http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Bioactivities of leaf and root extract of Ceriscoids turgida (Roxb.)
Md. Nazmul Hasan Zilani,Nazneen Ahmeda Sultana,Monjurul Kader Bakshi,Israt Jahan Shampa,Samia Jaman Sumi,Ohidul Islam 경희대학교 융합한의과학연구소 2018 Oriental Pharmacy and Experimental Medicine Vol.18 No.2
In traditional medicine leaf and root of Ceriscoides turgida (Roxb.) are commonly used to treat indigestion in child, leucorrhoea, dog bite, snake bite, scorpion string, epilepsy, stomachache and a number of ailments. The present study was carried out to investigate antioxidant, analgesic, antibacterial and cytotoxic activities of methanol extract of leaves and roots of C. turgida. Total flavonoids content was spectrophotometrically determined using aluminum chloride colorimetric assay while total phenolic and tannin content by Folin Chiocalteu’s reagent. Antioxidant activity was determined by DPPH free radical scavenging and reducing power assay. Analgesic activity was assessed by acetic acid induced writhing method. Antibacterial activity was evaluated by disc diffusion assay while brine shrimp lethality bioassay was carried out to verify the cytotoxic potential. Root extract contains greater amount of total phenolic (79.99 mg GAE/g dry extract) and flavonids content (35.27 mg QE/g dry extract) in comparison to leaf extract (30.75 mg GAE/g and 25.93 mg QE/g dry extract respectively). Root extracts showed DPPH scavenging (157.45 μg/mL) that was comparable to standard ascorbic acid (14.15 μg/mL). Reducing power of root extract was prominent than leaf extract in comparison to ascorbic acid. Both extract showed significant (P < 0.01) analgesic activity. In disc diffusion assay leaf extract showed greater antibacterial activity than root extract. Furthermore, extracts showed moderate cytotoxic effect. The present study demonstrates that methanol extract of C. turgida leaf and root has significant antioxidant and analgesic effect. The extracts also showed moderate antibacterial and cytotoxic activities.
Antibody-mediated oral GLP-1 gene delivery to treat type 2 diabetes
( Mohammad Nazmul Hasan ),김다혜,이지훈,황주나,조성필,이용규 한국공업화학회 2019 한국공업화학회 연구논문 초록집 Vol.2019 No.1
Diabetes mellitus is a global epidemic associated with uncontrolled elevation of blood glucose levels. GLP-1 prevents type 2 diabetic patients from experiencing hyperglycemic episodes without concern of unexpected hypoglycemic situation from conventional insulin treatment. However, the short half-life and rapid clearance of GLP-1 often limit its therapeutic use. Here we developed an oral GLP-1 gene delivery system to extend the antidiabetic effect of GLP-1. A nanocomplex for oral GLP-1 gene delivery has consisted of GLP-1 gene and vehicle with protamine and hIgG-Fc, an Fc segment from an FcRn receptor-specific antibody. The nanocomplex showed superior stability against pH fluctuation and enzymatic digestion in the gastrointestinal tract, and high cellular uptake to the intestinal cells. The functional expression of GLP-1 also led to the extended antidiabetic effect of GLP-1 in type 2 diabetic mice, suggesting a promise for the treatment of type 2 diabetes mellitus.
Chemical characterization and bioactivity of Trichosanthes dioica edible shoot extract
Md. Nazmul Hasan Zilani,Shaikh Jamal Uddin,Hemayet Hossain,Hazrina Hazni,Jamil A. Shilpi,Md. Golam Hossain 경희대학교 융합한의과학연구소 2018 Oriental Pharmacy and Experimental Medicine Vol.18 No.2
Present investigation was aimed to evaluate the traditional use of edible part of soft shoots of Trichosanthes dioica Roxb. (Cucurbitaceae) as an antidiabetic in mice model. In addition, antioxidant activity and chemical profiling of this plant part were also performed to support its observed activity. The extract was subjected to oral glucose tolerance test in normal and alloxan induced diabetic mice to explore its antihyperglycemic activity. Antioxidant capacity was analyzed by a number of in vitro assays. Quantification of bioactive polyphenols was done by HPLC. Liquid Chromatography coupled with Mass Spectrometry (LCMS) was used to identify chemical constituents present in the extract. Total polyphenol and flavonoids content were found in significant quantity. In DPPH radical scavenging assay the IC50 value of the extract was found to be 148.62 µg/mL. Reducing power of the extract was comparable with that of butylatedhydroxytoluene (BHT). HPLC analysis indicated that quercetin, rutin, p-coumaric acid and kaempferol were the major bioactive polyphenols present in the extract. Further chemical profiling using LCMS analysis was identified a total of nine compounds with different chemical classes. In OGTT, extract (400 mg/kg BW) showed a 31.13% decrease (p < 0.05) in blood glucose levels at 30 min compared to the normal control. In alloxan induced diabetic mice the extract at the doses of 200 mg and 400 mg/kg, showed significant decrease (p < 0.05) of blood glucose level compared to diabetic control. The extract showed oral glucose tolerance potential and antioxidant capacity which might be due to the presence of different compounds such as quercetin, rutin, kaempferol, oleanolic acid, β-sitosterol. The results support the scientific basis of it ethnobotanical uses in traditional medicinal practices of Bangladesh.
Khan, Nazmul Abedin,Hasan, Zubair,Jhung, Sung Hwa Elsevier 2018 Coordination Chemistry Reviews Vol.376 No.-
<P><B>Abstract</B></P> <P>Metal–organic frameworks (MOFs) have been fascinating because of their crystalline structures, permanent porosities, large surface areas, and potential applications. Moreover, the composition, pore architecture, morphology/size, and functionality of MOFs can be further tuned to enhance their efficiency in particular applications. Apparently, the modification of MOFs, including the formation of nanostructured and nanosized MOFs, has attracted intense interest in current MOF-related research and therefore widens their applicability in various research areas. In this review, the preparation of MOFs with various nanostructured features (such as hierarchical/hollow pore architectures and defected structure), together with MOF-based composites, analogous MOFs and nanosized MOFs, will be discussed systematically. Potential applications of such MOF-related materials, especially in adsorption/separation, catalysis, and drug delivery, will be addressed. Finally, some ideas on the possible future development of MOFs with various nanostructured features are suggested.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Nanostructured, nanosized and analogous metal-organic frameworks were reviewed. </LI> <LI> Core-shell, composite, hierarchical/hollow and defected MOFs were also discussed. </LI> <LI> Preparation of such various-structured, nano-sized and analogous MOFs was dealt. </LI> <LI> Possible applications in adsorption, catalysis, and drug delivery were summarized. </LI> <LI> Ideas for possible future development in “beyond pristine MOFs” are suggested. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Arifur Rahman,Nazmul Hasan Naheed,Sabreena Chowdhury Raka,Nazmul Qais,AZM Ruhul Momen 경희대학교 융합한의과학연구소 2020 Oriental Pharmacy and Experimental Medicine Vol.20 No.4
Inhibition of BCR–ABL tyrosine kinase plays a crucial role in the management of chronic myelogenous leukemia (CML). The suppression of CML is getting harder because of a distinct pattern of resistance. Developing new types of ABL tyrosine kinase inhibitors along with ABL2, CSF1R, KIT, LCK, PDGFRA, and PDGFRB inhibitors is the main objective of this study that may overcome the drug resistance issue. The current study has been conducted using a kinase database containing 177,000 bioactive molecules, the top 135 molecules were selected with the best docking score and subjected to comprehensive ADMET profiling, multi-target analysis. Based on consensus molecular docking score (AutoDock, Chimera, Achilles, and Mcule), 22 molecules have been screened out which later undertaken for ADME/T profiling. After profiling of ADME/T data, selected molecules subjected to docking with multiple targets. Finally, molecular dynamics simulations had performed to screen the binding accuracy of the four lead molecules with ABL1. MD simulations of the desired complex (ABL1, ABL2, CSF1R, KIT, LCK, PDGFRA, and PDGFRB, among them ABL1 was the prime target) performed and found that PCID 10181160 and PCID 72724706 are the most promising inhibitors comparing to imatinib. These lead molecules are the potential CML inhibitors that could resolve the resistance pattern. Further chemical synthesis, wet lab analysis, and experimental validation deserve the utmost attention.
Park, Eun Young,Hasan, Zubair,Khan, Nazmul Abedin,Jhung, Sung Hwa American Scientific Publishers 2013 Journal of Nanoscience and Nanotechnology Vol.13 No.4
<P>Adsorptive removal of bisphenol-A (BPA) using a MOF, Cr-benzenedicarboxylate (MIL-53), has been studied to understand the applicability of MOFs for the removal of hazardous endocrine disturbing chemicals from water. MIL-53 shows very fast adsorption in an hour and the adsorption capacity of MIL-53 is higher than that of activated carbon. Importantly, the adsorption of BPA over MIL-53 is very favorable especially at very low concentrations of BPA. Therefore, MOFs such as MIL-53 can be one of adsorbents that may be used in the adsorptive removal of BPA from contaminated water.</P>