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( Jiaofen Nan ),( Liangliang Zhang ),( Qiqiang Chen ),( Nannan Zong ),( Peiyong Zhang ),( Xing Ji ),( Shaohui Ma ),( Yuchen Zhang ),( Wei Huang ),( Zhongzhou Du ),( Yongquan Xia ),( Ming Zhang ) 대한소화기기능성질환·운동학회(구 대한소화관운동학회) 2018 Journal of Neurogastroenterology and Motility (JNM Vol.24 No.1
Background/Aims The Rome III criteria separated chronic constipation into functional constipation (FC) and constipation-predominant irritable bowel syndrome (IBS-C), but some researchers questioned the partitioning and treated both as distinct parts of a continuum. The study aims to explore the similarity and diversity of brain white matter between FC and IBS-C. Methods The voxel-wise analysis of the diffusion parameters was used to quantify the white matter changes of female brains in 18 FC patients and 20 IBS-C patients compared with a comparison group with 19 healthy controls by tract-based spatial statistics. The correlations between diffusive parameters and clinical symptoms were evaluated using a Pearson’s correlation. Results In comparison to healthy controls, FC patients showed a decrease of fractional anisotropy (FA) and an increase of radial diffusivity (RD) in multiple major fibers encompassing the corpus callosum (CC, P = 0.001 at peak), external capsule (P = 0.002 at peak), corona radiata (CR, P = 0.001 at peak), and superior longitudinal fasciculus (SLF, P = 0.002 at peak). In contrast, IBS-C patients showed FA and RD aberrations in the CC (P = 0.048 at peak). Moreover, the direct comparison between FC and IBS-C showed only RD differences in the CR and SLF. In addition, FA and RD in the CC were significantly associated with abdominal pain for all patients, whereas FA in CR (P = 0.016) and SLF (P = 0.040) were significantly associated with the length of time per attempt and incomplete evacuation separately for FC patients. Conclusion These results may improve our understanding of the pathophysiological mechanisms underlying different types of constipation. (J Neurogastroenterol Motil 2018;24:107-118)
Application assessments of concrete piezoelectric smart module in civil engineering
Nan Zhang,Huaizhi Su 국제구조공학회 2017 Smart Structures and Systems, An International Jou Vol.19 No.5
Traditional structural dynamic analysis and Structural Health Monitoring (SHM) of large scale concrete civil structures rely on manufactured embedding transducers to obtain structural dynamic properties. However, the embedding of manufactured transducers is very expensive and low efficiency for signal acquisition. In dynamic structural analysis and SHM areas, piezoelectric transducers are more and more popular due to the advantages like quick response, low cost and adaptability to different sizes. In this paper, the applicable feasibility assessment of the designed \"artificial\" piezoelectric transducers called Concrete Piezoelectric Smart Module (CPSM) in dynamic structural analysis is performed via three major experiments. Experimental Modal Analysis (EMA) based on Ibrahim Time Domain (ITD) Method is applied to experimentally extract modal parameters. Numerical modal analysis by finite element method (FEM) modeling is also performed for comparison. First ten order modal parameters are identified by EMA using CPSMs, PCBs and FEM modeling. Comparisons are made between CPSMs and PCBs, between FEM and CPSMs extracted modal parameters. Results show that Power Spectral Density by CPSMs and PCBs are similar, CPSMs acquired signal amplitudes can be used to predict concrete compressive strength. Modal parameter (natural frequencies) identified from CPSMs acquired signal and PCBs acquired signal are different in a very small range (~3%), and extracted natural frequencies from CPSMs acquired signal and FEM results are in an allowable small range (~5%) as well. Therefore, CPSMs are applicable for signal acquisition of dynamic responses and can be used in dynamic modal analysis, structural health monitoring and related areas.
Mode Analysis of Cascaded Four-Conductor Lines Using Extended Mixed-Mode S-Parameters
Nan Zhang,Wansoo Nah 한국전자파학회JEES 2016 Journal of Electromagnetic Engineering and Science Vol.16 No.1
In this paper, based on the mode analysis of four-conductor lines, the extended mixed-mode chain-parameters and S-parameters of fourconductor lines are estimated using current division factors. The extended mixed-mode chain-parameters of cascaded four-conductor lines are then obtained with mode conversion. And, the extended mixed-mode S -parameters of cascaded four-conductor lines can be predicted from the transformation of the extended chain-parameters. Compared to the extended mixed-mode S-parameters of fourconductor lines, the cross-mode S-parameters are induced in the extended mixed-mode S -parameters of cascaded four-conductor lines, due to the imbalanced current division factors of cascaded two sections. The generated cross-mode S-parameters make the equivalent different- and common-mode conductors not independent from each other again. In addition, a new mode conversion, which applies the imbalanced current division factors, between the extended mixed-mode S-parameters and standard S-parameters is also proposed in this paper. Finally, the validity of the proposed extended mixed-mode S-parameters and mode conversion is confirmed by a comparison of the simulated and estimated results of shielded cable.
Zhang, Nan,Ge, Guanghui,Xia, He,Li, Xiaozhen Techno-Press 2015 Wind and Structures, An International Journal (WAS Vol.21 No.3
A method for analyzing the coupled wind-vehicle-bridge system is proposed that also considers the shielding effect of the bridge tower with triangular wind barriers. The static wind load and the buffeting wind load for both the bridge and the vehicle are included. The shielding effects of the bridge tower and the triangular wind barriers are incorporated by taking the surface integral of the wind load. The inter-history iteration is adopted to solve the vehicle-bridge dynamic equations with time-varying external loads. The results show that after installing the triangular wind barriers in the area of the bridge tower, the bridge response and the vehicle safety factors change slightly. The peak value of the train car body acceleration is significantly reduced when the wind barrier size is increased.
Nan Shi,Hongwei Xu,Kaiyuan Guo,Chunyu Kang,Wei Zhang,Yingying Zhang,Liping Zhang,Jianxin Tan 한국화학공학회 2017 Korean Journal of Chemical Engineering Vol.34 No.8
Partitioning of microbial transglutaminase (MTG) from Amycolatopsis sp. in the polyethylene glycol (PEG)/salt-based ATPS was investigated for the first time. The key parameters such as the molecular weight of PEG (PEG 600-6000), the type and concentration of phase-forming salt (ammonium sulfate or phosphates), the pH of system (pH 5.0-8.5), and the concentration of neutral salt (0-6% NaCl, w/w) were determined. The partition coefficient of the enzyme was not linear with PEG molecular weight; PEG1000 gave better yield than others. The concentration of PEG1000, ammonium sulfate and NaCl, and the system pH showed effects with different extents on specific activity (SA) and yield of the enzyme. In the ATPS of 26% w/w PEG 1000 and 19% w/w ammonium sulfate in the presence of 5% w/w NaCl and at pH 6.0, MTG was partitioned into the PEG-rich phase with a maximum yield of 86.51% and SA was increased to 0.83. The results of SDS-PAGE showed the MTG produced by the test strain differed from the enzymes reported before. Thus, this study proves that ATPS can be used as a preliminary step for partial purification of MTG from Amycolatopsis sp. fermentation broth.
Optimizing DC Vaccination by Combination With Oncolytic Adenovirus Coexpressing IL-12 and GM-CSF
Zhang, Song-Nan,Choi, Il-Kyu,Huang, Jing-Hua,Yoo, Ji-Young,Choi, Kyung-Ju,Yun, Chae-Ok Nature Publishing Group 2011 MOLECULAR THERAPY Vol.19 No.8
<P>Dendritic cell (DC)-based vaccination is a promising strategy for cancer immunotherapy. However, clinical trials have indicated that immunosuppressive microenvironments induced by tumors profoundly suppress antitumor immunity and inhibit vaccine efficacy, resulting in insufficient reduction of tumor burdens. To overcome these obstacles and enhance the efficiency of DC vaccination, we generated interleukin (IL)-12- and granulocyte-macrophage colony-stimulating factor (GM-CSF)-coexpressing oncolytic adenovirus (Ad-ΔB7/IL12/GMCSF) as suitable therapeutic adjuvant to eliminate immune suppression and promote DC function. By treating tumors with Ad-ΔB7/IL12/GMCSF prior to DC vaccination, DCs elicited greater antitumor effects than in response to either treatment alone. DC migration to draining lymph nodes (DLNs) dramatically increased in mice treated with the combination therapy. This result was associated with upregulation of CC-chemokine ligand 21 (CCL21<SUP>+</SUP>) lymphatics in tumors treated with Ad-ΔB7/IL12/GMCSF. Moreover, the proportion of CD4<SUP>+</SUP>CD25<SUP>+</SUP> T-cells and vascular endothelial growth factor (VEGF) expression was decreased in mice treated with the combination therapy. Furthermore, combination therapy using immature DCs also showed effective antitumor effects when combined with Ad-ΔB7/IL12/GMCSF. The combination therapy had a remarkable therapeutic efficacy on large tumors. Taken together, oncolytic adenovirus coexpressing IL-12 and GM-CSF in combination with DC vaccination has synergistic antitumor effects and can act as a potent adjuvant for promoting and optimizing DC vaccination.</P>