First-principles study of the switching characteristics of the 15,16-dinitrile DDP/CPD-based optical molecular switch with carbon nanotube electrodes

Peng Zhao,Chang-feng Fang,Yi-ming Wang,Ya-xi Zhai,De-sheng Liu 한국물리학회 2009 Current Applied Physics Vol.9 No.6

We have studied the switching characteristics of an optical molecular switch based on the 15,16-dinitrile dihydropyrene/cyclophanediene (DDP/CPD) molecule with two single-walled carbon nanotube (SWCNT) electrodes using first-principles transport calculations. It is shown that the DDP shows an overall higher conductance than the CPD at low bias which is independently of the SWCNT chirality. Meantime, the conductance of the molecular switch can be tuned by the chirality of the SWCNT. We have studied the switching characteristics of an optical molecular switch based on the 15,16-dinitrile dihydropyrene/cyclophanediene (DDP/CPD) molecule with two single-walled carbon nanotube (SWCNT) electrodes using first-principles transport calculations. It is shown that the DDP shows an overall higher conductance than the CPD at low bias which is independently of the SWCNT chirality. Meantime, the conductance of the molecular switch can be tuned by the chirality of the SWCNT.

Realgar transforming solution suppresses angiogenesis and tumor growth by inhibiting VEGF receptor 2 signaling in vein endothelial cells

Peng Song,Yang Hai,Xin Wang,Longhe Zhao,Baoqiang Chen,Peng Cui,Qin-Jian Xie,Lan Yu,Yang Li,Zhengrong Wu,Hong Yu Li 대한약학회 2018 Archives of Pharmacal Research Vol.41 No.4

Realgar (As4S4), as an arsenic sulfide mineraldrug, has a good therapeutic reputation for anticancer inTraditional Chinese Medicine, and has recently beenreported to inhibit angiogenesis in tumor growth. However,considering the poor solubility and low bioavailability ofrealgar, large dose of realgar and long period of treatmentare necessary for achieving the effective blood medicineconcentration. In present study, we resolved the crucialproblem of poor solubility of realgar by using intrinsicbiotransformation in microorganism, and investigatedunderlying mechanisms of realgar transforming solution(RTS) for antiangiogenesis. Our results demonstrated thatRTS had a strong activity to inhibit HUVECs proliferation,migration, invasion, and tube formation. Moreover, RTSinhibited VEGF/bFGF-induced phosphorylation ofVEGFR2 and the downstream protein kinases includingERK, FAK, and Src. In vivo zebrafish and chickenchorioallantoic membrane model experiments showed thatRTS remarkably blocked angiogenesis. Finally, comparedwith the control, administration of 2.50 mg/kg RTSreached more than 50% inhibition against H22 tumorallografts in KM mice, but caused few toxic effects in thehost. The antiangiogenic effect was indicated by CD31immunohistochemical staining and alginate-encapsulatedtumor cell assay. In summary, our findings suggest thatRTS inhibits angiogenesis and may be a potential drugcandidate in anticancer therapy.

Design of the Magnetic Field Sensing System for Downlink Signal Reception and Interference Cancelling for Through-the-Earth Communication

Peng Zhao,Yu-zhong Jiang,Shu-xia Zhang,Wen-wei Ying 한국자기학회 2016 Journal of Magnetics Vol.21 No.3

A magnetic field sensing system with a single primary sensor and multiple reference sensors deployed locally and orthogonally, was proposed for downlink signal reception and interference cancelling for Through-the-Earth Communication (TEC). This paper mathematically analyzes a design optimization process for a search coil magnetometer (SCM), and applies that process to minimize the bandwidth of the primary SCM for TEC signal reception and the volume of reference SCMs for multiple distributions. The primary SCM achieves a 3-㏈ bandwidth of 7 ㎐, a sensitivity threshold of 120 fT/√㎐, and a volume of 2.32 × 10<SUP>−4</SUP>㎥. The entire sensing system volume is as small as 10<SUP>−2</SUP>㎥. Experiments with interference from industrial frequency harmonics demonstrated an average of 36 ㏈ and 18 ㏈ improvements in signal-to-interference ratio and signal-to-interference plus noise ratio, respectively, using multichannel recursive-least-squares algorithm. Thus, the proposed sensing system can reduce the interference effectively and allows reliable downlink signal reception.

Insights into chlorantraniliprole resistance of Chilo suppressalis: Expression profiles of ATP-binding cassette transporter genes in strains ranging from low- to high-level resistance

Peng Yingchuan,Zhao Jun,Sun Yang,Wan Peng,Hu Yanyue,Luo Guanghua,Qin Wenjing,Huang Shuijin 한국응용곤충학회 2021 Journal of Asia-Pacific Entomology Vol.24 No.2

The ATP-binding cassette (ABC) proteins are involved in trans-cellular transport of substances at inverse con centrations. After ABC genes were discovered to be involved in multidrug resistance in humans, increased attention was paid to the role of insect ABC genes in pesticide resistance. Chilo suppressalis, the most important Lepidopteran pest in rice production, has developed resistance to the insecticide chlorantraniliprole. However, few of the ABC genes that contribute to chlorantraniliprole resistance have been studied. Here, 47 genes encoding ABC transporters were identified, including five CsABCA, seven CsABCB, ten CsABCC, two CsABCD, one CsABCE, three CsABCF, 15 CsABCG, and four CsABCH genes. The expression profiles of these transporter genes were determined in three chlorantraniliprole-resistant strains: R1, R2, and HR, with a resistance ratio of 38.8, 110.4, and 249.6, respectively. CsABCA1, -D2, and -H2 were up-regulated in all resistant strains, and the trend in the transcript levels of all 47 CsABC genes fitted a descending curve from R1 to HR. Unexpectedly, CsABCF1, -G11 and -G12 were significantly down-regulated in HR. These results provide new insights into the roles of ABC transporters in chlorantraniliprole resistance in C. suppressalis.

온도에 의한 황산적늑대거미(거미목: 늑대거미과)의 성장과 생식에 관한 연구

Peng Y.J.Z.Zhao,J.P.Kim 외1명 한국거미연구소 1998 한국거미 Vol.14 No.2

Mechanical properties and cushioning mechanism of shear thickening fluid

Peng Zhao,Qian Chen,Xue Gao,Zhaoyong Wu 대한기계학회 2020 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.34 No.11

Shear thickening fluid (STF) is one type of dispersed system with rapidly changing rheological properties under an impulse load. The apparent viscosity of such a suspension system changes dramatically under high-speed impact, and the system can even change from suspension to quasi-solid. Once the load is removed, the STF will quickly return to its original state. In this paper, a mechanical model based on a particle-jammed model and added mass was proposed by calculating the acceleration response of the impact bar, and the local hardening phenomenon of STF in the low-speed impact test was interpreted. Then with the low-speed impact test, the rheological properties of STF in the cushioning process were recorded by a high-speed camera. Meanwhile, a comparison was made with the cushioning efficiency of AV-200, a closed-cell foam material, by using the force-displacement curve. Finally, based on the constitutive relation of STF and by using the fluid-solid coupling method in the FEM, the lowspeed impact test of STF was analyzed to obtain more comprehensive dynamic characteristics. The acceleration response obtained in the test was consistent with the theoretical results, which further verified the rationality and effectiveness of the theoretical model. Compared with AV-200, STF has a cushioning efficiency of 50 %-60 %, and its cushioning performance was superior to AV-200. Starting with the rheological cloud map of STF and the acceleration response of the impact bar by the numerical model, a comparison was made with the results of low-speed impact test, and a good agreement is observed.

Opportunistic Routing for Bandwidth-Sensitive Traffic in Wireless Networks with Lossy Links

Peng Zhao,Xinyu Yang 한국통신학회 2016 Journal of communications and networks Vol.18 No.5

Opportunistic routing (OR) has been proposed as a vi-able approach to improve the performance of wireless multihopnetworks with lossy links. However, the exponential growth ofthe bandwidth-sensitivemobile traffic (e.g.,mobile video streamingand online gaming) poses a great challenge to the performance ofOR in term of bandwidth guarantee. To solve this problem, a novelmechanism is proposed to opportunistically forwarding data pack-ets and provide bandwidth guarantee for the bandwidth-sensitivetraffic. The proposal exploits the broadcast characteristic of wire-less transmission and reduces the negative effect of wireless lossylinks. First, the expected available bandwidth (EAB) and the ex-pected transmission cost (ETC) under OR are estimated basedon the local available bandwidth, link delivery probability, for-warding candidates, and prioritization policy. Then, the policiesfor determining and prioritizing the forwarding candidates is de-vised by considering the bandwidth and transmission cost. Finally,bandwidth-aware routing algorithm is proposed to opportunisti-cally delivery data packets; meanwhile, admission control is ap-plied to admit or reject traffic flows for bandwidth guarantee. Ex-tensive simulation results show that our proposal consistently out-performs other existing opportunistic routing schemes in providingperformance guarantee.

Opportunistic Routing for Bandwidth-Sensitive Traffic in Wireless Networks with Lossy Links

Zhao, Peng,Yang, Xinyu The Korea Institute of Information and Commucation 2016 Journal of communications and networks Vol.18 No.5

Opportunistic routing (OR) has been proposed as a viable approach to improve the performance of wireless multihop networks with lossy links. However, the exponential growth of the bandwidth-sensitive mobile traffic (e.g., mobile video streaming and online gaming) poses a great challenge to the performance of OR in term of bandwidth guarantee. To solve this problem, a novel mechanism is proposed to opportunistically forwarding data packets and provide bandwidth guarantee for the bandwidth-sensitive traffic. The proposal exploits the broadcast characteristic of wireless transmission and reduces the negative effect of wireless lossy links. First, the expected available bandwidth (EAB) and the expected transmission cost (ETC) under OR are estimated based on the local available bandwidth, link delivery probability, forwarding candidates, and prioritization policy. Then, the policies for determining and prioritizing the forwarding candidates is devised by considering the bandwidth and transmission cost. Finally, bandwidth-aware routing algorithm is proposed to opportunistically delivery data packets; meanwhile, admission control is applied to admit or reject traffic flows for bandwidth guarantee. Extensive simulation results show that our proposal consistently outperforms other existing opportunistic routing schemes in providing performance guarantee.

On the No-Fault Insurance Movement in the United States and Its Inspiration for the Legislative Model of China’s Compulsory Traffic Insurance

ZHAO, PENG-JU(조평주),ZANG ZHEN(장전) 동아대학교 법학연구소 2023 國際去來와 法 Vol.- No.40

The popularity of automobiles has led to frequent traffic accidents, and the defects of the traditional automobile liability insurance have become increasingly apparent. The victims burden of proof in a traffic accident makes it hard for the victim to obtain relief in time. Consequently, the no-fault insurance movement began in the United States in the 1960s and 1970s. American scholars hoped that in the field of automobile insurance, like workers’ insurance, third-party insurance can be replaced by first-party insurance, making the traditional automobile liability insurance get rid of the shackles of tort liability. Yet, things backfired. The no-fault movement finally went nowhere under the opposition from various forces. Not only did it fail to be widely implemented in the United States, but the goal of making victims receive timely and effective relief to reduce lawsuits was not fully realized. But it cannot be denied that the no-fault movement still has a huge impact on the field of automobile liability insurance. The current circumstance of Chinas compulsory traffic insurance is highly similar to that of the United States in the 1960s and 1970s, and the existing compulsory traffic insurance system is also inspired by no-fault insurance to a certain extent. However, owing to the lack of recognition of the difference between no-fault insurance and no-fault liability, the legislative model of China’s compulsory traffic insurance is not no-fault insurance and is significantly different from traditional automobile liability insurance, forming a unique mixed legislative system. This model directly results in the confusion of the legal system of Chinas compulsory traffic insurance. Besides, because there are many problems in the scope of victim protection and the sub-item limit of liability in Chinas compulsory traffic insurance, the revision of Chinas compulsory traffic insurance is imperative. In this regard, the author holds that by reflecting on the no-fault insurance movement in the United States, the future reforms of Chinas compulsory traffic insurance should take “compulsory” as its core and strict liability its basis to build a legal system of compulsory traffic insurance that is in line with Chinas own reality. What’s more, in order to effectively protect victims and address the problems brought about by self-driving vehicles, China’s compulsory traffic insurance should also expand its protection objects, change the accident sub-item limit to the victim general limit system, and improve the system of the victim’s direct claim right.

Aberrant Expression of HOXA5 and HOXA9 in AML

Zhao, Peng,Tan, Li,Ruan, Jian,Wei, Xiao-Ping,Zheng, Yi,Zheng, Li-Xia,Jiang, Wei-Qin,Fang, Wei-Jia Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.9

Background: Aberrant expression of HOX gene expression has been observed in cancer. The purpose of this study was to investigate the alteration of HOXA5 and HOXA9 expression and their clinical significance in acute meloid leukemia (AML). Materials and Methods: The expression of HOXA5 and HOXA9 genes of bone marrow samples from 75 newly diagnosed AML patients and 22 healthy controls for comparison were examined by Real-time quantitative PCR (RQ-PCR) assay. Statistical analysis was conducted to evaluate HOXA5 and HOXA9 expression as possible biomarkers for AML. Results: The results showed that the complete remission rate (52.6%) of the patients who highly expressed HOXA5 and HOXA9 was significantly lower than that (88.9%) in patients who lowly express the genes (P=0.015). Spearmann correlation coefficients indicated that the expression levels for HOXA5 and HOXA9 genes were highly interrelated (r=0.657, P<0.001). Meanwhile, we detected significant correlations between HOXA9 expression and age in this limited set of patients (P=0.009). Conclusions: The results suggest a prognostic impact of increased expression of HOXA5 and HOXA9 in AML patients.