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        Preparation and drug release behavior of pH-responsive bovine serum albumin-loaded chitosan microspheres

        Xue Zou,Xiaowen Zhao,Lin Ye,Qi Wang,Hao Li 한국공업화학회 2015 Journal of Industrial and Engineering Chemistry Vol.21 No.1

        A novel inverse emulsion-ionic crosslinking approach was adopted to prepare pH-responsive chitosanmicrospheres and effect of preparation technique, such as chitosan concentration, emulsifierconcentration, water/oil ratio and homogenization speed, on the morphology and property of themicrospheres were investigated. The chitosan microspheres with spherical in shape, smooth surface,high productivity and promising pH responsiveness were obtained. On this basis, bovine serum albumin(BSA)-loaded chitosan microspheres was prepared to test the drug release behavior in buffers withdifferent pH values. BSA-chitosan microspheres with particle sizes in range from 5 to 10mmreleased BSAslowly in neutral medium and released rapidly in acidic medium, and exhibited obviously pH-responsiverelease behavior. Korsmeyer–Peppas model can be used for describing BSA release kinetics from chitosanmicrospheres, which corresponded with a Fickian release behavior, and the diffusion through theswelling of chitosan microspheres was the main factor in controlling BSA release.

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        Tribological Properties of PAO40@SiO2/UHMWPE Composites Subjected to Heavy-loading Conditions

        Yao Chenyu,Jia Dan,Wan Changxin,Li Jian,Zhan Shengpeng,Yang Tian,Qi Xiaowen,Liu Changxin,Duan Haitao 한국고분자학회 2022 폴리머 Vol.46 No.5

        In the present study, the ballistic impact resistance of kevlar reinforced polymer composites and shape memoryalloy sheet reinforced kevlar epoxy polymer composites have been compared numerically and experimentally. The testspecimens have been fabricated by the hand layup method, and the ballistic impact test has been conducted accordingto NIJ Level IIIA. In the current research, a new method has been proposed to measure the ballistic impact resistanceof the material by using Image J software. From the test results, it has been observed that reinforcement of shape memoryalloy in kevlar epoxy polymer composites has increased the ballistic impact resistance by 89-145% for the damaged areacompared with plain kevlar reinforced epoxy polymer composite. Also, the damaged area observed in the numerical andthe experimental results is almost the same.

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