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SCREENING OF BENZODIAZEPINES IN URINE BY THE IMMUNOASSAY AND QUANTITATION BY GC-NPD METHOD
Park, Jongsei,Park, Jeongeum,Park, Myung-Ja Korean Society of ToxicologyKorea Environmental Mu 1991 Toxicological Research Vol.7 No.1
We developed a simple method to determine benzodiazepines in biological samples using electron capature detectors and nitrogen-phosphorous detectors. The extraction of 13 benezodiazepines in urine at pH 9.5 with toluene and its analysis in GC/NPD showed the peaks in 9-16 min. In this retention time range, the biological backaground was fairly low and the drugs could be identified in low concentrations. The benzodiazepines in urine samples were screened by the fluorescence polarization immunoassay and positive samples were confirmed by the GC/NPD method.
Design and synthesis ofα,β-unsaturated carbonyl compounds as potential ACE inhibitors
Park Choo, Hea-Young,Peak, Kyung-Hee,Park, Jongsei,Kim, Dong Hyun,Chung, Hak Soon 梨花女子大學校 藥學硏究所 2000 藥學硏究論文集 Vol.- No.9
The α, β-unsaturated amide that is incorporated into the basic structural frame of a simple substrate molecule of angiotensin converting enzyme was found to serve as a Michael acceptor for the catalytic carboxylate of Glu-127, inhibiting the enzyme irreversibly.
Hong, Jongki,Park, Jongsei,Kim, Kang-Jin 한국분석과학회 1995 분석과학 Vol.8 No.4
Polychlorodibenzo-p-dioxins(PCDDs) have been prepared by microsacale pyrolysis of trichlorophenates. During the pyrolysis reaction, dechlorinated dibenzo-p-dioxins were also formed by the thermolysis of PCDDs. The dechlorination pathways of PCDDs were suggested in this reaction. The identification of these products was performed using capillary column gas chromatography-mass spectrometry.
Metabolism and Excretion Study of DW116, A New Fluoroquinolone, in Rats
Jung, Byung-Hwa,Park, Young-Han,Park, Jongsei,Chung, Bong-Chul The Pharmaceutical Society of Korea 1997 Archives of Pharmacal Research Vol.20 No.4
Metabolite identification and urinary and biliary excretion of the new fluoroquinolone antibacterial agent DW116 [1-(5-fluoro-2-pyridyl)-6-fluoro-7-(4-methyl-1 -piperazinyl)-1, 4-dihydro-4-oxoquinoline-3-carboxylic acid, hydrochloride] after oral administration have been studied in Sprague-Dawley rats. The excretion kinetics were monoexponential. Most of the drug was eliminated via the hepatic and renal routes. Mean renal clearance of DW116 was 73.4 ml/hr/kg and mean biliary clearance was 83.8 ml/hr/kg. The major metabolite excreted in the bile was identified as the glucuronide ester of the parent drug using base-hydrolysis of the conjugate metabolite followed by co-HPLC with standard compound, $^{19}$ F-NMR and LC-MS methods. The glucuronide conjugate was also found in urine. The mean urinary recoveries of free and total (free plus glucuronide ester) DW116 were $28.6{\pm}2.7% $and $36.4{\pm}1.8%$ of the administered dose and the corresponding biliary recoveries were $14.4{\pm} 5.5%$ and $37.0{\pm}7.6%$, respectively.