A Study of covert narcissism, self-control of willingness, and stress of clinical practice of nursing students and factors associated with stress of clinical practice

Narae Heo 한국간호과학회 2019 한국간호과학회 학술대회 Vol.2019 No.10

탈북 간호대학생의 학업에 대한 현상학적 연구:

허나래(Heo, Narae),김지영(Kim, Jiyoung) 학습자중심교과교육학회 2016 학습자중심교과교육연구 Vol.16 No.4

임상실습은 환자에게 전인간호를 수행하기 위한 핵심역량을 함양시키는 가장 중요한 간호교육 과정이다. 현재, 국내에서는 다양한 사회문화적 배경을 가진 학생들 이 간호대학에 진학하는 수가 증가하였으며, 탈북 간호대학생들도 이에 해당된다. 증가하는 진학률과 더불어 탈북학생들의 학업적응에 대한 문제가 이슈화 되고 있다. 이에 탈북 간호대학생의 임상실습 과정에서 경험하는 실제적 본질과 의미를 파악하기 위해 현상학적 연구방법을 적용하여 연구를 진행하였다. 연구 참여자는 S시 4개 대학교의 탈북 간호대학생 9명이었고, 자료수집 기간은 2014년 12월부터 2015년 6월 까지였다. 수집된 자료는 Colaizzi(1978)의 현상학적 분석방법과 절차에 따라 분석하였으며, 연구결과는 다음과 같다. 탈북 간호대학생의 임상실습 경험은 ‘언어의 장벽에 가로막힘’, ‘대인관계 문제에 봉착함’, ‘임상실습을 통해 자신을 고찰함’, ‘간호에 대한 인식을 형성해감’, ‘스스로 진로를 준비하는 계기가 됨’이라는 5개의 주제모음이 도출되었다. 탈북학생들이 임상실습에서의 경험을 파악하는 것은 다양한 교육전략을 계획하고 적용하는데 앞서, 학업상황을 이해하는데 의의가 있다고 사료된다. 이러한 결과는 학습자들을 전문 간호사 성장시키기 위한 전문 교과 과정 및 프로그램을 개발 하는데 있어 중요한 기초 자료가 될 것이다. The purpose of this research was to explore the clinical practicum experience of undergraduate nursing students who have defected from North Korea. Individual in-depth interviews were performed on eight third- and fourth-year nursing students who had defected from North Korea and participated in clinical practicum. The data were collected from December 2014 to April 2015 and analyzed using hermeneutics phenomenological method by Colazzi. Five essential themes were extracts that were as follows 1) Came across language barrier 2) Encounter trouble of interpersonal relationships 3) Self-reflection in nursing practicum 4) Stepping forward to become a professional nurse 5) Opportunity to prepare for their working This results can contribute to an understanding of at clinical practicum experience of undergraduate nursing students who have defected from North Korea. In addition, this research will provide foundational data in establishing education strategies at clinical setting to promote the students’ nursing competency, helping them apply in the field theoretical knowledge and nursing skill learned at clinical education while also developing clinical competency.

유방암 생존자의 자가관리 지지 경험

허석모(Heo, Seok-Mo),허나래(Heo, Narae) 한국성인간호학회 2016 성인간호학회지 Vol.28 No.4

여대생의 자아존중감에 미치는 영향

허나래(Narae Heo) 한국산학기술학회 2018 한국산학기술학회논문지 Vol.19 No.6

본 연구는 외모스트레스, 알코올 섭취량, 이상섭식태도가 여대생의 자아존중감에 미치는 영향을 파악하는데 목적이 있다. 본 연구의 총 참여자는 여대생 150명으로 2017년 3월부터 2017년 7월까지 설문조사를 시행하였다. 수집된 자료는 IBM SPSS Statistics 22.0을 이용하여 위계적 회귀 방법으로 분석하였다. 대상자의 외모스트레스 평균은 2.65점, 알코올 섭취 문제 평균은 9.6점, 이상섭식태도 평균은 2.24점, 자아존중감 평균은 29.77점으로 나타났다. 대상자의 자아존중감의 영향요인은 대학생활만족(β=-.226, p=.026)과 외모스트레스(β=-.318, p<.001)로 나타났으며 변수의 설명력은 11%였다. 본 연구결과를 통해 대학생활과 외모스트레스는 성격적 차원의 핵심요소인 자아존중감에 중요하게 작용하는 것을 확인할 수 있었다. 따라서, 여대생들이 직면하는 다양한 대학생활 환경을 객관적인 관점에서 인지하고 직면한 환경과 개인 상황과의 차이를 조절하여 자기 자신을 긍정적으로 바라 볼 수 있도록 실질적인 외적 자원이 학 · 내외적으로 제공되어야 할 필요가 있다. 또한, 외모스트레스 상황에서 유연하게 대처할 수 있는 긍정적인 자기내면화 모색, 건강한 자아상 형성, 감정 조절을 위한 성격자원을 활성화시키기 위한 완충자원을 제공하여 여대생들의 자아존종감을 향상시켜야 할 것으로 사료된다. This study was conducted to investigate the effects of appearance stress, alcohol intake, and eating attitude on self-esteem of female undergraduate students. Participants were 150 female undergraduate students who responded to a survey conducted from March to July of 2017. Data collected were analyzed by stepwise multiple regression analysis using an IBM SPSS 23.0. The influencing factors of self-esteem were satisfaction with college life and appearance stress, and the power of the variables was 11%. The results verified that college life and appearance stress were important factors influencing self-esteem, a critical element in the personality dimension that assesses self-affirmation. Therefore, self-esteem should be improved by providing a buffer to revitalize character resources for positive self-internalization, the formation of a healthy self-image and affect regulation which can enable one to flexibly cope with situations of appearance stress. Also, external resources should be provided inside and outside of school to help university students become cognizant of an objective perspective of the various environments of college life they face, as well as to have a positive view of themselves in college life by regulating the differences between the environments they face and their individual circumstances.

유방암 생존자들의 자가관리에 대한 현상학적 연구

허석모(Seok-Mo Heo),허나래(Narae Heo) 한국산학기술학회 2016 한국산학기술학회논문지 Vol.17 No.12

본 연구는 현상학적 방법을 적용하여 유방암 생존자들의 비약물적 추후 관리 경험에 대한 본질적 구조와 의미에 대해 심도 있게 파악하는 것을 목적으로 한다. 이번 연구에서 총 참여자는 10명으로 S시 E병원 외래에 정기적으로 내원하는 유방암 생존자로 수술, 화학요법, 방사선요법을 완료한 자들이었다. 자료수집 기간은 2014년 8월부터 2015년 2월까지로 수집된 자료는 심층면담 후 Colaizzi의 방법 적용하여 분석하였다. 연구결과, 7개의 주제와 16개의 하위범주가 도출되었다. 7개의 주제는 ‘1. 증상을 완화하기 위해 용이한 방법을 적용함, 2. 변화된 신체 상태를 위해 움직이려 함, 3. 재발 방지를 위해 특정식용 작물을 섭취함, 4. 건강을 유지하기 위한 식생활 양식이 있음, 5. 보완대체요법에 대해 항상 예의주시함, 6. 주치의 처방외 필요한 치료가 있음, 7. 자연친화적인 환경에서의 삶을 지향함’ 이었다. 이번 연구는 유방암 생존자들이 치료 후에 일상생활에서 어떻게 추후관리를 하는지 심도있게 파악하는 데 도움을 줄 것이다. 나아가 본 결과는 향후 유방암 생존자들에게 실제 관리 양식에 근거한 실행 가능한 지침과 프로그램을 제공하는데 있어 기초자료로써 제공될 것이다. The purpose of this study was to understand the essential structure and meaning of self-management intervention for breast cancer survivors by using non-pharmacological approaches. The study participants were 10 breast cancer survivors who were completing cancer treatment that involved surgery, chemotherapy, and radiation therapy. Data collected between August 2014 and February 2015 at E Hospital in S city were analyzed by using Colaizzi"s phenomenological method. Outcomes were classified into seven essential themes: 1) application of comfort measures to alleviate ongoing symptoms, 2) movement to change physical conditions, 3) special herbal intake to prevent recurrence, 4) a specially designed diet plan for health self-management, 5) constant awareness of complementary and alternative medicine, 6) unmet needs treated by one"s own doctor"s prescription, and 7) future life toward a nature-friendly environment. The study results contribute to a deeper understanding of self-management interventions in the daily lives of Korean breast cancer survivors. In addition, results provide an essential resource, based on actual self-management styles, that will help survivors to obtain guidance and participate in appropriate programs.

유방암 환자의 디스트레스가 피로에 미치는 영향: 삶의 질 매개 효과를 중심으로

허석모(Seok-Mo Heo),허나래(Narae Heo) 한국산학기술학회 2021 한국산학기술학회논문지 Vol.22 No.9

본 연구는 유방암 환자의 디스트레스가 피로에 미치는 영향을 확인 후, 디스트레스와 피로의 관계에서 삶의 질의 매개 효과를 파악하고자 하였다. 서울시에 있는 상급종합병원 1곳에 내원한 유방암 환자를 대상으로 하였으며, 2014년 2월부터 2014년 12월까지 디스트레스, 삶의 질, 피로에 관련된 문항에 응답한 자료 110부를 분석에 사용하였다. IBM SPSS statistics 26 프로그램을 사용하여 서술통계, t-test, ANOVA, Pearson 상관관계, 위계적 회귀분석을 적용하였고, Sobel test로 삶의 질 매개 효과를 검증하였다. 삶의 질은 디스트레스(r=-.41, p <.001)와 피로(r=-.61, p <.001)와 통계적으로 각각 유의한 음의 상관관계가 있었으며, 디스트레스와 피로는 유의한 양의 상관관계(r=.53, p <.001)가 있었다. 피로에 대한 디스트레스의 직접적인 영향은 유의미했으며(β= -.337, p <.001), 삶의 질을 통한 피로에 대한 디스트레스의 간접적인 영향이 유의미했다(Sobel test: Z=3.743, p <.001). 분석 결과, 디스트레스가 피로에 미치는 영향에 있어 삶의 질이 부분 매개 효과가 있음을 확인하였다. 따라서, 유방암 환자의 디스트레스가 피로에 미치는 영향을 감소시키기 위해서, 디스트레스의 원인을 확인하고 근거기반의 심리적 지원과 삶의 질을 향상을 위한 맞춤형 지지 프로그램을 개발하여 간호 중재에 적용할 필요가 있다. The purpose of this study was to identify the mediating effect of quality of life on the impact of distress on fatigue. The subjects in this study were breast cancer patients who visited a general hospital in Seoul, and 110 of data responding to questionnaires related to distress, quality of life and fatigue were used for the analysis. Descriptive statistics, t-test, analysis of variance (ANOVA) , Pearson correlation and hierarchical regression were applied using the SPSS WIN 26 program, and the quality of life mediating effect was verified with the Sobel test. Quality of life had a significant negative correlation with distress (r=-.41, p <.001) and fatigue (r=-.61, p <.001), respectively, but distress and fatigue showed a significant positive correlation (r=.53, p <.001). The direct effect of distress on fatigue was significant (β=-.337, p <.001), and the indirect effect of distress on fatigue through the quality of life was also significant (Sobel test: Z=3.743, p <.001). It was confirmed that the quality of life had a partial mediating effect on the influence of distress on fatigue. In order to reduce the effect of distress on fatigue in breast cancer patients, it is necessary to identify the causes of distress. A personalized support program should be developed, which can improve the patient’s evidence-based psychological support and quality of life for applying nursing interventions.

Effect of peanut shell extract supplementation on the growth performance, carcass characteristics and meat quality of broilers

Narae Han,Byong Won Lee,Jung Min Heo,Samooel Jung,Mihyang Kim,Jin Young Lee,Yu-Yong Lee,Moon Seok Kang,Hyun-Joo Kim 충남대학교 농업과학연구소 2022 Korean Journal of Agricultural Science Vol.49 No.3

Sex-Based Differences in Outcomes of Coronavirus Disease 2019 (COVID-19) in Korea

김지영,Heo Narae,강현철 한국간호과학회 2022 Asian Nursing Research Vol.16 No.4

Purpose: This study examined the factors affecting mortality and clinical severity score (CSS) of male and female patients with Coronavirus Disease 2019 (COVID-19) using clinical epidemiological information provided by the Korea Disease Control and Prevention Agency. Methods: This is a retrospective, observational cohort study. From January 21 to April 30, 2020, a total of 5624 patients who were released from quarantine or died were analyzed. Results: The factors influencing release or death that differed by sex were high heart rate and malignancy in males and chronic kidney disease in females. In addition, the factors influencing progression to severe CSS were high BMI (severe obesity) and rheumatic disease in males and high temperature, sputum production, absence of sore throat and headache, chronic kidney disease, malignancy, and chronic liver disease in females. Older age, low lymphocyte count and platelets, dyspnea, diabetes mellitus, dementia, and intensive care unit (ICU) admission affected mortality in all the patients, and older age, low lymphocyte count and platelets, fever, dyspnea, diabetes mellitus, dementia, and ICU admission affected progression to severe stage of CSS. Conclusions: This study is expected to contribute to the general results by analyzing nationally representative data. The results of this study present an important basis for development of differentiated nursing and medical management strategies in consideration of factors that influence treatment effects and outcomes according to sex of patients with COVID-19.

Low binding affinity and reduced complement-dependent cell death efficacy of ofatumumab produced using a plant system (<i>Nicotiana benthamiana</i> L.)

Jin, Narae,Lee, Jin Won,Heo, Woon,Ryu, Moon Young,So, Min Kyung,Ko, Byoung Joon,Kim, Hye-Yeon,Yoon, Sei Mee,Lee, Jinu,Kim, Joo Young,Kim, Woo Taek Elsevier 2019 Protein expression and purification Vol.159 No.-

<P><B>Abstract</B></P> <P>The plant protein production system is a platform that can not only reduce production costs but also produce monoclonal antibodies that do not have the risk of residual proteins from the host. However, due to the difference between post-translational processes in plants and animals, there may be a modification in the Fab region of the monoclonal antibody produced in the plant; thus, it is necessary to compare the antigen affinity of this antibody with that of the prototype. In this study, ofatumumab, a fully human anti-CD20 IgG1κ monoclonal antibody used for its non-cross resistance to rituximab, was expressed in <I>Nicotiana benthamiana</I>, and its affinities and efficacies were compared with those of native ofatumumab produced from CHO cells. Two forms of plant ofatumumab (with or without HDEL-tag) were generated and their production yields were compared. The HDEL-tagged ofatumumab was more expressed in plants than the form without HDEL-tag. The specificity of the target recognition of plant-derived ofatumumab was confirmed by mCherry-CD20-expressing HEK cells via immuno-staining, and the capping of CD20 after ofatumumab binding was also confirmed using Ramos B cells. In the functional equivalence tests, the binding affinities and complement-dependent cell cytotoxicity efficacy of plant-ofatumumab-HDEL and plant-ofatumumab without HDEL were significantly reduced compared to those of CHO-derived ofatumumab. Therefore, we suggest that although ofatumumab is not a good candidate as a template for plant-derived monoclonal antibodies because of its decreased affinity when produced in plants, it is an interesting target to study the differences between post-translational modifications in mammals and plants.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Ofatumumab, a fully human anti-CD20 IgG1κ monoclonal antibody, was successfully expressed in <I>Nicotiana benthamiana</I> leaves. </LI> <LI> The HDEL-tagged ofatumumab was more expressed in plants than the form without HDEL tag. </LI> <LI> Both plant-ofatumumabs retained the antigen binding specificities. </LI> <LI> Both plant-ofatumumabs showed reduced binding affinities to the target and reduced Complement dependent cell death efficacies than CHO cell expressed ofatumumab. </LI> </UL> </P>

Comprehensive Evaluation of the NeoBase 2 Non-derivatized MSMS Assay and Exploration of Analytes With Significantly Different Concentrations Between Term and Preterm Neonates

Lee Beomki,Heo Won Young,Kim Jee Ah,Lee Hyun-Seung,Hwang Narae,Park Hyung-Doo,Sung Se In,Chang Yun Sil,Park Won Soon,Lee Soo-Youn 대한진단검사의학회 2023 Annals of Laboratory Medicine Vol.43 No.2

Background: Despite the popularity of the NeoBase 2 Non-derivatized MSMS assay (PerkinElmer, Turku, Finland), there are no reports of its comprehensive evaluation, including the ability to distinguish transient tyrosinemia of the newborn (TTN) from tyrosinemia type 1 (TYR 1) using succinylacetone (SUAC). No newborn screening (NBS) cutoffs for preterm neonates in the Korean population have been suggested. We evaluated the NeoBase 2 assay and identified analytes requiring different cutoffs in preterm neonates. Methods: Residual NBS dried blood spot samples and proficiency testing (PT) materials of the Newborn Screening Quality Assurance Program and the Korean Association of External Quality Assessment Service were used. Precision, accuracy, limit of detection (LOD), lower limit of quantification (LLOQ), linearity, recovery, carryover, and performance of SUAC were evaluated. Cutoffs were determined, and analytes requiring different cutoffs in preterm neonates were investigated. Results: Mean CVs for within-run and between-day precision were within 15%. Accuracy analysis indicated high agreement with in-house derivatized assay results and results of other PT participants. All analytes demonstrated acceptable LOD, LLOQ, and linearity. Recoveries were acceptable, except for SUAC. Carryover was negligible. Cutoffs were established for all analytes; Tyr, adenosine, and C20:0-lysophosphatidylcholine required different cutoffs in preterm neonates. Differential diagnosis of TYR 1 and TTN was successful with simultaneous Tyr and SUAC measurement. Conclusions: The NeoBase 2 assay demonstrated satisfactory performance. The additional analytes provide a wider diagnostic coverage, and the simultaneous measurement of Tyr and SUAC is efficient in excluding TYR 1. The new cutoffs for preterm neonates may decrease false-positive rates, without compromising diagnostic sensitivity.