Deeper Wrinkle Formation and Less Melanin Production in Aged Korean Women with B Blood Type

( Jang-hee Oh ),( Inn-gyung Oh ),( Chi-hyun Park ),( Min Kyeong Shin ),( Se-rah Lee ),( Dong Hun Lee ),( Mira Choi ),( Seon-pil Jin ),( Hyun-sun Yoon ),( Soyun Cho ),( Jin Ho Chung ) 대한피부과학회 2018 Annals of Dermatology Vol.30 No.3

목향(木香)과 차전초(車前草)가 위암세포(胃癌細胞)의 활성(活性), 증식(增殖), 자기살해능(自己殺害能) 및 세포주기관련 유전자 발현에 미치는 영향

오희라,고성규,Oh, Hee-Rah,Ko, Seong-Gyu 대한암한의학회 2001 大韓癌韓醫學會誌 Vol.7 No.1

Objective: This experimental study was carried out to evaluate the effects of Saussurea Radix and Plantaginis Herba on cellular viability, proliferation, apoptosis and expression of the cell cycle-related genes in cultured gastric cancer cells. Method :MTT assay for analysis of cellular toxicity and the effect on suppression of cellular viability, $[^{3}H]$ thymidine incorporation assay for evaluation of the effect on suppression of DNA replication, tryphan blue exclusion assay for measurement of induction of apoptosis and Quantitative RT-PCR for analysis of the effects on expression of cell cycle or apoptosis-related genes were performed. Results: Antitumor activity of Saussurea Radix associated with inhibition of cell cycle progression and promotion of apoptosis caused by transcriptional regulation of p53, p21/Wafl and the other related genes was observed.

Transcaruncular Approach to Blowout Fractures of the Medial Orbital Wall

Joo yeon Oh,Sang hoon Rah,Yoon hee Kim 대한안과학회 2003 Korean Journal of Ophthalmology Vol.17 No.1

Transcutaneous and transconjunctival approaches are still frequently used to repair orbital wall fractures. However, medial orbital wall fracture remains a challenging area for plastic surgeons due to technical difficulties and postoperative scars. The transcaruncular approach is described and we present our experience with this approach to access the medial orbital wall in 10 patients with blowout fracture in the medial orbital region. All patients were corrected satisfactorily without cutaneous scar. The transcaruncular approach is a useful technique to repair medial orbital wall fractures.

정형 및 비정형 빅데이터를 이용한 양파 소비 예측

나형철(HyungChul Rah),오은화(Eunhwa Oh),유도일(Do-il Yoo),조완섭(Wan-Sup Cho),아지즈 나스리디노프(Aziz Nasridinov),박성호(Sungho Park),조용빈(Youngbeen Cho),류관희(Kwan-Hee Yoo) 한국콘텐츠학회 2018 한국콘텐츠학회논문지 Vol.18 No.11

인터넷 시대를 살아가는 현대인의 식품 소비는 다양한 대충 매체 및 소셜 미디어를 통해 신속하고 방대한 정보 전달에 영향을 받는 것으로 알려져 있다. 2018년 4월 국내 언론 보도에 따르면, 양파 재배 면적이 증가하고 양파 생산량이 증가할 것으로 예상되며, 이후에 양파 가격은 폭락할 것으로 예상되었다. 이러한 상황을 고려하여 SNS, 인터넷 정보 검색, 방송 프로그램에서 언급된 양파 관련 정보를 분석하여, 실제 가격폭락이 발생하기 전에, 양파 소비를 촉진할 수 있는 요인을 파악할 필요가 있다. 2018년 양파 생산량 증가에 따른 양파 가격 폭락이 예상되는 상황에, 가장 최근 양파 생산량 증가에 따라 가격 폭락을 경험하였던 2014년의 방송 프로그램 및 SNS가 양파 소비와 연계되었는지 파악하고자, 양파 소비 촉진과 관련된 정형 및 비정형 빅데이터를 수집하여, 양파 소비 촉진과 관련된 변수를 찾아 양파 가격 하락이 예상되는 2018년에 소비 촉진에 활용하고자 본 연구를 수행하였다. 연구 결과, 방송 뉴스의 양파 언급 기사 수(3~6주), 양파와 건강을 언급하는 방송 프로그램 수(11주), 양파의 효능을 언급하는 블로그의 댓글 빈도(5주)가 양파 구매금액 증가에 시차를 두고 양의 상관관계를 갖는 것을 확인한 본 연구 결과를 근거로, 양파 생산량 증가에 따른 양파 가격 폭락 시, 양파 소비 촉진을 위한 홍보에, 뉴스, 먹방, 쿡방 등의 방송 프로그램 및 블로그 등의 매체를 활용하는 소비촉진에 기여할 것으로 여겨진다. The social media data and the broadcasting data related to onion as well as agri-food consumer panel data were collected and investigated if the amount of money spent to purchase onion in year 2014 when onion price plunged latest were correlated with the frequencies of onion-related keywords in the social media data and the broadcasting programs because onion price in year 2018 is expected to plunge due to overproduction and there has been needs to analyze impacts of social media and broadcasting program on onion purchase in the previous similar events, and identify potential factors that can promote onion consumption in advance. What we identified from our study include a) broadcasting news programs mentioning words “onion,” were correlated with onion purchase with 3 - 6 weeks in advance; b) broadcasting entertainment programs mentioning words “onion and health,” were correlated with onion purchase with 11 weeks in advance; c) blog mentioning words “onion and efficacy,” were correlated with onion purchase with 5 weeks in advance. Our study provided a case on how social media and broadcasting programs could be analyzed for their effects on consumer purchase behavior using big data collection and analysis in the field of agriculture. We propose to use the findings from the study may be applied to promote onion consumption.

Study on Dosimetric Properties of Radiophotoluminescent Glass Rod Detector

Jeong Eun Rah,Dong Oh Shin,Jy Young Hong,Hee Sun Kim,Chun Il Lim,Hee Gyo Jeong,Tea Suk Suh 대한방사선방어학회 2006 방사선방어학회지 Vol.31 No.4

Apoptosis and Anti-proliferaction by Saussurea lappa and Pharbitis nil in AGS Human Gastric Cancer Cell Line

Ko Seong-Gyu,Oh Hee-Rah,Lee Sun-Dong,Hwang Gwi-Seo The Society of Internal Korean Medicine 2003 大韓韓方內科學會誌 Vol.24 No.1

Objectives : We performed this study to understand the molecular basis of the antitumor effect of Saussurea lappa, Pharbitis nil, Plantago asiatica and Taraxacum mongolicum, which have been used for cancer treatment in Korean traditional medicine. Design: We analyzed, the effect of these medicinal herbs on proliferation and apoptosis of tumor cells and its association with gene expression, We performed semi-quantitative reverse transcription-polymerase chain reaction(RT-PCR) analysis of cell cycle- and apoptosis-related genes using a gastric cancer cell line AGS. Results : Cell counting assay and $[^3H]thymidine$ uptake analysis showed that Saussurea lappa and Pharbitis nil strongly inhibit cell proliferation of AGS in a dose-dependent manner. Interestingly, gene espression assay revealed that mRNA espression levels of c-Jun, c-Fos, c-Myc, and Cyclin D1 were markedly decreased by Saussurea lappa and Pharbitis nil. Furthermore, Saussurea lappa was identified to activate expression of the p53 tumor suppressor and its downstream effector $p21^{Wafl}$, which leads to $G_1$ cell cycle arrest and apoptosis. These observations suggest that the anticancer effect of Saussurea lappa and Pharbitis nil might be associated with their regulatory capability of tumor-related gene expression.

急性期 腦卒中 患者의 機能回復度에 대한 臨床的 考察 : MBI, MAS를 이용하여

高性奎,吳熙羅 대한한방성인병학회 1997 韓方成人病學會誌 Vol.3 No.1

To evaluate objective validity of Oriental-medicine theraputic effect on the cerebrovascular accident, the functional improvements in Activities of Daily Living (ADL) and motor function were investigated using the score of Modified Barthel Index(MBI) and Motor Assessment Scale(MAS) in 34 acute stroke patients, which had been admitted to the Internal medicine department of Sang Ji Oriental Hospital from Novemver 1st 1996 to April 30th 1997. *상지대학교 한의과대학 부속병원 순환기내과학 교실 The results were as follows; 1. The changes in MBI and MAS scores at the time of admission, at 1 week and 2 weeks after have high correlations and statistically meaningful improvements and also by each Items. For 2 weeks after onset, there were functional improvements above 50% in both scales and more prominent improvements in the group of totally dependent. 2. On the changes in MBI and MAS scores by age, sex, cause of stroke, type of motor plegia and each Sasang constitution of inpatients in each groups, there were no statistically meaningful differences. 3. By site and size of lesion in the brain, there were statistically better high scores in the group of deep lesion than the mixed lesion, small lesion than large lesion on the changes in MAS scores after 2weeks, but there were no statistically meaningful differences on the changes in MBI scores. 4. As there was no statistically meaningful differences between changes in MBI and MAS scores by MBI scores at the time of admission, it has been found that functional state in the acute stage of stroke is not necessarily in proportion to prognosis in this study.

교정정수 변화에 의한 원통형이온함의 안정성 평가

라정은(Jeong Eun Rah),홍주영(Ju Young Hong),김귀야(Gwe Ya Kim),임천일(Chun il Lim),정희교(Hee Kyo Jeong),신동오(Dong Oh Shin),서태석(Tea Suk Suh) 대한방사선종양학회 2006 Radiation Oncology Journal Vol.24 No.2

목 적: 식품의약품안전청(Korea Food Drug Administration, KFDA)의 도움을 받아 1998년부터 2004년까지 장기 간에 걸친 교정정수의 분석을 통해 원통형이온함의 모델별 안정성을 확인하고자 한다. 대상 및 방법: 치료방사선기관에서 교정을 의뢰한 이온함 중 Farmer형의 원통형이온함만을 대상으로 하였으며 모델은 PTW사의 30001 (30006), 30013, 30002, 30004, 23333과 Capintec사의 PR06C, NE사의 2571, Exradin사의 A12 그리고 Wellhofer사의 FC65G (IC70) 등 총 9개 종류의 이온함에 대해 에어커마 교정정수 및 물흡수 선량 교정정수를 분석하였으며 에어커마 교정정수를 이용하여 계산한 물흡수선량 교정정수(cal. ND,W)와 실제측정에 의해 결정된 물흡수선량 교정정수(mea. ND,W)를 상호 비교하였다. 결 과: 교정정수 변화를 분석해 본 결과, PTW사의 30013 (30006), Wellhofer사의 FC65G (IC70) 그리고 NE사의 2571 이온함의 경우 측정 표준편차 0.2% 이내에서 잘 일치하여 다른 모델의 이온함에 비해 안정된 값을 가지는 것으로 나타났으며 계산에 의한 물흡수선량 교정정수와 실제 측정에 의해 결정된 물흡수선량 교정정수를 비교 분석한 결과는 모든 이온함에서 측정에 의한 물흡수선량 교정정수가 약 1.0% 큰 것으로 나타났다.결 론: 본 연구에서는 원통형이온함의 교정정수 값들에 대하여 장기간의 안정성 평가를 토대로 임상에서 요구되는 이온함의 선택 기준을 제시함으로써 표준체계에 따른 이온함의 선택 및 선량측정의 정확성을 향상시킬 것으로 기대한다. Purpose: To analyze the long-term stability of Farmer-type cylindrical ionization chambers by calibration factor provided from the KFDA (Korea Food Drug Administration) Materials and Methods: The cylindrical ionization chambers used in this study were the PTW 30001 (30006), 30013, 30002, 30004, 23333, the Capintec PR06C, the NE 2571, the Exradin A12 and the Wellhofer FC65G (IC70). We were analyzed that the Nk and ND,W calibration factor for the cylindrical chambers and compared between the measured ND,W and calculated ND,W calibration factor. Results: We have observed that the long-term stability of the PTW 30013 (30006), the Wellhofer FC65G (IC70) and the NE 2571 has varied within 0.2%. The measured ND,W calibration factor was about 1.0% higher than the calculated ND,W that determined by the Nk calibration factor. Conclusion: The study has evaluated that the long-term stability of the cylindrical chambers through analysis for the Nk and ND,W calibration factor. It has contributed to the improvement of clinical electron dosimetry in radiotherapy centers.

Beneficial effects of blood group antigen synthesis- increasing natural plant extracts and monosaccharides on extracellular matrix protein production in vivo

( Mira Choi ),( Jang Hee Oh ),( Min Kyeong Shin ),( Se Rah Lee ),( Dong Hun Lee ),( Seon Pil Jin ),( Soyun Cho ),( Jin Ho Chung ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.2

Background: Recent study has indicated that expression of ABO blood group (ABH) antigens are reduced in the sun exposed skin, suggesting that ABH antigens may be implicated in photoaging process. Objectives: To investigate the potential effects of ABH antigen synthesis-increasing molecules on the extracellular matrix protein production in human skin, which are mixtures of 5 natural plant extracts (Camellia sinensis leaf extract, Polygonum cuspidatum root extract, Ginkgo biloba leaf extract, Cynara scolymus leaf extract, Selaginellatamariscina extract) and 5 monosaccharides (D-Glucose, D-Galactose, L-fucose, N-acetyl-D-glucosamine, N-acetyl-D-galactosamine). Methods: Effects of one-time topical application with composition TYPE I (5 natural plant extracts) and TYPE II (5 monosaccharides) to the human buttock skin (n=6) and 24-week application with TYPE III (all of the ingredients) to the facial skin (n=22 for each) on extracellular matrix (ECM) protein expressions, wrinkle, and elasticity were determined by immunohistochemistry, Skin Viosiometer, and Cutometer. Results: One-time application of TYPE I and II increased perlecan and fibrillin-1 staining, respectively. 24-week application of TYPE III showed no significantimprovement of wrinkle and elasticity. However, it increased procollagen 1メ, tropoelastin, and fibrillin-1staining. Conclusion: These results suggest that these ingredients may help ECM protein production in human skin by long-term application for anti-aging cosmetic products.

Advanced Pharmacotherapy Evidenced by Pathogenesis of Autism Spectrum Disorder

Yeon Jung Lee,Soo Hyun Oh,Chan min Park,Min ha Hong,Ah Rah Lee,Hee Jeong Yoo,Chan Young Shin,Keun Ah Cheon,Geon Ho Bahn 대한정신약물학회 2014 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.12 No.1

In clinical practice, pharmacological treatment is mostly focused on behavioral symptoms in everyday life. Nevertheless, persistent effort continues to develop medication for causal treatment. Recent changes in diagnostic criteria from Diagnostic and Statistical Manual of Mental Disorders, 4th edition, text revision (DSM-IV-TR) to DSM-5 would affect not only diagnosing approaches, but also therapeutic approaches. Because previous pervasive developmental disorders have been integrated into a single entity, the autism spectrum disorder (ASD), we have to prepare for what medications are valuable for the ASD. In this article, we reviewed the following etiological treatment: acetylcholine and glutamate related medicine; amino acid medicine such as secretin, endogenous opioid, and oxytocin; complementary and alternative medicine such as chelating agents, vitamins, and omega-3; promising drugs related to the scope of pharmacogenetics currently under study.