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Stem Cell Tracing Through MR Molecular Imaging
Rasoul Yahyapour,Bagher Farhood,Ghazale Graily,Abolhasan Rezaeyan,Saeed Rezapoor,Hamid Abdollahi,Mohsen Cheki,Peyman Amini,Hengameh Fallah,Masoud Najafi,Elahe Motevaseli 한국조직공학과 재생의학회 2018 조직공학과 재생의학 Vol.15 No.3
Stem cell therapy opens a new window in medicine to overcome several diseases that remain incurable. It appears such diseases as cardiovascular disorders, brain injury, multiple sclerosis, urinary system diseases, cartilage lesions and diabetes are curable with stem cell transplantation. However, some questions related to stem cell therapy have remained unanswered. Stem cell imaging allows approval of appropriated strategies such as selection of the type and dose of stem cell, and also mode of cell delivery before being tested in clinical trials. MRI as a non-invasive imaging modality provides proper conditions for this aim. So far, different contrast agents such as superparamagnetic or paramagnetic nanoparticles, ultrasmall superparamagnetic nanoparticles, fluorine, gadolinium and some types of reporter genes have been used for imaging of stem cells. The core subject of these studies is to investigate the survival and differentiation of stem cells, contrast agent’s toxicity and long term following of transplanted cells. The promising results of in vivo and some clinical trial studies may raise hope for clinical stem cells imaging with MRI.
Amini, Mandana,Ma, Chun-lei,Farazifard, Rasoul,Zhu, Guoqi,Zhang, Yi,Vanderluit, Jacqueline,Zoltewicz, Joanna Susie,Hage, Fadi,Savitt, Joseph M.,Lagace, Diane C.,Slack, Ruth S.,Beique, Jean-Claude,Baud Society for Neuroscience 2013 The Journal of neuroscience Vol.33 No.13
<P>Ubiquitous classical (typical) calpains, calpain-1 and calpain-2, are Ca<SUP>+2</SUP>-dependent cysteine proteases, which have been associated with numerous physiological and pathological cellular functions. However, a clear understanding of the role of calpains in the CNS has been hampered by the lack of appropriate deletion paradigms in the brain. In this study, we describe a unique model of conditional deletion of both calpain-1 and calpain-2 activities in mouse brain, which more definitively assesses the role of these ubiquitous proteases in brain development/function and pathology. Surprisingly, we show that these calpains are not critical for gross CNS development. However, calpain-1/calpain-2 loss leads to reduced dendritic branching complexity and spine density deficits associated with major deterioration in hippocampal long-term potentiation and spatial memory. Moreover, calpain-1/calpain-2-deficient neurons were significantly resistant to injury induced by excitotoxic stress or mitochondrial toxicity. Examination of downstream target showed that the conversion of the Cdk5 activator, p35, to pathogenic p25 form, occurred only in the presence of calpain and that it played a major role in calpain-mediated neuronal death. These findings unequivocally establish two central roles of calpain-1/calpain-2 in CNS function in plasticity and neuronal death.</P>
Abolfazl Dastbaz,Rasoul Moradi,Saeed Mahruz Monfared,Younes Amini 한국화학공학회 2016 Korean Journal of Chemical Engineering Vol.33 No.7
Electrospun hybrid membranes were synthesized using electrospinning of Poly (vinylidenefluoride) - titanium tetraisopropoxide (PVDF-TTIP) sol. Asymmetric post-treatment of membrane conducted for deprotonation of titanate and making hydrophilic/hydrophobic dual characteristics. The membranes were characterized by various methods such as wettability, scanning electron microscopy, infrared spectroscopy, X-ray diffraction and liquid entry pressure tests. For evaluating the separation performance, these membranes were applied in the VMD process to treat water heavy metal contaminants. The effects of operating parameters such as flow rate, temperature and membrane properties as porosity, on contaminant removal and producing ultra-pure water have been studied.
Impact of Amino-Acid Coating on the Synthesis and Characteristics of Iron-Oxide Nanoparticles (IONs)
Ebrahiminezhad, Alireza,Ghasemi, Younes,Rasoul-Amini, Sara,Barar, Jaleh,Davaran, Soodabeh Korean Chemical Society 2012 Bulletin of the Korean Chemical Society Vol.33 No.12
Iron-oxide nanoparticles (IONs) with biocompatible coatings are the only nanostructural materials which have been approved by the FDA for clinical use. Common biocompatible coatings such as hydrocarbons, polymers, and silica have profound influences on critical characteristics of IONs. Recently, amino acids were introduced as a novel biocompatible coating. In the present study, the effects of amino acids on IONs synthesis and characteristics have been evaluated. Magnetite nanoparticles with L-arginine and L-lysine coatings were synthesised by a coprecipitation reaction in aqueous solvent and their characteristics were compared with naked magnetite nanoparticles. The results showed that amino acids can be a perfect coating for IONs and would increase particle stability without any significant effects on the critical properties of nanoparticles such as particle size and magnetization saturation value.
Javad Karimi-Sabet,Mojtaba Shariaty-Niassar,Rasoul Moradi,Younes Amini 한국화학공학회 2016 Korean Journal of Chemical Engineering Vol.33 No.10
A comparative study was conducted to evaluate the performance of two membrane types of electrospun poly(vinylidene fluoride) (PVDF) and commercial ploytetrafluoroethylene (PTFE). The optimized needleless electrospinning technique was used to prepare PVDF membranes. Scanning electron microscopy (SEM), wettability tests, water flux, mechanical strength and liquid entry pressure (LEP) measurements were performed to evaluate the prepared membrane. Air gap membrane distillation (AGMD) experiments were carried out to investigate the salt rejection performance and the durability of membranes. The results show that our nanofibrous PVDF membrane presents higher water permeation flux (>20 kg/m2 h) compared to commonly used PTFE. In addition, the experimental data confirms that competitive salt rejection efficiency (>99.8%) was obtained in this new membrane.
Impact of Amino-Acid Coating on the Synthesis and Characteristics of Iron-Oxide Nanoparticles (IONs)
Alireza Ebrahiminezhad,Younes Ghasemi,Sara Rasoul-Amini,Jaleh Barar,Soodabeh Davaran 대한화학회 2012 Bulletin of the Korean Chemical Society Vol.33 No.12
Iron-oxide nanoparticles (IONs) with biocompatible coatings are the only nanostructural materials which have been approved by the FDA for clinical use. Common biocompatible coatings such as hydrocarbons, polymers, and silica have profound influences on critical characteristics of IONs. Recently, amino acids were introduced as a novel biocompatible coating. In the present study, the effects of amino acids on IONs synthesis and characteristics have been evaluated. Magnetite nanoparticles with L-arginine and L-lysine coatings were synthesised by a coprecipitation reaction in aqueous solvent and their characteristics were compared with naked magnetite nanoparticles. The results showed that amino acids can be a perfect coating for IONs and would increase particle stability without any significant effects on the critical properties of nanoparticles such as particle size and magnetization saturation value.