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<i>In vitro</i> inhibitory effects of Wen‐pi‐tang‐Hab‐Wu‐ling‐san on human cytochrome P450 isoforms
Lee, H. W.,Kim, D. W.,Phapale, P. B.,Lim, M. ‐,S.,Park, J.,Seo, J. J.,Park, K. M.,Park, Y. ‐,K.,Yoon, Y. ‐,R. Blackwell Publishing Ltd 2011 Journal of clinical pharmacy and therapeutics Vol.36 No.4
<P><B>Summary</B></P><P><B>What is known and Objective: </B> Although Wen‐pi‐tang‐Hab‐Wu‐ling‐san (WHW), an oriental herbal medicine, has been prescribed for the treatment of chronic renal failure (CRF) in Korean clinics, no studies regarding WHW–drug interactions had been reported. The purpose of this study was to evaluate the possibility that WHW inhibits the catalytic activities of major cytochrome P450 (CYP) isoforms.</P><P><B>Methods: </B> The abilities of various WHW extracts to inhibit phenacetin O‐de‐ethylation (CYP1A2), tolbutamide 4‐methylhydroxylation (CYP2C9), omeprazole 4′‐hydroxylation (CYP2C19), dextromethorphan O‐demethylation (CYP2D6), chlorzoxazone 6‐hydroxylation (CYP2E1) and midazolam 1‐hydroxylation (CYP3A4) were assessed using human liver microsomes.</P><P><B>Results and Discussion: </B> WHW extract at concentrations up to 100 μ<SMALL>m</SMALL> showed negligible inhibition of the six CYP isoforms tested (CYP1A2, CYP2C9, CYP2C19, CYP2D6, CYP2E1 and CYP3A4), with apparent IC<SUB>50</SUB> values (concentration of the inhibitor causing 50% inhibition of the original enzyme activity) of 817.5, 601.6, 521.7, 310.2, 342.8 and 487.0 μg/mL, respectively.</P><P><B>What is new and Conclusion: </B> Our <I>in vitro</I> findings suggest that WHW extract at concentrations corresponding to a clinically recommended dosage range has no notable inhibitory effects on CYP isoforms. Therefore, we believe that WHW extract may be free of drug–herb interactions when co‐administered with other medicines. However, <I>in vivo</I> human studies are needed to confirm these results.</P>
Kim, J C,Ha, Y J,Roh, S A,Choi, E Y,Yoon, Y S,Kim, K P,Hong, Y S,Kim, T W,Cho, D H,Kim, S Y,Kim, Y S Nature Publishing Group 2013 The British journal of cancer Vol.108 No.9
<P><B>Background:</B></P><P>Surrogate biomarkers for metastatic colorectal cancer (mCRC) are urgently needed to achieve the best outcomes for targeted therapy.</P><P><B>Methods:</B></P><P>A clinical association analysis was performed to examine the three single-nucleotide polymorphisms (SNPs) that were previously proposed as markers of chemosensitivity to the cetuximab (124 patients) and bevacizumab regimens (100 patients) in mCRC patients. In addition, biological correlations were examined for the candidate SNPs in terms of their regulatory pathway.</P><P><B>Results:</B></P><P>For cetuximab regimens, patients homozygous for the wild-type alleles (<I>GG</I>) of <I>LIFR rs3729740</I> exhibited a 1.9 times greater overall response rate (ORR) and 1.4 months longer progression-free survival (PFS) than those homozygous or heterozygous for the mutant allele (<I>GA</I> and <I>AA</I>; <I>P</I>=0.022 and 0.027, respectively). For bevacizumab regimens, patients homozygous for the minor alleles (<I>TT</I>) of <I>ANXA11 rs1049550</I> exhibited an ORR twice as high as those homozygous or heterozygous for the ancestral allele (<I>CC</I> and <I>CT</I>; <I>P</I>=0.031). Overall response rate gain was achieved up to 10% in patients with wild-type <I>LIFR rs3729740</I> patients either with wild-type <I>KRAS</I> or skin toxicity (<I>P</I>=0.001) respectively. Specifically in clones treated with cetuximab and bevacizumab regimens, active p-ERK and MMP-9 expressions were significantly reduced in clones expressing wild-type <I>LIFR rs3729740</I> (<I>P</I>=0.044) and in those expressing minor-type <I>ANXA11 rs1049550</I> (<I>P</I>=0.007), respectively.</P><P><B>Conclusion:</B></P><P><I>LIFR rs3729740</I> and possibly <I>ANXA11 rs1049550</I> may be useful as biomarkers for predicting whether mCRC patients are sensitive to relevant target regimens, although further validation in large cohorts is needed.</P>
진행성 전신경화증 환자에서 식도관련증상과 식도 운동성과의 상호관계
송인성(I S Song),최규완(K W Choi),김정룡(C Y Kim),정영화(Y H Chung),이풍렬(P L Rhee),정현채(H C Jung),송영욱(Y W Song),이효석(H S Lee),윤용범(Y B Yoon) 대한소화기학회 1988 대한소화기학회지 Vol.20 No.3
N/A To investigate the correlation of esophageal symptoms w ith esophageal manometric parameters in patients with progressive systemic sclerosis (PSS) we tested esophageal motility in 10 patients with PSS who were admitted to Seoul National University Hospital from Feb. 1988 to Aug. 1988 and in 5 normal subjects, and we analyzed every parameters. The results were as follows: 1) 4 patients with esophageal symptoms showed marked decrease of lower esophageal sphincter pressure (LESP) (9.I+4.4 mmHg vs 27.9+8.5 mmHg; p< 0.005) while 6 patients having no esophageal symptoms showed normal LESP (29.4+4.0 mmHg vs 27.9+8.5 mmHg). 2) Normally propagating peristaltic waves were not found in the lower esophageal bodies of 4 patients who had esophagea] symptoms. On the other hand, among 6 patients without symptoms, 3 patients showed no propagating peristaltic waves while the other 3 patients showed normally propagating peristaltic waves in the lower esophagus. 3) The amplitudes of contraction waves at upper esophageal body of patients with esophageal symptoms were decreased compared with those of patients who had no esophageal symptom. (29.0+6.1 mmHg vs 21.0+4.4 mmHg; p<0.05) 4) In cases not showing normally propagating peristaltic waves, nonpropagating, hroad-based, low-amplitude contractions were found at the lower esophageal body. In conclusion, LESP is the esophageal manornetric parameter vhich seemed to be the most closely correlated with esophagea) symptoms in patients with PSS. And PSS seems to influence the upper esophageal contraction. Our data also indicates that esophageal manometry may be useful in the early detection of esophageal involvement in patients with PSS.
핵융합로용 저 방사화 페라이트강(JLF-1)의 피로균열진전 거동
윤한기(H.K. Yoon),이상필(S.P. Lee),공유식(Y.S. Kong),김사웅(S.W. Kim),박원조(W.J. Park),A.Kohyama(A. Kohyama) 대한기계학회 2002 대한기계학회 춘추학술대회 Vol.2002 No.5
The objective of this study is to investigate fatigue life and fatigue crack propagation behavior in the Reduced Activation Ferritic Steel (RAFs) JLF-I. The experiment of fatigue life for JLF-I steel have been carried out for the stress ratio R=0 at room temperature. The fatigue crack propagation behavior of the JLF-I steel was investigated by the constant-amplitude loading test for the stress ratios R=0.1, 0.3 and 0.5 respectively. The effects of stress ratios and specimen size on the fatigue crack growth behaviors for JLF-I steel were discussed within the Paris law. At room temperature, the fatigue limits of longitudinal and transverse direction to the rolling direction were 470 MPa and 490 MPa at 1X 10_7<br/> cycles. respectively. The base material of JLF-I steel showed the isotropic behavior in fatigue properties of the rolling direction and the test temperature. The fatigue crack propagation rate of a half size specimen was similar to that of a full size specimen at the stress ratios of 0.1, 0.3 and 0.5 respectively. The fatigue crack propagation behavior of this material was evaluated by using a half size specimen.
Role of Pd nanoparticles in gas sensing behaviour of Pd@In2O3 yolk-shell nanoreactors
Rai, P.,Yoon, J. W.,Kwak, C. H.,Lee, J. H. Royal Society of Chemistry 2016 Journal of Materials Chemistry A Vol.4 No.1
<P>Pd@In2O3 yolk-shell nanoparticles (NPs) were synthesized by a simple solution route using Pd@ C core-shell NPs as template and applied for gas sensing. A glucose-assisted hydrothermal method was used for the synthesis of Pd@C core-shell NPs. Pd@In2O3 yolk-shell NPs were formed after calcination (450 degrees C for 3h) of Pd@C core-shell NPs containing indium precursor. In the Pd@In2O3 yolk-shell geometry, about 50-70 nm Pd NPs were present at the periphery of an In2O3 shell (10-20 nm thickness). The In2O3 shell was composed of similar to 10 nm primary particles. The role of Pd NPs in gas sensing behavior of In2O3 has been investigated. The loading of In2O3 with Pd NPs improved the response for reducing gases, but reduced the response for oxidizing gases. The response of Pd@In2O3 yolk-shell NPs to ethanol was approximately 14 times higher than that of pure In2O3 hollow nanospheres at 350 degrees C. However, no response was recorded for NO2 for Pd@In2O3 as compared to In2O3 (resistance ratio R-s = 2.50) at 350 degrees C. The maximum response of Pd@In2O3 yolk-shell NPs to 5 ppm ethanol was 159.02 at 350 degrees C, which was approximately 2.5 times higher than those for other interfering gases (NO2, p-xylene, trimethylamine, HCHO, CO and H-2). The effect of humidity on the gas sensing characteristics of Pd@In2O3 yolk-shell NPs suggested that the present sensor can be used to detect ppm-level ethanol even in highly humid atmosphere (80% RH). The improved gas sensing performance of Pd@In2O3 yolk-shell NPs was attributed to catalytic activity of Pd NPs as well as hollow spaces that allowed the accessibility of Pd NPs to gas molecules.</P>