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Park, Seongbeom,Yoon, Uicheul The Korean Society of Medical and Biological Engin 2017 의공학회지 Vol.38 No.2
Enlargement of the lateral ventricles have been identified as a surrogate marker of neurological disorders. Quantitative measure of the lateral ventricle from MRI would enable earlier and more accurate clinical diagnosis in monitoring disease progression. Even though it requires an automated or semi-automated segmentation method for objective quantification, it is difficult to define lateral ventricles due to insufficient contrast and brightness of structural imaging. In this study, we proposed a fully automated lateral ventricle segmentation method based on a graph cuts algorithm combined with atlas-based segmentation and connected component labeling. Initially, initial seeds for graph cuts were defined by atlas-based segmentation (ATS). They were adjusted by partial volume images in order to provide accurate a priori information on graph cuts. A graph cuts algorithm is to finds a global minimum of energy with minimum cut/maximum flow algorithm function on graph. In addition, connected component labeling used to remove false ventricle regions. The proposed method was validated with the well-known tools using the dice similarity index, recall and precision values. The proposed method was significantly higher dice similarity index ($0.860{\pm}0.036$, p < 0.001) and recall ($0.833{\pm}0.037$, p < 0.001) compared with other tools. Therefore, the proposed method yielded a robust and reliable segmentation result.
Seongbeom Park,Young Hee Sung,Woo Ram Kim,Young Noh,Eung Yeop Kim 대한신경과학회 2023 Journal of Clinical Neurology Vol.19 No.2
Background and Purpose The correlation between dopamine transporter (DAT) imaging and neuromelanin-sensitive magnetic resonance imaging (NM-MRI) in early-stage Parkinson’s disease (PD) has not yet been established. This study aimed to determine the correlation between NM-MRI and DAT positron-emission tomography (PET) in patients with earlystage PD. Methods Fifty drug-naïve patients with early-stage PD who underwent both 0.8-mm isovoxel NM-MRI and DAT PET were enrolled retrospectively. Using four regions of interest (nigrosome 1 and nigrosome 2 [N1 and N2] regions) from a previous study, the contrast ratios (CRs) of 12 regions were measured: N1, N2, flipped N1, flipped N2, combined N1 and N2, and whole substantia nigra pars compacta [SNpc] (all on both sides). The clinically more affected side was separately assessed. The standardized uptake value ratios (SUVRs) were measured in the striatum using DAT PET. A partial correlation analysis was performed between the SUVR and CR measurements. Results CR of the flipped left N1 region was significantly correlated with SUVR of the right posterior putamen (p=0.047), and CR values of the left N1 region, left N2 region, flipped right N1 region, and combined left N1 and N2 regions were significantly correlated with SUVR of the left posterior putamen (p=0.011, 0.038, 0.020, and 0.010, respectively). SUVR of the left anterior putamen was significantly correlated with CR of the left N2 region (p=0.027). On the clinically more affected side, the CR values of the N1 region, combined N1 and N2 regions, and the whole SNpc were significantly correlated with SUVR of the posterior putamen (p=0.001, 0.024, and 0.021, respectively). There were significant correlations between the SUVR of the anterior putamen and the CR values of the N1 region, combined N1 and N2 regions, and whole SNpc (p=0.027, 0.001, and 0.036, respectively). Conclusions This study found that there were significant correlations between CR values in the SNpc on NM-MRI and striatal SUVR values on DAT PET on both sides in early-stage PD.
고효율 페로브스카이트 태양전지 광활성층을 위한 가압열처리 방법
이성범 ( Seongbeom Lee ),김단비 ( Danbi Kim ),정우현 ( Woo Hyeon Jeong ),양현석 ( Hyun-seock Yang ),이보람 ( Bo Ram Lee ),최효성 ( Hyosung Choi ),박성흠 ( Sung Heum Park ),손세모 ( Semo Son ) 한국화상학회 2021 한국화상학회지 Vol.27 No.1
페로브스카이트 태양전지는 빠른 속도로 효율 개선이 이루어지며 차세대 친환경 에너지원으로 각광받고 있다. 가공 매개변수의 영향을 강하게 받는 유-무기 혼합 페로브스카이트 태양전지에서 고품질의 광 활성층을 제조하는 것은 매우 중요하다. 본 연구에서는 Methylammonium Lead Iodide(MAPbI<sub>3</sub>) 광활성층 제작 시, 결정화가 이루어지는 열처리 과정에서 압력을 가함으로써 용매가 증발하는 속도를 조절할 수 있는 가압열처리 공정방법(pressure assisted annealing process, PA method)을 개발하였다. 본 연구에서 개발한 광 활성층 제조방법은 보다 오래 용매를 활성층 내에 머물게 할 수 있어서 MAPbI<sub>3</sub>의 중간단계에서 그레인의 성장을 극대화 할 수 있으며, 이를 통해 고품질 페로브스카이트 광 활성층의 제조를 가능하게 한다. 또한 본 가압열처리 방법으로 형성시킨 페로브스카이트 광 활성층을 도입하여 태양전지를 제조하였을 경우, 소자의 최고 성능은 기존의 방법으로 제조된 소자와 비교하여 24.4 mA cm<sup>-2</sup>의 높은 단락 전류밀도, 0.96 V의 개방전압, 0.75의 필 팩터를 나타내며 17.3 %의 에너지 전환효율을 나타내었다. Perovskite solar cells have been rapidly improved in device efficiency and are in the spotlight as a next-generation eco-friendly energy source. Achieving high-quality photo-active layer influenced by processing parameters is critical to the device performance of organic-inorganic hybrid perovskite solar cells. In this study, a pressure assisted annealing process (PA method) was developed to control the evaporation speed of the solvent inside perovskite layer. By applying pressure during the annealing process for crystallization of the methylammonium Lead Iodide (MAPbI<sub>3</sub>), we could control the evaporation speed of solvent to promote crystal growth of MAPbI<sub>3</sub> which enables to manufacture high-quality perovskite photo-active layers. As a result, the PA device exhibited a high PCE of ~17.3 % with significantly enhanced short-circuit current of ~24.4 mA cm<sup>-2</sup>, an open-circuit voltage of 0.96 V and a fill factor of 0.75.
배성범(Seongbeom Bae),이병욱(Byung-Ook Lee),김영기(Youngki Kim),박상진(Sangjin Park) 한국중독정신의학회 2008 중독정신의학 Vol.12 No.2
알코올 의존 환자에 대한 기존의 국내 연구에서 사회인구 학적 변인이 치료 경과에 미치는 영향에 대한 보고가 거의 없었으나 본 연구에서는 결혼 상태가 재입원 즉 재발에 상당 한 영향을 주고 있어 단주 및 지속적인 외래 치료를 유지하는데 배우자의 역할이 중요함을 생각해 볼 수 있었다. 가장 주목할 만한 본 연구의 결과로는 입원 기간 중 절대적인 단주 프로그램의 수행 횟수 및 입원 기간에 비해 단주 프로그램에 얼마나 열심히 참여했는지가 향후 치료 경과에 중요함을 알 수 있었고 이는 제독 치료만을 마치고 퇴원을 원하는 환자들에게 단주 프로그램 참여를 권하는 데 있어 객관적인 근거로 사용될 수 있을 것으로 기대된다. 또한 동반된 신체 질환이 많을수록 재입원을 많이 하는 것으로 나타난 결과를 통해 임상 각 과와의 긴밀한 치료 협력 체계 구축을 통해 타 과적 처치가 끝난 후 단주 치료로 연계함으로써 단주 치료의 기회를 더욱 늘릴 수 있을 것으로 생각되었다. Objectives:The purpose of this study was to evaluate the effect of abstinence programs on the prognosis of alcoholic patients. Other factors that might also influence the prognosis of alcohol dependence were identified. Methods:A retrospective study was done by reviewing medical records of patients diagnosed as alcohol dependent between January 1, 2001 and December 31, 2005 at the National Health Insurance Medical Center, Ilsan Hospital, and data from the records of 207 patients who have been followed up on for more than 1 year were analyzed. The data included sociodemographic information. Results:Married patients were found to have a lower readmission rate com-pared to those who were single, divorced, bereaved, and separated, and those with alcoholic liver disease were more likely to relapse. Patients who had been re-admitted had statistically lower abstinence program participation numbers and participations (rates=participation number divided by admission day). Even in the re-admission group, the abstinence period was found to be longer in patients who had participated in more abstinence pro-grams during admission. Conclusion:Participation in inpatient abstinence programs was found to be a major factor of the patients’ prognosis. The role of spouses of alcoholic patients was also found to be important in preventing their re-admission.
Size tailoring of aqueous germanium nanoparticle dispersions.
Kim, Seongbeom,Walker, Bright,Park, Song Yi,Choi, Hyosung,Ko, Seo-Jin,Jeong, Jaeki,Yun, Myoung Hee,Lee, Jeong Chul,Kim, Dong Suk,Kim, Jin Young RSC Pub 2014 Nanoscale Vol.6 No.17
<P>We demonstrate a practical route to synthesize Ge nanoparticles (NPs) in multi-gram quantities via the laser pyrolysis of GeH4 gas. The size of the as-produced Ge NPs can be precisely controlled in the range of 19.0 to 65.9 nm via a subsequent etching procedure using a dilute H2O2 solution. Stable water dispersions of Ge NPs yield particles with a Ge/GeO2 core-shell structure, however, the oxide shell can easily be removed and passivated by treatment with HCl. The feed materials used in this process are readily available and lead to non-toxic, water-based dispersions of Ge NPs. The scalability and convenience of this procedure make it attractive as a method to obtain Ge NP dispersions for use in applications such as optoelectronic devices and biosensors.</P>