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- 저자 : Pinaki Ghosh (검색결과 4 건)
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( Md Azharuddin ),( Mohammad Adil ),( Prem Kapur ),( Pinaki Ghosh ),( Manju Sharma ) 대한간학회 2020 춘·추계 학술대회 (KASL) Vol.2020 No.1
Aims: Surgical site infection (SSI) is a common and postoperative complication in patients who underwent solid organ transplant and it makes extensive healthcare burden. So far, the pooled prevalence and microorganisms causing SSI among liver transplantation has not been reported well. This evidence-based systematic literature review and meta-analysis aimed to find the pooled prevalence of SSI. Methods: A systematic literature search on PubMed/Medline, Embase was conducted to identify the study determining the prevalence of SSI among patients who underwent liver transplantation, published from inception to May 2020. We calculated pooled prevalence (%) with 95% confidence interval (CI) with a random-effect model. A meta-analysis was performed using “meta” package through R 3.5.0. software. Results: A total of fifteen studies with 5,952 study subjects were included in this analysis. The rate of SSI was ranged between 9.0% and 96.4%. The pooled prevalence of SSI was 27.0% (95% CI: 16.09 to 40.01%) with high degree of heterogeneity (I2 = 99%, heterogeneity-P<0.01). The included studies reported a higher percentage of organ-space SSI (70.2%), followed by incisional, superficial, and deep SSI. The incidence rate of SSI was ranged from 0.34-10.3 episodes per 100 transplantation. Staphylococcus aureus (76.5%) was the most common pathogen identified, followed by Coagulase-negative staphylococci (35.0%) and Escherichia coli (21.25%). Conclusions: The current result suggests the overall prevalence of SSI infection was high. However, due to a high degree of heterogeneity, resulting a considerable amount of clinical uncertainty regarding the prevalence of SSI among patients who underwent liver transplantation. Therefore, studies are required to confirm the present findings.
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Md Azharuddin,Mohammad Adil,Rashid Ali Khan,Pinaki Ghosh,Prem Kapur,Manju Sharma 대한골다공증학회 2020 Osteoporosis and Sarcopenia Vol.6 No.2
This paper systematically and critically reviewed all published economic evaluations of drugs for the treatment postmenopausal osteoporosis. A systematic search was conducted using relevant databases for economic evaluations to include all relevant English articles published between January 2008 to January 2020. After extracting the key study characteristics, methods and outcomes, we evaluated each article using the Quality of Health Economic Studies (QHES) and the Consolidated Health Economic Evaluation Reporting Standards (CHEERS) instruments. A total of 49 studies met the inclusion criteria. Majority of studies were funded by the industry and reported favorable cost-effectiveness. Based on the QHES total scores, studies (n = 35) were found to be industry-funded with higher QHES mean 82.44 ± 8.69 as compared with nonindustry funding studies (n = 11) with mean 72.22 ± 17.67. The overall mean QHES scores were found to be higher 79.06 ± 11.84, representing high quality (75-100) compared to CHEERS scores (%) 75.03 ± 11.21. The statistical pairwise comparison between CHEERS mean (75.03 ± 11.21) and QHES mean (79.06 ± 11.84) were not statistically significant (P ¼ 0.10) whereas, QHES score showed higher means as compared to CHEERS. This study suggests the overall quality of the published literatures was relatively few high-quality health economic evaluation demonstrating the cost-effectiveness of drugs for postmenopausal osteoporosis, and the majority of the literature highlights that methodological shortcoming.
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Kandhare, Amit D.,Kumar, V. Shiva,Adil, Mohammad,Rajmane, Anuchandra R.,Ghosh, Pinaki,Bodhankar, Subhash L. 경희한의학연구센터 2012 Oriental Pharmacy and Experimental Medicine Vol.12 No.4
Peptic ulcer owes its pathological features to disregulated oxido-nitrosative and necrotic changes in gastrointestinal mucosa. Xanthium strumarium L. is a ubiquitous, abundant herb possessing an array of pharmacological properties. In view of anti-inflammatory and antioxidant activity of Xanthium strumarium L., the present investigation was designed to unravel its antiulcer potential in pylorus ligation induced gastric ulcer in laboratory animals. X. srtumarium L. leaves were extracted by refluxing with 95 % ethanol to obtained X. srtumarium L. ethanolic extract (XSEE). After 1 h pretreatment period of XSEE (100, 200 and 400 mg/kg) gastric ulcer was induced by ligation of pylorus portion of stomach. Various parameters including volume of gastric fluid, pH of gastric fluid, free as well as total acidity were measured in the gastric fluid whereas ulcer area, ulcer index, mucin content, superoxide dismutase, myeloperoxidase, nitric oxide, total calcium, histamine level, membrane bound inorganic phosphate (Na-K-ATPase), TNF-${\alpha}$ level, DNA fragmentation were determined in the gastric tissue. Pretreatment with XSEE (200 and 400 mg/kg) significantly and dose dependently (P<0.01 and P<0.001) decreased ulcer area, ulcer index, macroscopical gastric damage score, volume of gastric fluid, free acidity as well as total acidity and mucin content. It also significantly increased pH of gastric fluid. Rats treated with XSEE (200 and 400 mg/kg) significantly and dose dependently (P<0.01 and P<0.001) attenuated decreased level of superoxide dismutase, nitric oxide and Na-K-ATPase. It also significantly decreased level of myeloperoxidase, calcium and inflammatory cytokine i.e. TNF-${\alpha}$. XSEE treated rats showed significant reduction in the pylorus ligation induced apoptotic changes. The possible mechanism by which Xanthium strumarium exerts its gastro-protective action may be due to free radical quenching, DNA repair and down regulation of oxidative-nitrosative stress along with cytokines.
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