http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Kubota, Akane,Ito, Shogo,Shim, Jae Sung,Johnson, Richard S.,Song, Yong Hun,Breton, Ghislain,Goralogia, Greg S.,Kwon, Michael S.,Laboy Cintró,n, Dianne,Koyama, Tomotsugu,Ohme-Takagi, Masaru,Prune Public Library of Science 2017 PLoS genetics Vol.13 No.6
<▼1><P>Photoperiod is one of the most reliable environmental cues for plants to regulate flowering timing. In <I>Arabidopsis thaliana</I>, CONSTANS (CO) transcription factor plays a central role in regulating photoperiodic flowering. In contrast to posttranslational regulation of CO protein, still little was known about <I>CO</I> transcriptional regulation. Here we show that the CINCINNATA (CIN) clade of class II TEOSINTE BRANCHED 1/ CYCLOIDEA/ PROLIFERATING CELL NUCLEAR ANTIGEN FACTOR (TCP) proteins act as <I>CO</I> activators. Our yeast one-hybrid analysis revealed that class II CIN-TCPs, including TCP4, bind to the <I>CO</I> promoter. TCP4 induces <I>CO</I> expression around dusk by directly associating with the <I>CO</I> promoter <I>in vivo</I>. In addition, TCP4 binds to another flowering regulator, GIGANTEA (GI), in the nucleus, and induces <I>CO</I> expression in a <I>GI</I>-dependent manner. The physical association of TCP4 with the <I>CO</I> promoter was reduced in the <I>gi</I> mutant, suggesting that GI may enhance the DNA-binding ability of TCP4. Our tandem affinity purification coupled with mass spectrometry (TAP-MS) analysis identified all class II CIN-TCPs as the components of the <I>in vivo</I> TCP4 complex, and the <I>gi</I> mutant did not alter the composition of the TCP4 complex. Taken together, our results demonstrate a novel function of CIN-TCPs as photoperiodic flowering regulators, which may contribute to coordinating plant development with flowering regulation.</P></▼1><▼2><P><B>Author summary</B></P><P>For plant adaptation to seasonal environments, a crucial developmental event is flowering, as proper timing of flowering affects reproductive success. Although plants monitor various environmental parameters to optimize this timing, photoperiod information is important for plants to regulate seasonal flowering time, because changes in photoperiod occur in a predictable manner throughout the year. The model plant <I>Arabidopsis thaliana</I> responds to photoperiodic changes and flowers under long-day conditions. Based on genetic analyses using mutants defective in the photoperiodic flowering response, we learned that the transcription factor referred to as CONSTANS (CO) plays a central role in regulating the timing of flowering by directly controlling the expression of florigen (flowering-inducing substrate) gene. Long-day afternoon expression of <I>CO</I> is critical for this regulation; however, we had limited knowledge of <I>CO</I> transcriptional regulation. Here we identified that a group of plant-specific transcription factors belonging to the <I>TCP</I> gene family function as novel <I>CO</I> transcriptional activators. We demonstrated that TCP transcription factors regulate <I>CO</I> transcription together with known regulators of <I>CO</I>. Our results imply that plants utilize multiple transcription factors to precisely coordinate the expression of the key regulator gene, <I>CO</I>, which will directly affect flowering time.</P></▼2>
Evaluating the activity of N-89 as an oral antimalarial drug
Nagwa S. M. Aly,Hiroaki Matsumori,Thi Quyen Dinh,Akira Sato,Shin-Ichi Miyoshi,장경수,유학선,Takaaki Kubota,Yuji Kurosaki,Duc Tuan Cao,Gehan A. Rashed,김혜숙 대한기생충학ㆍ열대의학회 2023 The Korean Journal of Parasitology Vol.61 No.3
Despite the recent progress in public health measures, malaria remains a troublesome disease that needs to be eradicated. It is essential to develop new antimalarial medications that are reliable and secure. This report evaluated the pharmacokinetics and antimalarial activity of 1,2,6,7-tetraoxaspiro[7.11]nonadecane (N-89) using the rodent malaria parasite Plasmodium berghei in vivo. After a single oral dose (75 mg /kg) of N-89, its pharmacokinetic parameters were measured, and t1/2 was 0.97 h, Tmax was 0.75 h, and bioavailability was 7.01%. A plasma concentration of 8.1 ng/ml of N-89 was maintained for 8 h but could not be detected at 10 h. The dose inhibiting 50% of parasite growth (ED50) and ED90 values of oral N-89 obtained following a 4-day suppressive test were 20 and 40 mg/kg, respectively. Based on the plasma concentration of N-89, we evaluated the antimalarial activity and cure effects of oral N-89 at a dose of 75 mg/kg 3 times daily for 3 consecutive days in mice harboring more than 0.5% parasitemia. In all the N-89- treated groups, the parasites were eliminated on day 5 post-treatment, and all mice recovered without a parasite recurrence for 30 days. Additionally, administering oral N-89 at a low dose of 50 mg/kg was sufficient to cure mice from day 6 without parasite recurrence. This work was the first to investigate the pharmacokinetic char-acteristics and antimalarial activity of N-89 as an oral drug. In the future, the following steps should be focused on developing N-89 for malaria treatments; its administration schedule and metabolic pathways should be investigated.
비정질 Se 광도전 타겟을 이용한 고감도 HARP 촬상관의 제작 및 특성
박욱동,김기완,Kubota, M.,Suzuki, S.,Katoh, T.,Tanioka, K. 경북대학교 센서기술연구소 1997 센서技術學術大會論文集 Vol.8 No.1
A high sensitivity HARP(High-gain Avalanche Rushing amorphous Photoconductor) image pickup tube using 4 μm thick amorphous Se photoconductive target was fabricated and its characteristics were investigated. When the target voltage was increased more than 360 V, the signal current increases rapidly and the dark current of the target was suppressed at 3.2 nA up to the voltage of 490 V. And the peak spectral response of the target was obtained at the wavelength of 460 nm. Also the amplitude response of the HARP tube was 7.5% at 800 TV lines, and the decay lag was 3.4%.
Molecular basis of flowering under natural long-day conditions in <i>Arabidopsis</i>
Song, Young Hun,Kubota, Akane,Kwon, Michael S.,Covington, Michael, F.,Lee, Nayoung,Ella, R. Taagen,Cintró,n, Dianne Laboy,Hwang, Dae Yeon,Akiyama, Reiko,Sarah, K. Hodge,Huang, He,Nguyen, Nhu H. Nature Publishing Group 2018 Nature plants Vol.4 No.10
<P>Plants sense light and temperature changes to regulate flowering time. Here we show that expression of the <I>Arabidopsis</I> florigen gene, <I>FLOWERING LOCUS T</I> (<I>FT</I>), peaks in the morning during spring, a different pattern than we observe in the lab. Providing our lab growth conditions with a red/far-red light ratio similar to open field conditions and daily temperature oscillation is sufficient to mimic the <I>FT</I> expression and flowering time in natural long days. Under the adjusted growth conditions, key light signaling components, such as phytochrome A (phyA) and EARLY FLOWERING 3 (ELF3), play important roles in morning <I>FT</I> expression. These conditions stabilize CONSTANS (CO) protein, a major <I>FT</I> activator, in the morning, which is likely a critical mechanism for photoperiodic flowering in nature. Refining the parameters of our standard growth conditions to more precisely mimic plant responses in nature can provide a powerful method for improving our understanding of seasonal response.</P>