Cancer risk based on alcohol consumption levels: a comprehensive systematic review and meta-analysis

Seunghee Jun(Seunghee Jun),Hyunjin Park(Hyunjin Park),Ui-Jeong Kim(Ui-Jeong Kim),Eun Jeong Choi(Eun Jeong Choi),Hye Ah Lee(Hye Ah Lee),Bomi Park(Bomi Park),Soon Young Lee(Soon Young Lee),Sun Ha Jee(Su 한국역학회 2023 Epidemiology and Health Vol.45 No.-

OBJECTIVES: Alcohol consumption is a well-established risk factor for cancer. Despite extensive research into the relationship between alcohol consumption and cancer risk, the effect of light alcohol consumption on cancer risk remains a topic of debate. To contribute to this discourse, we conducted a comprehensive systematic review and meta-analysis. METHODS: Our systematic review aimed to investigate the associations between different levels of alcohol consumption and the risk of several cancer types. We focused on analyzing prospective associations using data from 139 cohort studies. Among them, 106 studies were included in the meta-analysis after a quantitative synthesis. RESULTS: Our analysis did not find a significant association between light alcohol consumption and all-cause cancer risk (relative risk, 1.02; 95% confidence interval, 0.99 to 1.04), but we observed a dose-response relationship. Light alcohol consumption was significantly associated with higher risks of esophageal, colorectal, and breast cancers. Light to moderate drinking was associated with elevated risks of esophageal, colorectal, laryngeal, and breast cancers. Heavy drinking was also found to contribute to the risk of stomach, liver, pancreas, and prostate cancers, thereby increasing the risk of almost all types of cancer. Additionally, females generally had lower cancer risks compared to males. CONCLUSIONS: Our findings highlight that cancer risks extend beyond heavy alcohol consumption to include light alcohol consumption as well. These findings suggest that there is no safe level of alcohol consumption associated with cancer risk. Our results underscore the importance of public health interventions addressing alcohol consumption to mitigate cancer risks.

MFC-Based Structural Health Monitoring Using a Miniaturized Impedance Measuring Chip for Corrosion Detection

Park, Seunghee,Grisso, Benjamin L.,Inman, Daniel J.,Yun, Chung-Bang SPRINGER VERLAG KG 2007 RESEARCH IN NONDESTRUCTIVE EVALUATION Vol.18 No.2

<P> This article presents an experimental study using an active sensing device that consists of a miniaturized impedance-measuring chip (AD5933) and a self-sensing macrofiber composite (MFC) patch to detect corrosion in aluminum structures widely used for aerospace, civil, and mechanical systems. A simple beam structure made from a 6063 T5 aluminum alloy was selected for corrosion-detection testing. Four different corrosion cases with two different locations and two different degrees at each location were artificially inflicted on the beam using hydrochloric (HCI) acid. To identify the degrees and locations of the corrosion, the electromechanical impedance-based damage-detection technique using the proposed active sensing device was investigated. Root-mean-square deviation (RMSD) metric of the real part of the impedances obtained from the MFC patch was selected as a damage-sensitive feature. Experimental results have verified that the proposed approach can be an effective tool for detection and quantification of corrosion in aluminum structures.</P>

Conformational Studies of Zn(Ⅱ)-binding Tallysomycin Complex by NMR

Park,Seunghee,Kim,Daesung,Won,Hoshik,Chung,Hansun 漢陽大學校 自然科學硏究所 1997 自然科學論文集 Vol.16 No.-

Zn가 항암제 tallysomycin과 착물을 형성할 때 Zn, NC3, C6등 착물의 입체구조와 연관된 가능한 키랄성을 결정하였다. NMR 실험결과는 β-aminoalanine, β-hydroxyhistidine, 그리고 pyrimidinemoiety의 질소주게와 금속과의 결합을 가지고 있음을 나타내는데, 여러 배위결합 양식에 따라 미결정된 NC3-C6의 키랄성을 결정하였다. 실험은 tallysomycin의 β-aminoalanine, sugar ring, β-hydroxyhistidine등 작용기들의 입체특이성을 고려하였다. Mannose의 carbamide, propionamide 곁가지의 수소결합 가능성과 연관된 입체구조, Zn과 H₂O의 결합에 따른 입체구조도 고려 하였다. NMR 실험결과를 기초로한 체계적인 키랄성의 결정 결과는 NC3-C6에 대하여 S-S 형태가 구조적으로 유리한 것이 얻어졌으며, 만일 NC3가 R-입체구조를 가질 경우 C6 키랄중심에 내부 strain에너지가 있어야 하는 결과를 얻었다. The systematic chirality investigations were made on the basis of the fact that zinc-binding tallysomycin (ZnTLMA) could have chiral centers (Zn, NC3, C6) at possible 4-, 5-, and 6-coordination models. Although our NMR data exhibit that the ligation sites are β-aminoalanine, β-hydroxyhistidine, and pyrimidine moiety, all possible coordination modes were tested out to see what kind of chiralities on NC3-C6 are favorable to each coordination mode. Tests were also made by considering the specific configuration of functional groups, including β-aminoalanine, sugar ring, and β-hydroxyhistidine. Tests were finally extended to zinc-water binding and specific conformational studies by introducing various hydrogen bonding networks associated with the propionamide side chain and the carbamide group of mannose. Results of systematic chirality investigations exhibit that the S-S configuration of NC3-C6 is favorable to all of coordination models, but the R-S configuration, if exist, should have internal strain on C6 chiral center.

Electro-Mechanical Impedance-Based Wireless Structural Health Monitoring Using PCA-Data Compression and <i>k</i>-means Clustering Algorithms

Park, Seunghee,Lee, Jong-Jae,Yun, Chung-Bang,Inman, Daniel J. Sage Publications 2008 Journal of intelligent material systems and struct Vol.19 No.4

<P>This article presents a practical method for an electro-mechanical impedance-based wireless structural health monitoring (SHM), which incorporates the principal component analysis (PCA)-based data compression and k-means clustering-based pattern recognition. An on-board active sensor system, which consists of a miniaturized impedance measuring chip (AD5933) and a self-sensing macro-fiber composite (MFC) patch, is utilized as a next-generation toolkit of the electromechanical impedance-based SHM system. The PCA algorithm is applied to the raw impedance data obtained from the MFC patch to enhance a local data analysis-capability of the on-board active sensor system, maintaining the essential vibration characteristics and eliminating the unwanted noises through the data compression. Then, the root-mean square-deviation (RMSD)-based damage detection result using the PCA-compressed impedances is compared with the result obtained from the raw impedance data without the PCA preprocessing. Furthermore, the k-means clustering-based unsupervised pattern recognition, employing only two principal components, is implemented. The effectiveness of the proposed methods for a practical use of the electromechanical impedance-based wireless SHM is verified through an experimental study consisting of inspecting loose bolts in a bolt-jointed aluminum structure.</P>

PZT-based active damage detection techniques for steel bridge components

Park, Seunghee,Yun, Chung-Bang,Roh, Yongrae,Lee, Jong-Jae Institute of Physics Publishing 2006 Smart materials & structures Vol.15 No.4

<P>This paper presents the results of experimental studies on piezoelectric lead-zirconate–titanate (PZT)-based active damage detection techniques for nondestructive evaluations (NDE) of steel bridge components. PZT patches offer special features suitable for real-time <I>in?situ</I> health monitoring systems for large and complex steel structures, because they are small, light, cheap, and useful as <I>built-in</I> sensor systems. Both impedance and Lamb wave methods are considered for damage detection of lab-size steel bridge members. Several damage-sensitive features are extracted: root mean square deviations (RMSD) in the impedances and wavelet coefficients (WC) of Lamb waves, and the times of flight (TOF) of Lamb waves. Advanced signal processing and pattern recognition techniques such as continuous wavelet transform (CWT) and support vector machine (SVM) are used in the current system. Firstly, PZT patches were used in conjunction with the impedance and Lamb waves to detect the presence and growth of artificial cracks on a 1/8 scale model for a vertical truss member of Seongsu Bridge, Seoul, Korea, which collapsed in 1994. The RMSD in the impedances and WC of Lamb waves were found to be good damage indicators. Secondly, two PZT patches were used to detect damage on a bolt-jointed steel plate, which was simulated by removing bolts. The correlation of the Lamb wave transmission data with the damage classified by in and out of the wave path was investigated by using the TOF and WC obtained from the Lamb wave signals. The SVM was implemented to enhance the damage identification capability of the current system. The results from the experiments showed the validity of the proposed methods. </P>

Rewritable, Printable Conducting Liquid Metal Hydrogel

Park, Jung-Eun,Kang, Han Sol,Baek, Jonghyek,Park, Tae Hyun,Oh, Seunghee,Lee, Hyungsuk,Koo, Min,Park, Cheolmin American Chemical Society 2019 ACS NANO Vol.13 No.8

<P>The development of high-performance printable electrical circuits, particularly based on liquid metals, is fundamental for device interconnection in flexible electronics, motivating numerous attempts to develop a variety of alloys and their composites. Despite their great potential, rewritable and printable electronic circuits based on liquid metals are still manufactured on demand. In this study, we demonstrate liquid metal-based hydrogels suitable for rewritable, printable electrical circuits. Our liquid metal hydrogels are based on sedimentation-induced composites of eutectic gallium-indium (EGaIn) particles in poly(ethylene glycol) diacrylate (PEGDA). The EGaIn particles are vertically phase-segregated in the PEGDA. When a composite surface with high EGaIn content is gently scratched, the surface covering PEGDA is removed, followed by the rupture of the native oxide layers of the particles, and the exposed EGaIn becomes conductive. The subsequent water-driven swelling of PEGDA on the scratched surface completely erases the conductive circuit, causing the system to reset. Our friction-responsive liquid metal hydrogel exhibits writing-erasing endurance for 20 cycles, with a dramatic change in the electrical resistance from metal (∼1 Ω) to insulator (∼10<SUP>7</SUP> Ω). By employing surface friction pen printing, we demonstrate mechanically flexible, rewritable, printable electrical conductors suitable for displays.</P> [FIG OMISSION]</BR>

A study on development of car seat thermal comfort evaluation system

( Seunghee Hong ),( Daee Kim ),( Young Seo ),( Baekhee Lee ),( Hyunkyu Park ),( Yeongsik Kim ),( Se Jin Park ) 한국감성과학회 2017 한국감성과학회 국제학술대회(ICES) Vol.2017 No.-

In the automobile industry, the technical characteristic of each component has been exploding improved. The technology level is capable of benchmarking from many manufacturers and it is possible to maintain a similar level, so recently, the sensitivity aspect given to users has emerged as an important part. Among them, the seat is in contact with the passenger's body during boarding, and it has a very close relationship to judging the comfort or discomfort. In this research, we tried to develop a seat thermal comfort evaluation method to evaluate the influence of the characteristic on the real environment and the human sensibility, based on the physical properties of the seat cover. In addition, by using the qualitative data (subjective assessment questionnaire) and quantitative evaluations (temperature / humidity, physiological signal; EEG, ECG, GSR), the validity of the evaluation method was verified. As a result, it was observed that the variation of the temperature and humidity of the seat cushion with the change of the seasons had a very significant effect on the comfort of the seat. In addition, it proved that the seat thermal comfort evaluation system satisfying the sensitivity from the physical property is valid.

Health monitoring of steel structures using impedance of thickness modes at PZT patches

Park, Seunghee,Yun, Chung-Bang,Roh, Yongrae,Lee, Jong-Jae Techno-Press 2005 Smart Structures and Systems, An International Jou Vol.1 No.4

This paper presents the results of a feasibility study on an impedance-based damage detection technique using thickness modes of piezoelectric (PZT) patches for steel structures. It is newly proposed to analyze the changes of the impedances of the thickness modes (frequency range > 1 MHz) at the PZT based on its resonant frequency shifts rather than those of the lateral modes (frequency range > 20 kHz) at the PZT based on its root mean square (RMS) deviations, since the former gives more significant variations in the resonant frequency shifts of the signals for identifying localities of small damages under the same measurement condition. In this paper, firstly, a numerical analysis was performed to understand the basics of the NDE technique using the impedance using an idealized 1-D electro-mechanical model consisting of a steel plate and a PZT patch. Then, experimental studies were carried out on two kinds of structural members of steel. Comparisons have been made between the results of crack detections using the thickness and lateral modes of the PZT patches.

Regenerative Applications Using Tooth Derived Stem Cells in Other Than Tooth Regeneration: A Literature Review

Park, Yun-Jong,Cha, Seunghee,Park, Young-Seok Hindawi Publishing Corporation 2016 Stem cells international Vol.2016 No.-

<P>Tooth derived stem cells or dental stem cells are categorized according to the location from which they are isolated and represent a promising source of cells for regenerative medicine. Originally, as one kind of mesenchymal stem cells, they are considered an alternative of bone marrow stromal cells. They share many commonalties but maintain differences. Considering their original function in development and the homeostasis of tooth structures, many applications of these cells in dentistry have aimed at tooth structure regeneration; however, the application in other than tooth structures has been attempted extensively. The availability from discarded or removed teeth can be an innate benefit as a source of autologous cells. Their origin from the neural crest results in exploitation of neurological and numerous other applications. This review briefly highlights current and future perspectives of the regenerative applications of tooth derived stem cells in areas beyond tooth regeneration.</P>

Atmospheric deposition of anthropogenic inorganic nitrogen in airborne particles and precipitation in the East Sea in the northwestern Pacific Ocean

Park, Geun-Ha,Lee, Seon-Eun,Kim, Young-il,Kim, Dongseon,Lee, Kitack,Kang, Jeongwon,Kim, Yeo-Hun,Kim, Haryun,Park, Seunghee,Kim, Tae-Wook Elsevier 2019 Science of the Total Environment Vol.681 No.-

<P><B>Abstract</B></P> <P>The atmospheric deposition of anthropogenic nitrogen is an increasingly important new source of nitrogen to the ocean. Coastal areas east of the Korean Peninsula are suitable for the investigation of the effects of atmospheric anthropogenic nitrogen on the ocean nutrient system because of the low riverine discharge rates and the prevailing influence of the East Asian outflow. Thus, we measured the concentrations of nitrate (NO<SUB>3</SUB> <SUP>−</SUP>) and ammonium (NH<SUB>4</SUB> <SUP>+</SUP>) in airborne particles and in precipitation from March 2014 to February 2016 at a coastal site (37.08°N, 129.41°E) on the east coast of Korea. The dry deposition of NO<SUB>3</SUB> <SUP>−</SUP> (27–30 mmol N m<SUP>−2</SUP> yr<SUP>−1</SUP>) was far greater than that of NH<SUB>4</SUB> <SUP>+</SUP> (6–8 mmol N m<SUP>−2</SUP> yr<SUP>−1</SUP>). The greater rate of dry NO<SUB>3</SUB> <SUP>−</SUP> deposition was associated with air masses traveling over northeastern China and central Korea. In contrast, the rates of wet deposition of NO<SUB>3</SUB> <SUP>−</SUP> (17–24 mmol N m<SUP>−2</SUP> yr<SUP>−1</SUP>) and NH<SUB>4</SUB> <SUP>+</SUP> (14–27 mmol N m<SUP>−2</SUP> yr<SUP>−1</SUP>) were comparable and were probably associated with in-cloud scavenging of these ions. The results indicate that the total deposition of NO<SUB>3</SUB> <SUP>−</SUP> and NH<SUB>4</SUB> <SUP>+</SUP> combined could contribute to ~2.4% and ~1.9% of the primary production in the coastal areas east of the Korean Peninsula and in the East Asian marginal seas, respectively, which would be a lower bound because the dry deposition of reactive nitrogen gas was not included. Our study shows that the atmospheric input of anthropogenic NO<SUB>3</SUB> <SUP>−</SUP> and NH<SUB>4</SUB> <SUP>+</SUP> may substantially increase phytoplankton biomass in the coastal waters of the East Sea near the Korean Peninsula.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Atmospheric Nitrogen Deposition (AND) was 64–89 mmol N m<SUP>−2</SUP> yr<SUP>−1</SUP> in the East Sea. </LI> <LI> AND was enhanced in air masses traveling over northeastern China and central Korea. </LI> <LI> AND could contribute to ~1.9% of the primary production of East Asian seas. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>