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Pin1 is required for ultraviolet A-stimulated cyclooxygenase-2 induction in mouse epidermal cells
Quyen, B.T.,Choi, H.K.,Kang, K.W. Elsevier ; Elsevier Science Pub. Co 2013 Cancer letters Vol.335 No.1
Ultraviolet A (UVA) radiation (320-400nm) is considered a major cause of human skin photoaging and skin cancer. Overexpression of cyclooxygenase-2 (COX-2) leads to prostanoid formation in skin tissue, disturbs the balance between proliferation and apoptosis, and subsequently promotes tumorigenesis. The peptidyl-prolyl isomerase Pin1 is known to be overexpressed in most cancer cell types and plays an important role in oncogenesis. Here, we studied whether exposure of JB6 Cl41 mouse epidermal cells to UVA affects COX-2 expression and the possible involvement of Pin1 activation. UVA increased COX-2 protein expression and prostaglandin E2 production in an energy-dependent manner. Pre-exposure of JB6 Cl41 cells to UVA potentiated epidermal growth factor-induced anchorage-independent growth; this effect was significantly suppressed by inhibition of COX-2. UVA-stimulated COX-2 expression was significantly decreased by inhibition of Pin1. The increased COX-2 gene transcription in response to UVA was preceded by activation of the transcription factors nuclear factor-κB (NF-κB), cAMP response element-binding protein (CREB), CCAAT/enhancer-binding proteins α and β (C/EBPα and C/EBPβ) and c-Jun/activator protein-1 (AP-1). Pin1 inhibitor treatment suppressed the activation of NF-κB, CREB, and C/EBP by UVA irradiation. Conversely, JB6 C141 cells overexpressing Pin1 showed increased basal COX-2 expression and NF-κB, CREB, C/EBP, and AP-1 activities. These results suggest that UVA-induced COX-2 expression is mediated by Pin1 activation and this is associated with malignant transformation of epidermal cells.
Quyen Van Nguyen,Hang Thi Khuat,Yen‑Ngoc Thi Nguyen,Dung Thi Vu,Thu‑Ha Bui,부경환 한국식물생명공학회 2020 Plant biotechnology reports Vol.14 No.5
Drynaria bonii H. Christ is a medicinal plant that has traditionally been used for the treatment of chronic diseases and tuberculosis. However, D. bonii has not yet been cultivated or propagated. In this study, we optimized the conditions for the spore culture of D. bonii to produce sporophytes. First, we evaluated the efects of various factors, such as temperature, light intensity, potting material, and pH, on spore germination and early gametophyte development. Under optimal culture conditions, 95–99% of the spores germinated within 2 weeks of culture. Next, based on these results, we established a culture system for gametophyte development and sporophyte production. Mature gametophytes frst appeared 5 months post-germination (mpg), and at 12 mpg, the rate of production of heart-shaped gametophytes reached 56.6%. Sporophytes at the early frst-leaf stage frst appeared at 6 mpg, and at 12 mpg, the rate of formation of sporophytes reached 15.4%. Interestingly, 6.3% of all gametophytes produced multiple sporophytes. Additionally, 42–62% of the gametophytes also produced multiple secondary gametophytes, indicating a high potential of D. bonii gametophytes to generate new gametophytes and, subsequently, sporophytes. When transferred to new trays or pots, sporophytes grew well and showed 100% survival. Overall, we conclude that this spore culture system can be successfully used for the propagation of D. bonii sporophytes.
Quyen Thi Tran, Jung-woo Chae 忠南大學校 醫藥品開發硏究所 2021 藥學論文集 Vol.36 No.-
Clevudine (CLV) and entecavir (ETV) were approved in Korea in 2006. While ETV is recommended as first-line monotherapies for treatment chronic hepatitis B in many countries, the application of CLV is limited in Korea and Philippine due to concern about CLV-induced myopathy. Our meta-analysis study was performed to compare the efficacy and safety of CLV to ETV based on literature reviews. Electronic databases were searched and four studies with a total of 697 patients were included in our study. Results showed that virological re- sponse at 48 weeks of treatment was not significantly different between CLV and ETV (RR: 1.05, 95% CI: 0.96-1.14, I2 = 0%). The result for alanine aminotransferase normalization rate (RR: 1.05, 95% CI: 0.96-1.14, I2 = 0%) and serological response (RR: 0.59, 95% CI: 0.27-1.29, I2 = 57%) also showed a similar between CLV and ETV. The results at 24 weeks showed no statistically significant difference between CLV and ETV as well. These results suggest that CLV may have similar efficacy as ETV.
Multi-Carrier Differential Chaos-Shift Keying with Repeated Spreading Sequence
Quyen, Nguyen Xuan The Korean Institute of Communications and Informa 2018 Journal of communications and networks Vol.20 No.3
This paper proposes a multi-carrier differential chaos-shift keying (MC-DCSK) system using repeated spreading sequence (RSS), namely RSS-MC-DCSK, for chaos-based wireless communications. In the proposed system, instead of transmitting the chaotic spreading sequence on a predefined subcarrier as in conventional MC-DCSK, a DCSK-modulated signal, of which each two-bit duration consisting of reference and data-bearing sequences is sent via this subcarrier. Meanwhile, a repeated spreading sequence is produced by copying the reference sequence of the DCSK-modulated signal to the same and next bit periods. The parallel bit streams are multiplied with this RSS and the resulting signals are then conveyed by corresponding subcarriers. In the receiver, the signal retrieved from the predefined subcarrier is DCSK-demodulated and simultaneously used to recover the repeated spreading sequence. The correlative demodulation is performed for all the signals retrieved from the remaining subcarriers to decode the data. The structure and operation of the proposed system are described. Bit error rate (BER) performance under a multipath Rayleigh fading channel is theoretically analyzed and then verified by numerical simulations. In addition, the BER performance, energy and spectral efficiencies of RSS-MC-DCSK are evaluated in comparison to those of MC-DCSK.