Combination of alpha lipoic acid and metformin supplement improve assisted reproductive technologies outcomes in polycystic ovary syndrome patients

Rahil Jannatifar,Hamid Piroozmanesh,Seyedeh Saeideh Sahraei,Elham Asa 대한해부학회 2022 Anatomy & Cell Biology Vol.55 No.2

The correlation of Septin4 gene expression with sperm quality, DNA damage, and oxidative stress level in infertile patients

Rahil Jannatifar,Hamid Piroozmanesh,Fahimeh Naghi Jalalabadi,Hamid Reza Momeni 대한해부학회 2023 Anatomy & Cell Biology Vol.56 No.4

Septin4 belong to a family of polymerizing GTP-binding proteins that are required for many cellular functions, such as membrane compartmentalization, vesicular trafficking, mitosis, and cytoskeletal remodeling. Since, Septin4 is expressed specifically in the testis, we aimed to determine the association between Septin4 gene expression with sperm quality, DNA damage, and stress oxidative level in infertile patients. The present study included 60 semen samples that grouped into three groups: normozoospermia (n=20), asthenozoospermia (n=20), astheno-teratozoospermia (n=20). Initially, semen parameters were analyzed by using the World Health Organization protocol. The mRNA expression of Septin4 in sperm was examined using reverse transcription-polymerase chain reaction. Oxidative stress markers, i.e., total antioxidant capacity, superoxide dismutase, catalase, glutathione peroxidase, and malondialdehyde, were determined by ELISA kit. The current study showed a statistically significant highly positive correlation in Septin4 gene expression with sperm motility, normal morphology, viability, capacity, and sperm mitochondrial membrane potential (MMP). However, it showed significant negative correlation with sperm DNA fragmentation. Septin4 had a significant correlation with stress oxidative factor and antioxidant enzyme levels. In conclusion, Septin4 gene expression provides clinical useful information for the diagnosis of male infertility. It might be a marker for discrimination between fertile and infertile patients. The current study showed a statistically significant highly positive correlation in Septin4 gene expression with sperm motility, normal morphology, viability, capacity, and sperm MMP. However, it shows significant negative correlation with sperm DNA fragmentation. Septin4 had a significant correlation with stress oxidative factor and antioxidant enzyme levels.

성별에 따른 근로자의 업무상 근골격계질환 산재 승인 영향요인

왕라일(Hwang, RahIl),김경하(Kim, Kyung Ha),석민현(Suk, Min Hyun),정성원(Jung, Sung Won) 대한근관절건강학회 2014 근관절건강학회지 Vol.21 No.1

Purpose: This study examined gender differences on Musculoskeletal disease (MSD) medical status, the characteristics of the approved patients in workers, and the factors affected approval. Methods: Claim data for the MSD to the Korea Workers Compensation & Welfare Services (2011) were employed. The medical status by gender was analyzed using t-test, chi square-test and multivariate logistic regression models. Results: The number of claims for MSD has continuously increased in females but not in males since 2006. The severity measured by the care duration, surgery experience and disability grade has been substantially higher in males than in females. Age, size of company, types of occupation, work duration and the weight of materials handled daily were associated with the approval. When males were considered, the work duration, the weight of materials handled daily and parts of the body were statistically significant predictors of approval in males. In case of female, there were meaningful predictors in types of industry and parts of the body. Conclusion: These findings suggest that gender-specific risk factors of MSD should be measured and the management program for MSD should be developed.

No difference in outcomes with 15 mm vs. 20 mm lumen-apposing metal stents for endoscopic ultrasound-guided gastroenterostomy for gastric outlet obstruction: a meta-analysis

Shyam Vedantam,Rahil Shah,Sean Bhalla,Shria Kumar,Sunil Amin 대한소화기내시경학회 2023 Clinical Endoscopy Vol.56 No.3

Background/Aims: We compared outcomes between use of 15 vs. 20 mm lumen-apposing metal stents (LAMSs) in endoscopic ultrasound-guided gastroenterostomy (EUS-GE) for gastric outlet obstruction. Methods: Databases were queried for studies that used LAMS for EUS-GE to relieve gastric outlet obstruction, and a proportional meta-analysis was performed. Results: Thirteen studies were included. The 15 mm and 20 mm LAMS had pooled technical success rates of 93.2% (95% confidence interval [CI], 90.5%–95.2%) and 92.1% (95% CI, 68.4%–98.4%), clinical success rates of 88.6% (95% CI, 85.4%–91.1%) and 89.6% (95% CI, 79.0%–95.1%), adverse event rates of 11.4% (95% CI, 8.1%–15.9%) and 14.7% (95% CI, 4.4%–39.1%), and reintervention rates of 10.3% (95% CI, 6.7%–15.4%) and 3.5% (95% CI, 1.6%–7.6%), respectively. Subgroup analysis revealed no significant differences in technical success, clinical success, or adverse event rates. An increased need for reintervention was noted in the 15 mm stent group (pooled odds ratio, 3.59; 95% CI, 1.40–9.18; p=0.008). Conclusions: No differences were observed in the technical, clinical, or adverse event rates between 15 and 20 mm LAMS use in EUS-GE. An increased need for reintervention is possible when using a 15 mm stent compared to when using a 20 mm stent.

Dynamic Type-2 Fuzzy Time Warping (DT2FTW): A Hybrid Model for Uncertain Time-Series Prediction

Aref Safari,Rahil Hosseini,Mahdi Mazinani 한국지능시스템학회 2021 INTERNATIONAL JOURNAL of FUZZY LOGIC and INTELLIGE Vol.21 No.4

Prediction of time series is associated with nondeterministic pattern analysis for uncertain conditions. Therefore, it is necessary to develop high-quality prediction methods for real-world applications. Type-2 fuzzy systems can handle high-order uncertainties, such as sequential dependencies associated with time series. Precise and reliable prediction can help to develop reasonable strategies and assist specialists in planning the best policies for modeling events in uncertain time series. In this study, a hybrid model (dynamic type-2 fuzzy time warping [DT2FTW]) was proposed for handling high-order uncertainties in time-series prediction. A type-2 fuzzy intelligent system was developed alongside a dynamic time warping algorithm for predicting the patterns’ similarity in long-time series for time-series prediction. The results demonstrate that the proposed DT2FTW model yields more reliable predictions on global standard benchmarks such as the Mackey-Glass, Dow Jones, and NASDAQ time-series. The results also confirm that the proposed DT2FTW model has lower error rates than its counterpart algorithms in terms of the root mean square error (RMSE), mean absolute error (MAE), and mean percentage error (MPE). In addition, the results confirm the superiority of the proposed model with an average area under the ROC curve (AUC) of 94%, with the 95% confidence interval (92%-95%).

장기요양 급여이용행태별 가족부양자 부양특성 비교

한은정(EunJeong Han),황라일(RahIl Hwang),박세영(SeYoung Park),이정석(JungSuk Lee) 한국사회정책학회 2019 한국사회정책 Vol.26 No.3

장기요양 노인과 가족의 삶의 질을 보호하기 위해서는 노인을 돌보는 가족의 부양현황과 부양부담에 정책적 관심을 기울일 필요가 있다. 본 연구는 장기요양 급여이용 행태별로 가족부양자의 부양 현황과 부양부담을 조사하고 급여이용행태별 부양특성의 차이를 비교하기 위해 시도하였다. 본 연구의 자료는 건강보험정책연구원의 ‘2016 장기요양 등급인정자의 급여이용 행태별 부양실태조사’를 통해 수집되었다. 본 조사는 2016년 6월 ~ 7월 2개월간 총 2,603명의 가족부양자를 대상으로 부양 현황 및 우울, 건강행태, 스트레스, 부양부담감 등에 대해 훈련된 면접원의 일대일면접방식으로 이루어졌다. 재가급여 이용 그룹, 시설급여 이용 그룹, 가족수발 그룹(미이용), 요양병원 이용 그룹(미이용) 4개 그룹으로 구분하여 급여이용 행태별 부양현황 및 부양부담 등을 분석하였다. 본 연구결과 급여 이용행태에 관계없이 응답자의 과반수 이상은 다른 가족구성원으로부터 도움을 받고 있었으나, 재가인 경우 다른 가족으로부터 도움을 받고 있는 비율이 가장 낮은 것으로 나타났다. 가족수발 및 요양병원 이용 그룹에서는 비용에 대한 부담을 높게 인식하고 있었다. 재가와 가족수발 그룹의 경우 시설 및 요양병원 그룹과 비교할 때, 가족부양자의 식사, 운동, 수면, 휴식 등 건강행태가 모두 열악한 수준이었고, 건강상태 악화 경험 비율이 높고, 주관적 건강수준 역시 낮게 나타났다. 더구나 가족부양자의 스트레스, 부양부담, 우울 또한 더 높은 수준이었고, 가족수발 그룹에서는 스트레스 경험 시 ‘그냥 참음’ 비율도 높게 나타났다. 본 연구를 통해 장기요양 급여이용행태별로 가족부양자의 인구사회학적 특성, 부양 현황 및 부양부담 특성에 차이가 있음을 확인하였다. 장기요양 가족부양자 지원 정책 개발 시, 급여이용행태별 가족부양자의 부양특성의 차이를 고려한 접근이 필요하겠다. This study aims to investigate and compare differences in caregiving burdens among family members with the disabled elderly according to the utilization of long-term care. We obtained the data from the project ‘2016 Survey on Family Caregivers’ Burden with Long-term Care Beneficiaries’, studied by the Institute for National Health Insurance. This survey was conducted from June 13 to July 17 2016, and the questionnaires included items of family caregivers’ characteristics and caregiving burdens. Total 2,603 family caregivers completed questionnaires. They were classified into 4 groups according to their utilization of long-term care(home care, institutional care, family care, and long-term care hospital services). As a result, more than half of respondents received help from other families. The group of home care reported relatively smaller help from other families. The groups of family care and long-term care hospital services reported statistically significant higher economic burden. The groups of home care and family care suffered from lack of healthy behaviors such as diet, exercise, and sleeping rest, and their subjective health level were low. And they also reported the higher levels of caregiving stress, depression, and caregiving burden, compared with the groups of institutional care and long-term care hospital services. Our findings suggest that it is needed to consider differences in caregiving burdens among family members by the type of benefits to develop family caregiver support programs.

Sphingomonas Paucimobilis : A Rare Infectious Agent Found in Cerebrospinal Fluid

Goker, Tuncer,Asik, Rahile Zulal,Yilmaz, Muhammet Bahadir,Celik, Ilhami,Tekiner, Ayhan The Korean Neurosurgical Society 2017 Journal of Korean neurosurgical society Vol.60 No.4

Sphingomonas paucimobilis (S. paucimobilis) is a gram negative bacillus. It has existed in soil, drinking water and plants. It has been isolated from distilled water tanks, respirators, and hemodialysis devices at the hospital setting. Patients with chronic disorders or immune suppression may be susceptible to infections with it. This microorganism has also been reported to infect healthy persons. Both nosocomial and community-acquired infections have been reported. So far, a variety of infections have been reported, including sepsis, septic pulmonary embolism, septic arthritis, peritonitis, and endophthalmitis. Only 2 cases of meningitis have been reported so far in the literature. So far, no previous reports of culture proliferation have been reported in patients with external ventricular drains, as was the case in our patient. Therefore, our case is the first to have S. paucimobilis proliferation in cerebrospinal fluid culture during intensive care unit stay for an external ventricular drain.

Evaluation of PRE and POST Herbicides on Growth Features, Nodulation, and Nitrogen Fixation of Three Cultivars of Chickpea (Cicer aritinium L.)

Meisam Zargar,Amir Lakzian,Rahil Rasooli,Ebrahim Izadi-Darbandi 한국작물학회 2020 Journal of crop science and biotechnology Vol.23 No.2

It is exceptionally difficult to have productive farming without the use of herbicides. It has been found that they create difficulties in the growth and biological nitrogen fixation of some legume crops after their application. Adverse impacts may result from a direct effect of the herbicide on rhizobial growth and/or an indirect effect on plant growth. In order to study the effect of some PRE and POST herbicides on nodulation, nitrogen fixation, and growth characteristics of three chickpea cultivars, a greenhouse trial was conducted in a completely randomized design with factorial arrangement and three replications. Pyridate, imazethapyr, and trifluralin were applied with the recommended rates of 1100, 100, and 720 g ai ha-1, respectively, and also non-treated control on three chickpea cultivars (ILS482, Hashem, and Kaka). The results showed that trifluralin and pyridate herbicides had the highest and the least negative impact on growth characteristics of three examined cultivars. Pyridate showed a positive effect on vegetative characteristics but nodulation and total nitrogen contents in the shoots of chickpea cultivars decreased significantly. Results also revealed that root and shoot growth, nodulation, and nitrogen fixation diminished significantly when imazethapyr and trifluralin were applied to Hashem and ILC482 cultivars. It seems that pyridate is an appropriate herbicide for broadleaf weed control in chickpea fields.

노인장기요양기관에 근무하는 간호사의 근무실태 및 직무만족도 영향 요인

이정석(Lee, JungSuk),황라일(Hwang, RahIl),임민경(Lim, MinKyung) 한국보건간호학회 2015 韓國保健看護學會誌 Vol.29 No.3

장기요양 인정자의 사망 전 의료 및 요양서비스 이용 양상 분석

한은정(Eun-jeong Han),황라일(RahIl Hwang),이정석(Jung-suk Lee) 한국사회정책학회 2018 한국사회정책 Vol.25 No.1

본 연구는 노인장기요양보험 인정자 중에서 사망한 자의 임종 관련 의료비를 분석함으로써, 향후 임종 관련 의료비의 효율적 관리방안과 양질의 임종관리 제공방안을 모색하는데 목적이 있다. 본 연구에서 활용한 자료는 건강보험 및 노인장기요양보험 급여이용자료, 통계청 사망원인 통계자료이며, 2008년 7월 1일부터 2012년 12월 31일까지 장기요양 인정등급을 받고 같은 기간 내 사망한 자 총 271,474명을 최종 분석대상자로 하였다. 연구결과 대상자는 여성(60.6%), 75세 이상(74.7%)이 다수를 차지했고, 대부분이 2개 이상의 질환을 보유하고 있었으며, 특히 고혈압(44.3%), 치매(42.3%), 뇌졸중(29.9%) 등 비율이 높았다. 사망원인은 순환기계질환(29.8%), 암(15.3%), 선천성 기형, 변형 및 염색체 이상(14.7%) 등의 순이었고, 사망장소로는 의료기관(64.4%), 자택(22.0%), 사회복지시설(9.2%) 순이었다. 대상자의 등급인정 이후 사망까지 소요시간은 평균 516.2일이었고, 대상자 중 99.3%는 사망 전 1년간 건강보험 또는 장기요양보험 급여를 이용하였다. 특히, 1인당 평균 총 급여비는 사망한 달에 가까워질수록 규모가 커져, 사망 전 12개월 보다 사망 전 1개월에 3배 이상 높아졌다. 또한, 사망 전 1개월간 대상자의 31.8%는 연명치료 범위에 해당하는 치료를 받은 것으로 나타났다. 향후 장기요양 인정자의 임종 관련 불필요한 의료이용 감소 및 효율적 의료관리를 위해 건강보험과 장기요양보험 급여의 통합적 임종관리 전달체계 확립과 호스피스 등 임종케어의 적극적 도입을 제안한다. Purpose: This study empirically investigates the utilization and expenditure of health care and long-term care at the last year of life for long-term care beneficiaries in Korea. Methods: This study used National Health Insurance and Long-term Care Insurance claims data of 271,474 LTCI beneficiaries, who died from July 2008 to December 2012. Their cause of death, place of death, health care costs, and the provision of aggressive care were analyzed. Results: Cardio-vascular disease(29.8%) and cancer(15.3%) were reported as their major cause of death, and hospital(64.4%), home(22.0%), social care facility(9.2%) were analyzed as the place of death. 99.3% of subjects used both health care and long-term care during the last 1 year of life. The average survival period were 516.2 days after they were LTCI beneficiaries. The health care expenditure gradually increased near the death, and the last month were three times more rather than the first month. Furthermore, 31.8% experienced some aggressive cares(CPR, blood transfusion, hemo-dialysis, etc.) at the last month of life. Conclusion: The results of this study suggest that it is important to develop the end of life care policies(for example, hospice, advanced care directives) for the LTCI beneficiaries. They might contribute to the improvement of quality of life and the reduction of health care expenditure of the elderly at the end-of-life.