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정낙은,최영석,이한영 大韓法醫學會 2000 대한법의학회지 Vol.24 No.2
Because the postmortem changes rapidly distort values of many constituents in the body fluids, the determination of postmortem chemical changes and relation among body fluids is very important in medicolegal community. A laboratory result is not useful if appropriate data for comparison are lacking. The aim of this paper is to determine the reference ranges and the postmortem changes for chemical constituents in postmortem specimen, We examined 17 clinical laboratory parameters in cadaveric blood and vitreous humor obtained from 51 autopsy cases. The mean, standard error, standard deviation and confidence interval of all measured constituents were shown in Table 2 & Figure 1. The postmortem blood level of amylase, phosporus, LDH, ALT, AST and CPK are very higher than those of antemortem blood. The postmortem vitreous level of total bilirubin, trglyceride, GGT, alkaline phosphatase, albumin total protein and cholesterol are very low and is not reliable. The ratio of vitreous/blood in calcium, BUN, creatine and uric acid are 0.74, 0.68, 0.29 and 0.23 in decreasing orders(Table 3,4). For the medical examiner or pathologist, routine chemical examinations of the vitreous humor can provide evidence of abnormality not apparent in gross or microscopic examination of the tissue. A more extensive study will be required, using a larger number of subjects, to establish the full range of variability.
정낙은,이한영,이원태 大韓法醫學會 1999 대한법의학회지 Vol.23 No.2
Background : The determination of postmortem chemical changes and rdlations among body fluids is very important in medicolegal community. Alaboratory result is not useful if appropriate data for comparison are lacking. We think that it is easy to collect specimens from cows and to evaluate the effect of factors which can be artificially controlled. The establishment of reference ranges of chemical constituents on body fluid in cows is the purpose of this study. Method : Studies were performed on 33 deceased cows at the slaugherhouse. Immediately after death, specimens were obtained from the cervial vein and both eyes. All speimens were centrifuged and the supernatants were removed and frozen at-70c until analyzed. The seven chemical contituents(total protein, glucose, creatinine, calcium, sodium and chloride and potassium) were measured, and the reference range were determined. Result : The mean, standard error, standard deviation and reference range of all measured constituents were shown in table 2,3. In comparison mean value of viterous humor with that of blood, the level of total protein was profoundly low(5%). Those of calcium(68%), glucose(40%), and creatinine(36%) were also low. The mean value of sodium showed the similar level(101%), but those of potassium(120%) and chloride(119%) were higher than in blood. Conclusion : The comparison of a locally produced, small set of values often is not appropriate because the underlying statistical assumption are not fulfulled and because of the unbalanced sample size. A more extensive study will be required, using a larger number of subjects, to establish the full range of viariablitily and the effects of factors such as temperature of the postmortem environment.
체외수정시술을 위한 과배란유도시 Nafarelin 과 Triptorelin 사용에 따른 임상성적의 비교
목정은,김낙연,김정훈,강병문,장윤석 울산대학교 의과대학 1996 울산의대학술지 Vol.5 No.1
Gonadotropin-releasing hormone agonists(GnRH-a) vary in structure and route of administration. We performed this study to compare patient response to intranasal nafarelin acetate versus subcutaneous triptorelin as adjuncts to ovulation induction for in vitro fertilization(IVF). From October 1995 to May 1996, sixty-four patients with tubal factor infertility entering their 79 cycles of IVF were randomized to receive either intranasal nafarelin acetate(Group Ⅰ, 38 cycles) or subcutaneous triptorelin(Group Ⅱ, 41 cycles). Controlled ovarian hyperstimulation(COH) using luteal long protocol of GnRH-a was used in all patients. Patient characteristics in the two groups did not differ significantly, nor did sperm parameters or endocrine profiles. There was no significant difference in ovarian response as indicated by duration of GnRH-a administration before ovarian stimulation, number of ampules of gonadotropin used and duration of gonadotropin administration in ovarian stimulation, and serum E( ) level and number of follicles(≥14mm) on the day of hCG administration between the two groups. There were no significant differences in clinical results of oocyte and embryo obtained such as number of oocytes retrieved, oocytes fertilized, embryos cleaved, embryos frozen, and embryos transfered between the two groups. There were also no significant differences between group Ⅰ and group Ⅱ in clinical pregnancy rate(31.6% versus 34.1%) and abortion rate per clinical pregnancy(8.3% versus 14.3%). This study suggests that intranasal nafarelin acetate as well as subcutaneous triptorelin can be used successfully in ovulation induction using luteal long protocol of GnRH-a.
권태정,정낙은 大韓法醫學會 2000 대한법의학회지 Vol.24 No.2
Pulmonary lymphangioleiomyomatosis is a rare disease which is defined as an abnormal proliferation of smooth muscles around lymphatics, venules, and bronchioles. The most frequent presenting complaint is dyspnea, either in conjuction with pneumothorax, chylothorax, or on exertion. Common extrapulmonary features are retroperitoneal adenopathy, tuberous sclerosis and renal angiomyolipomas. This case was a 34-year-old pregnant woman who died of pneumothorax. She had no past history of illness. At autopsy, both lungs showed honey-comb appearance, and was proven histopathologically pulmonary lymphangioleiomyomatosis. The proliferating smooth muscles were immunoreactive for alpha-smooth muscle actin and HMB-45. Multiple angiomyolipomas of left kidney coexisted. However, no stigmata of tuberous sclerosis was present. Pregnancy was thought to aggravate her clinical course.