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Effect of Ginkgo biloba Extract (EGb 761) on Serum Cholesterol Levels in Wild-type C57Bl/6 Mice
Jin Sung Hong,Jin Woo Kim,Byung Il Yoon,Ki-Jong Rhee,Chang Six Rha,Bae Dong Jung 대한의생명과학회 2017 Biomedical Science Letters Vol.23 No.2
Ginkgo biloba extract (EGb 761) is a standardized extract of Ginkgo biloba leaves and has anti- atherosclerosis properties. Many patients with atherosclerosis disorders take Ginkgo biloba extracts to supplement current therapy. In addition, normal healthy individuals also take Ginkgo biloba extracts for prophylactic purposes. However, it is unknown whether supplementation of Gingko biloba extracts in healthy individuals offer a benefit. In this study, we assessed whether EGb 761 could provide beneficial effects on serum cholesterol levels in normal mice. Wild-type C56Bl/6 mice were orally administered EGb 761 at 25 mg/kg (Group 3) or 50 mg/kg (Group 4) every other day for 40 days. We found that the serum levels of HDL-cholesterol (HDL-C) were significantly increased in EGb 761 and lovastatin treated groups. Treatment with EGb 761 and lovastatin resulted in reduced serum total cholesterol and LDL-cholesterol (LDL-C) compared to control group. Serum lecithin cholesterol acyltransferase (LCAT) levels were higher in EGb 761 and lovastatin treated group compared to the control group. However, no difference was observed in serum APO A-I levels between the control group and treatment group. These results suggest that EGb 761 can increase HDL-C resulting in increased serum LCAT levels.
Rha, Sun Y,Jeung, Hei C,Yang, Woo I,Kim, Jin J,Oh, Tae J,An, Sung W,Chung, Hyun C National Hellenic Research Foundation 2006 ONCOLOGY REPORTS Vol.15 No.4
<P>We analyzed hTERT splicing patterns with respect to telomerase activity in breast cancer. Using a cDNA microarray in 22 cell lines, we observed the difference in expression profiling based on the different levels of full-length variant expression with 71 selected genes. Using 33 known genes that act with the telomerase complex, we performed unsupervised clustering with all cell lines, and found a clustering tendency related to the full-length variant expression level. Using array-based CGH, highly altered genomic copy number changes were found more often in MCF-7 (159 genes) than in MDA-MB-231 (109 genes) and MDA-MB-435 (49 genes), suggesting more genomic changes in MCF-7 cells. On comparing MCF-7 with MDA-MB231 and MDA-MB-435 cell lines, we identified 8 genes with different copy numbers, including dystroglycan, which is located in the p12-21.2 area of chromosome 3. In conclusion, alterations in the level of the full-length variant of hTERT showed different gene expression profiles and genomic copy number changes in breast cancer, which require further study into their cause-and-effect relationship.</P>
Expression pattern of IQGAP1 in sinonasal inverted papillomas and squamous cell carcinomas.
Jin, Jun,Lee, Jin Woo,Rha, Ki-Sang,Kim, Dong Woon,Kim, Yong Min Triological Foundation [etc.] 2012 The Laryngoscope Vol.122 No.12
<P>The scaffold protein IQGAP1 is a ubiquitously expressed 190 kDa protein that participates in protein-protein interactions, integrating diverse signaling pathways. In this study, we examined the expression of IQGAP1 in sinonasal inverted papillomas (IP) and sinonasal squamous cell carcinomas (SCC), which include IP with SCC (IPcSCC) and SCC alone. We also tried to elucidate whether the amount of IQGAP1 expression is related with any clinicopathologic features of sinonasal SCCs.</P>
Sang-Hyun Ihm,Kwang-il Kim,Kyung Jin Lee,Jong Won Won,Jin Oh Na,Seung-Woon Rha,Hack-Lyoung Kim,Sang-Hyun Kim,Jinho Shin 대한심장학회 2022 Korean Circulation Journal Vol.52 No.1
In primary prevention for cardiovascular diseases, there are significant barriers to adherence including freedom from symptoms, long latency for therapeutic benefits, life-long duration of treatment, and need for combined lifestyle changes. However, to implement more systematic approaches, the focus on adherence improvement needs to be shifted away from patient factors to the effects of the treatment team and healthcare system. In addition to conventional educational approaches, more patient-oriented approaches such as patient-centered clinical communication skills, counseling using motivational strategies, decision-making by patient empowerment, and a multi-disciplinary team approach should be developed and implemented. Patients should be involved in a program of self-monitoring, self-management, and active counseling. Because most effective interventions on adherence improvement demand greater resources, the health care system and educational or training system of physicians and healthcare staff need to be supported for systematic improvement.
( Sung Hun Park ),( Chang Yu Park ),( Ji No Na ),( Cheol Ung Choi ),( Hongeuy Lim ),( Jin Won Kim ),( Eung Joo Kim ),( Seung Woon Rha ),( Hong Seog Seo ),( Dong Joo Oh ) 대한내과학회 2014 대한내과학회 추계학술발표논문집 Vol.2014 No.1
Background: We evaluated the prevalence of gastroesophageal refi ux diseases (GERD) in noncardiac chest pain (NCCP) patients, risk factors for GERD, and status of prescriptions for GERD in Korean population. Methods: This was a retrospective non-interventional observational nation-wide multicenter (45 centers) study. Patients who had a normal coronary angiogram (CAG) and upper gastroendoscopy within 2 years after CAG were enrolled. The prevalence of GERD among them was examined. Other gastrointestinal diseases including peptic ulcer diseases or gastritis were also examined. We compared the risk factors for GERD between the GERD group and non-GERD group. The ratio of patients who had a medications for gastrointestinal diseases (antacids or proton-pump inhibitor) was also examined. Results: Total of nine hundred four patients were enrolled. The prevalence of GERD among NCCP patients was 436(48. 2%) of 904 patients. Peptic ulcer disease were present in 154 patients, 17. 0%. The prevalence of gastritis was 659(72. 9%) of 904 patients. There was no difference in risk factors for GERD between GERD group and non- GERD group. Medications for GERD and other gastrointestinal diseases were prescribed in 742 patients, 82. 1% of all the NCCP patients. Conclusions: GERD were common (42. 8%) in Korean NCCP patients and most of them (82. 1%) were prescribed for GI medications in Korea. But we could not fi nd any differences in risk factors between GERD and non-GERD groups.
S-264 The impact of anemia on two-year clinical outcomes in patients with Acute MI undergoing PCI
( Sang Jin Jeon ),( Ji Young Park ),( Sung Kee Ryu ),( Jae Woong Choi ),( Seung Woon Rha ),( Byoung Geol Choi ),( Hong Seog Seo ),( Dong Joo Oh ) 대한내과학회 2016 대한내과학회 추계학술발표논문집 Vol.2016 No.1
Background:?Anemia is an aggravating factor of cardiovascular disease. However, it is controversial whether anemia itself has adverse impact on clinical outcomes of the patients with acute myocardial infarction (AMI) treated with percutaneous coronary intervention (PCI) with drug-eluting stents (DESs). Methods:?In this study, a total of 881 consecutive AMI patients underwent PCI between 2004 and 2010 were analyzed. Anemia was defined using WHO criteria: hemoglobin level <13 g/dL for men and <12 g/dL for women. The patients were divided into the two groups: the anemia group (n=349) and the non-anemia group (n=532). Six-month angiographic and 2-year major clinical outcomes were compared between the two groups. Results:?At baseline, the anemia group had more female, elderly, hypertension, diabetes mellitus, chronic renal-insufficiency, and higher levels of cardiac markers than the non-anemia group. At 6 months, major angiographic outcomes were similar between the two groups. The incidence of vascular complicat-ions during PCI and stent thrombosis were similar between the two groups. To adjust confounders, we performed propensity score matching (PSM) analysis, and after PSM, AMI patients with anemia had higher cumulative incidence of total death, cardiac death, recurrent myocardial infarction (MI), target lesion revascularization (TLR)-major adverse cardiac events (MACEs), and all MACEs up to 2 years. After PSM, multivariate analysis showed that the anemia was an independent predictor of death at 2 years?[adjusted OR; 2.5, CI; 1.3-4.9, p<0.001] Conclusions:?Anemia on admission in patients with AMI undergoing PCI with DESs was associated with higher individual and composite adverse cardiovascular events compared to those of AMI patients without anemia up to 2 years. Keywords:?Anemia, Myocardial infarction, Percutaneous coronary intervention