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Wnt/β-catenin signaling activator restores hair regeneration suppressed by diabetes mellitus
( Yeong Chan Ryu ),( You-rin Kim ),( Jiyeon Park ),( Sehee Choi ),( Geon-uk Kim ),( Eunhwan Kim ),( Yumi Hwang ),( Heejene Kim ),( Soon Sun Bak ),( Jin Eun Lee ),( Young Kwan Sung ),( Gyoonhee Han ),( 생화학분자생물학회 2022 BMB Reports Vol.55 No.11
Diabetes mellitus is one of the most prevalent diseases in modern society. Many complicationssuch as hepatic cirrhosis, neuropathy, cardiac infarction, and so on are associated with diabetes. Although a relationship between diabetes and hair loss has been recently reported, the treatment of diabetic hair loss by Wnt/β-catenin activators has not been achieved yet. In this study, we found that the depilation-induced anagen phase was delayed in both db/db mice and high-fat diet (HFD) and streptozotocin (STZ)-induced diabetic mice. In diabetic mice, both hair regrowth and wound-induced hair follicle neogenesis (WIHN) were reduced because of suppression of Wnt/β- catenin signaling and decreased proliferation of hair follicle cells. We identified that KY19382, a small molecule that activates Wnt/β-catenin signaling, restored the capabilities of regrowth and WIHN in diabetic mice. The Wnt/β-catenin signaling activator also increased the length of the human hair follicle which was decreased under high glucose culture conditions. Overall, the diabetic condition reduced both hair regrowth and regeneration with suppression of the Wnt/β-catenin signaling pathway. Consequently, the usage of Wnt/β-catenin signaling activators could be a potential strategy to treat diabetes-induced alopecia patients. [BMB Reports 2022; 55(11): 559-564]
구기자에서 큰이십팔점박이무당벌레(Henosepilachna vigintioctomaculata)의 온도조건에 따른 발육특성과 친환경제재에 의한 방제효과
강찬영(Chan-Yeong Kang),류태희(Tae-Hee Ryu),정유빈(Yu-Bin Jung),고나연(Na-Yeon Ko),권혜리(Hye-Ri Kwon),서미자(Mi-Ja Seo),유용만(Yong-Man Yu),윤영남(Young-Nam Youn),김영국(Yeong-Guk Kim) 충남대학교 농업과학연구소 2014 농업과학연구 Vol.41 No.4
Host plants of the Henosepilachna vigintioctomaculata are known as Solanaceae plants such as potato, tomato, eggplant and Lycium chinense. Henosepilachna vigintioctomaculata (Motschulsky) cause continuous damage from early June to mid-August in leaves of L. chinense under environmental-friendly management in Cheongyang, Chungnam. The developmental period of egg and larva of H. vigintioctomaculata were investigated. H. vigintioctomaculata were reared on L. chinense at several temperatures, for example, 15, 20, 25 and 30°C in the laboratory. In addition, the control effect of 5 eco-friendly agricultural materials were examined. As results, hatching rate is the highest to 91% at 25°C. Egg periods were 10.8, 7.7, 5.1 and 3.7 days at each tested temperature, respectively. And the total developmental periods from egg to adult were 42.7, 26.3, 18.4 and 19.4 days at each tested temperature, respectively. Otherwise, their eclosion rates from pupa to adult were showed 58%, 77%, 85%, 65% at each tested temperature, respectively. As a result of the control effect, both adults and larvae of H. vigintioctomaculata were shown a high mortality to mixture with extract of Sophora flavescens, Chenopodium ambrosioides and Melia azedarach. Additional, larvae is shown high mortality to extract of Azadirachta indica and Cymbopogon nardus. Thus H. vigintioctomaculata might be controled by using plant extract of eco-friendly agricultural materials in due season.
Kim Eunhwan,Seo Seol Hwa,Hwang Yumi,Ryu Yeong Chan,Ryu Yeong Chan,Lee Kyoung-Mi,Lee Jin Woo,Park Kwang Hwan,Choi Kang-Yell 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-
Diabetic wound healing, including diabetic foot ulcer (DFU), is a serious complication of diabetes. Considering the complexity of DFU development, the identification of a factor that mediates multiple pathogeneses is important for treatment. In this study, we found that CXXC-type zinc finger protein 5 (CXXC5), a negative regulator of the Wnt/β-catenin pathway, was overexpressed with suppression of the Wnt/β-catenin pathway and its target genes involved in wound healing and angiogenesis in the wound tissues of DFU patients and diabetes-induced model mice. KY19334, a small molecule that activates the Wnt/β-catenin pathway by inhibiting the CXXC5-Dvl interaction, accelerated wound healing in diabetic mice. The enhancement of diabetic wound healing could be achieved by restoring the suppressed Wnt/β-catenin signaling and subsequently inducing its target genes. Moreover, KY19334 induced angiogenesis in hindlimb ischemia model mice. Overall, these findings revealed that restorative activation of Wnt/β-catenin signaling by inhibiting the function of cytosolic CXXC5 could be a therapeutic approach for treating DFUs.
Ryu, Tae-In,Song, Myung-Kwan,Lee, Myung-Jin,Jin, Sung-Ho,Kang, Sun-Woo,Lee, Jin-Yong,Lee, Jae-Wook,Lee, Chan-Woo,Gal, Yeong-Soon Korean Chemical Society 2009 Bulletin of the Korean Chemical Society Vol.30 No.10
Three heteroleptic ruthenium sensitizers, Ru(L)($L^1)(NCS)_2$ [L = 4,4'-dicarboxylic acid-2,2'-bipyridine, Ru-T1: $L^1$ = (E)-2-(4'-methyl-2,2'-bipyridin-4-yl)-3-(thiophen-2-yl)acrylonitrile, Ru-T2: $L^2$ = (E)-3-(5'-hexyl-2,2'-bithiophen-5- yl)-2-(4'-methyl-2,2'-bipyridin-4-yl)acrylonitrile, and Ru-T3: $L^3$ = (E)-3-(5"-hexyl-2,2':5',2"-terthiophen-5-yl)-2- (4'-methyl-2,2'-bipyridin-4-yl)acrylonitrile)], were synthesized and used as photosensitizers in nanocrystalline dyesensitized solar cells (DSSCs). The introduction of the 3-(5-hexyloligothiophen-5-yl)acrylonitrile group increased the conjugation length of the bipyridine donor ligand and thus improved their molar absorption coefficient and light harvesting efficiency. DSSCs with the configuration of Sn$O_2$: F/Ti$O_2$/ruthenium dye/liquid electrolyte/Pt devices were fabricated using these Ru-$T1{\sim}T3$ as a photosensitizers. Among the devices, the DSSCs composed of Ru-T2 exhibited highest power conversion efficiency (PCE) of 2.84% under AM 1.5 G illumination (100 mW/$cm^2$).
민양원,Yeong Chan Lee,Kyunga Kim,Seungho Ryu,Kyoung Sub Hong,Han Ho Jeon,Yong Sung Kim,박종헌,손희정,이풍렬 대한내과학회 2020 The Korean Journal of Internal Medicine Vol.35 No.5
Background/Aims: Effect of proton pump inhibitor (PPI) use on the risk of hip fracture is controversial. This study aimed to clarify the association between PPI use and hip fracture risk using a large cohort. Methods: This study recruited participants from the nationwide cohort (n = 1,025,340). After exclusion of participants who had hip fractures or were aged less than 40 years during the baseline period (2002 to 2004), 371,806 participants were followed to 2013. Participants prescribed PPIs for more than 90 days during baseline period were defined as users. Fracture cases were defined when participants were hospitalized with claims of a hip fracture. Results: During 4,159,343 person-years of follow-up, fractures developed more often in PPI users than in nonusers (relative risk [RR], 1.787; 95% confidence interval [CI], 1.260 to 2.534; p = 0.002). The results persisted after adjusting for age, sex, and many drugs relevant to osteoporosis or influential in bone health. Furthermore, fracture risk associated with PPI use increased with duration of use (p trend < 0.001). The fully adjusted RRs of hip fracture development were 1.350 (95% CI, 1.203 to 1.515) for 1- to 90-day users, 1.487 (95% CI, 0.957 to 2.311) for 91- to 180-day users, and 1.771 (95% CI, 0.931 to 3.368) for > 180-day users. The positive association between PPI use and fracture was also confirmed in a subgroup with health screening data where further adjustment for body mass index, smoking status, alcohol consumption, and physical activity was available (adjusted RR, 2.025; 95% CI, 1.151 to 3.564, p = 0.014). Conclusions: PPI use is associated with hip fracture development.
고영찬(YEONG-CHAN KO),김종인(JONG-IN KIM),류청로(CHEONG-RO RYU) 한국해양공학회 2000 韓國海洋工學會誌 Vol.14 No.3
This study aims to examine the characteristics of the water quality variation in relation to the change of water exchange rate with respect to the development phases of the Pusan port. To clarify the characteristics, water exchange caused by the variations of coastline shape and water surface area was examined by the numerical experiments using the Lagrangian particle tracking model based on 2-D shallow water equation. As the results of numerical experiments, it was proved that the water exchange in the Pusan port was decreased mainly due to the port development and the breakwaters construction. During the port development phases from 1875 to 1998, 35 % of the sea-space in the port had decreased to make hinterland spaces. This resulted in the loss of wet-land and coastline change as well as decrease of the water exchange rate at the sea side. The city population in that period had rapidly increased from several thousands to 4 millions, resulting in the large discharge of sewages into the port area Under the these environmental conditions, it can be clearly said that the water quality in the Pusan port is sensitively affected by the discharge of urban sewages decrease of the water exchange rate in relation to port and urban developments. In the study, the temporal changes of water quality were discussed with respect to the port development phases. It was clear that the water quality was controlled by the exchange rate change under the port development as well as the input impact into the port from the urbanized city area. To make clean sea of the Pusan port, it is suggested that the sewage control, the water exchange and coastline control should be systematically checked under the concept of eco-friendly development and environmental management.