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Seiya Ueno,Ryuichi Watanabe 한국항공우주학회 2008 한국항공우주학회 학술발표회 논문집 Vol.- No.-
This paper treats with the calculation procedure of reference trajectory to be applied to emergency guidance and control law for future reusable space transportation systems, such as spaceplane. The reusable transportation system is required to return to the landing area safely even if unexpected malfunction causes and the mission is aborted. Low computational load is necessary lor the emergency guidance law because reference trajectory must be calculated through an onboard computer within a short time. And also the reference trajectory is required to be followed by a spaceplane with low performance in maneuver. Thus it is desired that the reference trajectory is provided as a solution of minimum curvature problem, which is an optimal control problem. This paper proposes the calculation procedure of optimal control problem without iterative calculation. Homotopy method is applied to solve optimal control problems. Numerical results show that calculation of define integral provides three dimensional optimal trajectory.
Artificial intelligence for endoscopy in inflammatory bowel disease
( Kento Takenaka ),( Ami Kawamoto ),( Ryuichi Okamoto ),( Mamoru Watanabe ),( Kazuo Ohtsuka ) 대한장연구학회 2022 Intestinal Research Vol.20 No.2
Inflammatory bowel disease (IBD), with its 2 subtypes, Crohn’s disease and ulcerative colitis, is a complex chronic condition. A precise definition of disease activity and appropriate drug management greatly improve the clinical course while minimizing the risk or cost. Artificial intelligence (AI) has been used in several medical diseases or situations. Herein, we provide an overview of AI for endoscopy in IBD. We discuss how AI can improve clinical practice and how some components have already begun to shape our knowledge. There may be a time when we can use AI in clinical practice. As AI systems contribute to the exact diagnosis and treatment of human disease, we should continue to learn best practices in health care in the field of IBD. (Intest Res 2022;20:165-170)
Stem cell-based therapy for inflammatory bowel disease
Hiromichi Shimizu,Kohei Suzuki,Mamoru Watanabe,Ryuichi Okamoto 대한장연구학회 2019 Intestinal Research Vol.17 No.3
Inflammatory bowel disease (IBD) is an idiopathic, multi-etiological disease characterized by inflammation and mucosal destruction of the gastrointestinal tract. Despite the remarkable advance in immunomodulating therapies, there still remains a certain population of patients who are refractory to conventional as well as biologic therapies and fail to achieve mucosal healing. To improve the prognosis of those patients, at least 2 types of stem cells have been tested for their potential therapeutic use. Transplantation of hematopoietic stem cells or mesenchymal stem cells have been tested in several clinical studies, but their beneficial effect still remains controversial. In this review, we would like to overview the recent clinical challenges of stem cell-based therapies in IBD and also introduce our new therapeutic plan of intestinal stem cell transplantation for IBD, based on our ex vivo intestinal organoid culture technique.