폐부종과 심정지가 발생한 페노바비탈 중독환자

오동렬,이운정,박규남,김세경,김영민,이환,유은영,최경호,정시경 大韓應急醫學會 1999 대한응급의학회지 Vol.10 No.2

Phenobarbital is a long-acting barbiturate causing generalized depression of neuronal activity in the brain. Its effect is primarily achieved through enhanced GABA-mediated synaptic inhibition. Its use as an antiepileptic agent was first described in 1912. Before the introduction of phenytoin, phenobarbital is used as sedative-hypnotics. It is used for the treatment of epilepsy and status epilepticus. All barbiturates, including phenobarbital, have a high potential for abuse. They were frequently used for suicide attempts in the past, but they have in large part been replaced by benzodiazepines. The onset of symptoms depends on the drug and the route of administration. Mild to moderate barbiturate intoxication resembles ethanol inebriation with slurred speech, ataxia, and lethargy. Severe acute barbiturate intoxication is life threatening. Early deaths are generally cardiovascular-related. Hypotension, shock, pulmonary edema, and cardiac arrest that occurs with large doses are caused by depression of central sympathetic tone and as well as by direct depression of cardiac contractility. The potentially fatal oral dose of phenobarbital is 6-10g. We describe an 23-year-old woman with pulmonary edema, and cardiac arrest ingestion of 18grams of phenobarbital. She was completely recovered by successful cardiopulmonary resuscitation and homoperfusion. We report a case with literature review.

두개강내 해면상혈관종의 임상양상 및 수술적 치료의 효용

오창완,정영섭,김동규,백선하,조병규,왕규창,한대희 대한신경외과학회 1997 Journal of Korean neurosurgical society Vol.26 No.6

抗精神病藥物에 依한 無顆粒細胞症 治驗 1例

吳東財,申榮宇,張煥一,趙京杉,朴康圭 大韓神經精神醫學會 1985 신경정신의학 Vol.24 No.1

The authors experienced a female schizophrenic patient who revealed severely decreased leucocytes (350/㎣) with the manifestation of high fever, chillness and sore throat after the oral administration of neuroleptics. Agranulocytosis induced with the use of neuroleptic drugs has been well known complication in psychiatric practice although it is quite rare. In this case, following the combined use of neuroleptics (thioridazine halopondol and chlorproonazine), severe decrement of leucocytes (mainly lymphocytes with few neutrophils) was noticed on peripheral blood and marked decrement of erythroid series, especially of myeloid series, with decrement of total cellular elements were confirmed through the biopsy of bone marrow. She did not responded at all to the massive administration of antibiotics, but dramatic improvement was noticed both clinically and in the follow-up biopsy findings of bone marrow after two times trial of leukapheresis.

청년에서 발생한 외상성 및 자발성 두개내 동맥 박리에 의한 허혈성 뇌경색

이동국,서상일,김태일,곽규호,도진국,김미숙,오희종 대한신경과학회 1998 대한신경과학회지 Vol.16 No.2

合成洗劑 生分解 및 環境毒性에 관한 硏究

朱興珪,崔圭行,吳東植 조선대학교 약학연구소 1990 藥學硏究誌 Vol.12 No.1

Alkyl benzene sulfonate, Persists for long Periods in stream because of its resistance to biologic degradation. Its biodegradation is varied in the environment. This investigation was undertaken in oder to know the biodegradation of synthetic detergents which are comprising soft and hard form from may to september 1990. The biodegradation by settling, aeration and activated sludge were determined. The reduction rates of ABS were 22.92%, 10.05% by settlings for 5 days at 25℃ and 52.20%, 82.74% by aeration and average rate 90.98% of LAS by the activated sludge processing. When activated sludge Processing is carried out in the 30% of LAS, the significant downfall of the biodegradation rate to 87.59% is caused by the withering up of bacteria activity as the poison of LAS directly affects microorganism. In dealing with the TLm of LAS systemed synthetic detergent during 24 hours has revealed 40 ppm and the TLm during 48 hours has revealed 24 ppm.

마취흰쥐에서 天麻鉤藤飮의 心血管作用에 對한 硏究

배남규,문석재,임동윤,권오성 대한본초학회 1997 大韓本草學會誌 Vol.12 No.2

The present study was attempted to investigate the cardiovascular effects of Cheonmagudeumg-Eum (CMGDE), which is known to be one of chinese medical prescriptions used in treatment of hypertension, in the anesthetized rats and to clarify the mechanism of its pharmacological action, making use of its water extract. 1. CMGDE (5-45 ㎎/㎏), given into a femoral vein of the rat, produced a dose-dependent hypotensive and bradycardic responses while even much larger doses of it (10-90 ㎎/㎏), given into the rectum, did induced negligible hypotensive responses. 2. CMGDE-induced depressor responses were inhibited greatly by pretreatment with phentolamine (an adrenergic α-receptor antagonist), but not by pretreatment with atropine (an antimuscarinic agent) and chlorisondamine (an autonomic ganglionic blocker). 3. Pressor responses evoked by intravenous norepinephrine were attenuated significantly by pretreatment of CMGDE-infusion with a rate of 45㎎/㎏/20min. 4. In the rat aortic strips, phenylephrine (an adrenergic α1-receptor agonist) and high potassium (a membrane depolarizing agent) caused potent contractile responses, respectively. However, in the presence of CMGDE (2㎎/㎖), the contractile responses of phenylephrine (10-5M) and high potassium (5.6×10 exp (-2)M) were markedly inhibited. Taken together, these experimental results suggest strongly that Cheonmagudeung-Eum may cause the hypotensive responses in the anesthetized normotensive rat, indicating that this cardiovascular effects of CMGDE is likely due to the blockade of adrenergic α-receptors without cholinergic effects.

最近 8年間의 精神神經科 入院 外來 및 患者에 對한 統計的 考察(1960年∼1967年)

李哲奎,盧英一,張煥一,金明源,任允明,韓東洙,吳承煥,金光日 大韓神經精神醫學會 1969 신경정신의학 Vol.8 No.1

1) The number of the out-and in-patients had increased year after year (Table Ⅰ & Ⅲ). 2) Schizophrenia was the greatest number of the in-patients and its rate to whole was 49.1 percent, and neurosis was the greatest number of the out-patients and its rate to whole was 41.66 per cent (Table Ⅰ & Ⅶ). 3) In in-patients, hysteria revealed relatively large in percentage as 11.8% than the other groups (Table Ⅰ). 4) The rate of the male hysteria patients to all male patients was 3.5 per cent and the rate of female hysteria was 20.5 per cent (Table Ⅱ). 5) In in-patients, all the patients of general paresis and alcoholism were only males in sex(Table Ⅱ). 6) In in-patients of schizophrenia, the ratio of the male patients to the female patients was 57.0 : 43.0, but the each rate of each total numbers of the all diseases of the both sexes was almost same (Table Ⅲ). 7) The largest age group of the all patients was between 21∼30 years old, and the next was between 31∼40 years in in-patients (Table Ⅲ). 8) The largest age group of schizophrenia patients was between 21∼30 years and that of M.D.R patients was between 31∼40 years in in-patients (Table Ⅲ). 9) In in-patients of hysteria, the largest age group was between 31∼40 years, and the next was between 21∼30 years (Table Ⅲ). 10) The results of treatment in in-patients were as followings; Recovered; 27.6% Much improved; 43.1% Slightly improved and no changed; 28.2% (Table Ⅳ) 11) The results of treatment in schizophrenia of the in-patients were as followings; Recovered; 19.1% Much improved; 48.3% Slightly improved and no changed; 32.1% (Table Ⅴ) 12) The mode of treatment had been somewhat changed during last 8 years from 1960 to 1967 in treatment of the in-patients (Table Ⅵ). (1) The combined therapy of tranquilizers and EST had been increased, but the therapy of tranquilizer alone or EST alone had been decreased, compared to 1960. (2) The therapy of ICT in the treatment of in-patients had been much decreased.

대학생의 여가활동에 관한 연구

이규동,오현환 建國大學校 敎育硏究所 1993 論文集 Vol.17 No.-

The purpose of this study was to observe and analyze the recreational activities of the college students in terms of finding some possible ways to lead them into a sound, positive living mode. For this purpose, a total of 300 college students - 150 male and 150 female evenly- were given the questionnaire on which how to spend their leisure time was asked. The result is as follows : 1) According to the feedback, most collegian have the leisure times from 3 to 5 hours a day. 2) In a time-free from school classes, the 10% of them is engaged in some physical activities, which consists of the 3% for soccer, the 1.7% for pingpong and tennis, the 1.3% for basketball, and the 1% baseball. 3) The 14.3 precent of the total numbers spends their leisure times after all the classes are over in some physical activities. The 3.7% of the given percentage are playing tennis, the 2.7% playing soccer, the 2.3% going to health club, and the 2% pingpong. 4) A 17% of the percentage consists of those who are devoted to some physical activities for the recreation of the holidays and the weekends. Of the 17%, a 3.7% climbs mountain, a 3.3% is engaged in playing tennis, 2% in pingpong and health club, 1.7% in rope-skipping, and 1.7% in swimming. 5) Their attitudes toward the sport game in the leisure time were very serious to a degree of fighting to the last. 6) Most students tend to avoid having their physical activities early in the morning : therefore, it is necessary to encourage them to do physical activities in the morning. 7) Most of those who don't make use of their leisure time for doing something physical tend to spend their time in their home watching some sport game on T. V. rather than directly going to playing ground to see it because a number of broadcasting T. V. stations hookup a number of sport games.

작업환경측정이 작업환경개선에 미치는 효과

함정오,안규동,황규윤,이병국,이성수,정두신 가톨릭대학산업의학센타 산업의학연구소 1992 韓國의 産業醫學 Vol.31 No.3

To investigate the effect of environmental measurement on the improvement of working condition in small and medium sized industries and to evaluate the usefulness of this measurement which is covered by Occupational Safety and Health Act for the protection of workers from hazardous working condition, authors selected 107 small and medium sized manufacturing industries mainly from Chunan area and partly from lead using industries which were in special contract of agent specific occupational health service with Institute of Industrial Medicine, Soonchunhyang University. Environmental measurements were provided twice in interval of 6 months to study industries. At the end of second measurement questionnaires were collected to check the usefulness of this measurement for the workers and industries itself. The results obtained were as follows: 1. Out of 107 manufacturing industries, the most frequently measured index of harmful agent in environmental measurement was noise, and the next indices were dust, organic solvents and special chemicals in descending order. While the excess rates of measurement over Permissible Exposure Level(PEL) in the first measurement were 19.3% in noise, 22.8% in dust, 14.3% I organic solvents and 20.3% in special chemicals measurement, those in second measurement were 26.0% in noise, 14.7% in dust, 10.0% in organic solvents and 29.5% in special chemicals measurement, respectively. 2. The supply rate of protective equipment and the labeling condition of health and safety poster in the later period of study were improved than early period. 3. Most persons in charge of health and safety management(97.2%) had engaged in other administrative works and only 2.8% of study industries had independent occupational safety and health personnels who engaged only in health and safety of workers. 4. The purpose of environmental measurement answered by the eligible of persons each industries was to report at the regional office of labor affair. Only 7 out of 107 industries answered that their measurements were for the real improvement of working condition and 3 industries for the fulfilment of requirement of trade union. 5. While 86.0% in industries (92/107) felt the report of environmental measurement was helpful to set up protective equipment program to prevent workers from harmful condition, 66.4% in industries answered that it was useful for the establishment of health education program. The measurement of environmental conditions were also useful for the installation of ventilatory system of workplace, for the isolation of work process and for the improvement of work process. But 8.4% in industries answered that it was not useful at all.

복합레진의 표면거칠기에 따른 투명도와 표면 색상의 차이에 관한 연구

조규정,박수정,조현구,김동준,황윤찬,오원만,황인남 大韓齒科保存學會 2006 Restorative Dentistry & Endodontics Vol.31 No.4

본 연구는 복합레진의 표면 연마에 의한 표면 거칠기가 표면 색상과 투명도에 어떤 영향을 미치는가를 알아보고자 시행하였다. Charisma (Heraeus Kulzer GmbH, Domagen, Germany)의 B1과 A3, Esthet-X (DENTSPLY Caulk, Milford, USA)의 B1과 B3 레진으로 거칠기에 따른 표면 색상을 평가하기 위한 직경 8㎜, 두께 5㎜의 시편을 제작하고, Sof-Lex finishing & polishing system(3M, ESPE Dental Products. St. Paul USA)의 C, M, F, 및 SF 디스크로 시편의 한쪽 면을 연마하였으며, 연마 전 Mylar strip으로 압축된 면을 대조군으로 하였다. 거칠기에 따른 투명도의 차이를 평가하기 위한 두께 1 ㎜의 시편을 Charisma의 A3로 제작하여, 한쪽 면을 600, 1000, 1500 및 2000번 사포로 연마하였다. 각 시편의 연마 전과 후, 연마면의 CIE L^(*)a^(*)b^(*)값과 1 ㎜ 시편의 백색과 흑색 배경판 상에서의 Y값을 spectrophotometer인 Spectrolino (GretagMacbech, Regensdorf, Switzerland)를 사용해 측정 분석하였으며, 각 시편의 연마 전과 후의 평균 표면 조드 (Ra)값을 Surface Roughness Tester SJ-301 (Mytutoyo, Tokyo, Japan)로 측정했다. L^(*)값은 재료와 색상에 상관없이 가장 거친 Sof-lex C 디스크로 연마한 군에서 가장 높은 값을 보였으며 (p < 0.05). Esthet-X B3군을 제외한 모든 군에서 Ra값이 감소함에 따라 L^(*)값도 낮아졌다. a^(*)값은 표면 거칠기에 따라 특정한 변화 양상을 보이지 않았으며, b^(*)값은 Esthet-X B1군을 제외한 모든 군에서 Sof-lex SF 디스크로 연마 시 가장 높은 값을 보였으며 (p < 0.05), Charisma B1과 Esthet-X B3군에서 Ra값과 비교적 높은 상관 관계를 보였다. Contrast ratio는 1000번과 1500번 사포로 연마한 군간을 제외한 모든 군 간에 유의한 차이를 보여으며 (p < 0.05). 표면 거칠기가 감소함에 따라 contrast ratio도 감소하였다(R2 = 0.801). The objectives of this were to evaluate the effect of surface roughness on the surface color and translucency of the composite reins. Two composite resins (Esthet-X, Dentsply, Milford, USA and Charisma, Kulzer, Domagen, Germany) were used to investigate the surface color. Charisma was used to investigate the translucency. 40 disc samples (diameter: 8 ㎜, thickness: 5 ㎜) were made by each product to measure the surface color. Ploymerized each sample's one side was treated by Sof-Lex finishing and polishing system (Group C, M, F, SF). 40 disc samples (diameter: 6 ㎜, thickness: 1 ㎜) were prepared to measure the opacity. 1 ㎜ samples were ground one side with #600, #1000, #1500 and #2000 sandpapers. CIE L^(*)a^(*)b^(*) values of each 5 ㎜ thickness samples, and XYZ values of 1 ㎜ thickness samples on the white and black background were measured with spectrophotometer (Spectrolino, GretagMacbeth, Regensdorf, Switzerland). Mean surface roughness (Ra) of all samples before and after surface treatment was measured using the Surface Roughness Tester SJ-301 (Mytutoyo, Tokyo, Japan). Regardless of type and shade of the composite resin, L^(*) values measured in group C were higher than others (p < 0.05), and L^(*) value decreased as the Ra value decreased except B3 shade of Esthet-X. But there were no significant difference in a^(*) values among groups. In control group and SF, highest b^(*) values were measured (p < 0.05), except B1 shade of Esthet-X. Contrast ratio decreased as the Ra value decreased (p < 0.05). With the above results, difference of surface roughness has influence on surface color and translucency of dental composite resins. 〔J Kor Acad Cons Dent 31(4):312-322, 2006〕