Development of a Radiopharmaceutical using 166Ho-chitosan Complexes against Prostate Cancer

Park KyongBae,Ryu JeiMan,Seong SeungKyoo,Bae EunJung,Song YoungJun,Jung YongHo,Kwak ChuI,Park MunSoo,Lee SangEun,Shin ByungChul,Shigematsu Akiyo 大韓藥學會 2003 大韓藥學會 總會 및 學術大會 Vol.2003 No.1

Enhanced proton conductivity of yttrium-doped barium zirconate with sinterability in protonic ceramic fuel cells

Park, Ka-Young,Seo, Yongho,Kim, Ki Buem,Song, Sun-Ju,Park, Byoungnam,Park, Jun-Young Elsevier 2015 Journal of Alloys and Compounds Vol.639 No.-

<P><B>Abstract</B></P> <P>In this study, we report the effects of various ceramic processing methods with different sintering aids on the relative density, crystallinity, microstructure, and electrical conductivity of proton conducting BaZr<SUB>0.85</SUB>Y<SUB>0.15</SUB>O<SUB>3−</SUB> <I> <SUB>δ</SUB> </I> (BZY) pellets in details. First, the BZY ceramic pellets are fabricated by the solid-state reactive sintering by adding diverse sintering aids including CuO, NiO, ZnO, SnO, MgO, and Al<SUB>2</SUB>O<SUB>3</SUB>. Among these, CuO is found to be the most effective sintering aid in terms of the sintering temperature and total conductivity. However, transition metals as sintering aids have detrimental effects on the electrical conductivity of the BZY electrolytes. Second, the BZY electrolytes have been synthesized by four different methods: the solid-state, combustion, hydrothermal, and polymer gelation methods. The BZY pellets synthesized by the polymer gelation method exhibit dense microstructure with a high relative density of 95.3%. Moreover, the electrical conductivity of the BZY pellets synthesized by the polymer gelation method is higher than those prepared by the solid-state methods under the same test conditions: 1.28×10<SUP>−2</SUP> Scm<SUP>−1</SUP> (by the polymer gelation method) vs. 0.53×10<SUP>−2</SUP> Scm<SUP>−1</SUP> by the solid-state method at 600°C in wet 5% H<SUB>2</SUB> in Ar.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Report effects of ceramic processing methods on the electrical conductivity of BZY. </LI> <LI> Present effects of sintering aids on the conductivity and density of BZY. </LI> <LI> CuO is the most effective sintering aid for the BZY. </LI> <LI> Polymer gelation is the most effective method in terms of conductivity of BZY. </LI> <LI> Grain boundary conductivity of the polymer gelation BZY is higher than others. </LI> </UL> </P>

Reed Solomon VLSI Codec for HDTV

Yongho Park,Sangjin Park 대한전자공학회 1994 대한전자공학회 학술대회 Vol.1994 No.7

Operation Protocols To Improve Durability of Protonic Ceramic Fuel Cells

Park, Ka-Young,Kim, You-Dong,Lee, John-In,Saqib, Muhammad,Shin, Ji-Seop,Seo, Yongho,Kim, Jung Hyun,Lim, Hyung-Tae,Park, Jun-Young American Chemical Society 2019 ACS APPLIED MATERIALS & INTERFACES Vol.11 No.1

<P>To develop reliable and durable protonic ceramic fuel cells (PCFCs), the impacts of the operation protocols of PCFCs on the cell durability are investigated through analyses of the main degradation mechanisms. We herein propose three appropriately designed control protocols, including cathode air depletion, shunt current, and fuel cell/electrolysis cycling, to fully circumvent the operating-induced degradation of PCFCs. For this purpose, anode-supported cells, comprised of a NiO-BaCe<SUB>0.7</SUB>Zr<SUB>0.1</SUB>Y<SUB>0.1</SUB>Yb<SUB>0.1</SUB>O<SUB>3−δ</SUB> anode, BaCe<SUB>0.7</SUB>Zr<SUB>0.1</SUB>Y<SUB>0.1</SUB>Yb<SUB>0.1</SUB>O<SUB>3−δ</SUB> electrolyte, and NdBa<SUB>0.5</SUB>Sr<SUB>0.5</SUB>Co<SUB>1.5</SUB>Fe<SUB>0.5</SUB>O<SUB>5+δ</SUB>-Nd<SUB>0.1</SUB>Ce<SUB>0.9</SUB>O<SUB>2−δ</SUB> composite cathode, are prepared, and their long-term performances are evaluated under a galvanostatic condition of 0.5 A·cm<SUP>-2</SUP> at 650 °C. The cell voltages of the protected cells using the operation protocols to prevent performance degradation are stably maintained under the applied current density for more than 1200 h without any noticeable degradation, whereas the performance of the unprotected cell gradually decreased with time, and the decay ratio was 14.9% over 850 h. The significant performance decay of the unprotected cell is strongly associated with the cathode degradation phenomenon, which was caused by the water vapor continuously produced during the electrochemical reactions. Hence, the performance recovery of the PCFCs with the operation protocols is achieved by incrementally decreasing the cathode potential (close to a value of zero) to minimize the effect of high <I>P</I><SUB>H</SUB><SUB><SUB>2</SUB></SUB><SUB>O</SUB> and <I>P</I><SUB>O</SUB><SUB><SUB>2</SUB></SUB> during the PCFC operations.</P> [FIG OMISSION]</BR>

Graphite patterning in a controlled gas environment

Park, Joonkyu,Kim, K B,Park, Jun-Young,Choi, T,Seo, Yongho IOP Pub 2011 Nanotechnology Vol.22 No.33

<P>Although a number of methods using scanning probe lithography to pattern graphene have already been introduced, the fabrication of real devices still faces limitations. We report graphite patterning using scanning probe lithography with control of the gas environment. Patterning processes using scanning probe lithography of graphite or graphene are normally performed in air because water molecules forming the meniscus between the tip and the sample mediate the etching reaction. This water meniscus, however, may prevent uniform patterning due to its strong surface tension or large contact angle on surfaces. To investigate this side effect of water, our experiment was performed in a chamber where the gas environment was controlled with methyl alcohol, oxygen or isopropanol gases. We found that methyl alcohol facilitates graphite etching, and a line width as narrow as 3 nm was achieved as methyl alcohol also contains an oxygen atom which gives rise to the required oxidation. Due to its low surface tension and highly adsorptive behavior, methyl alcohol has advantages for a narrow line width and high speed etching conditions.</P>

현대사회의 경력개발 이슈

박용호 ( Park Yongho ) 인천대학교 사회과학연구원 2013 사회과학연구 Vol.3 No.-

The academic field of Human Resource Development(HRD) is composed of three areas including individual development(ID), organization development(OD), and career development(CD). However, the career development have not been investigated enough so far. This study aims to show the current research issue in career development area in HRD and to provide the suggestion for future study. Traditionally, the career has been defined as the series of work related experience. Based on this definition, the career development has been discussed as the series of the short cycle which may be applied to individual's career stages. In this modern society, there are several career development issues which may be discussed academically for future studies. In modern society characterized rapid changing and globalization, firstly, the subjective career success may be the key evaluation criteria of career development. Second, the career mobility has been enhanced in modern society, and this trend has been named boundaryless career. Third, the individual's responsibility has been critical in managing his own career. This trend has been protean career. Fourth, work and life balance is another key issue in discussing career development. Lastly, career competency is another academically interesting subject. Based on the current career development issue, this study suggest the practical suggestion for HRD practitioners.

제32회 전국수학교육연구대회 특집/논문초록 : 논문초록 ; 수학교육공학 : 테크놀로지를 활용한 교수학적 환경에서 대수적 연산오류지도에 관한 연구

박용호 ( Park Yongho ),탁동호 ( Tag Dongho ) 한국수학교육학회 2004 뉴스레터 Vol.20 No.1

프로티언 경력태도가 사내창업가역량을 매개로 조직몰입에 미치는 영향

박용호 ( Park Yongho ),임지은 ( Lim Jieun ),김민지 ( Kim Minji ) 인천대학교 사회과학연구원 2018 사회과학연구 Vol.11 No.2

본 연구는 사내창업가들의 프로티언 경력태도가 조직몰입에 미치는 영향을 사내창업가역량의 매개효과를 고려하여 살펴보고자 하였다. 이를 위해 기업 내에서 혁신업무를 수행하는 사내창업가들을 대상으로 자료를 수집하여 분석을 실시하였다. 본 연구에서는 프로티언 경력태도에서의 하위요인 중에서는 자기주도적 경력 관리를, 사내창업가역량 중에서는 학습지향역량을, 그리고 조직몰입의 하위 요인 중에서는 정서적 몰입을 사용하여 자료를 수집하였다. 연구결과는 프로티언 경력태도가 조직몰입에 영향을 미치기 위해서는 사내창업가역량의 매개효과가 필요하다는 사실을 확인시켜 주었다. 즉, 개인의 자기주도적 경력관리가 새로운 것을 학습하는 능력을 향상시켜주고, 이러한 학습역량의 향상이 조직에 정서적으로 더욱 몰입하게 한다는 결과를 확인할 수 있었다. 이러한 결과에 기초하여 본 연구에서는 결론을 도출하고 이론적, 실천적 시사점 및 향후 연구에 대한 제언을 제공하고 있다. This study was to examine the mediation effect of corporate entrepreneurs’ competency in the relationship between protean career attitude and organizational commitment. For this research purpose, the data were collected from the corporate entrepreneurs who are taking responsibility in doing innovative projects in each organization. In this study, the self-directed management dimension for protean career attitude, learning orientation competency for corporate entrepreneurs’ competency, and affective commitment for organizational commitment were used in measurement scales. The study results showed that there is mediation effect of corporate entrepreneurs’ competency in the relationship between protean career attitude and organizational commitment. In other words, the self-directed career management can enhance the competency in learning new skill and knowledge. Then the enhanced learning ability also provide the foundation of higher affective commitment in organization. Based on the study results, the conclusion was provided. Also the theoretical and practical implication and suggestion for the future study were provided.

Adenoviral vector-mediated glucagon-like peptide 1 gene therapy improves glucose homeostasis in Zucker diabetic fatty rats

Lee, Yongho,Kwon, Mi Kyong,Kang, Eun Seok,Park, Young Mi,Choi, Seung Ho,Ahn, Chul Woo,Kim, Kyung Sub,Park, Chul Won,Cha, Bong Soo,Kim, Sung Wan,Sung, Je Kyung,Lee, Eun Jig,Lee, Hyun Chul John Wiley Sons, Ltd. 2008 The journal of gene medicine Vol.10 No.3

<B>Background</B><P>Glucagon-like peptide-1 (GLP-1) is a gut-derived incretin hormone that plays an important role in glucose homeostasis. Its functions include glucose-stimulated insulin secretion, suppression of glucagon secretion, deceleration of gastric emptying, and reduction in appetite and food intake. Despite the numerous antidiabetic properties of GLP-1, its therapeutic potential is limited by its short biological half-life due to rapid enzymatic degradation by dipeptidyl peptidase IV. The present study aimed to demonstrate the therapeutic effects of constitutively expressed GLP-1 in an overt type 2 diabetic animal model using an adenoviral vector system.</P><B>Methods</B><P>A novel plasmid (pAAV-ILGLP-1) and recombinant adenoviral vector (Ad-ILGLP-1) were constructed with the cytomegalovirus promoter and insulin leader sequence followed by GLP-1(7–37) cDNA.</P><B>Results</B><P>The results of an enzyme-linked immunosorbent assay showed significantly elevated levels of GLP-1(7–37) secreted by human embryonic kidney cells transfected with the construct containing the leader sequence. A single intravenous administration of Ad-ILGLP-1 into 12-week-old Zucker diabetic fatty (ZDF) rats, which have overt type 2 diabetes mellitus (T2DM), achieved near normoglycemia for 3 weeks and improved utilization of blood glucose in glucose tolerance tests. Circulating plasma levels of GLP-1 increased in GLP-1-treated ZDF rats, but diminished 21 days after treatment. When compared with controls, Ad-ILGLP-1-treated ZDF rats had a lower homeostasis model assessment for insulin resistance score indicating amelioration in insulin resistance. Immunohistochemical staining showed that cells expressing GLP-1 were found in the livers of GLP-1-treated ZDF rats.</P><B>Conclusions</B><P>These data suggest that GLP-1 gene therapy can improve glucose homeostasis in fully developed diabetic animal models and may be a promising treatment modality for T2DM in humans. Copyright © 2007 John Wiley & Sons, Ltd.</P>

역량개발기회와 리더-구성원 교환관계가 고용가능성에 미치는 영향

박용호(Yongho Park) 한국콘텐츠학회 2015 한국콘텐츠학회논문지 Vol.15 No.10

본 연구는 고용가능성과 이에 영향을 미치는 것으로 확인된 리더-구성원 교환관계(Leader-Member Exchange: LMX), 역량개발기회참여, 그리고 주관적 경력성공 사이의 영향관계를 파악하는데 목적이 있다. 이러한 연구 목적을 달성하기 위해 최종적으로 수집된 257명의 응답자들로부터 수집된 자료를 통해 연구결과가 도출되었다. 수집된 자료는 SPSS(WIN20.0) 통계프로그램을 이용하여 분석하였다. 연구변인들 사이의 상관관계를 파악하기 위해 Pearson의 적률상관계수가 산출되었으며, 고용가능성에 미치는 영향관계를 파악하기 위해 중다회귀분석(Multiple Regression Analysis)이 실시되었다. 본 연구의 결과는 다음과 같다. 첫째, 고용가능성과 리더-구성원 교환관계, 역량개발기회참여, 그리고 주관적 경력성공 사이에는 유의미한 상관관계가 존재하는 것으로 확인되었다. 둘째, 역량개발기회는 전체 고용가능성 변인의 분산을 약 10%정도 설명하고 있는 것으로 파악되었으며, 이에 비해 리더-구성원 교환관계는 유의미한 영향력이 없는 것으로 확인되었다. 이러한 결과를 바탕으로 논의와 후속연구를 위한 제언이 제공되었다. The purpose of this study was to investigate the effects of leader-member exchange(LMX), participation in the opportunities for competency development, and subjective career success. LMX and participation in the opportunities for competency development were the independent variables and the subjective career success was used as control variable. Based on the data collected from 257 employees of a Korean financial company, correlation analysis and multiple regression analysis were conducted through the using SPSS/WIN 20.0 statistical package program. The results showed the statistically significant correlation between employability and other research variables. Also, results identified that participation in the opportunities had largest influence on the employability and LMX had no significant effects on the employability. The discussion and proposition for the future studied were provided.