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- 저자 : Priyanka Prem (검색결과 2 건)
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Sri Rahavi Boovarahan,Harini Venkatasubramanian,Nidhi Sharma,Sushma Venkatesh,Priyanka Prem,Gino A. Kurian 대한약학회 2021 Archives of Pharmacal Research Vol.44 No.6
Recent studies have shown that pre and postconditioningthe heart with sodium thiosulfate (STS) attenuateischemia–reperfusion (IR) injury. However, the underlyingmechanism involved in the cardioprotective signaling pathwayis not fully explored. This study examined the existinglink of STS mediated protection (as pre and post-conditioningagents) with PI3K, mTOR, and mPTP signaling pathwaysusing its respective inhibitors. STS was administeredto the isolated perfused rat heart through Kreb’s Heinselitbuff er before ischemia (precondition: SIPC) and reperfusion(postcondition: SPOC) in the presence and absence ofthe PI3K, mTOR, and mPTP signaling pathway inhibitors(wortmannin, rapamycin, and glibenclamide respectively). SIPC failed to improve the IR injury-induced altered cardiachemodynamics, increased infarct size, and the releaseof cardiac injury markers in the presence of these inhibitors. On the other hand, the SPOC protocol eff ectively renderedthe cardioprotection even in the PI3K/mTOR/K ATP inhibitorspresence. Interestingly, the SIPC’s identifi ed mode ofaction viz reduction in oxidative stress and the preservationof mitochondrial function were lost in the inhibitors’presence. Based on the above results, we conclude that theunderlying mechanism of SIPC mediated cardioprotectionworks via the PI3K/mTOR/K ATP signaling pathway axisactivation.
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( Garima Yadav ),( Meenakshi Rao ),( Meenakshi Gothwal ),( Pratibha Singh ),( Priyanka Kathuria ),( Prem Prakash Sharma ) 대한산부인과학회 2021 Obstetrics & Gynecology Science Vol.64 No.5
Objective The primary objective of this study was to establish the presence of nerve fibers in the eutopic endometrium of women with endometriosis and to determine whether these nerve fibers are exclusive to endometriosis or are also found in other pelvic pathologies associated with dysmenorrhea. Methods Endometrial tissue was obtained by aspiration (Pipelle), endometrial curettage, or following hysterectomy in women with endometriosis confirmed through histopathological examination, leiomyomas, and adenomyosis. The eutopic endometrium was subjected to immunohistochemical staining to detect PGP 9.5, which is a highly specific pan-neuronal marker. The nerve fiber density was correlated with the patient’s pain score, as indicated by the Visual Analog Scale. A control group was formed by staining the endometrium of women presenting with dysmenorrhea but without the above-mentioned disorders. Results Nerve fibers were observed in sections of the endo-myometrium (in the deep endometrium) in 68% of patients with endometriosis who underwent hysterectomy or a deep endometrial biopsy. Nerve fibers were not observed in the aspirated endometrium of women with endometriosis. Only 13.7% of women with adenomyosis and 3.3% of women with fibroids had nerve fibers in their endometrium. Nerve fiber density was correlated with pain score in women with endometriosis. Conclusion Nerve fibers were found in the functional layer of eutopic endometrium in women with endometriosis; hence, we concluded that the presence of nerve fibers in the eutopic endometrium could diagnose endometriosis with a fairly good specificity of 92.7%. However, the absence of nerve fibers does not always exclude the disease.
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