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Huang, Yue-Han,Chen, Zhen-Kun,Huang, Ka-Te,Li, Peng,He, Bin,Guo, Xu,Zhong, Jun-Qiao,Zhang, Qi-Yu,Shi, Hong-Qi,Song, Qi-Tong,Yu, Zheng-Ping,Shan, Yun-Feng Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.3
Aim: To study any correlation of LKB1 expression with prognosis in hepatocellular carcinoma (HCC) cases. Methods: A total of 70 HCC patients and 20 primary intrahepatic stone patients in the first affiliated hospital of Wenzhou Medical College were enrolled in this study. LKB1 expression was detected by immunohistochemistry. Patients were followed-up and prognostic factors were evaluated. Result: LKB1 expression was decreased in the HCC samples. Loss of LKB1 expression in HCC was significantly related to histologic grade (P=0.010), vascular invasion (P=0.025) and TMN stage (P=0.011). Patients showing negative LKB1 expression had a significantly shorter disease-free and overall survival than those with positive expression (P = 0.001, P=0.000, respectively). Multivariate Cox regression analysis indicated that LKB1 expression level was an independent factor of survival (P = 0.033). Conclusion: HCC patients with decreased expression LKB1 have a poor prognosis. The loss of LKB1 expression is correlated with a lower survival rate.
Study on the Flavonoids of Lespedeza hedysaroides
Yu-qing Wang,Alamus,Qi-zhong Sun,Hong-xin Wu 한국초지조사료학회 2009 한국초지조사료학회 학술대회논문집 Vol.2009 No.08
Chemical investigation of the aerial parts of Lespedaza hedysaroides resulted in the isolation of 8 flavonoids:orientin (1), isoorientin (2), vitexin (3), isovitexin (4), Isomyricitrin (5), meletin-3-O-β-d-glucoside (6), luteolin-7-O-glucoside (7), 6-Xylopyranosylluteolin (8), The result showed t㏊t Lespedeza hedysaroides was rich in flavonoid glycosides, espically of C-glycosylflavones which have good Pharmacia and bioactive. So Lespedeza hedysaroides was concluded that it has vast prospect for exploitation and utilization.
Root Health Evaluation of Different Alfalfa Varieties in Agricultural and Animal Husbandly Areas
Qi-zhong Sun,Li-jun Xu,Zhu Yu,Shu-fen Zhao 한국초지조사료학회 2009 한국초지조사료학회 학술대회논문집 Vol.2009 No.08
Research on alfalfa root morphology and health is very important in development of technology for efficient improvement and production of alfalfa. The objectives of this study were to evaluate the root morphology and health of two alfalfa varieties, Algonquin and Golden Queen, to determine relationships among root morphology traits and root health. Results from these analyses indicated t㏊t yield was 6.77-43.93 t/h㎡, total root length ranged from 215.17-708.89 ㎜, root surface area ranged from 93.61-717.06 ㎠, volume ranged from 3.24-57.72㎤. Results from these analyses indicated t㏊t root infestation score was the lowest averaged over age of alfalfa stand in Algonquin. Yield in 2-yr old stands was greater in Golden Queen compared to Algonquin.
Qi Yang,Yu Zhong,Xiaoming Li,Xin Li,Kun Luo,Xiuqiong Wu,Hongbo Chen,Yang Liu,Guangming Zeng 한국공업화학회 2015 Journal of Industrial and Engineering Chemistry Vol.28 No.-
In this study, the bromate removal was investigated in continuous fixed-bed column using Fe(II)–Al(III)layered double hydroxide (LDH). With increase of column bed depth from 1.0 to 3.0 cm, breakpoint time(tb) increased from 51 to 175 h while throughput volume raised from 12.24 to 42.00 L at breakthroughpoint. The bromate removal was attributed to the reduction of Fe(II) present in LDH. The breakthroughcurve was simulated well by Thomas model, but BDST model was the only effective to initial part(1–10%). The maximum removal capacity (N0) calculated by Thomas model reached 71.01 mmol/g atflow rate (3 mL/min).
Identification and Functional Analysis of LsMNPV Anti-apoptosis Genes
Kim, Yu-Sin,Xiao, Hua-Zhong,Du, En-Qi,Cai, Guo-Shuai,Lu, Song-Ya,Qi, Yi-Peng Korean Society for Biochemistry and Molecular Biol 2007 Journal of biochemistry and molecular biology Vol.40 No.4
Three anti-apoptosis genes, Ls-iap2, iap3 and p49 were found in Leucania separata multiple nuclear polyhedrovirus. Amino acid sequence homology of Ls-IAP2 and Ls-IAP3 with Op-IAP2 and Op-IAP3 from Orgyia pseddotsugata MNPV were 20% and 42%, while that of Ls-P49 is 28% with Sl-P49 from Spodoptera littorolis MNPV. Ls-IAP2 contains one baculoviral IAP repeat (BIR) domain followed by a RING domain, while Ls-IAP3 contains two BIRs and a RING. Ls-P49 contains a reactive site loop, predicted cleavage site (KKLD$^{74}{\downarrow}$G) that is different from Sl-P49 (TVID$^{94}{\downarrow}$G). Expressed Ls-iap3 or Ls-p49 under presence of actinomycin D in SF9 cells, DNA ladder assayrevealed that Ls- IAP3 or Ls-P49 could block the apoptosis of SF9 cells induced by actinomycin D. Replication of p35 deficient-mutant Autographa californica MNPV in SF9 cells was also rescued when Ls-iap3 or Ls-p49 was expressed transiently. No anti-apoptotic activity was observed for Ls-IAP2. The results showed that both of Ls-IAP3 and Ls-P49 were functional apoptotic suppressors in SF9 cells.
Tang, Yu-Long,Qi, Xing-Shun,Guo, Xiao-Zhong Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.17
Background: There is no consensus regarding the selection of treatment options for hepatocellular carcinoma (HCC) after initial transarterial chemoembolization (TACE). This meta-analysis aimed to explore the survival benefit of hepatic resection after initial TACE for the treatment of HCC. Materials and Methods: We searched three major databases to identify all relevant papers comparing the outcomes of hepatic resection after initial TACE versus TACE alone for the treatment of HCC. Hazard ratios (HRs) with 95% confidence intervals (95%CIs) were calculated to evaluate the survival benefit of hepatic resection after initial TACE over TACE alone. Results: Three of 2037 initially identified papers were included. All of them were cohort studies from Asia. There was a significantly better overall survival (OS) in patients undergoing hepatic resection after initial TACE than in those undergoing TACE alone (HR=0.63, 95%CI=0.52-0.76, P<0.00001). The heterogeneity among studies was not statistically significant (P=0.96; I2=0%). Conclusions: Hepatic resection could improve the OS of HCC patients treated with initial TACE. Further randomized controlled trials should be necessary to identify the target population for the sequential use of hepatic resection after initial TACE and to compare the outcomes between patients undergoing hepatic resection after initial TACE session versus those undergoing TACE alone.