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( Seong Hwan Park ),( Kee Don Choi ),( Kyoungwon Jung ),( Yangsoon Park ),( Sunpyo Lee ),( Eun Jeong Gong ),( Hee Kyong Na ),( Ji Yong Ahn ),( Kee Wook Jung ),( Jeong Hoon Lee ),( Do Hoon Kim ),( Ho J 대한간학회 2018 Gut and Liver Vol.12 No.3
Background/Aims: We aimed to investigate whether the current indications for curative endoscopic resection (ER) of gastric cancer (GC) can be applied to GC caused by adenoma. Additionally, we attempted to identify factors predictive of lesions subsequently found in addition to the expanded indications for ER. Methods: We retrospectively analyzed 342 patients diagnosed with GC caused by adenoma who underwent ER at a single tertiary center between February 2011 and December 2014. The gross whole tumor size was measured using the endoscopically resected specimen. The microscopic whole tumor size was measured using mapping paper. The estimated cancer size was calculated using the microscopic whole tumor size and the square root of the carcinoma component. Results: A gross whole tumor size ≥3 cm, carcinoma component ≥35%, and gross ulceration were predictive of lesions other than the expanded indications for ER. The overall rate of lymph node metastasis was 0.3% (1/327), which only occurred in one patient with a lesion other than the expanded indications (4.5%, 1/22). Conclusions: The current indications for curative ER in GC can be applied to GC caused by adenoma. In cases suspected of having lesions other than the expanded indications, patients should be cautiously selected for ER to reduce the risk of an inappropriate procedure. (Gut Liver 2018;12:246-254)
Kim, Sun A,Lee, Yangsoon,Jung, Dawoon E,Park, Kyung Hwa,Park, Jeong Youp,Gang, Jingu,Jeon, Sun Bok,Park, Eui Chul,Kim, Young-Gun,Lee, Bogman,Liu, Qing,Zeng, Wen,Yeramilli, Subramanyam,Lee, Soojin,Koh, Japanese Cancer Association 2009 CANCER SCIENCE Vol.100 No.5
<P>The identification of novel tumor-specific proteins or antigens is of great importance for diagnostic and therapeutic applications in pancreatic cancer. Using oligonucleotide microarrays, we identified a broad spectrum of differentially expressed pancreatic cancer-related genes. Of these, we selected an overexpressed expressed sequence taq and cloned a 721-bp full-length cDNA with an open reading frame of 196 amino acids. This novel gene was localized on the Homo sapiens 16p13.3 chromosomal locus, and its nucleotide sequence matched the Homo sapiens similar to common salivary protein 1 (LOC124220). We named the gene pancreatic adenocarcinoma up-regulated factor. The pancreatic adenocarcinoma up-regulated factor was secreted into the culture medium of pancreatic adenocarcinoma up-regulated factor-overexpressing Chinese hamster ovary cells, had an apparent molecular mass of approximately 25 kDa, and was N-glycosylated. The induction of pancreatic adenocarcinoma up-regulated factor in Chinese hamster ovary cells increased cell proliferation, migration, and invasion ability in vitro. Subcutaneous injection of mice with Chinese hamster ovary/pancreatic adenocarcinoma up-regulated factor cells resulted in 3.8-fold greater tumor sizes compared to Chinese hamster ovary/mock cells. Reverse transcription-polymerase chain reaction and western blotting with antirecombinant human pancreatic adenocarcinoma up-regulated factor antibodies confirmed that pancreatic adenocarcinoma up-regulated factor was highly expressed in six of eight pancreatic cancer cell lines. Immunohistochemical staining of human pancreatic cancer tissues also showed pancreatic adenocarcinoma up-regulated factor overexpression in the cytoplasm of cancer cells. Transfection with pancreatic adenocarcinoma up-regulated factor-specific small-interfering RNA reduced cancer cell migration and invasion in vitro. Treatment with antirecombinant human pancreatic adenocarcinoma up-regulated factor in vitro and in vivo reduced proliferation, migration, invasion, and tumorigenic ability. Collectively, our results suggest that pancreatic adenocarcinoma up-regulated factor is a novel secretory protein involved in pancreatic cancer progression and might be a potential target for the treatment of pancreatic cancer.</P>
Kim, Joo Young,Kim, Ki-Suk,Kim, Kyung-Jo,Park, In Ja,Lee, Jong Lyul,Myung, Seung-Jae,Park, Yangsoon,Park, Young Soo,Yu, Chang Sik,Kim, Jin Cheon,Yu, Eunsil,Jang, Hyeung-Jin,Hong, Seung-Mo Wolters Kluwer Health, Inc. All rights reserved. 2015 The American journal of surgical pathology Vol.39 No.5
According to the 2010 World Health Organization classification, all gastrointestinal neuroendocrine tumors (NETs) are classified as malignant except for L-cell-type (glucagon-like peptide [GLP] and peptide YY [PYY]-producing) NETs. However, L-cell immunophenotype in rectal NETs has not been widely studied previously. Immunohistochemical labeling of L-cell markers with GLP1 and PYY was performed in 208 surgically or endoscopically resected rectal NET cases with tissue microarrays and was compared with clinicopathologic features and patient survival. Rectal NETs with non-L-cell immunophenotype and large tumor size (>1 cm) were associated with increased tumor grading, advanced T category, lymphovascular and perineural invasions, and lymph node and distant metastases (P<0.001, each). Rectal NET patients with non-L-cell phenotype and measuring >1 cm had significantly worse survival outcome than other groups by univariate (P<0.001) and multivariate (P<0.001) analyses. In summary, non-L-cell immunophenotype and large tumor size are associated with increased tumor grading and staging, concurrently indicating that they are independently poor prognostic indicators in rectal NET patients. Therefore, combining L-cell phenotype and tumor size can demonstrate the clinical behavior of rectal NETs more precisely than use of L-cell immunophenotype alone.
최근 임상검체에서의 혐기성 세균 분리 현황 및 혐기성 균혈증의 임상적 특징
박용정,이양순,김명숙,최준용,용동은,정석훈,김준명,이경원,정윤섭 대한감염학회 2009 감염과 화학요법 Vol.41 No.4
Background : Anaerobic bacteria can cause various infections, and their incidence may differ greatly, depending on the country or hospital. We investigated recent trends in anaerobe isolation and clinical characteristics of anaerobic bacteremia in one hospital in Korea to facilitate diagnosis and treatment of anaerobic infections. Materials and Methods : Anaerobic bacteria isolated from blood, body fluids and abscess specimens at a university hospital in Korea during 2007 and 2008 were analyzed. The medical records of 82 anaerobic bacteremia patients were reviewed. A retrospective cohort study was conducted to determine the risk factors for in-hospital mortality of patients with anaerobic bacteremia. Results : A total of 289 non-duplicated anaerobic isolates were recovered from blood, body fluids and abscess specimens. Bacteroides fragilis (73 isolates, 25.3%) was the most common organism followed by Clostridium perfringens (22 isolates, 7.6%), Peptoniphilus asaccharolyticus (21 isolates, 7.3%) and Anaerococcus prevotii (19 isolates, 6.6%). Eighty-four isolates were recovered from blood specimens, among which B. fragilis (24 isolates) and C. perfringens (21 isolates) were the most frequently isolated organisms. Among the 196 underlying diseases of anaerobic bacteremia patients, neoplastic, infectious, and gastrointestinal diseases accounted for 54 (27.6%), 46 (23.5%), and 41 (20.9%) cases, respectively. The alimentary tract was the most common suspected portal of entry. The in-hospital mortality rate of anaerobic bacteremia patients was 34.2%, and neutropenia at the time of blood culture was the only statistically significant factor associated with mortality in this study. Anaerobes were isolated in 1.4% of all positive blood cultures. Conclusions : B. fragilis and C. perfringens are expected to be commonly isolated from clinical specimens. Despite its low prevalence, anaerobic bacteremia displays a significant in-hospital mortality rate. Ongoing investigations into anaerobic bacteremia are necessary because of ambiguous risk factors for mortality.
Lee, Yangsoon,Park, Yongjung,Kim, Myung Sook,Yong, Dongeun,Jeong, Seok Hoon,Lee, Kyungwon,Chong, Yunsop American Society for Microbiology 2010 Antimicrobial Agents and Chemotherapy Vol.54 No.9
<B>ABSTRACT</B><P>We determined the antimicrobial susceptibilities of 255 clinical isolates of anaerobic bacteria collected in 2007 and 2008 at a tertiary-care hospital in South Korea. Piperacillin-tazobactam, cefoxitin, imipenem, and meropenem were highly active β-lactam agents against most of the isolates tested. The rates of resistance of <I>Bacteroides fragilis</I> group organisms and anaerobic Gram-positive cocci to moxifloxacin were 11 to 18% and 0 to 27%, respectively.</P>
The protease inhibitor, elafin, induces p53-dependent apoptosis in human melanoma cells
Yu, Kyung Sook,Lee, Yangsoon,Kim, Chung Mi,Park, Eui-Chul,Choi, Juhyun,Lim, Dae-Sik,Chung, Young-Hwa,Koh, Sang Seok Wiley Subscription Services, Inc., A Wiley Company 2010 International journal of cancer: Journal internati Vol.127 No.6
<P>Expression of the protease inhibitor elafin is deregulated in several human cancers. However, functions of the protein in cancer are yet to be established. Here, we show that elafin elicits pro-apoptotic effects in melanoma cells but not in normal melanocytes. Elafin triggered the intrinsic apoptotic pathway as evidenced by the increased caspase 9 activity and unaltered caspase 8 activity. Caspase 9-specific siRNA, but not caspase 8-specific siRNA, dramatically abrogated elafin-induced apoptosis. Elevated level of p53 was observed, resulting in increased transcriptional activation and consequent expression of downstream effector molecules (Bax, Puma, Noxa, p21). Moreover, the apoptotic effect of elafin was inhibited by p53-specific siRNA and the p53 inhibitor pifithrin-α. Elafin treatment of xenograft mice of melanoma cells led to significantly smaller tumor sizes compared with those of untreated control mice. Immunohistochemical analysis revealed decreased elafin expression in melanoma tissue specimens. Western blot and reverse transcription analyses indicated transcriptional repression of the elafin gene in melanoma cells. Our results collectively indicate that elafin induces apoptosis in melanoma cells through a p53-dependent intrinsic apoptotic pathway, and that repression of elafin expression in melanoma may contribute to disease progression.</P>
Expression of Lysyl Oxidase Predictive of Distant Metastasis of Laryngeal Cancer
Lee, Yoon Se,Park, Yangsoon,Kwon, Minsu,Roh, Jong-Lyel,Choi, Seung-Ho,Nam, Soon Yuhl,Kim, Sang Yoon SAGE Publications 2017 Otolaryngology-head and neck surgery Vol.156 No.3
<P>Conclusion. A high expression level of LOX is associated with lymph node and distant metastasis as well as poor prognosis among patients with laryngeal cancer.</P>