed power conversion efficiencies (PCEs) of 8.2% and 5.1%, respectively, while the HC-A3-based DSSC achieved a PCE of 7.7%. In the case of HC-A4, both the short-circuit photocurrent densities (J<SUB>sc</SUB>) and open-circuit voltages (V<SUB>oc</SUB>) of DSSCs were simultaneously improved to a large extent due to the more effective prevention of π-π stacking of organic dye molecules and the better light-harvesting effect at short wavelengths. The HC-A5-based DSSC exhibited a much lower short-circuit current (J<SUB>sc</SUB>) and open-circuit voltages (V<SUB>oc</SUB>) compared to the HC-A4-based DSSC, due to the fact that the dihedral angle of the π-conjugated linkers was too high for electron injection into the TiO<SUB>2</SUB> conduction band (CB) level. This had a reduced effect on preventing the π-π stacking of dye molecules, resulting in lower J<SUB>sc</SUB> and V<SUB>oc</SUB> values.

Sulfur to oxygen substitution in BiOCuSe and its effect on the thermoelectric properties

Han, M. K.,Jin, Y. S.,Yu, B.,Choi, W.,You, T. S.,Kim, S. J. Royal Society of Chemistry 2016 Journal of Materials Chemistry A Vol.4 No.36

<P>The effects of S doping at the oxygen site on the thermoelectric properties of BiOCuSe have been investigated. The partial substitution of S ions at the O sites of BiOCuSe was achieved by sulfurization using CS2 gas. Analysis of the powder X-ray diffraction data indicates that the ZrCuSiAs structure of BiOCuSe is retained after sulfurization. Substitution of O with S leads to an increase in the lattice parameters and a decrease in the band gap. The electrical conductivity rises due to the increase of the electronic contribution with doping. S-doped BiOCuSe materials behave as a p-type semiconductor. The thermoelectric properties of S-doped BiOCuSe materials can be understood through the analysis of the electronic band structure and the density of states close to the Fermi level. The substitution of O sites with S provides possible directions toward the enhancement of the thermoelectric figure of merit of oxide materials with low electrical conductivity.</P>

農業協同組合 組織을 통한 새마을運動의 發展方案

柳泰永,白大鉉,鄭燦吉,任文淳,崔圭洪,朴康柱 건국대학교 1987 새마을연구논문집 Vol.6 No.-

불소화된 폴리우레탄의 열 및 이온 전도 특성

유종성,권정옥,노시태 한국공업화학회 2003 응용화학 Vol.7 No.2

Segmented polyurethanes with perfluoropolyether(PFPE) and poly(ethylene oxide) blocks were synthesized by reacting a fluorinated macrodiol and poly(ethylene glycol) (PEG) in different ratios with methylenebis(phyenyleneisocyanate) (MDI) in the presence of a solvent. Themal and ionic conductivities were studied as s function of fluorine content of Polyurethanes. The chemical structures were characterized by Fourier transform infrared, NMR spectroscopies, and thermal and mechanical properties of FPU investigated by differential scanning calorimetry and dynamic mechanical analysis. The surface properties were analyzed by using contct angle meter. The ionic conductivity of FPU-LiCF_3SO_3 complexs were investigated through changes in the polymer composition. The relative molar ration of PFPE and PEG in the polymer played an important role in the conductivity and thermal properties.

급성신우신염 환자의 항생제 사용 및 경제성에 관한 연구

유영인,안혜원,김주휘,윤덕심,황광서 한국병원약사회 1997 병원약사회지 Vol.14 No.2

In order to evaluate the cost of hospitalization for anti-infective therapy against acute pyelonephrites(APN), we performed a retrospective study on the therapeutic regimens for the patients(pt) diagnosed and admitted to a 600-bed teaching hospital in Korea. The regimen of each pt was compared to the published guidelines of ten areas on initiation, selection, and follow-up. All comparisons were performed with t-test and the level of significance was set at p<0.05. Among 170 APN pts treated between 1992 and 1994, 112pts(65.9%) were analyzed excluding pts with either complications, immunosuppression or age less than 18months old. 99pts(88.4%) were female with 53pts (female 47) between 21-40years old in agreement with the reports that pts with APN were predominantly female younger than 50y.o. Therapeutic regimen in 45pts(40.2%) was completely in agreement with all ten areas of the guidelines, 66pts (58.9%) in more than 9 areas and 96pts(85.7%) in more than 8 areas. Frequently ignored areas were usage of aminoglycosides(65.1%), antibiotic therapy duration(27.6%), and transition to an appropriate oral antibiotic agent(22.9%). Most interestingly, pt's hospital stay was extened significantly by 1.2days (20%, p<0.05), when any area of guidelines was not observed. Therefore, violation of guidelines raised the cost of all the drugs by 32.9%(11.9%/day), and that of antibiotic, by 38.6%(16.6%/day). Inclusion of the admixture service fee of \748 IM or \904 for IV blunted the differeneces. Our analysis clearly shows that the appropriate antibiotic use suitable to criteria reduced cost of treating APN including hospitalization period. Furthermore, since the total cost of the therapy is dependent on that of the labor others, rising rapidly in the developing countries, a further evaluation is required for the successful pharmaceutical care.

ZnIn₂S₄단결정 박막의 성장과 광학적 특성

홍광준,유상하,방진주,김소형,여희숙,양혜정,김현수 경북대학교 센서기술연구소 2002 센서技術學術大會論文集 Vol.13 No.1