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Jinhee,Woo,Hee-Tae,Roh,Chan-Ho,Park,Byung-Kon,Yoon,Do-Yeon,Kim,Ki-Ok,Shin 한국응용과학기술학회 (구.한국유화학회) 2019 한국응용과학기술학회지 Vol.36 No.3
We investigated the effect of moderate- and high-intensity resistance training on hippocampal neurotrophic factors and peripheral CCL11 levels in high-fat diet (HFD)-induced obese mice. C57/black male mice received a 4 weeks diet of normal (control, CON; n = 9) or a high-fat diet (HF; n = 27) to induce obesity. Thereafter, the HF group was subdivided equally into the HF, HF + moderate-intensity exercise (HFME), and HF + high-intensity exercise (HFHE) groups ( n = 9, respectively), and mice were subjected to ladder-climbing exercise for 8 weeks. The hippocampal brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) levels were significantly lower in the HF group than in the CON group ( p < 0.05). In addition, in the HFME and HFHE groups were significantly higher than in the HF group ( p < 0.05). The peripheral CCL11 levels were significantly higher in the HF group than in the CON group ( p < 0.05). In addition, in the HFME and HFHE groups were significantly lower than in the HF group ( p < 0.05). However, there was no significant difference according to the exercise intensity among the groups. Collectively, these results suggest that obesity can induce down-regulation of neurotrophic factors and inhibition of neurogenesis. In contrast, regardless of exercise intensity, resistance training may have a positive effect on improving brain function by inducing increased expression of neurotrophic factors.
Jinhee,Woo,Ki-Ok,Shin,Chan-Ho,Park,Byung-Kon,Yoon,Do-Yeon,Kim,Ju-Yong,Bae,Yul-Hyo,Lee,Kangeun,Ko,Hee-Tae,Roh 한국응용과학기술학회 (구.한국유화학회) 2019 한국응용과학기술학회지 Vol.36 No.3
The purpose of this study was to investigate the effects of different types of exercise training on neurodegeneration and cognitive function in mice with impaired glucose tolerance (IGT). Thirty-six male C57BL/6 mice were randomly assigned to the control (CO, n = 9) and impaired glucose tolerance (IGT, n = 27) groups. The IGT group consumed 45% high fat diet for 4 weeks and received 40 mg/kg of streptozotocin twice in the lower abdomen to induce IGT. After the IGT induction period, the IGT group was subdivided into IGT + sedentary (IGT, n = 9), IGT + endurance exercise (IGTE, n = 9), and IGT + resistance exercise (IGTR, n = 9). The IGTE and IGTR groups performed treadmill and ladder climbing exercises 5 times per week for 8 weeks, respectively. Fasting glucose and glycated hemoglobin (HbA1c) levels were significantly higher in IGT group than in CO, IGTE, and IGTR groups ( p < 0.05). HOMA-IR was significantly higher in IGT group than CO group ( p < 0.05). Hippocampal catalase (CAT) was significantly lower in IGT group than in CO group ( p < 0.05), while beta-amyloid (Aβ) was significantly higher in IGT group than in CO group ( p < 0.05). Hippocampal tau was significantly higher in IGT group than in CO, IGTE, and IGTR groups ( p < 0.05). The Y-maze test performance for cognitive function was significantly lower in IGT group than in CO, IGTE, and IGTR groups ( p <0.05). These results suggest that IGT induces neurodegeneration and negatively affects cognitive function, while regular exercise may be effective in alleviating neurodegeneration and cognitive decline regardless of exercise type.
Analysis of Promoter Elements for Transcriptional Expression of Rat p53 Gene in Regenerating Liver
Park, Jong-sang,Choi, Jinhee,Lee, minhyung,Park, Sunhee,Song, Haisun,Yu, Sunhee The Korea Science and Technology Center 1999 BMB Reports Vol.32 No.1
We previously found three transcription factor-binding motifs in the rat p53 promoter. They are two recognition motifs of NF1-like protein (NF1-like element 1 : -296~-312, NF1-like element 2:-195~-219) and a bHLH protein binding element (-142~-146). In this study, we investigated the DNA-protein complex formation of the three elements with nuclear extracts from both normal and regenerating liver to find the element involved in the induced transcription of p53. The level of each DNA-protein complex on NF1-like and bHLH motifs was not changed. Instead, a new element located at-264~-284 was detected in the DNase I footprinting assay with regenerating nuclear extract. This element has partial homology to the AP1 consensus motif. However, the competition studies with diverse oligonucleotides suggest that the binding protein is not AP1. An in vitro transcription assay shows that this element is important for the transcriptional activation of the rat p53 promoter. Therefore, for the induced transcription of the rat p53 promoter, the-264~-284 region is required in addition to two NF1-like and one bHLH motif.
Keyword extraction for blogs based on content richness
Park, Jinhee,Kim, Jaekwang,Lee, Jee-Hyong SAGE Publications 2014 JOURNAL OF INFORMATION SCIENCE Vol.40 No.1
<P>In this paper, a method is proposed to extract topic keywords of blogs, based on the richness of content. If a blog includes rich content related to a topic word, the word can be considered as a keyword of the blog. For this purpose, a new measure, richness, is proposed, which indicates how much a blog covers the trendy subtopics of a keyword. In order to obtain trendy subtopics of keywords, we use outside topical context data – the web. Since the web includes various and trendy information, we can find popular and trendy content related to a topic. For each candidate keyword, a set of web documents is retrieved by Google, and the subtopics found in the web documents are modelled by a probabilistic approach. Based on the subtopic models, the proposed method evaluates the richness of blogs for candidate keywords, in terms of how much a blog covers the trendy subtopics of keywords. If a blog includes various contents on a word, the word needs to be chosen as one of the keywords of the blog. In the experiments, the proposed method is compared with various methods, and shows better results, in terms of hit count, trendiness and consistency.</P>
Pt Nanoparticle-Reduced Graphene Oxide Nanohybrid for Proton Exchange Membrane Fuel Cells
Park, Dae-Hwan,Jeon, Yukwon,Ok, Jinhee,Park, Jooil,Yoon, Seong-Ho,Choy, Jin-Ho,Shul, Yong-Gun American Scientific Publishers 2012 Journal of Nanoscience and Nanotechnology Vol.12 No.7
<P>A platinum nanoparticle-reduced graphene oxide (Pt-RGO) nanohybrid for proton exchange membrane fuel cell (PEMFC) application was successfully prepared. The Pt nanoparticles (Pt NPs) were deposited onto chemically converted graphene nanosheets via ethylene glycol (EG) reduction. According to the powder X-ray diffraction (XRD) pattern and transmission electron microscopy (TEM) analysis, the face-centered cubic Pt NPs (3-5 nm in diameter) were homogeneously dispersed on the RGO nanosheets. The electrochemically active surface area and PEMFC power density of the Pt-RGO nanohybrid were determined to be 33.26 m2/g and 480 mW/cm2 (maximum values), respectively, at 75 degrees C and at a relative humidity (RH) of 100% in a single-cell test experiment.</P>
Jinhee Park,Kunhyung Bae,Soo-Sung Park,Michael Seungcheol Kang 대한정형외과학회 2023 Clinics in Orthopedic Surgery Vol.15 No.3
Background: Ogden type IV tibial tuberosity fractures, defined as a type of fracture with posterior–inferior metaphyseal extension (Salter-Harris type II variant), are uncommon but challenging pediatric fractures. The purpose of this study was to investigate the clinical and radiological presentation and associated surgical outcomes. Methods: Ten previously healthy patients who had been surgically treated at the authors’ institution between 2015 and 2018 with at least 2 years of postoperative follow-up were included. Demographic, clinical, and radiological characteristics and treatment/ follow-up data were investigated. Results: All included patients were male. All injuries resulted from jump-landings. Unacceptable remaining angular deformity after closed reduction, particularly increased posterior tibial slope angle, was the leading cause of surgery. All preoperative magnetic resonance images (MRIs) showed entrapped periosteum on the anteromedial side of the proximal tibial physis. Surgical removal of the entrapped periosteum achieved successful reduction. Metaphyseal fracture angles between the fracture plane of the metaphyseal beak and the posterior tibial condyle on the axial image of MRI were relatively constant, with an average of 24.3° ± 6.0°. Mean bone age at the time of trauma was older than mean chronological age (16.4 ± 1.0 years vs. 14.6 ± 1.1 years, respectively; p = 0.005). All patients reached skeletal maturity within 2 postoperative years, with little posttraumatic residual height growth (mean, 1.6 ± 0.7 cm from injury to skeletal maturity). At final follow-up, no patients showed significant angular deformity, tibial length discrepancy, or functional deficit. Conclusions: In healthy adolescents, Ogden type IV tibial tuberosity fractures typically occur by jump-landing injuries, when they have little residual growth remaining. Therefore, accurate fracture reduction was required because of limited remodeling potential. Patients with unacceptable reduction should be investigated for entrapped periosteum on the anteromedial side of the physis because it was the primary obstacle in achieving adequate reduction.