Mg₂SiO₄ : La, Ho 열형광선량계에서 활성제 농도가 글로우 커브에 미치는 영향 La, Ho TLD on Activation Concentration

김영국,손인호,채건식,노경석,오재근,이은숙 경남대학교 신소재연구소 1996 論文集 Vol.6 No.-

본 연구에서는 Mg₂SiO₄에 활성화 물질로 La, Ho를 첨가하여 열형광체를 제작하였고 불순물의 농도를 1wt.% ∼5 wt.%까지 변화시키면서 열평광강도의 glow curve를 측정하였다. 도한 열형광체의 glow curve를 peak shape법으로 분석해서 TL특성에 대한 포획 매개변수와 활성화 에너지, 발광차수, 선량의존성등을 조사하였으며, 그 물리적 특성을 조사하고 선량계로서 타당성과 실용성을 확인하였다. The Mg₂SiO₄: La, Ho thermoluminescent phospher has been prepared by sintring Mg₂SiO₄after doping the transition elements La and Ho. The heating rate is 10℃/sec at this thermoluminescent phospher are heated. The maximum peaks are found in the measured Mg₂SiO₄: La and Ho. TL glow curve at 229℃ and 345 C when the 1 wt.%-5 wt.%. The glow curve of TLD increased TL intensity and temperature of peak appears to the high temperature when the heating rate is l0℃/sec-25℃/sec. The activation energy of the main peak has been estimated by the peak shape method. The estimated activation energies are 1.77 eV. 1.52 eV respectively. The thermoluminescence process in Mg₂SiO₄: La and Ho are found to the 2nd order when the main peak of the glow curve is analyzed by peak shape method. The dose responses of Mg₂SiO₄: La and Ho TLD are linear up to intensity of X-ray.

ERK1/2 activation in quercetin-treated BEAS-2B cell plays a role in Nrf2-driven HO-1 expression

이윤진,Jun-Hwan Song,Myung-Ho Oh,Yong-Jin Lee,김용배,Jae-Hyuk Im,이상한 대한독성 유전단백체 학회 2011 Molecular & cellular toxicology Vol.7 No.4

Quercetin, a member of the flavonoids,has been heralded as chemopreventive agent, generally because of its free radical-scavenging and antiproliferative activities. In this process, NF-E2-related factor-2 (Nrf2) plays a role in protecting cells from oxidative damage; however, the exact mechanisms in which bronchial epithelial cells respond to quercetin by activating Nrf2 are not fully understood. Here, we report the role of extracellular signal-regulated kinase (ERK) activation in response to quercetin. Quercetin treatment decreased the viability of human bronchial epithelial BEAS-2B cells in a dose- and time-dependent manner. ERK1/2 was activated within 10 min of quercetin addition and then remained increased above control level throughout 48 h, whereas AKT phosphorylation was suppressed from the first 1 h of quercetin treatment. Inhibition of Erk1/2 phosphorylation attenuated quercetin-induced loss of cell viability. Nrf2levels in both nuclear and whole cell lysates increased after quercetin treatment and was accompanied by the increase of heme oxygenase-1 (HO-1) protein level,indicating that increased HO-1 expression is Nrf2-mediated. Activation of the Nrf2/HO-1 system after quercetin treatment was suppressed by the pretreatment with MEK inhibitor, PD98059. Also, silencing Nrf2 with siRNA decreased cell viability and augmented cytotoxic effect of anticancer drug LBH589. Overall, our results indicate that quercetin induces the up-regulation of Nrf2-mediated HO-1 expression, at least in part, via MEK/ERK1/2 signaling, as an adaptive mechanism which may provide advantages for cell proliferation and enhance survival despite endogenous and/or exogenous oxidative insults.

Anti-Inflammatory and Cytoprotective Effects of TMC-256C1 from Marine-Derived Fungus <i>Aspergillus</i> sp. SF-6354 via up-Regulation of Heme Oxygenase-1 in Murine Hippocampal and Microglial Cell Lines

Kim, Dong-Cheol,Cho, Kwang-Ho,Ko, Wonmin,Yoon, Chi-Su,Sohn, Jae Hak,Yim, Joung Han,Kim, Youn-Chul,Oh, Hyuncheol MDPI AG 2016 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Vol.17 No.4

<P>In the course of searching for bioactive secondary metabolites from marine fungi, TMC-256C1 was isolated from an ethyl acetate extract of the marine-derived fungus <I>Aspergillus</I> sp. SF6354. TMC-256C1 displayed anti-neuroinflammatory effect in BV2 microglial cells induced by lipopolysaccharides (LPS) as well as neuroprotective effect against glutamate-stimulated neurotoxicity in mouse hippocampal HT22 cells. TMC-256C1 was shown to develop a cellular resistance to oxidative damage caused by glutamate-induced cytotoxicity and reactive oxygen species (ROS) generation in HT22 cells, and suppress the inflammation process in LPS-stimulated BV2 cells. Furthermore, the neuroprotective and anti-neuroinflammatory activities of TMC-256C1 were associated with upregulated expression of heme oxygenase (HO)-1 and nuclear translocation of nuclear factor-E2-related factor 2 (Nrf2) in HT22 and BV2 cells. We also found that TMC-256C1 activated p38 mitogen-activated protein kinases (MAPK) and phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathways in HT22 and BV2 cells. These results demonstrated that TMC-256C1 activates HO-1 protein expression, probably by increasing nuclear Nrf2 levels via the activation of the p38 MAPK and PI3K/Akt pathways.</P>

폴리에틸렌 글리콜과 아세트산의 에스테르화 반응을 통한 메조포러스 TiO_2의 제조 및 광촉매 산화반응에의 적용

오송택,최재석,이한수,이호인 한국공업화학회 2003 응용화학 Vol.7 No.1

TiO_2 was prepared through esterification between polyethlene glycol(PEG)and actic acid, and was applied to the photocatalytic decomposition of 2-isopropy1-6-nrthy1-4-pyrimidinol. Photocatalytic activity was increased with the increase of pore size which was produced by prmoving PEG diring calcination When excess amout of H_2O was added the catalytic removing PEG during calcination When excess amout of H_2O was added, the catalytic activtiy and pore size dercased as a result of direct hydrolsis vetween titanium precursor and water added. When the amount of PEG increased, esterification occurred more but the activity and the surface area of TiO_2 were derased, esterification because of agglomeration among PEG molecules.

SAW를 이용한 ZnSe의 TAV 연구

오재근,손인호,채건식,김영국 경남대학교 환경문제연구소 1993 환경연구 Vol.15 No.-

The energy gap in ZnSe sing1e crystal epilayer have been studied by measuring Transverse Acoustoelectric Voltage(TAV). The energy gap of ZnSe was 2.6eV at room temperature. Trap levels were calculated by Heating rate, Peak shape and Initial rise methods respectively. Also we can calculated cross section of ZnSe.

턱끝절골술 : 189명에 대한 고찰

오갑성,백룡민,이태일,임재호,백세민 대한미용성형외과학회 1997 Archives of Aesthetic Plastic Surgery Vol.3 No.1

The chin plays a decisive role in the contour of the lower face. And harmonious jaw will correspond to good facial profile and positive image. Osseous genioplasty is a widely used method to correct the 3-dimensional(sagittal, vertical, transverse) deformity of the chin with minimal complications. During an 8 year period from 1988, the authors at the In-Je University Seoul Paik Hospital experienced 198 patients of osseous genioplasty. Results of clinical analysis are as follows: 1)Mail to female ratio was 1 : 3 with female being predoniment. The average age was 24.9 years. 2) Horizontal advancement genioplasty in 169 cases was the most common precedure with 7.0mm of average advancement. There was 4 cases of horizontal retrusion with average retrusion of 4.3mm. 52 cases had vertical augmentation with average of 7.5mm increase. 9 cases had vertical reduction with average redution of 4.9mm. 3) Although malocclusion is not necessarilly contraindication to genioplasty alone, genioplasty following surgical with or without orthodontical correction of malocclusion is the way to get better result with patient satisfaction. 4) 77% of the patients had adjunctive procedures simultaneously to acheive a better contour and profile 5) Complications such as hematoma, infection, fracture, nerve damage were minimal.

외상성 뇌손상 심도에 따른 인지 장애와 시간 경과 후 변화

박재설,오상우,노승호 圓光大學校 醫科大學 神經精神科學敎室 2000 圓光精神醫學 Vol.16 No.1

급성전골수성백혈병에서 백혈구성분채집술에 이은 치명적인 뇌출혈 2예

오윤정,박소윤,김윤정,한동석,김현수,최진혁,남동기,임호영,김효철,주희재 아주대학교 의과학연구소 1998 아주의학 Vol.3 No.1

The aim of this study is to report 2 cases of acute promyelocytic leukemia who died from intracranial hemorrhage following leukapheresis and to provide proper preventive measures against hemorrhage following leukapheresis. From 1994 to 1997, a total of twenty-six patients with leukemia underwent leukapheresis to control hyperleukocytosis at Ajou University Hospital. Two patients with acute promyelocytic leukemia received all-trans retinoic acid but developed drug-induced hyperleukocytosis. Shortly after leukapheresis, they died from intracranial hemorrhage. The risk factors for fatal hemorrhage are thought to be coexisting disseminated intravascular coagulation(DIC), thrombocytopenia aggravated by leukapheresis, exacerbated coagulopathy related to mechanical trauma through leukapheresis and the excess use of citrate during leukapheresis. To reduce the risk of the bleeding associated with leukapheresis, it is necessary to replace platelet sufficiently before and after leukapheresis and to give calcium to correct coagulopathy induced by excess citrate which is used as anticoagulant as well as the correction of disseminated intravascular coagulation.

새로운 행정의 관리방식으로서의 Governance의 이해와 적용

오시환,이재호 진주여자전문대학 1998 論文集 Vol.21 No.-

The study of this purpose is to explore the concept and application of governance. Government and government leaders continue attempting to find a better way of governing. The term Governance refers to a change in the meaning of government. In contemporary public administration, the concept of choice is governance. There are many uses of governance. For example, it refers minimal state, corporate governance. The study stipulate one meaning to show how the term can contribute to the analysis of change in contemporary public administration. It means the new public management. To apply governance the four models and the four dimensions of evaluation are used : Market Government, Participate Government, Flexible Government, and Deregulated Government. A careful look at the dimensions of change should enable readers to understand the strengths, weakness, implications, and interactions of the four models as well as of the specific reforms that are derived from them. Four emerging visions of governance each contain some conception of the public interest and an overall idea of what constitutes good government.

複合組織鋼이 腐蝕疲勞크랙傳播特性에 미치는 食鹽水 濃度의 影響

吳世旭,姜鎬珉,兪在煥 東亞大學校 海洋資源硏究所 1989 硏究論文集 Vol.2 No.1

The corrosion fatigue test was performed under rotated bending in salt solution having a concentration from 0.01 wt percent to 3.5 wt percent to investigate the corrosion fatigue crack propagation characteristics for dual phase steel. Corrosion pits were occurred in martensite, and microcracks occurred at corrosion pits were selectively propagated towared martensite because slip bands were not found in ferrite which were encapsulated by martensite. The number of corrosion pits, the diameter of corrosion pits and the length of corrosion cracks for M.E.F. and raw material(R.M)were increased with the concentration of salt solution and the number of cycles. The initiation of crack was almost same regardless of the concentration of salt solution; approximately N??/N??=20% in case of M.E.F. and N??/N??=14% in case of raw material (R.M.) The difference of corrosion fatigue crack propagation was increased with an increase in concentration of salt solution. The corrosion resistance effect of dual phase steel was smaller than that of raw material (R.M.) in corrosion fatigue crack propagation rate.